Choose the semisynthetic penicillin which has an
extended spectrum of activity against many gram
negative bacilli, is acid resistant but not penicillinase
resistant:
A. Cloxacillin
B. Amoxicillin
C. Phenoxymethyl penicillin
D. Piperacillin

1 Answer

Answer :

B. Amoxicillin

Related questions

Description : Select the semisynthetic penicillin which is not acid resistant: A. Phenoxymethyl penicillin B. Ampicillin C. Carbenicillin D. Cloxacillin

Last Answer : C. Carbenicillin

Description : Semisynthetic penicillins developed so far have overcome the following drawbacks of benzylpenicillin except: A. Lack of efficacy against gram negative bacilli B. Susceptibility to bacterial penicillinase C. Inactivation by gastric acid D. Potential to cause hypersensitivity reactions

Last Answer : D. Potential to cause hypersensitivity reactions

Description : Amoxicillin + Clavulanic acid is active against the following organisms except: A. Methicillin resistant Staph. aureus B. Penicillinase producing Staph. aureus C. Penicillinase producing N.gonorrhoeae D. β-lactamase producing E.coli

Last Answer : A. Methicillin resistant Staph. aureus

Description : If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then: A. He will develop similar reaction whenever penicillin is injected ... oral phenoxymethyl penicillin safely D. All natural and semisynthetic penicillins are contraindicated for him

Last Answer : D. All natural and semisynthetic penicillins are contraindicated for him

Description : Which of the following is not a semisynthetic penicillin: A. Procaine penicillin B. Ampicillin C. Cloxacillin D. Carbenicillin

Last Answer : A. Procaine penicillin

Description : Features of phenoxymethyl penicillin include the following: A. It is acid stable and orally active B. Its antibacterial spectrum is similar to that of benzyl penicillin C. It is used for less serious penicillin G sensitive infections D. All of the above are correct

Last Answer : D. All of the above are correct

Description : Gram negative organisms are largely insensitive to benzyl penicillin because: A. They produce large quantities of penicillinase B. They do not utilise D-alanine whose incorporation in the cell wall is inhibited ... multilayer cell wall of gram negative bacteria D. Both A' and B' are correct

Last Answer : . Benzyl penicillin is not able to penetrate deeper into the lipoprotein-peptidoglycan multilayer cell wall of gram negative bacteria

Description : Which of the following is a second generation cephalosporin that is highly resistant to gram negative β-lactamases, and cures penicillinase positive as well as negative gonococcal infection by a single intramuscular dose: A. Cephalexin B. Cefuroxime C. Cefoperazone D. Ceftazidime

Last Answer : B. Cefuroxime

Description : Amoxicillin + Clavulanic acid is active against the following organism except (a) Methicillin resistant Staph. aureus (b) Penicillinase producing Staph. aureus (c) Penicillinase producing n. gonorrhoeae (d) ß-lactamase producing E. coli

Last Answer : Ans: A

Description : If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then (a) He will develop similar reaction whenever penicillin is injected ( ... oral phenoxymethyl penicillin safely (d) All natural and semisynthetic penicillins are contraindicated for him

Last Answer : Ans: D

Description : Which of the following is not a semisynthetic penicillin ? (a) Procaine penicillin (b) Ampicillin (c) Cloxacillin (d) Carbenicillin

Last Answer : Ans: A

Description : The following statement is not true of sulbactam: A. It is a broad spectrum β-lactamase inhibitor B. It does not augment the activity of ampicillin against bacteria that are sensitive ... β-lactamases D. Combined with ampicillin, it is highly effective against penicillinase producing N. gonorrhoeae

Last Answer : C. It induces chromosomal β-lactamases

Description : Nalidixic acid is primarily active against: A. Cocci B. Bacilli C. Gram positive bacteria D. Gram negative bacteria

Last Answer : D. Gram negative bacteria

Description : Piperacillin differs from carbenicillin in the following respect(s): A. It is more active against Pseudomonas aeruginosa B. It is active against Klebsiella as well C. It is acid resistant D. Both ‘A’ and ‘B’ are correct

Last Answer : D. Both ‘A’ and ‘B’ are correct

Description : This drug has activity against many strains of Pseudomomas aeruginosa. However, when it is used alone, resistance has emerged during the course of treatment. The drug should not be used in ... with tazobactam (a) Amoxicillin (b) Aztreonam (c) Imipenem (d) Piperacillin (e) Vancomycin

Last Answer : Ans: D

Description : Metronidazole is used in peridontal abscess because of activity against: A. Entamoeba histolytica B. Giardia lamblia C. Anaerobic bacilli D. Aerobic gram positive cocci

