Description : A 19-year-old woman with recurrent sinusitis has been treated with different antibiotics on several occasions. During the course of one such treatment she developed a severe diarrhea and was hospitalized. ... difficile? (a) Ampicillin (b) Cefazolin (c) Clindamycin (d) Metonidazole (e) Tetracycline
Last Answer : Ans: D
Description : A woman’s neglected hangnail has developed into a mild staphylococcal cellulites. Which of the following regimens would be appropriate oral therapy? (a) Dicloxacillin 125 mg q6h (b) Vancomycin 250 mg q6h (c) Methicillin 500 mg q6h (d) Cefazolin 1 g q8h (e) Penicillin V 500 mg q6h
Last Answer : Ans: A
Description : A patient needs antibiotic treatment for native valve, culture-positive infective enterococcal endocarditis. His medical history includes a severe anaphylactic reaction to penicillin G during the past year. ... /clavulanate (b) Aztreonam (c) Cefazolin plus genatamicin (d) Meropenem (e) Vancomycin
Last Answer : Ans: E
Description : A 36-year-old woman recently treated for leukemia is admitted to hospital with malaise, chills and high fever. Gram stain of blood reveals the presence of gramnegative bacilli. The initial diagnosis is ... (b) Aztreonam (c) Cefazolin (d) Imipenem plus cilastatin (e) Ticarcillin plus clavulanic acid
Last Answer : Ans: B
Description : Select the antibiotic whose dose must be reduced in patients with renal insufficiency (a) Ampicillin (b) Chloramphenicol (c) Tobramycin (d) Erythromycin
Last Answer : Ans: C
Description : Highest incidence of antibiotic associated pseudo membranous enterocolitis has been noted with the use of (a) Ampicillin (b) Chloramphenicol (c) Vancomycin (d) Clindamycin
Description : An aminoglycoside antibiotic should not be used concurrently with the following drug (a) Ampicillin (b) Vancomycin (c) Ciprofloxacin (d) Rifampin
Description : Which of the following drugs has demonstrated in vitro activity against Mycobacterium avium-intracellular(MAI)? (a) Vancomycin (b) Clarithromycin (c) Erythromycin base (d) Troleandomycin (e) Erythromycin estolate
Description : In which of the following groups do all four drugs warrant careful monitoring for drugrelated seizures in high-risk patients? (a) Penicillin G, imipenem, amphotericin B, metronidazol ... (d) Cycloserine, metronidazole, vancomycin, sulfadiazine (e) Metronidazole, imipenem, doxycycline, erythromycin
Description : The persistent suppression of bacterial growth that may occur following limited exposure to some antimicrobial drugs is called (a) Time-dependent killing (b) The post antibiotic effect (c) Clinical synergy (d) Concentration – dependent killing (e) Sequential blockade
Description : A woman has an upper respiratory infection. Six years ago, she experienced an episode of bronchospasm follwing penicillin V therapy. The cultures now reveal a strain of streptococcus pneumoniae that is ... ? (a) Amoxicillin/clavulanate (b) Erythromycin (c) Ampicillin (d) cefaclor (e) Cyclacillin
Description : Choose the correct statement about the role of opioid antimotility drugs in the management of diarrhoeas (a) They are used to control diarrhoea irrespective of its etiology (b) They should be ... therapy of diarrhoea (d) They are the drugs of choice in irritable bowel syndrome diarrhoea
Description : A high school student presents with headache, fever, and cough of 2 day's duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this ... initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin
Description : Which one of the following antibiotics is likely to be most effective agent in the treatment of an infection due to enterococci if used in conjuction with penicillin G? (a) Amikacin (b) Gentamicin (c) Netilmicin (d) Streptomycin (e) Tobramycin
Description : The aminoglycoside antibiotic which is distinguished by its resistance to bacterial aminoglycoside inactivating enzymes is (a) Kanamycin (b) Sisomicin (c) Amikacin (d) Tobramycin
Description : Isoniazid is a primary antitubercular agent that (a) Requires pyridoxine supplementation (b) May discolor the tears, saliva, urine or feces orange-red (c) Causes ocular complications that are reversible if ... (d) May be ototoxic and nephrotoxic (e) Should never be used due to hepatotoxic potential
