Description : Which one of the following metabolites is not directly produced in the hexose monophosphate pathway? (A) Fructose-6-phosphate (B) Dihydroxy acetone phosphate (C) CO2 (D) Erythrose-4-phosphate
Last Answer : Answer : B
Description : Hemolytic anemia is caused by the deficiency of certain enzymes of the pentose phosphate pathway, the principal enzyme involved is (A) Glucose-6-phosphate dehydrogenase (B) Aldolase (C) Fructose 1, 6-bisphosphatase (D) Phosphohexose isomerase
Last Answer : Answer : A
Description : Pentose phosphate pathway is of significance because it generates (A) NADPH for reductive synthesis (B) Regenerates glucose 6-phosphate (C) Generates fructose 6-phosphate (D) Forms glyceraldehyde 3-phosphate
Description : The reaction catalysed by phosphofructokinase (A) Is activated by high concentrations of ATP and citrate (B) Uses fruitose-1-phosphate as substrate (C) Is the rate-limiting reaction of the glycolytic pathway (D) Is inhibited by fructose 2, 6-bisphosphate
Last Answer : C
Description : Which of the following is a substrate for aldolase activity in Glycolytic pathway? (A) Glyceraldehyde-3-p (B) Glucose-6-p (C) Fructose-6-p (D) Fructose1, 6-bisphosphate
Last Answer : D
Description : Which of the following regarding thromboxane A2 is true? C A. It degrades basement membranes B. It is produced via the lipoxygenase pathway C. It stimulates platelet aggregation D. None of these
Last Answer : It stimulates platelet aggregation
Description : .In developing plaque; the adhesive polymer produced by streptococcus mutans is synthesis from: A. Glucose B. Fructose C. Sucrose D. Lactose E. Amylose
Last Answer : C. Sucrose
Description : Which pathway is correct for catabolism of purines to form uric acid? (A) Guanylate→Adenylate→Xanthine→hypoxanthine→Uric acid (B) Guanylate→inosinate→Xanthine→hypoxanthine→Uric acid (C) Adenylate→Inosinate→Xanthine hypoxanthine→Uric acid (D) Adenylate→Inosinate→hypoxanthine Xanthine→Uric acid
Last Answer : Answer : D
Description : Cancer cells may become resistant to amethopterin by (A) Developing mechanisms to destroy amethopterin (B) Amplification of dihydrofolate reducatse gene (C) Mutation in the dihydrofolate reductase ... is no longer inhibited by amethopterin (D) Developing alternate pathway of thymidylate synthesis
Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Description : In the pathway of de novo synthesis of purine nucleotides, all the following are allosteric enzymes except (A) PRPP glutamyl amido transferase (B) Adenylosuccinate synthetase (C) IMP dehydrogenase (D) Adenylosuccinase
Description : In the synthetic pathway of epinephrine, disulfiram (antabuse) inhibits the enzyme: (A) Tyrosine hydroxylase (B) Dopamine β-hydroxylase (C) DOPA decarboxylase (D) N-methyl transferase
Description : Substrate-linked phosphorylation occurs in (A) Glycolytic pathway(B) Citric acid cycle (C) Both (A) and (B) (D) None of these
Last Answer : Answer : C
Description : In conversion of lactic acid to glucose, three reactions of glycolytic pathway are circumvented, which of the following enzymes do not participate? (A) Pyruvate carboxylase (B) Phosphoenol pyruvate carboxy kinase (C) Pyruvate kinase (D) Glucose-6-phosphatase
Description : Which one of the following statements is not characteristic of allosteric enzymes? (A) They frequently catalyze a committed step early in a metabolic pathway (B) They are often composed of subunits (C) They follow Michaelis-Menten kinetics (D) They frequently show cooperativity for substrate binding
Description : The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms
Description : Glycerol can enter glycolytic pathway via (A) Dihydroxyacetone phosphate (B) 1, 3-Biphospoglycerate (C) 3-Phosphoglycerate (D) 2-Phosphoglycerate
Description : Glycolytic pathway is located in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Nucleus
Description : An allosteric enzyme is generally inhibited by (A) Initial substrate of the pathway (B) Substrate analogues (C) Product of the reaction catalysed by allosteric enzyme (D) Product of the pathway
Description : The rate limiting reaction in the lipogenic pathway is (A) Acetyl-CoA carboxylase step (B) Ketoacyl synthase step (C) Ketoacyl reductase step (D) Hydratase step
Description : The main source of reducing equivalents (NADPH) for lipogenesis is (A) Pentose phosphate pathway (B) Citric acid cycle (C) Glycolysis (D) Glycogenolysis
Description : The main pathway for denovo synthesis of fatty acids occur in (A) Cytosol (B) Mitochondria (C) Microsomes (D) Nucleus
Description : In the pathway leading to biosynthesis of acetoacetate from acetyl-CoA in liver, the immediate precursor of aceotacetate is (A) Acetoacetyl-CoA (B) 3-Hydroxybutyryl-CoA (C) 3-Hydroxy-3-methyl-glutaryl-CoA (D) 3-Hydroxybutyrate