Last Answer : C. Anaerobic bacilli

Description : Features of clindamycin include the following: A. It is primarily active against aerobic gram negative bacilli B. It can be used topically to treat infected acne vulgaris C. It is not absorbed orally D. It is used to treat pseudomembranous enterocolitis

Last Answer : B. It can be used topically to treat infected acne vulgaris

Description : Aminoglycoside antibiotics have the following property common to all members: A. They are primarily active against aerobic gram negative bacilli B. They are more active in acidic medium C. They ... cells and are distributed in total body water D. They are nearly completely metabolized in liver

Last Answer : A. They are primarily active against aerobic gram negative bacilli

Description : Gram negative organisms are largely insensitive to benzyl penicillin because (a) They produce large quantities of penicillinase (b) They do not utilize D-alanine whose incorporation in the cell wall is ... lipoprotein-peptidoglycan multiplayer cell wall of gram-negative bacteria (d) Both (a) and (b)

Last Answer : Ans: C

Description : The drug of choice for penicillinase producing Neisseria gonorrhoeae urethritis is: A. Amoxicillin B. Erythromycin C. Ceftriaxone D. Doxycycline

Last Answer : C. Ceftriaxone

Description : Sulbactam differs from clavulanic acid in that: A. It is not a progressive inhibitor of β-lactamase B. It does not inhibit β-lactamase produced by gram negative bacilli C. It is quantitatively more potent D. It per se inhibits N.gonorrhoeae

Last Answer : D. It per se inhibits N.gonorrhoeae

Description : The most important mechanism by which gram negative bacilli acquire chloramphenicol resistance is: A. Decreased permeability into the bacterial cell B. Acquisition of a plasmid encoded ... the bacterial ribosome for chloramphenicol D. Switching over from ribosomal to mitochondrial protein synthesi

Last Answer : B. Acquisition of a plasmid encoded for chloramphenicol acetyl transferas

Description : If a necrotizing soft tissue infection is considered, therapy mandates: a. Empiric administration of antibiotics active against gram-positive, gram-negative, and anaerobic bacteria b. Due to usually ... is mandatory d. The use of hyperbaric oxygen has been demonstrated to be clearly advantageous

Last Answer : Answer: a, c Identification of a necrotizing, soft tissue infection mandates immediate operative intervention with aggressive resection of all involved tissues and empiric ... remains without controlled trials demonstrating any additional benefits derived from hyperbaric oxygen therapy

Description : The fluoroquinolones have improved over nalidixic acid in the following respect(s): A. They have higher antimicrobial potency B. They have extended antimicrobial spectrum C. Development of bacterial resistance against them is slow and infrequent D. All of the above

Last Answer : D. All of the above

Description : The most important reason for highly restricted use of penicillin G injections in present day therapeutics is its: A. Narrow spectrum of activity B. Potential to cause hypersensitivity reaction C. Short duration of action D. Neurotoxicity

Last Answer : B. Potential to cause hypersensitivity reaction

Description : Piperacillin differs from carbenicillin in the following respect(s) (a) It is more active against pseudomonas aeruginosa (b) It is active against Klebsiella also (c) It is acid resistant (d) Both (a) and (b)

Last Answer : Ans: D

Description : An adult patient with a history of bacterial endocarditis requires prophylactic administration of antibiotics prior to removal of teeth. Indicate the pre-operative regimen:** A. Amoxicillin 2 gram ... orally six hours before operation C. Tetracycline 250-500 mg orally 2 hours before treatment

Last Answer : A. Amoxicillin 2 gram one hour before operation orally

Description : Choose the correct statement about rifampin: A. It is the most active drug on slow growing tubercle bacilli B. Its antitubercular efficacy is lower than that of isoniazid C. It is active against many atypical mycobacteria D. It does not effectively cross blood-CSF barrier

Last Answer : C. It is active against many atypical mycobacteria

Description : Beta - lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be ... ? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin

Last Answer : Ans: B

Description : Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of (a) Gram-negative bacillary septicemia (b) Tuberculosis (c) Penicillin-resistant gonococcal infections (d) Syphilis (e) Gram-negative meningitis due to susceptible organisms

Last Answer : Ans: C

Description : The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity

Last Answer : B. It acts by inhibiting bacterial protein synthesis

Description : Superinfections are more common with: A. Use of narrow spectrum antibiotics B. Short courses of antibiotics C. Use of antibiotics that are completely absorbed from the small intestines D. Use of antibiotic combinations covering both gram positive and gram negative bacteria

Last Answer : D. Use of antibiotic combinations covering both gram positive and gram negative bacteria

Description : Choose the orally active third generation cephalosporin having good activity against gram positive cocci as well: A. Cefdinir B. Ceftazidime C. Cefoperazone D. Ceftizoxime

