Description : The early pregnancy uterus is sensitive to the following oxytocic: A. Oxytocin B. Methylergometrine C. Prostaglandin F2α D. Both ‘A’ and ‘B’ are correct
Last Answer : C. Prostaglandin F2α
Description : The prostanoid that consistently constricts blood vessels is (a) Prostaglandin E2 (b) Prostaglandin F2a (c) Thromboxane A2 (d) Prostacyclin
Last Answer : Ans: C
Description : A 60-year-old woman has glaucoma following cataract surgery. Which of the following can be used to reduce intraocular pressure? (a) Leukotriene LTD4 or its analogs (b) Prostaglandin E2 or its analogs ( ... analogs (d) Slow-reacting substance of anaplylaxis (SRS-A) (e) Thromboxane A2 or its analogs
Description : The drug of choice for controlling postpartum haemorrhage is: A. Oxytocin B. Methylergometrine C. Dihydroergotamine D. Prostaglandin E2
Last Answer : B. Methylergometrine
Description : Cervical priming with prostaglandin results in (a) Facilitation of sperm movement through cervical canal (b) Increased cervical tone (c) Softening of cervix (d) Increased cervical secretions
Description : The following prostanoid is a potent inducer of platelet aggregation (a) Prostacyclin (b) Prostaglandin E2 (c) Prostaglandin D2 (d) Thromboxane A2
Last Answer : Ans: D
Description : Which of the following eicosanoids is generated through the lipozygenase pathway ? (a) Prostaglandin E2 (b) Thromboxane A2 (c) Prostacyclin (d) Leukotriene C4
Description : In addition to their ability to decrease inflammatory prostaglandin synthesis, some non-steroidal anti-inflammatory drugs (NSAIDs) may owe part of their effects to their ability to (a) Inhibit leukocyte migration (b ... (c) Stabilize lysosmal membranes (d) All of the above (e) None of the above
Description : Which of the following prostaglandin analogs is used specifically for the treatment of NSAID induced gastrointestinal ulcertation? (a) Alprostadil (b) Misoprostol (c) Carboprost (d) Dinoprostone (e) Epoprostenol
Last Answer : Ans: B
Description : A 65-year-old is interested in taking ginkgo. Which of the following statements is correct regarding ginkgo? (a) Ginkgo is contraindicated in diabetes and pregnancy (b) There is a ... drug-herb interaction between ginkgo and phenelzine (e) Ginkgo is contraindicated in patients with gallstone pain
Description : Match the source gland with its respective hormone and function and select the correct option. Source Hormone Function gland (a) Anterior Oxytocin Contraction of uterus pituitary muscles during ... (c) Corpus Estrogen Supports pregnancy luteum (d) Thyroid Thyroxine Regulates blood calcium level
Last Answer : (b) Posterior Vasopressin Stimulates pituitary reabsorption of water in the distal tubules in the nephron
Description : A 45-year-old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti-inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side ... appropriate? (a) Aspirin (b) Celecoxib (c) Ibuprofen (d) Indomethacin (e) Piroxicam
Description : The following drug is used for cervical priming to facilitate labour: A. Oxytocin B. Clomiphene C. Progesterone D. Prostaglandin E2
Last Answer : D. Prostaglandin E2
Description : Aspirin reduces fever by (a) Decreasing heat production in the body (b) Enhancing cutaneous blood flow (c) Inducing sweating (d) Both (b) and (c)
Description : Aspirin produces analgesia by (a) Preventing sensitization of peripheral pain receptors (b) Affecting gating of pain impulses at spinal level (c) Raising pain threshold at subcortical level (d) Both (a) and (b)
Description : Morphine dependence is characterized by (a) Marked drug seeking behavior (b) Physical dependence without psychic dependence (c) Physical as well as psychic dependence (d) Both (a) and (c)
Description : Morphine produces analgesia by acting at (a) Peripheral pain receptors (b) A spinal site (c) Suspraspinal sites (d) Both (b) and (c)
Description : Autacoids differ from hormones in that (a) Autacoids are involved only in the causation of pathological states (b) Autacoids do not have a specific cell/ tissue of origin (c) Autacoids generally act locally at the site of generation and release (d) Both (b) and (c)
Description : Which type of patient is most likely to hypersensitive to aspirin? (a) Intrinsic asthamatic (b) Extrinsic asthamatic (c) Chronic bronchitic (d) Patient with viral injection (e) Both (c) and (d)
Last Answer : Ans: A
Description : Accidental poisonings are common with both aspirin and ibuprofen, two OC drugs available in tasty chewable tablets. In cases of overdose, aspirin is more likely than ibuprofen to cause (a) ... Instability (b) Hepatic necrosis (c) Metabolic acidosis (d) Thrombocytopenia (e) Ventricular arrhythmias
Description : Generally the earliest manifestation of salicylism is (a) Visual disturbance (b) Excitement (c) Hyperventillation (d) Tinnitus
