Description : Aspirin reduces fever by: A. Decreasing heat production in the body B. Enhancing cutaneous blood flow C. Inducing sweating D. Both ‘B’ and ‘C’ are correct
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : Fentanyl transdermal patches have been used postoperatively to provide transdermal analgesia. The most dangerous adverse effect of this mode of administration is (a) Cutaneous reactions (b) Diarrhea (c) Hypertension (d) Relaxation of skeletal muscle (e) Respiratory depression
Last Answer : Ans: E
Description : Aspirin produces analgesia by (a) Preventing sensitization of peripheral pain receptors (b) Affecting gating of pain impulses at spinal level (c) Raising pain threshold at subcortical level (d) Both (a) and (b)
Last Answer : Ans: D
Description : Which type of patient is most likely to hypersensitive to aspirin? (a) Intrinsic asthamatic (b) Extrinsic asthamatic (c) Chronic bronchitic (d) Patient with viral injection (e) Both (c) and (d)
Last Answer : Ans: A
Description : Accidental poisonings are common with both aspirin and ibuprofen, two OC drugs available in tasty chewable tablets. In cases of overdose, aspirin is more likely than ibuprofen to cause (a) ... Instability (b) Hepatic necrosis (c) Metabolic acidosis (d) Thrombocytopenia (e) Ventricular arrhythmias
Last Answer : Ans: C
Description : In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is (a) Acid – base and electrolytc disturbances (b) Hypersensitivity and idiosyncratic reactions (c) Gastric mucosal damage (d) Salicylism
Description : An opioid analgesic is preferred over aspirin like analgesic in the following condition. (a) Acute gout (b) Burn (c) Toothache (d) Neuralgia
Last Answer : Ans: B
Description : Instead of being effective in hyperuricaemia following drug is contradictred in the treatment of gout (a) Indomethacin (b) Diclofenac (c) Piroxicam (d) Aspirin
Description : Aspirin in low doses produces longlasting inhibition (a) Platelets contain low quantity of COX (b) Platelets cannot synthesize fresh COX molecules (c) Platelets bind aspirin with high affinity (d) Platelet COX is inducible
Description : Which of the following is an irreversible inhibitor of cyclooxygenase ? (a) Aspirin (b) Phenylbutazone (c) Indomethacin (d) Piroxicam
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible
Description : Potential adverse effects associated with aspirin include all of the following except (a) Gastrointestinal ulceration (b) Renal dysfunction (c) Enhanced methotrexate toxicity (d) Cardiac arrhythmias (e) Hypersensitivity asthma
Description : All of the following medications should not be used routinely in pregnant patients during the third trimester except (a) Acetaminophen (b) Nonsteroidal anti-inflammatory drugs (c) Warfarin (d) Lithium (e) Aspirin
Description : A 65-year-old is interested in taking ginkgo. Which of the following statements is correct regarding ginkgo? (a) Ginkgo is contraindicated in diabetes and pregnancy (b) There is a ... drug-herb interaction between ginkgo and phenelzine (e) Ginkgo is contraindicated in patients with gallstone pain
Description : Which of the following medications would represent arthritis therapy that is least likely to cause gastric ulceration? (a) Aspirin (b) Acetaminophen (c) Piroxicam (d) Meclofenamate (e) Rofecoxib
Description : The action of aspirin that results in its greater efficacy as an antithrombotic (anti-platelet) drug is its ability to (a) Inhibit lipoxygenase as well as cyclooxygenase (b) Selectively inhibit ... I (c) Inhibit leukocyte migration (d) Promote uric acid excretion (e) Acetylate cyclooxygenase
Description : Which of the following compounds is most likely to lower circulating levels of leukotrienes? (a) Zileuton (b) Montelukast (c) Carprofen (d) Aspirin (e) Allopurinol
Description : The toxicity spectrum of aspirin does not include (a) Increased risk of encephalopathy in children with viral infections (b) Increased risk of peptic ulcers (c) Hyperprothrombinemia (d) Metabolic acidosis (e) Respiratory alkalosis
Description : A 45-year-old surgeon has developed symmetric early morning stiffness in her hands. She wishes to take a nonsteroidal anti-inflammatory drug to relieve these symptoms and wants to avoid gastrointestinal side ... appropriate? (a) Aspirin (b) Celecoxib (c) Ibuprofen (d) Indomethacin (e) Piroxicam
Description : The main advantage of ketorolac over aspirin is that ketorolac (a) Can be combined more safely with an opioid such as codeine (b) Can be obtained as an over-the-counter agent (c) Does not ... (e) Is less likely to cause acute renal failure in patients with some preexisting degree of renal impairment
Description : Which one of the following drugs is not useful in dysmenorrhea? (a) Aspirin (b) Colchicine (c) Ibuprofen (d) Rofecoxib (e) Naproxen
Description : Which of the following is a reversible inhibitor of platelet cyclooxygenase? (a) Alprostadil (b) Aspirin (c) Ibuprofen (d) LTC4 (e) Misoprostol
