What are the major differences between fatty acid synthesis and beta oxidation of fatty acid?

What are the major differences between fatty acid synthesis and beta oxidation of fatty acid?
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Answer :

Beta oxidation is taking place in mitochondria, fatty acid synthesis is in cytoplasm. Oxidation enzymes are independent, synthetic enzymes are grouped as a multi-enzyme complex. During oxidation, 2 carbon units are removed as acetyl CoA, during synthesis, 2 carbon units are added as 3 carbon malonyl CoA. For oxidation, NAD and FAD are necessary, for synthesis, NADPH is used.
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De novo synthesis of fatty acids requires all of the following except (A) Biotin (B) NADH (C) Panthothenic acid (D) ATP

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Which of the following is required as a reductant in fatty acid synthesis? (A) NADH (B) NADPH (C) FADH2 (D) FMNH2

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Last Answer : C

What is the action of insulin on fatty acid synthesis?

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Last Answer : Insulin favours lipogenesis.

How is fatty acid synthesis regulated?

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Last Answer : Key enzyme, acetyl CoA carboxylase, is stimulated by citrate and inhibited by palmitoyl CoA.

What are the sources of NADPH for fatty acid synthesis?

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Last Answer : Glucose-6-phosphate dehydrogenase, malic enzyme, cytoplasmic malate dehydrogenase.

What are the steps in which NADPH is used in fatty acid synthesis?

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Last Answer : Step 4 (Keto acyl reductase) and Step 6 (Enoyl reductase).

Acetyl CoA from mitochondria is transferred to cytoplasm for the de novo synthesis of fatty acid, by which enzyme?

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Last Answer : ATP citrate lyase.

What is the rate limiting enzyme of de novo synthesis of fatty acid?

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Last Answer : Acetyl CoA carboxylase.