Description : In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is (a) Acid – base and electrolytc disturbances (b) Hypersensitivity and idiosyncratic reactions (c) Gastric mucosal damage (d) Salicylism
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues
Description : Following mediators are involved in acute inflammation except (a) Histamine (b) Leukotrienes (c) Interferons (d) Bradykinin
Description : Lower dose of naloxone is required to (a) Antagonise the actions of nalorphine (b) Antagonise the actions of pentazocine (c) Precipitate withdrawal in mildly morphine dependent subjects (d) Precipitate withdrawal in highly morphine dependent subjects
Description : Which action of morphine is incompletely reversed by naloxone ? (a) Analgesia (b) Respiratory depression (c) Sedation (d) Miosis
Description : Pentazocine differs from morphine in that (a) It is inactive by the oral route (b) It does not produce physical dependence (c) It has a lower ceiling of analgesic effect (d) Its action is not blocked by naloxone
Description : Which of the following is an agonistantagonist type of opioid analgesic (a) Pethidine (b) Pentazocine (c) Fentanyl (d) Buprenorphine
Description : Morphine has high affinity for the following opioid receptor(s). (a) µ (Mu) (b) k (Kappa) (c) d (Delta) (d) All of the above
Description : An opioid analgesic is preferred over aspirin like analgesic in the following condition. (a) Acute gout (b) Burn (c) Toothache (d) Neuralgia
Description : Select the analgesic which acts through opioids as well as additional spinal monoaminergic mechanisms. (a) Tramadol (b) Ethoheptazine (c) Dextropropoxyphene (d) Alfentanil
Description : Which of the following opioid analgesics is similar to codeine in pharmacological profile but is less constipating ? (a) Methadone (b) Buprenorphine (c) Butorphanol (d) Dextropropoxyphene
Description : Which of the following opioids is more potent than morphine ? (a) Pethidine (b) Fentanyl (c) Dextropropoxyphene (d) Tramadol
Description : Morphine is contraindicated in head injury because (a) It does not relieve the pain of head injury (b) It can raise intracranial tension (c) It can cause constipation (d) It is liable to cause addiction
Description : Instead of being effective in hyperuricaemia following drug is contradictred in the treatment of gout (a) Indomethacin (b) Diclofenac (c) Piroxicam (d) Aspirin
Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine (a) Selegiline (b) Chlorgiline (c) Moclobemide (d) Tranylcypromine
Description : Instead of depressing, morphine stimulates (a) Vasomotor centre (b) Edinger westphal nucleus (c) Temperature regulating centre (d) Cough centre
Description : In man sedation caused by morphine is characterized by (a) Initial excitement (b) Little or no motor incoordination (c) Rise in seizure threshold (d) All of the above
Description : Which of the following bones is affected more by glucocorticoid induced osteoporosis? (a) Femur (b) Humerus (c) Radius (d) Lumber vertebra
Description : The following adverse effect of corticosteroids is due to their mineralocorticoid action (a) Osteoporosis (b) Rise in blood pressure (c) Moon face (d) Increased susceptibility to infection
Description : Systemic corticosteroid therapy is not used routinely and is reserved only for severe cases of (a) Exfoliative dermatitis (b) Posterior uveitis (c) Acute rheumatic fever (d) Hodgkin’s disease
Description : For limiting cerebral edema due to brain tumour, the preferred corticosteroids are betamenthasone/dexamethasone because (a) They do not cause Na+ and water retention (b) They are more potent (c) They can be administered intravenously (d) They inhibit brain tumours
Description : Corticosteroid therapy is practically mandatory in the following condition. (a) Septic shock (b) Renal transplant (c) Rheumatoid arthritis (d) Ulcerative colitis
Description : Which of the following glucocorticoids has significant mineralocorticoid activity also ? (a) Hydrocortisone (b) Triamcinolone (c) Dexamethasone (d) Betamethasone
Description : Main effect of sulphinpyrazone in hyperuricaemia is (a) Suppress the symptoms (b) Promote the elimination of urate (c) prevent urate synthesis (d) All of the above
Description : Corticosteroids exert anti-inflammatory action by inhibiting the following enzyme (a) Cycloxygenase (b) Lipozygenase (c) Phospholipase - A (d) Phosphodiesterase
Description : Aspirin in low doses produces longlasting inhibition (a) Platelets contain low quantity of COX (b) Platelets cannot synthesize fresh COX molecules (c) Platelets bind aspirin with high affinity (d) Platelet COX is inducible
Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible
Description : Which of the following durgs is a monamine oxidase inhibitor, but is used to treat hypertension? (a) Tranylcypromine (Parnate) (b) Reserpine (c) Propranolol (Inderal) (d) Pargyline (Eutonyl) (e) Imipramine (Tofranil)