Description : The second messenger for glucocorticoids is (A) Cyclic AMP (B) Cyclic GMP (C) Inositol triphosphate (D) No second messenger is required
Last Answer : Answer : D
Description : Second messenger for glucagons is (A) Cyclic AMP (B) Diacylglycerol (C) Cyclic GMP (D) Inositol triphosphate
Last Answer : Answer : A
Description : The second messenger for PTH is (A) Cyclic AMP (B) Cyclic GMP (C) Diacylglycerol (D) Inositol triphosphate
Description : All the following statements about ACTH are true except (A) It is a tropic hormone (B) Its target cells are located in adrenal cortex (C) Its receptors are located in the cell membrane (D) Its second messenger is inositol triphosphate
Description : Inositol triphosphate is the second messenger for (A) Gastrin (B) Cholecystokinin (C) Oxytocin (D) All of these
Description : One of the following is not used as a second messenger by hormones: (A) mRNA (B) cAMP (C) Calcium ions (D) Myoinisotol 1, 4, 5 triphosphate
Description : Activated phospholipase C acts on (A) Phosphatidyl inositol-4, 5-biphosphate (B) Inositol-1, 4, 5-triphosphate (C) Protein kinase C (D) Pl-3 kinase
Description : Protein kinase C is activated by (A) Cyclic AMP (B) Cyclic GMP (C) Diacyl glycerol (D) Inositol triphosphate
Last Answer : Answer : C
Description : The best understood intracellular messenger is cyclic AMP (cAMP). Which of the following statement(s) concerning this intracellular messenger is/are correct? a. Intracellular cyclic AMP is constantly ... of adenylate cyclase d. cAMP is the only cyclic nucleotide active as an intracellular messenger
Last Answer : Answer: a, b The prototypic intracellular messenger is cAMP. To function as a mediator, the concentration of cAMP must change rapidly. In resting cells, cAMP is continuously being degraded by ... produce cGMP. Intracellular calcium ions also serve as second messengers in a large number of cells
Description : All of the following subserve as intracellular second messengers in receptor mediated signal transduction except: A. Cyclic AMP B. Inositol trisphosphate C. Diacyl glycerols D. G proteins
Last Answer : D. G proteins
Description : Actions of 5-HT2 receptor activation are primarily mediated by: A. Increased membrane permeability to Na+ ions B. Increased formation of cAMP C. Activation of guanylyl cyclase D. Generation of inositol trisphosphate and diacyl glycerols
Last Answer : D. Generation of inositol trisphosphate and diacyl glycerols
Description : Which of the following does not act interacellularly to produce physiologic effects a. Triiodothyronine b. Inositol triphosphate c. Aldosterone d. Cyclic AMP e. Doapamine
Last Answer : Doapamine
Description : All the following statements about steroid hormones are true except (A) They are hydrophobic (B) They require carriers to transport them in circulation (C) Their receptors are intracellular (D) They require cyclic AMP as second messenger
Description : Which of the following eicosanoids is generated through the lipozygenase pathway ? (a) Prostaglandin E2 (b) Thromboxane A2 (c) Prostacyclin (d) Leukotriene C4
Last Answer : Ans: D
Description : In addition to their ability to decrease inflammatory prostaglandin synthesis, some non-steroidal anti-inflammatory drugs (NSAIDs) may owe part of their effects to their ability to (a) Inhibit leukocyte migration (b ... (c) Stabilize lysosmal membranes (d) All of the above (e) None of the above
Description : A 60-year-old woman has glaucoma following cataract surgery. Which of the following can be used to reduce intraocular pressure? (a) Leukotriene LTD4 or its analogs (b) Prostaglandin E2 or its analogs ( ... analogs (d) Slow-reacting substance of anaplylaxis (SRS-A) (e) Thromboxane A2 or its analogs
Last Answer : Ans: C
Description : The following eicosanoid is generated through the lipoxygenase pathway: A. Prostaglandin E2 B. Thromboxane A2 C. Leukotriene C4 D. Prostacyclin
Last Answer : C. Leukotriene C4
Description : Second messengers a. are substances that interact with first messengers inside cells b. are substances that bind to first messengers in the cell membrane c. are hormones secreted by cells ... the intracellular responses to many different hormonesand neurotransmitters e. are not formed in the brain
Last Answer : mediate the intracellular responses to many different hormonesand neurotransmitters
Description : Which of the following will result from blockade of H2 receptors? (a) Decreased camp in cardiac muscle (b) Increased camp in cardiac muscle (c) Decreased IP3 in gastric mucosa (d) Increased IP3 in gastric mucosa (e) Increased IP3 in smooth muscle
Last Answer : Ans: A
Description : All the following hormones use cAMP as a second messenger except (A) Estrogen (B) FSH (C) Luteinizing (D) Glucagon
Description : Hormone that bind to cell surface receptor and require the second messenger camp is (A) Antidiuretic hormone (B) Cholecystokinin (C) Calcitriol (D) Gastrin
Description : Long chain fatty acyl CoA esters are transported across the mitochondrial membrane by (A) cAMP (B) Prostaglandin (C) Carnitine (D) Choline
Description : A 55-year-old male undergoes a total abdominal colectomy. Which of the following statement(s) is/are true concerning the hormonal response to the surgical procedure? a. Adrenocorticotropic ... in serum insulin and a fall in glucagon accelerate hepatic glucose production and maintain gluconeogenesis
Last Answer : Answer: a, c One of the earliest consequence of a surgical procedure is the rise in levels of circulating cortisol that occur in response to a sudden outpouring of ACTH ... hepatic glucose production, and, with other hormones (epinephrine and glucocorticoids), gluconeogenesis is maintained
Description : Binding of catecholamines to α2− adrenergic receptors (A) Increases the intracellular concentration of cAMP (B) Increases the intracellular concentration of cGMP (C) Decreases the intracellular concentration of cAMP (D) Decreases the intracellular concentration of cGMP
Description : Which of the following statements are true of the multiple organ dysfunction syndrome (MODS)? A. The two-hit model proposes that secondary MODS may be produced when even a relatively ... intensive care units has decreased owing to increased awareness, prevention, and treatment of the syndrome.