Description : ω-oxidation is normally a very minor pathway and is brought by hydroxylase enzymes involving (A) Cytochrome a (B) Cytochrome b (C) Cytochrome c (D) Cytochrome p-450
Description : For conjugation with many enogenous and exogenous substances before elimination in urine, the uronic acid pathway provides (A) Active glucuronate (B) Gulonate (C) Xylulose (D) Xylitol
Description : The pentose phosphate pathway protects erythrocytes against hemolysis by assisting the enzyme: (A) Superoxide dismutase (B) Catalase (C) Glutathionic peroxidase (D) Cytochrome oxidase ENZYMES 149
Description : The transketolase enzyme in the pentose phosphate pathway requires the B vitamin. (A) Pantothenic acid (B) Thiamin (C) Riboflavin (D) Nicotinic acid
Description : In pentose phosphate pathway, D-ribulose5-phosphate is converted to D-ribose-5- phosphate by the enzyme: (A) Fumarase (B) Ketoisomerase (C) G-6-PD (D) Epimerase
Description : The enzymes of the pentose phosphate pathway are found in the (A) Cytosol (B) Mitochondria (C) Nucleus (D) Endoplasmic reticulum
Description : The hydrogen acceptor used in pentose phosphate pathway is (A) NAD (B) NADP (C) FAD (D) FMN
Description : The hexose monophosphate pathway includes the enzyme: (A) Maltase dehydrogenase (B) Hexokinase (C) α-Ketoglutarate dehydrogenase (D) Glucose-6-phosphate dehydrogenase
Description : The pathway of glycogen biosynthesis involves a special nucleotide of glucose. In the reaction below, NuDP stands for NuDP Glucose + glycogenn → NuDP + glycogenn+1 (A) ADP (B) GDP (C) UDP (D) CDP
Description : In the erythrocytes, the net production of ATP molecules by the Rapport-Leubering pathway is (A) 0 (B) 2 (C) 4 (D) 8
Description : Most major metabolic pathways are considered mainly either anabolic or catabolic. Which of the following pathway is most correctly considered to be amphibolic? (A) Citric acid cycle (B) Gluconeogenesis (C) Lipolysis (D) Glycolysis
Description : All the enzymes of glycolysis pathway are found in (A) Extramitochondrial soluble fraction of the cell (B) Mitochondria (C) Nucleus (D) Endoplasmic reticulum
Description : In the glycolytic pathway, enolpyruvate is converted to ketopyruvate by (A) Pyruvate kinase (B) Phosphoenolpyruvate (C) Pyruvate dehydrogenase (D) Spontaneously
Description : In glycolytic pathway, iodacetate inhibits the activity of the enzyme: (A) Phosphotriose isomerase (B) Glyceraldehyde-3-phosphate dehydrogenase (C) Pyruvate kinase (D) Phosphofructokinase
Description : The enzyme of the glycolic pathway, sensitive to inhibiton by fluoride ions is (A) Hexokinase (B) Aldolase (C) Enolase (D) Pyruvate kinase
Description : A pathway that requires NADPH as a cofactor is (A) Extramitochondrial folic acid synthesis (B) Ketone body formation (C) Glycogenesis (D) Gluconeogenesis
Description : The most important source of reducing equivalents for FA synthesis on the liver is (A) Glycolysis (B) HMP-Shunt (C) TCA cycle (D) Uronic acid pathway
Description : A pathway that requires NADPH as a cofactor is (A) Fatty acid oxidation (B) Extra mitochondrial denovo fatty acid synthesis (C) Ketone bodies formation (D) Glycogenesis
Description : Refsum’s disease results from a defect in the following pathway except (A) Alpha-oxidation of fatty acids (B) Beta-oxidation of fatty acids (C) Gamma-oxidation of fatty acids (D) Omega-oxidation of fatty acids
Description : Which of the following can be oxidized by β-oxidation pathway? (A) Saturated fatty acids (B) Monosaturated fatty acids (C) Polyunsaturated fatty acids (D) All of these
Description : Insulin is a protein which controls (A) Blood clotting (B) Metabolic pathway (C) Digestion (D) Kreb’s cycle
Description : The alternate complement pathway doesn’t involve (A) Antigen-antibody complex (B) Complement 3 (C) Factors B and D (D) Membrane attack unit
Description : Factors B and D are required in (A) The classical pathway of complement fixation (B) The alternate complement pathway (C) Both (A) and (B) (D) None of these
Description : C1 component of classical complement pathway is made up of (A) Complements 1q and 1r (B) Complements 1q and 1s (C) Complements 1r and 1s (D) Complements 1q, 1r and 1s
Description : Which of the following enzymes in Glycolytic pathway is inhibited by fluoride? (A) Glyceraldehyde-3-p dehydrogenase (B) Phosphoglycerate kinase (C) Pyruvate kinase (D) Enolase
Description : Most of the metabolic pathways are either anabolic or catabolic. Which of the following pathways is considered as “amphibolic” in nature? (A) Glycogenesis (B) Glycolytic pathway (C) Lipolysis (D) TCA cycle
Description : In conversion of Lactic acid to Glucose, three reactions of Glycolytic pathway are circumvented, which of the following enzymes do not participate? (A) Pyruvate Carboxylase (B) Phosphoenol pyruvate carboxy kinase (C) Pyruvate kinase (D) Glucose-6-phosphatase