Description : Measurement of insulin clearance test is a measure of (A) Glomerular filtration rate (B) Filtration factor (C) Renal plasma flow (D) Tubular secretory mass
Last Answer : Answer : A
Description : Creatinine EDTA clearance is a test to measure (A) Renal plasma flow (B) Filtration fraction (C) Glomerular filtration rate (D) Tubular function
Last Answer : Answer : C
Description : Inulin clearance is a measure of (A) Glomerular filtration rate (B) Tubular secretion flow (C) Tubular reabsorption rate (D) Renal plasma flow
Last Answer : Answer : B
Description : If a drug undergoes net tubular secretion, its renal clearance will be: A. More than the glomerular filtration rate B. Equal to the glomerular filtration rate C. Less than the glomerular filtration rate D. Equal to the rate of urine formation
Last Answer : A. More than the glomerular filtration rate
Description : Para-amino hippurate excretion test is an indicator of (A) Glomerular filtration (B) Tubular secretion (C) Tubular reabsorption (D) Renal plasma flow
Last Answer : Answer : D
Description : The Tm for PAH i.e the maximal secretory capacity of the tubule for PAH can be used to gavge the (A) Extent of tubular damage FATS AND FATTY ACID METABOLISM 81 (B) Impairment of the capacity of the tubule to perform osmotic work (C) Impairment of renal plasma flow (D) Glomerular filtration rate
Description : Measurement of inulin renal clearance is a measure for (A) Effective renal blood flow (B) Renal drug excretion rate (C) Active renal secretion (D) Glomerular filtration rate
Last Answer : (D) Glomerular filtration rate
Description : Phenolsulphonephthalein excretion test is an indicator of (A) Glomerular filtration (B) Tubular secretion (C) Tubular reabsorption (D) Renal blood low
Description : The primary mechanism by which antidiuretic hormone reduces urine volume is: A. Decrease in glomerular filtration rate B. Decreased renal blood flow C. Decreased water permeability of descending limb of loop of Henle D. Increased water permeability of collecting duct cells
Last Answer : D. Increased water permeability of collecting duct cells
Description : An early feature of renal disease is (A) Impairment of the capacity of the tubule to perform osmotic work (B) Decrease in maximal tubular excretory capacity (C) Decrease in filtration factor (D) Decrease in renal plasma flow
Last Answer : A
Description : The plasma half life of pencillin-G is longer in the new born because their (a) Plasma protein level is low (b) Drug metabolizing enzymes are immature (c) Glomerular filtration rate is low (d) Tubular transport mechanisms are not well developed
Last Answer : Ans: D
Description : The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed
Last Answer : D. Tubular transport mechanisms are not well developed
Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion
Last Answer : B. Plasma protein binding
Description : Glomerular filtration rate can be measured by (A) Endogenous creatinine clearance (B) Para-aminohippurate test (C) Addis test (D) Mosenthal test
Description : In studies of the human body, which of the following terms is used to describe the first step in the production of urine? Is it: a) tubular secretion b) tubular reabsorption c) glomerular filtration d) none of these
Last Answer : ANSWER: C -- GLOMERULAR FILTRATION
Description : Match the items given in column I with those in column II and select the correct option given below. Column I Column II A. Glycosuria (i) Accumulation of uric acid in joints B. Gout (ii) Mass of crystallised salts within the kidney ... (iii) (iv) (c) (ii) (iii) (i) (iv) (d) (iv) (i) (ii) (iii)
Last Answer : (d) (iv) (i) (ii) (iii)
Description : Which of the following is true concerning a 68 year old male with type 2 diabetes diagnosed with type IV renal tubal acidosis? 1) Aminoaciduria would be expected. 2) Fludrocortisone treatment is effective ... 4) Increased urinary bicarbonate would be expected. 5) Normal renal handling of K+ and H+
Last Answer : Answers-2 H+ secretion, sodium reabsorption and ammonia production diminishes. RTA 4 is in effect hyporeninaemic hypoaldosteronism or failure of aldosterone action and thus helped treated with ... particularly. Aminoaciduria and increased urine bicarbonate are features of RTA types 1 and 2.
Description : Among the following, a test of Glomerular function is (A) Urea clearance (B) PSP excretion test (C) PAH clearance (D) Hippuric acid excretion test
Last Answer : B. Drug metabolizing enzymes are immature
Description : If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr
Last Answer : B. 2.0 L/hr
Description : The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high
Last Answer : C. Tubular transport mechanisms are not well developed
Description : When fluid intake is normal, the specific gravity of urine should be a) 1.010-1.025. Urine specific gravity is a measurement of the kidney's ability to concentrate urine. b) 1.000. The ... intake. d) greater than 1.025. A urine specific gravity greater than 1.025 may indicate overhydration.
Last Answer : a) 1.010-1.025. Urine specific gravity is a measurement of the kidney’s ability to concentrate urine.
