If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then (a) He will develop similar reaction whenever penicillin is injected (b) He can be given ampicillin safely (c) He can be given oral phenoxymethyl penicillin safely (d) All natural and semisynthetic penicillins are contraindicated for him

If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then (a) He will develop similar reaction whenever penicillin is injected (b) He can be given ampicillin safely (c) He can be given oral phenoxymethyl penicillin safely (d) All natural and semisynthetic penicillins are contraindicated for him
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If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then: A. He will develop similar reaction whenever penicillin is injected B. He can be given ampicillin safely C. He can be given oral phenoxymethyl penicillin safely D. All natural and semisynthetic penicillins are contraindicated for him

Description : If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then: A. He will develop similar reaction whenever penicillin is injected ... oral phenoxymethyl penicillin safely D. All natural and semisynthetic penicillins are contraindicated for him

Last Answer : D. All natural and semisynthetic penicillins are contraindicated for him

Which of the following is not a semisynthetic penicillin ? (a) Procaine penicillin (b) Ampicillin (c) Cloxacillin (d) Carbenicillin

Description : Which of the following is not a semisynthetic penicillin ? (a) Procaine penicillin (b) Ampicillin (c) Cloxacillin (d) Carbenicillin

Last Answer : Ans: A

The most frequent side effect of oral ampicillin is (a) Nausea and vomiting (b) Loose motions (c) Constipation (d) Urticaria

Description : The most frequent side effect of oral ampicillin is (a) Nausea and vomiting (b) Loose motions (c) Constipation (d) Urticaria

Last Answer : Ans: B

Select the semisynthetic penicillin which is not acid resistant: A. Phenoxymethyl penicillin B. Ampicillin C. Carbenicillin D. Cloxacillin

Description : Select the semisynthetic penicillin which is not acid resistant: A. Phenoxymethyl penicillin B. Ampicillin C. Carbenicillin D. Cloxacillin

Last Answer : C. Carbenicillin

A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is sensitive to all of the following drugs. Which of these drugs would be the best choice for this patient? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin

Description : A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is ... ? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin

Last Answer : Ans: B

A patient needs antibiotic treatment for native valve, culture-positive infective enterococcal endocarditis. His medical history includes a severe anaphylactic reaction to penicillin G during the past year. The best approach would be treatment with (a) Amoxicillin/clavulanate (b) Aztreonam (c) Cefazolin plus genatamicin (d) Meropenem (e) Vancomycin

Description : A patient needs antibiotic treatment for native valve, culture-positive infective enterococcal endocarditis. His medical history includes a severe anaphylactic reaction to penicillin G during the past year. ... /clavulanate (b) Aztreonam (c) Cefazolin plus genatamicin (d) Meropenem (e) Vancomycin

Last Answer : Ans: E

Beta – lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be effective against all strains of each of the above organisms? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin

Description : Beta - lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be ... ? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin

Last Answer : Ans: B

Choose the semisynthetic penicillin which has an extended spectrum of activity against many gram negative bacilli, is acid resistant but not penicillinase resistant: A. Cloxacillin B. Amoxicillin C. Phenoxymethyl penicillin D. Piperacillin

Description : Choose the semisynthetic penicillin which has an extended spectrum of activity against many gram negative bacilli, is acid resistant but not penicillinase resistant: A. Cloxacillin B. Amoxicillin C. Phenoxymethyl penicillin D. Piperacillin

Last Answer : B. Amoxicillin

A woman’s neglected hangnail has developed into a mild staphylococcal cellulites. Which of the following regimens would be appropriate oral therapy? (a) Dicloxacillin 125 mg q6h (b) Vancomycin 250 mg q6h (c) Methicillin 500 mg q6h (d) Cefazolin 1 g q8h (e) Penicillin V 500 mg q6h

Description : A woman’s neglected hangnail has developed into a mild staphylococcal cellulites. Which of the following regimens would be appropriate oral therapy? (a) Dicloxacillin 125 mg q6h (b) Vancomycin 250 mg q6h (c) Methicillin 500 mg q6h (d) Cefazolin 1 g q8h (e) Penicillin V 500 mg q6h