Description : Systemic corticosteroid therapy is not used routinely and is reserved only for severe cases of (a) Exfoliative dermatitis (b) Posterior uveitis (c) Acute rheumatic fever (d) Hodgkin’s disease
Description : Cylcoocygenase-II specific inhibitors block the following (a) Production of cytoprotective prostaglandins (b) Tumor necrosis factor - a (c) Production of prostaglandins responsible for pain and inflammation
Description : Which of the following enzymes is ultimately responsible for the production of prostaglandins associated with inflammatory reactions? (a) Phospholipase (b) Lipoxygenase (c) Cyclooxygenase-I (d) Cyclooxygenase II (e) Xanthine oxidase
Description : A FDA – approved ingredient for protection against painful sensitivity of the teeth due to cold, heat, acids, sweets or contact is (a) Dicalcium phosphate (b) Sodium lauryl sulfate (c) 5% potassium nitrate (d) Zinc chloride (e) Calcium carbonate
Description : The following adverse effect of corticosteroids is due to their mineralocorticoid action (a) Osteoporosis (b) Rise in blood pressure (c) Moon face (d) Increased susceptibility to infection
Description : The prostanoid that consistently constricts blood vessels is (a) Prostaglandin E2 (b) Prostaglandin F2a (c) Thromboxane A2 (d) Prostacyclin
Description : A very common side effect of morphine is (a) Allergic response (b) Blood dyscrasias (c) Constipation (d) Liver damage (e) Visceral pain
Description : Colchicine is used mainly to treat (a) Gout (b) Arthiritis (c) Diabetes (d) Carcinomas (e) High blood pressure
Description : Acute or chronic colchicine toxicity may be identified by which of the following signs/symptoms? (a) Alopecia (b) Blood dyscrasias (c) Severe gastrointestinal upset (d) All of the above (e) None of the above
Description : A drug that decreases blood pressure and has analgesic and spasmolytic effects when given intrathecally is (a) Atenolol (b) Clonidine (c) Morphine (d) Nitroprusside (e) Prazosin
Description : Morphine dependence is characterized by (a) Marked drug seeking behavior (b) Physical dependence without psychic dependence (c) Physical as well as psychic dependence (d) Both (a) and (c)
Description : Morphine produces analgesia by acting at (a) Peripheral pain receptors (b) A spinal site (c) Suspraspinal sites (d) Both (b) and (c)
Description : The early pregnancy uterus is sensitive to the following oxytocic (a) Oxytocin (b) Methylergometrine (c) Prostaglandin F2a (d) Both (a) and (b)
Description : Autacoids differ from hormones in that (a) Autacoids are involved only in the causation of pathological states (b) Autacoids do not have a specific cell/ tissue of origin (c) Autacoids generally act locally at the site of generation and release (d) Both (b) and (c)
Description : Generally the earliest manifestation of salicylism is (a) Visual disturbance (b) Excitement (c) Hyperventillation (d) Tinnitus
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues
Description : Following mediators are involved in acute inflammation except (a) Histamine (b) Leukotrienes (c) Interferons (d) Bradykinin
Description : Lower dose of naloxone is required to (a) Antagonise the actions of nalorphine (b) Antagonise the actions of pentazocine (c) Precipitate withdrawal in mildly morphine dependent subjects (d) Precipitate withdrawal in highly morphine dependent subjects
Description : Which action of morphine is incompletely reversed by naloxone ? (a) Analgesia (b) Respiratory depression (c) Sedation (d) Miosis
Description : Pentazocine differs from morphine in that (a) It is inactive by the oral route (b) It does not produce physical dependence (c) It has a lower ceiling of analgesic effect (d) Its action is not blocked by naloxone
Description : Which of the following is an agonistantagonist type of opioid analgesic (a) Pethidine (b) Pentazocine (c) Fentanyl (d) Buprenorphine
Description : Morphine has high affinity for the following opioid receptor(s). (a) µ (Mu) (b) k (Kappa) (c) d (Delta) (d) All of the above
Description : Select the analgesic which acts through opioids as well as additional spinal monoaminergic mechanisms. (a) Tramadol (b) Ethoheptazine (c) Dextropropoxyphene (d) Alfentanil
Description : Which of the following opioid analgesics is similar to codeine in pharmacological profile but is less constipating ? (a) Methadone (b) Buprenorphine (c) Butorphanol (d) Dextropropoxyphene
Description : Which of the following opioids is more potent than morphine ? (a) Pethidine (b) Fentanyl (c) Dextropropoxyphene (d) Tramadol
Description : Morphine is contraindicated in head injury because (a) It does not relieve the pain of head injury (b) It can raise intracranial tension (c) It can cause constipation (d) It is liable to cause addiction
Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine (a) Selegiline (b) Chlorgiline (c) Moclobemide (d) Tranylcypromine
Description : Instead of depressing, morphine stimulates (a) Vasomotor centre (b) Edinger westphal nucleus (c) Temperature regulating centre (d) Cough centre