Description : In a patient with culture-positive enterococcal endocarditis who has failed to respond to vancomycin because of resistance, the treatment most likely to be effective is (a) Clarithromycin (b) Erythromycin (c) Linezolid (d) Minocycline (e) Ticarcillin
Description : Which of the following statements about vancomycin is accurate? (a) It is bacteriostatic (b) It binds to PBPs (c) It is not susceptible to penicillinase (d) It has the advantage of oral bioavailability (e) Staphylococcal enterocolitis occurs commonly with its use
Description : This drug has activity against many strains of Pseudomomas aeruginosa. However, when it is used alone, resistance has emerged during the course of treatment. The drug should not be used in ... with tazobactam (a) Amoxicillin (b) Aztreonam (c) Imipenem (d) Piperacillin (e) Vancomycin
Description : Clarithromycin and erythromycin have very similar spectrums of antimicrobial activity. The major advantage of clarithromytcin is that it (a) Eradicates mycoplasmal infections in a single dose (b ... not inhibit live drug-metabolizing enzymes (e) Acts on methicillin-resistant strains of staphylococci
Description : Beta - lactamase production by strains of Haemophilus influenzae, Moraxella catarrhalis, and Neissera gonorrhoeae confers resistance against penicillin G.which one of the following antibiotics is most likely to be ... ? (a) Ampicillin (b) Ceftriaxone (c) Clindamycin (d) Gentamicin (e) Piperacillin
Description : Which one of the following statements about ampicillin is false? (a) Its activity is enhanced by sulbactam (b) It causes maculopapular rashes (c) It is the drug of choice for Listeria monocytogenes infection (d) It eradicates most strains of MRSA (e) Pseudomembranous colitis may occur with its use
Description : The drug of choice for treatment of methicillin resistant Staphylococcus aureus infection is (a) Cloxacillin (b) Vancomycin (c) Erythromycin (d) Amikacin
Description : Which one of the following statements about one daily dosing with aminoglycosides is false ? (a) It is convenient for outpatient therapy (b) Adjustment of dosage is less important in renal ... often less toxic than conventional (multiple)dosing regimens (e) Under-dosing is less of a problem
Description : Which type of antimicrobial drug combination is most likely to exhibit antagonism ? (a) Bactericidal + Bactericidal (b) Bactericidal + Bacteriostatic for a highly sensitive organism (c) Bactericidal + Bacteriostatic for a marginally sensitive organism (d) Bacteriostatic + Bacteriostatic
Description : Which antimicrobial should be avoided in patients of liver disease ? (a) Chlortetracycline (b) Cotrimoxazole (c) Cephalexin (d) Ethambutol
Description : Which of the following organisms is notorious for developing antimicrobial resistance rapidly ? (a) Streptococcus pyogenes (b) Meningococcus (c) Treponema pallidum (d) Escherichia coli
Description : Prolonged oral therapy with the following antibiotic can damage intestinal villi resulting in statorrhoea and loose motions (a) Ampicillin (b) Tetracycline (c) Neomycin (d) Nystatin
Description : Amoxicillin is inferior to ampicillin for the treatment of the following infection (a) Typhoid (b) Shigella enteritis (c) Subacute bacterial endocarditis (d) Gonorrhoea
Description : The most frequent side effect of oral ampicillin is (a) Nausea and vomiting (b) Loose motions (c) Constipation (d) Urticaria
Description : Which of the following is not a semisynthetic penicillin ? (a) Procaine penicillin (b) Ampicillin (c) Cloxacillin (d) Carbenicillin
Description : If a patient gives history of urticaria, itching and swelling of lips following injection of penicillin G, then (a) He will develop similar reaction whenever penicillin is injected ( ... oral phenoxymethyl penicillin safely (d) All natural and semisynthetic penicillins are contraindicated for him
Description : Currently the drug of choice for emperic treatment of typhoid fever is (a) Chloramphenicol (b) Cotrimoxaxole (c) Ciprofloxacin (d) Ampicillin