Last Answer : Ans: A

Benzathine penicillin injected once every 4 weeks for 5 years or more is the drug of choice for (a) Agranulocytosis patients (b) Prophylaxis of bacterial endocarditis in patients with valvular defects (c) Prophylaxis of rheumatic fever (d) Treatment of anthrax

Description : Benzathine penicillin injected once every 4 weeks for 5 years or more is the drug of choice for (a) Agranulocytosis patients (b) Prophylaxis of bacterial endocarditis in patients with valvular defects (c) Prophylaxis of rheumatic fever (d) Treatment of anthrax

Last Answer : Ans: C

Prolonged oral therapy with the following antibiotic can damage intestinal villi resulting in statorrhoea and loose motions (a) Ampicillin (b) Tetracycline (c) Neomycin (d) Nystatin

Description : Prolonged oral therapy with the following antibiotic can damage intestinal villi resulting in statorrhoea and loose motions (a) Ampicillin (b) Tetracycline (c) Neomycin (d) Nystatin

Last Answer : Ans: C

An intradermal penicillin sensitivity test has been performed on a patient and found to be negative. This indicates that: A. Penicillin antibodies are not present in his body B. He will not develop any reaction when full dose of penicillin is injected C. He will not develop anaphylactic reaction when full dose of penicillin is injected D. He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

Description : An intradermal penicillin sensitivity test has been performed on a patient and found to be negative. This indicates that: A. Penicillin antibodies are not present in his body B. He will ... He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

Last Answer : D. He is unlikely to develop immediate type of hypersensitivity reaction when full dose of penicillin is injected

Which of the following is not a semisynthetic penicillin: A. Procaine penicillin B. Ampicillin C. Cloxacillin D. Carbenicillin

Description : Which of the following is not a semisynthetic penicillin: A. Procaine penicillin B. Ampicillin C. Cloxacillin D. Carbenicillin

Last Answer : A. Procaine penicillin

The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its (a) Narrow spectrum of activity (b) Potential to cause hypersensitivity reaction (c) Short duration of action (d) Neurotoxicity

Description : The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its (a) Narrow spectrum of activity (b) Potential to cause hypersensitivity reaction (c) Short duration of action (d) Neurotoxicity

Last Answer : Ans: B

Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct

Description : Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct

Last Answer : D. All of the above are correct

Penicillins interfere with bacterial cell wall synthesis by (a) Inhibiting synthesis of N-acetyl muramic acid pentapeptide (b) Inhibiting conjugation between N-acetyl muramic acid and N-acetyl glucosamine (c) Inhibiting transpeptidases and carboxy peptidases which cross link the peptidoglycan residues (d) Counterfeiting for D-alanine in the bacterial cell wall

Description : Penicillins interfere with bacterial cell wall synthesis by (a) Inhibiting synthesis of N-acetyl muramic acid pentapeptide (b) Inhibiting conjugation between N-acetyl muramic acid and N-acetyl ... link the peptidoglycan residues (d) Counterfeiting for D-alanine in the bacterial cell wall

Last Answer : Ans: C

The most frequent side effect of oral ampicillin is: A. Nausea and vomiting B. Loose motions C. Constipation D. Urticaria

Description : The most frequent side effect of oral ampicillin is: A. Nausea and vomiting B. Loose motions C. Constipation D. Urticaria

Last Answer : B. Loose motions

The penicillin G preparation with the longest duration of action is (a) Benzathine penicillin (b) Sodium penicillin (c) Potassium penicillin (d) Procaine penicillin

Description : The penicillin G preparation with the longest duration of action is (a) Benzathine penicillin (b) Sodium penicillin (c) Potassium penicillin (d) Procaine penicillin