Description : Renal glycosuria occurs due to (A) Increased filtration of glucose in glomeruli (B) Increased secretion of glucose by renal tubular cells (C) Decreased reabsorption of glucose by renal tubular cells (D) Increased conversion of glycogen into glucose in tubular cells
Description : Excretion of phenolsulphanpthalein (PSP) reflects (A) Glomerulonephritis (B) Maximaltabular excretory capacity (C) Filtration factor (D) Renal plasma flow
Description : Among the following, the most sensitive indicator of glomerular function is (A) Serum urea (B) Serum creatinine (C) Urea clearance (D) Creatinine clearance
Description : The most important channel of elimination of digoxin is: A. Glomerular filtration B. Tubular secretion C. Hepatic metabolism D. Excretion in bile
Last Answer : A. Glomerular filtration
Description : Interindividual variations in equieffective doses of a drug are most marked if it is disposed by: A. Glomerular filtration B. Tubular secretion C. Both glomerular filtration and tubular secretion D. Hepatic metabolism
Last Answer : D. Hepatic metabolism
Description : A 60-year-old man was diagnosed last year with adenocarcinoma of the lung, and a 4 cm mass lesion was treated with a right lower lobectomy. He now has an ... 2) Membranous glomerulonephritis 3) Minimal change glomerulonephritis 4) Nodular glomerulosclerosis 5) Rapidly progressive glomerulonephritis
Last Answer : Answers-2 Most cases of membranous GN are idiopathic, but in some patients there is a history of an infection or a malignancy (usually lung) with antigenemia.
Description : An important finding in glycinuria is (A) Excess excretion of oxalate in the urine (B) Deficiency of enzyme glycinase (C) Significantly increased serum glycine level (D) Defect in renal tubular reabsorption of glycine
Description : Which of the following concerning the pH of urine is correct? 1) is a useful indicator of the acid/base balance of the blood 2) rises on a vegetarian diet 3) is determined by the concentration of ... lower than 5.5 in renal tubular acidosis 5) would be above 7.0 after prolonged and severe vomiting
Last Answer : Answers-2 c - excretion of ammonium occurs when an acid urine is produced but the pH of urine is of course determined by the concentration of H+ ions d-unable to lower the pH to ... and distal nephron and this perpetuates the metabolic alkalosis until the fluid balance is restored with IV fluids.
Description : Filtration fraction can be calculated from (A) Standard urea clearance and PSP excretion (B) Maximum urea clearance and PSP excretion (C) Maximum urea clearance and PAH clearance (D) Inulin clearance and PAH clearance
Description : Which one of the following correctly explains the function of a specific part of the human nephron? (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the ... blood capillaries (d) Afferent arteriole : carries the blood away from the glomerulus towards renal vein.
Last Answer : (a) Podocytes : create minute spaces (slit pores) for the filtration of blood into the Bowman’s capsule
Description : All the following statements about renal tubular acidosis are correct except (A) Renal tubules may be unable to reabsorb bicarbonate (B) Renal tubules may be unable to secrete hydrogen ions (C) Plasma chloride is elevated (D) Anion gap is decreased
Description : A simple way to assess tubular function is to withhold food and water for 12 hours and, then, measure (A) Serum urea (B) Serum creatinine (C) Urine output in one hour (D) Specific gravity of urine
Description : Assertion `:-` Tubular is of considerable importance in Marine teleost fishes. Reason `:-` These fishes have no glomerular kidney .
Last Answer : Assertion `:-` Tubular is of considerable importance in Marine teleost fishes. Reason `:-` These fishes ... D. If both Assertion & Reason are false.
Description : If the GFR is 125 mL/min and the renal plasma flow is 700 mL/min, the filtration fraction is
Last Answer : If the GFR is 125 mL/min and the renal plasma flow is 700 mL/min, the filtration fraction is A. About 6% B. About 18% C. About 12% D. About 24%
Description : ADH test is based on the measurement of (A) Specific gravity of urine (B) Concentration of urea in urine (C) Concentration of urea in blood (D) Volume of urine in ml/minute
Description : Which of the following factors is responsible for the formation of concentrated urine? (a) Hydrostatic pressure during glomerular filtration. (b) Low levels of antidiuretic hormone. (c) ... the medullary interstitium in the kidneys. (d) Secretion of erythropoietin by Juxtaglomerular complex.
Last Answer : (c) Maintaining hyperosmolarity towards the medullary interstitium in the kidneys.
Description : When the nurse notes that the post cardiac surgery patient demonstrates low urine output (< 25 ml/hr) with high specific gravity (> 1.025), the nurse suspects: a) Inadequate fluid volume Urine ... by high urine output with low specific gravity. d) Anuria The anuric patient does not produce urine.
Last Answer : a) Inadequate fluid volume Urine output of less than 25 ml/hr may indicate a decrease in cardiac output. A high specific gravity indicates increased concentration of solutes in the urine which occurs with inadequate fluid volume.
Description : Urea clearance is the (A) Amount of urea excreted per minute (B) Amount of urea present in 100 ml of urine (C) Volume of blood cleared of urea in one minute (D) Amount of urea filtered by glomeruli in one minute
Description : The formula to calculate maximum urea clearance is U V× B , where U denotes (A) Concentration of urea in urine in gm/24hr (B) Concentration of urea in urine in mg/100 ml (C) Concentration of urea in blood in mg/100 ml (D) Volume of urine in ml/mt
Description : The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant
Last Answer : C. Volume of distribution
Description : High plasma protein binding: A. Increases volume of distribution of the drug B. Facilitates glomerular filtration of the drug C. Minimises drug interactions D. Generally makes the drug long acting
Last Answer : D. Generally makes the drug long acting