Last Answer : A. Cefdinir

Description : Which of the following penicillins are readily destructed by stomach acid: A. Methicillin B. Cloxacillin C. Phenoxy methyl D. Penicillin G

Last Answer : D. Penicillin G

Description : As an antitubercular drug, isoniazid has the following advantages except: A. It is tuberculocidal B. It acts on both extra and intracellular bacilli C. Tubercle bacilli do not develop resistance against it D. It is cheap

Last Answer : C. Tubercle bacilli do not develop resistance against it

Description : A 67-year-old male presents with an intraabdominal abscess secondary to perforated sigmoid diverticulitis. The following statement(s) is/are true concerning his intraabdominal abscess. a. Culture will ... gram-negative enteric bacilli d. The most common anaerobic islet will be a Bacteroides species

Last Answer : Answer: b, c, d Typically an intraabdominal infection results in perforation of a hollow viscus and the ensuing contamination of a normally sterile peritoneal cavity. The normal ... Bacteroides species (especially B. fragilis, Clostridium), and anaerobic cocci are most consistently isolated

Description : The most important mechanism by which gram negative bacilli acquire chloramphenicol resistance is (a) Decreased permeability into the bacterial cell (b) Acquisition of a plasmid encoded ... bacterial ribosome for chloramphenicol (d) Switching over from ribosomal to mitochondrial protein synthesis

Last Answer : Ans: B

Description : Tinidazole differs from metronidazole in that: A. It is not active against anaerobic bacteria B. It has a broader spectrum of activity C. It has a longer elimination half life D. It has better oral absorption

Last Answer : C. It has a longer elimination half life

Description : Methicillin resistant staphylococci do not respond to β-lactam antibiotics because: A. They produce a β-lactamase which destroys methicillin and related drugs B. They elaborate an amidase which destroys ... low affinity for β-lactam antibiotics D. They are less permeable to β-lactam antibiotics

Last Answer : C. They have acquired penicillin binding protein which has low affinity for β-lactam antibioti

Description : Distinctive features of gatifloxacin include the following except: A. Higher affinity for the enzyme topoisomerase IV B. Activity restricted to gram negative bacteria C. Potential to prolong QTc interval D. Employed to treat community acquired pneumonia

Last Answer : B. Activity restricted to gram negative bacteria

Description : Choose the antimalarial drug effective against multidrug resistant P. falciparum, which rapidly terminates an attack of malarial fever, but has a short duration of action, so that recrudescence is common: A. Proguanil B. Mefloquine C. Amodiaquine D. Artemisinin

Last Answer : D. Artemisinin

Description : Compared to erythromycin, azithromycin has: A. Extended antimicrobial spectrum B. Better gastric tolerance C. Longer duration of action D. All of the above

Last Answer : D. All of the above

Description : The following fluoroquinolones have augmented activity against gram positive bacteria except: A. Lomefloxacin B. Levofloxacin C. Gatifloxacin D. Moxifloxacin

Last Answer : A. Lomefloxacin

Description : The distinctive feature(s) of sparfloxacin compared to ciprofloxacin is/are: A. Enhanced activity against gram positive bacteria B. Lack of pharmacokinetic interaction with theophylline and warfarin C. Higher incidence of phototoxic reaction D. All of the above

Last Answer : D. All of the above

Description : Which fluoroquinolone has enhanced activity against gram positive bacteria and anaerobes: A. Pefloxacin B. Ciprofloxacin C. Sparfloxacin D. Norfloxacin

Last Answer : C. Sparfloxacin

Description : ‘Red man syndrome’ has been associated with rapid intravenous injection of the following antibiotic: A. Vancomycin B. Clindamycin C. Cefoperazone D. Piperacillin

Last Answer : A. Vancomycin

Description : The β-lactam antibiotic(s) that prolong(s) bleeding time by altering surface receptors on platelets is/are: A. Carbenicillin B. Piperacillin C. Cefotaxime D. Both `A’ and `B’ are correct

Last Answer : A. Carbenicillin

Description : The following strategy will promote rather than curb emergence of antibiotic resistant micro-organisms: A. Whenever possible use broad spectrum antibiotics B. Prefer a narrow spectrum ... Prefer short and intensive courses of antibiotics D. Use antibiotic combinations for prolonged therapy

Last Answer : A. Whenever possible use broad spectrum antibiotics

Description : Indicate the attribute that is common to both polymyxin B and bacitracin: A. Both are active against gram negative bacteria B. Both are too toxic for systemic use C. Both act by inhibiting bacterial cell wall synthesis D. Both a

Last Answer : B. Both are too toxic for systemic use