Last Answer : Ans: A

In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients? (a) Penicillin G, imipenem, amphotericin B, metronidazol (b) Penicillin G, chlormphenicol, tetracycline, vancomycin (c) Imipenem, tetracycline, vancomycin, sulfadiazine (d) Cycloserine, metronidazole, vancomycin, sulfadiazine (e) Metronidazole, imipenem, doxycycline, erythromycin

Description : In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients? (a) Penicillin G, imipenem, amphotericin B, metronidazol ... (d) Cycloserine, metronidazole, vancomycin, sulfadiazine (e) Metronidazole, imipenem, doxycycline, erythromycin

Last Answer : Ans: A

Which one of the following antibiotics is likely to be most effective agent in the treatment of an infection due to enterococci if used in conjuction with penicillin G? (a) Amikacin (b) Gentamicin (c) Netilmicin (d) Streptomycin (e) Tobramycin

Description : Which one of the following antibiotics is likely to be most effective agent in the treatment of an infection due to enterococci if used in conjuction with penicillin G? (a) Amikacin (b) Gentamicin (c) Netilmicin (d) Streptomycin (e) Tobramycin

Last Answer : Ans: D

Highest incidence of antibiotic associated pseudo membranous enterocolitis has been noted with the use of (a) Ampicillin (b) Chloramphenicol (c) Vancomycin (d) Clindamycin

Description : Highest incidence of antibiotic associated pseudo membranous enterocolitis has been noted with the use of (a) Ampicillin (b) Chloramphenicol (c) Vancomycin (d) Clindamycin

Last Answer : Ans: D

An aminoglycoside antibiotic should not be used concurrently with the following drug (a) Ampicillin (b) Vancomycin (c) Ciprofloxacin (d) Rifampin

Description : An aminoglycoside antibiotic should not be used concurrently with the following drug (a) Ampicillin (b) Vancomycin (c) Ciprofloxacin (d) Rifampin

Last Answer : Ans: B

Amoxicillin is inferior to ampicillin for the treatment of the following infection (a) Typhoid (b) Shigella enteritis (c) Subacute bacterial endocarditis (d) Gonorrhoea

Description : Amoxicillin is inferior to ampicillin for the treatment of the following infection (a) Typhoid (b) Shigella enteritis (c) Subacute bacterial endocarditis (d) Gonorrhoea

Last Answer : Ans: B

Currently the drug of choice for emperic treatment of typhoid fever is (a) Chloramphenicol (b) Cotrimoxaxole (c) Ciprofloxacin (d) Ampicillin

Description : Currently the drug of choice for emperic treatment of typhoid fever is (a) Chloramphenicol (b) Cotrimoxaxole (c) Ciprofloxacin (d) Ampicillin

Last Answer : Ans: C

Select the antibiotic whose dose must be reduced in patients with renal insufficiency (a) Ampicillin (b) Chloramphenicol (c) Tobramycin (d) Erythromycin

Description : Select the antibiotic whose dose must be reduced in patients with renal insufficiency (a) Ampicillin (b) Chloramphenicol (c) Tobramycin (d) Erythromycin

Last Answer : Ans: C

Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis? (a) Ampicillin (b) Cefazolin (c) Ganciclovir (d) Tobramycin (e) Vancomycin

Description : Which one of the following antimicrobial drugs does not require supplementation of dosage following hemodialysis? (a) Ampicillin (b) Cefazolin (c) Ganciclovir (d) Tobramycin (e) Vancomycin

Last Answer : Ans: E

Which one of the following statements about ampicillin is false? (a) Its activity is enhanced by sulbactam (b) It causes maculopapular rashes (c) It is the drug of choice for Listeria monocytogenes infection (d) It eradicates most strains of MRSA (e) Pseudomembranous colitis may occur with its use

Description : Which one of the following statements about ampicillin is false? (a) Its activity is enhanced by sulbactam (b) It causes maculopapular rashes (c) It is the drug of choice for Listeria monocytogenes infection (d) It eradicates most strains of MRSA (e) Pseudomembranous colitis may occur with its use

