Description : C22 and C24, fatty acids required for the synthesis of sphingolipids in brain are formed by (A) De novo synthesis (B) Microsomal chain elongation (C) Mitochondrial chain elongation (D) All of these
Last Answer : Answer : B
Description : All the following statements about acetyl CoA carboxylase are true except (A) It is required for de novo synthesis of fatty acids (B) It is required for mitochondrial elongation of fatty acids ( ... for microsomal elongation of fatty acids (D) Insulin converts its inactive form into its active form
Description : Epinephrine increases all of the following except (A) Glycogenolysis in muscles (B) Lipolysis in adipose tissue (C) Gluconeogenesis in muscles (D) Glucagon secretion
Last Answer : Answer : C
Description : The output of free fatty acids from adipose tissue is reduced by (A) Insulin (B) Glucagon (C) Growth hormone (D) Epinephrine
Last Answer : Answer : A
Description : Release of free fatty acids from adipose tissue is increased by all of the following except (A) Glucagon (B) Epinephrine (C) Growth hormone (D) Insulin
Last Answer : Answer : D
Description : The desaturation and chain elongation system of polyunsaturated fatty acids are greatly diminished in the absence of (A) Insulin (B) Glycagon (C) Epinephrine (D) Thyroxine
Description : Which of the following regulates lipolysis in adipocytes? (A) Activation of fatty acid synthesis mediated by CAMP (B) Glycerol phosphorylation to prevent futile esterification of fatty acids (C) ... result of hormone stimulated increases in CAMP levels (D) Activation of CAMP production by Insulin
Description : The desaturation and chain elongation system of polyunsaturated fatty acid are enhanced by (A) Insulin (B) Glucagon (C) Epinephrine (D) Thyroxine
Description : Extramitochondrial synthesis of fatty acids occurs in (A) Mammary glands (B) Lungs (C) Brain (D) All of these
Description : Action of Insulin does not include the following: A. Facilitation of glucose transport into cells B. Facilitation of glycogen synthesis by liver C. Facilitation of neoglucogenesis by liver D. Inhibition of lipolysis in adipose tissue
Last Answer : . Facilitation of neoglucogenesis by liver
Description : Fatty acids are a major energy source for the body. Which of the following statement(s) is/are true concerning the use of fatty acids as an energy source? a. Fatty acids are stored in ... 25% of total nonprotein caloric needs supplied via total parenteral nutrition should be in the form of fat
Last Answer : Answer: a, b, d In most tissues, fatty acids are readily oxidized for energy. They are especially important energy sources for the heart, liver and skeletal muscle. In ... administered to patients receiving total parenteral nutrition should comprise about 5-30% of total nonprotein caloric needs
Description : Prostaglandins stimulate (A) Aggregation of platelets (B) Lipolysis in adipose tissue (C) Bronchodilatation (D) Gastric acid secretion
Description : When the stired triacylglycerol is lipolysed in the adipose tissue blood levels of _____ increased. (A) FFA only (B) Glycerol only (C) Free fatty acids (FFA) and Glycerol (D) Triacyl glycero
Description : Free fatty acids released from adipose tissue are transported in blood by (A) Albumin (B) VLDL (C) LDL (D) HDL
Description : The enzyme regulating extramitochondrial fatty acid synthesis is (A) Thioesterase (B) Acetyl CoA carboxylase (C) Acyl transferase (D) Multi-enzyme complex
Description : A cofactor required for the conversion of acetyl-CoA to malonyl-CoA in extramitochondrial fatty acid synthesis is (A) Biotin (B) FMN (C) NAD (D) NADP
Description : Which of the following cofactors or their derivatives must be present for the conversion of acetyl CoA to malonyl CoA extramitochondrial fatty acid synthesis? (A) Biotin (B) FAD (C) FMN (D) ACP
Description : For extramitochondrial fatty acid synthesis, acetyl CoA may be obtained from (A) Citrate (B) Isocitrate (C) Oxaloacetate (D) Succinate
Description : NADPH required for fatty acid synthesis can come from (A) Hexose monophosphate shunt (B) Oxidative decarboxylation of malate (C) Extramitochondrial oxidation of isocitrate (D) All of these
Description : In the extra mitochondrial synthesis of fatty acids, CO2 is utilized (A) To keep the system anaerobic and prevent regeneration of acetyl CoA (B) In the conversion of malonyl to CoA hydroxybutyryl CoA (C ... of acetyl CoA to malonyl CoA (D) In the formation of acetyl CoA from 1 carbon intermediates
Description : The major site for elongation of medium chain fatty acids is (A) Mitochondria (B) Cytosol (C) Microsomes (D) All of these
Description : Chain elongation of fatty acids in mammalian liver occurs in (A) Nucleus (B) Ribosomes (C) Lysosomes (D) Microsomes
Description : Chain elongation of fatty acids occurring in mammalian liver takes place in which of the following subcellular fractions of the cell? (A) Nucleus (B) Ribosomes (C) Lysosomes (D) Microsomes