Description : Select the antibiotic which is equally effective whether injected 8 hourly or 24 hourly, provided the total daily dose remains the same: A. Gentamicin B. Sod. penicillin G C. Cefazolin D. Vancomycin
Last Answer : A. Gentamicin
Description : Select the antibiotic whose dose must be reduced in patients with renal insufficiency: A. Ampicillin B. Chloramphenicol C. Tobramycin D. Erythromycin
Last Answer : C. Tobramycin
Description : All of the following drugs are suitable oral therapy for a lower urinary tract infection due to Pseudomonas aeruginosa except (a) Norfloxacin (b) Trimethoprim-sulfamethxazole (c) Ciprofloxacin (d) Carbenicillin (e) Methenamine mandelate
Description : An advantage of bleomycin over most antineoplastic drugs is its (a) Rapid onset of action (b) Lack of toxicity to all normal cells (c) Relative lack of bone marrow toxicity (d) Very broad spectrum of activity (e) Both (a) and (b)
Description : Which one of the following drugs is most likely to be effective against multidrug – resistant strains of M tuberculosis, including those resistant to streptomycin? (a) Amikacin (b) Clarithromycin (c) Gentamicin (d) Meropenem (e) Spectinomycin
Description : Tetracyclines are still the first choice drugs for the following disease. (a) Granuloma linguinale (b) Chancroid (c) Syphilis (d) Gonorrhoea in patients allergic to penicillin
Description : Sulfamethoxypyridazine and other related long acting sulfonamides have now gone into disuse because (a) They have produced serious cutaneous reactions (b) They have produced high incidence of crystalluria (c) They interact with many drugs (d) They do not penetrate blood-brain barrier
Description : Methicillin resistant staphylococci do not respond to ß-lactam antibiotics because (a) They produce a ß-lactamase which destroys methicillin and related drugs (b) They elaborate an amidase which destroys ... low affinity for ß-lactam antibiotics (d) They are less permeable to ß-lactam antibiotics
Description : Select the antimicrobial agent that can be used to treat with both methicillin resistant and vancomycin resistant Staphylococcus aureus infection: A. Clarithromycin B. Clindamycin C. Linezolid D. Lincomycin
Last Answer : C. Linezolid
Description : Teicoplanin has the following feature(s): A. Antimicrobial activity and indications similar to vancomycin B. Long elimination half-life C. Efficacy in systemic infections by oral route D. Both ‘A’ and ‘B’ are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : Choose the antimicrobial which acts by interfering with DNA function in the bacteria: A. Chloramphenicol B. Ciprofloxacin C. Streptomycin D. Vancomycin
Last Answer : B. Ciprofloxacin
Description : Highest incidence of antibiotic associated pseudomembranous enterocolitis has been noted with the use of: A. Ampicillin B. Chloramphenicol C. Vancomycin D. Clindamycin
Last Answer : D. Clindamycin
Description : Concurrent use of an aminoglycoside antibiotic should be avoided with the following antibiotic: A. Ampicillin B. Vancomycin C. Ciprofloxacin D. Rifampin
Last Answer : B. Vancomycin
Description : A patient of bronchial asthma maintained on theophylline developed upper respiratory tract infection. Which antimicrobial if used can increase the risk of developing theophylline toxicity: A. Ampicillin B. Cephalexin C. Cotrimoxazole D. Erythromycin
Last Answer : D. Erythromycin
Description : Amoxicillin + Clavulanic acid is active against the following organism except (a) Methicillin resistant Staph. aureus (b) Penicillinase producing Staph. aureus (c) Penicillinase producing n. gonorrhoeae (d) ß-lactamase producing E. coli
Description : A man has an Escherichia coli bacteremia with a low-grade fever (101.6°F). Appropriate management of his fever would be (a) Give acetaminophen 650 mg orally every 4 hours (b) Give aspirin 650 ... fever curve to monitor his response to antibiotic therapy (e) Use tepid water baths to reduce the fever
Description : Spectinomycin is an aminoglycoside-like antibiotic indicated for the treatment of (a) Gram-negative bacillary septicemia (b) Tuberculosis (c) Penicillin-resistant gonococcal infections (d) Syphilis (e) Gram-negative meningitis due to susceptible organisms