Last Answer : Ans: D

Semisynthetic penicillins developed so far have overcome the following drawbacks of benzylpenicillin except: A. Lack of efficacy against gram negative bacilli B. Susceptibility to bacterial penicillinase C. Inactivation by gastric acid D. Potential to cause hypersensitivity reactions

Description : Semisynthetic penicillins developed so far have overcome the following drawbacks of benzylpenicillin except: A. Lack of efficacy against gram negative bacilli B. Susceptibility to bacterial penicillinase C. Inactivation by gastric acid D. Potential to cause hypersensitivity reactions

Last Answer : D. Potential to cause hypersensitivity reactions

Your 23-year-old female patient is pregnant and has gonorrhea. The past medical history includes anaphylaxis following exposure to amoxicillin. Worried about compliance, you would like to treat this patient with a singly dose, so you chose (a) Cefixime (b) Ceftriaxone (c) Ciprofloxacin (d) Spectinomycin (e) Tetracycline

Description : Your 23-year-old female patient is pregnant and has gonorrhea. The past medical history includes anaphylaxis following exposure to amoxicillin. Worried about compliance, you would like to treat this patient ... chose (a) Cefixime (b) Ceftriaxone (c) Ciprofloxacin (d) Spectinomycin (e) Tetracycline

Last Answer : Ans: D

Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin

Description : Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin

Last Answer : Ans: A

Gram negative organisms are largely insensitive to benzyl penicillin because (a) They produce large quantities of penicillinase (b) They do not utilize D-alanine whose incorporation in the cell wall is inhibited by benzyl penicillin (c) Benzyl penicillin is not able to penetrate deeper into the lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria (d) Both (a) and (b)

Description : Gram negative organisms are largely insensitive to benzyl penicillin because (a) They produce large quantities of penicillinase (b) They do not utilize D-alanine whose incorporation in the cell wall is ... lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria (d) Both (a) and (b)

Last Answer : Ans: C

Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys methicillin and related drugs (c) They have acquired a penicillin binding protein which has low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics

Description : Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys ... low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics

Last Answer : Ans: C

Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of (a) Gram-negative bacillary septicemia (b) Tuberculosis (c) Penicillin-resistant gonococcal infections (d) Syphilis (e) Gram-negative meningitis due to susceptible organisms

Description : Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of (a) Gram-negative bacillary septicemia (b) Tuberculosis (c) Penicillin-resistant gonococcal infections (d) Syphilis (e) Gram-negative meningitis due to susceptible organisms

Last Answer : Ans: C

The drug of choice for scarlet fever is (a) Tetracycline (b) Sulfonamides (c) Penicillin (d) Chloromycetin (e) Novobiocin

Description : The drug of choice for scarlet fever is (a) Tetracycline (b) Sulfonamides (c) Penicillin (d) Chloromycetin (e) Novobiocin

Last Answer : Ans: C

Which of the following penicillins are readily destructed by stomach acid: A. Methicillin B. Cloxacillin C. Phenoxy methyl D. Penicillin G

Description : Which of the following penicillins are readily destructed by stomach acid: A. Methicillin B. Cloxacillin C. Phenoxy methyl D. Penicillin G

Last Answer : D. Penicillin G

All of the following drugs are suitable oral therapy for a lower urinary tract infection due to Pseudomonas aeruginosa except (a) Norfloxacin (b) Trimethoprim-sulfamethxazole (c) Ciprofloxacin (d) Carbenicillin (e) Methenamine mandelate

Description : All of the following drugs are suitable oral therapy for a lower urinary tract infection due to Pseudomonas aeruginosa except (a) Norfloxacin (b) Trimethoprim-sulfamethxazole (c) Ciprofloxacin (d) Carbenicillin (e) Methenamine mandelate

Last Answer : Ans: B

A single oral dose of the following drug can cure most cases of uncomplicated gonorrhoea (a) Ciprofloxacin (b) Cotrimoxazole (c) Spectinomycin (d) Doxycycline