Description : Mitochondrial membrane is permeable to (A) Short chain fatty acids (B) Medium chain fatty acids (C) Long chain fatty acids (D) All of these
Description : Mitochondrial thiokinase acts on (A) Short chain of fatty acids (B) Medium chain fatty acids (C) Long chain fatty acids (D) All of these
Description : Long chain fatty acids penetrate the inner mitochondrial membrane (A) Freely (B) As acyl-CoA derivative (C) As carnitine derivative (D) Requiring Na dependent carrier
Description : All the following statements about brown adipose tissue are true except (A) It is rich in cytochromes (B) It oxidizes glucose and fatty acids (C) Oxidation and phosphorylation are tightly coupled in it (D) Dinitrophenol has no effect on it
Description : α-Oxidation of fatty acids occurs mainly in (A) Liver (B) Brain (C) Muscles (D) Adipose tissue
Description : The enzymes of the citric acid cycle are located in (A) Mitochondrial matrix (B) Extramitochondrial soluble fraction of the cell (C) Nucleus (D) Endoplasmic reticulum
Description : Brown adipose tissue is characterized by which of the following? (A) Present in large quantities in adult humans (B) Mitochondrial content higher than white adipose tissue (C) Oxidation and phosphorylation are tightly coupled (D) Absent in hibernating animals
Description : The metabolic actions of adrenaline include the following except: A. Glycogenolysis in liver and muscle B. Inhibition of neoglucogenesis in liver C. Lipolysis in adipose tissue D. Release of potassium from liver followed by its uptake
Last Answer : B. Inhibition of neoglucogenesis in liver
Description : Acetyl CoA required for extra mitochondrial fatty acid synthesis is produced by (A) Pyruvate dehydrogenase complex (B) Citrate lyase (C) Thiolase (D) Carnitine-acyl transferase
Description : A pathway that requires NADPH as a cofactor is (A) Fatty acid oxidation (B) Extra mitochondrial denovo fatty acid synthesis (C) Ketone bodies formation (D) Glycogenesis
Description : Chain elongation of fatty acid is taking place in which site?
Last Answer : Microsomal elongation system is more active.
Description : Glycerol released from adipose tissue by hydrolysis of triglycerides is mainly (A) Taken up by liver (B) Taken up by extrahepatic tissues (C) Reutilised in adipose tissue (D) Excreted from the body FATS AND FATTY ACID METABOLISM 85
Description : Glycerol-3-phosphate for the synthesis of triglycerides in adipose tissue is derived from (A) Phosphatidic acid (B) Diacylglycerol (C) Glycerol (D) Glucose
Description : Free glycerol cannot be used for triglyceride synthesis in (A) Liver (B) Kidney (C) Intestine (D) Adipose tissue
Description : In adipose tissue, glycerol-3-phosphate required for the synthesis of triglycerides comes mainly from (A) Hydrolysis of pre-existing triglycerides (B) Hydrolysis of phospholipids (C) Dihydroxyacetone phosphate formed in glycolysis (D) Free glycerol
Description : The maximum possible chain length of fatty acids formed in the pathway of de novo synthesis is (A) 16 Carbon atoms (B) 18 Carbon atoms (C) 20 Carbon atoms (D) 24 Carbon atoms
Description : A soluble system for synthesis of fatty acids have been isolated from avian liver, required for the formation of long chain fatty acids by this system is (A) ATP (B) Acetyl CoA (C) NADPH (D) All of these
Description : A pathway that requires NADPH as a cofactor is (A) Extramitochondrial folic acid synthesis (B) Ketone body formation (C) Glycogenesis (D) Gluconeogenesis
Description : Epinephrine decreases (A) Glycogenesis (B) Glycogenolysis (C) Gluconeogenesis (D) Lipolysis
Description : Glucagon (A) Increases protein synthesis (B) Inhibits lipolysis in adipocytes (C) Increases gluconeogenesis in liver (D) Stimulates muscle glycogenolysis
Description : Action of insulin on lipid metabolism is (A) It increases lipolysis and increases triglyceride synthesis (B) It decreases lipolysis and increases triglyceride synthesis (C) It decreases ... and decreases triglyceride synthesis (D) It increases synthesis of triglyceride and increased ketogenesis
Description : Long chain fatty acyl CoA esters are transported across the mitochondrial membrane by (A) cAMP (B) Prostaglandin (C) Carnitine (D) Choline
Description : Oxidation of fatty acids occurs (A) In the cytosol (B) In the matrix of mitochondria (C) On inner mitochondrial membrane (D) On the microsomes
Description : Calcitriol synthesis involves (A) Both liver and kidney (B) Intestine (C) Adipose tissue (D) Muscle
Description : Adipose tissue which is a store house for triacyl glycerol synthesis the same using (A) The glycerol released by hydrolysis of triacyl glycerol (B) The glycerol-3-phosphate obtained in the metabolism of glucose (C) 2-phosphoglycerate (D) 3-phosphoglycerate
Description : Which of the following types of drug metabolizing enzymes are inducible: A. Microsomal enzymes B. Nonmicrosomal enzymes C. Both microsomal and nonmicrosomal enzymes D. Mitochondrial enzymes
Last Answer : A. Microsomal enzymes