Description : A single oral dose of the following drug can cure most cases of uncomplicated gonorrhoea (a) Ciprofloxacin (b) Cotrimoxazole (c) Spectinomycin (d) Doxycycline

Last Answer : Ans: A

Which of the following statements about vancomycin is accurate? (a) It is bacteriostatic (b) It binds to PBPs (c) It is not susceptible to penicillinase (d) It has the advantage of oral bioavailability (e) Staphylococcal enterocolitis occurs commonly with its use

Description : Which of the following statements about vancomycin is accurate? (a) It is bacteriostatic (b) It binds to PBPs (c) It is not susceptible to penicillinase (d) It has the advantage of oral bioavailability (e) Staphylococcal enterocolitis occurs commonly with its use

Last Answer : Ans: C

The most suitable tetracycline for use in a patient with impaired renal function is (a) Chlortetracycline (b) Demeclocycline (c) oxytetracycine (d) Doxycycline

Description : The most suitable tetracycline for use in a patient with impaired renal function is (a) Chlortetracycline (b) Demeclocycline (c) oxytetracycine (d) Doxycycline

Last Answer : Ans: D

A high school student presents with headache, fever, and cough of 2 day’s duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this patient appears to have atypical pneumonia. You should initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin

Description : A high school student presents with headache, fever, and cough of 2 day's duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this ... initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin

Last Answer : Ans: C

In a patient with culture-positive enterococcal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is (a) Clarithromycin (b) Erythromycin (c) Linezolid (d) Minocycline (e) Ticarcillin

Description : In a patient with culture-positive enterococcal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is (a) Clarithromycin (b) Erythromycin (c) Linezolid (d) Minocycline (e) Ticarcillin

Last Answer : Ans: D

The preparation of penicillin preferred for treatment of syphilis is: A. Sodium penicillin G B. Benzathine penicillin G C. Penicillin V D. Ampicillin

Description : The preparation of penicillin preferred for treatment of syphilis is: A. Sodium penicillin G B. Benzathine penicillin G C. Penicillin V D. Ampicillin

Last Answer : B. Benzathine penicillin G

Indicate the disease in which penicillin G continues to be used as first line treatment in all cases (unless contraindicated), because the causative organism has not developed resistance so far: A. Gonorrhoea B. Syphilis C. Staphylococcal abscess D. Haemophillus influenzae meningiti

Description : Indicate the disease in which penicillin G continues to be used as first line treatment in all cases (unless contraindicated), because the causative organism has not developed resistance so far: A. Gonorrhoea B. Syphilis C. Staphylococcal abscess D. Haemophillus influenzae meningiti

Last Answer : B. Syphilis

Select the antibiotic which is equally effective whether injected 8 hourly or 24 hourly, provided the total daily dose remains the same: A. Gentamicin B. Sod. penicillin G C. Cefazolin D. Vancomycin

Description : Select the antibiotic which is equally effective whether injected 8 hourly or 24 hourly, provided the total daily dose remains the same: A. Gentamicin B. Sod. penicillin G C. Cefazolin D. Vancomycin

Last Answer : A. Gentamicin

Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b) Is active against strains of streptococci that are resistant to erythromycin (c) Is more active against Mycobacterium avium complex (d) Does not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci

Description : Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b ... not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci

Last Answer : Ans: C

The most likely explanation of differing sensitivities of different bacteria to various penicillins is: A. Differing susceptibilities of the various penicillins to β-lactamases produced by different bacteria B. Differing affinities of penicillin binding proteins present in different bacteria towards various penicillins C. Differing penetrability of various penicillins into different bacteria D. Differing rates of cell wall synthesis by different bacteria

Description : The most likely explanation of differing sensitivities of different bacteria to various penicillins is: A. Differing susceptibilities of the various penicillins to β-lactamases produced by different ... into different bacteria D. Differing rates of cell wall synthesis by different bacteria

Last Answer : B. Differing affinities of penicillin binding proteins present in different bacteria towards various penicillins