Last Answer : Answer: ABC DISCUSSION: MODS is part of a clinical continuum that begins with the systemic inflammatory response syndrome, which is the host's stress response to any major insult such ... pathogenesis of MODS, the incidence of MODS continues to increase without a significant improvement in outcome
Description : Which of the following statement(s) is/are true concerning cell membrane receptors? a. The largest family of cell surface receptors are the G-protein-linked receptors b. Activities of the ... through the use adenylate cyclase d. Tyrosine kinase receptors are considered G-protein-linked receptors
Last Answer : Answer: a, c All water-soluble regulatory molecules bind to the cell surface receptor proteins. Binding of the appropriate ligand evokes an intracellular signal which usually regulates ... are adenylate cyclase, which converts ATP to cAMP, and the polyphosphoinositide-specific phospholipase C
Description : The GABAB receptor: A. Is an intrinsic ion channel containing receptor B. Mediates neuronal depolarization C. Is insensitive to blockade by bicuculline D. Regulates intracellular cAMP
Last Answer : C. Is insensitive to blockade by bicuculline
Description : Which of the following effects of epinephrine would be blocked by phentolamine but not by metoprolol ? (a) Cardiac stimulation (b) Contractionof radial smooth muscle in the iris (c) Increase of camp in fat (d) Relaxation of bronchial smooth muscle (e) Relaxation of the uterus
Last Answer : Ans: B
Description : The symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) ... bronchial tissue (d) Decreased calcium influx into the mast cell (e) Decreased prostaglandin production
Description : The Symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) ... bronchial tissue (d) Decreased calcium influx into the mast cells (e) Decreased prostaglandin production
Description : Of the following classifications of medications, which is known to inhibit prostaglandin synthesis or release? a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs ... to cause immunosuppression. d) Antineoplastic agents Antineoplastic agents are known to cause immunosuppression.
Last Answer : a) Nonsteroidal anti-inflammatory drugs (NSAIDs) in large doses NSAIDs include aspirin and ibuprofen.
Description : Hormone receptors that stimulate cAMP production (A) are part of a complex of two proteins that transform the external signal into internal cAMP production (B) are proteins distinct and separate from those ... binding of the hormone (D) are not very specific and bind a number of different hormones
Last Answer : Answer : B
Description : Leukotrienes: 1) Are formed from the cyclooxygenase pathway 2) Are synthesized by fibroblasts 3) Decrease vascular permeability 4) Leukotriene D4 has been identified as SRS-A which causes bronchial wall smooth muscle relaxation 5) Stimulate mucus secretion
Last Answer : Answers-5 Leukotrienes are synthesized by leucocytes.They are mediators of allergic reaction. They increase vascular permeability and attract neutrophils and eosinophils to inflammatory sites. ... stimulate mucus production, an important consideration in the pathophysiology of bronchial asthma.
Description : Which one of the following is not a secondary messenger in hormone action? (a) cAMP (b) cGMP (c) Calcium (d) Sodium
Last Answer : d) Sodium
Description : Glutathione is a constituent of (A) Leukotriene A4 (B) Thromboxane A1 (C) Leukotriene C4 (D) None of these
Description : Pruning in old fruit trees increases fruit bud formation by increasing ______: a. Carbohydrates b. New vegetative growth c. Hormonal contents d. Cell sap
Last Answer : New vegetative growth
Description : ___is rupture of red cells with release of intracellular haemoglobin can occur if the Antibody has the property of hemolysin. a) Agglutination b) Hemolysis c) Reaction
Last Answer : b) Hemolysis is the rupture of red blood cells with the release of intracellular hemoglobin, and it can occur if the antibody has the property of hemolysin. Hemolysis is the destruction or ... bacteria, and viruses, and it is a key principle in many diagnostic tests for infectious diseases.
Description : Which of the following product of PIP`""_(2)` diffuses into the cytoplasm triggering the release of `Ca^(2+)` for intracellular calcium-mediated proce
Last Answer : Which of the following product of PIP`""_(2)` diffuses into the cytoplasm triggering the release of `Ca^(2 ... `IP_3` B. DG C. cAMP D. Protein kinase
Description : Methylxanthines exert the following action (s) at cellular/molecular level (a) Intracellular release of Ca2+ (b) Antagonism of adenosine (c) Inhibition of phosphodiesterase (d) All of the above
Description : Methylxanthines exert the following action(s) at cellular/molecular level: A. Intracellular release of Ca2+ B. Antagonism of adenosine C. Inhibition of phosphodiesterase D. All of the above
Last Answer : D. All of the above
Description : Cromolyn has as its major action (a) Block of calcium channels in lymphocytes (b) Block of mediator release from mast cells (c) Block of phosphodiesterase in mast cells and basophils (d) Smooth muscle relaxation in the bronchi (e) Stimulation of cortisol release by the adrenals
Description : Rapid intravenous injection of clonidine causes rise in BP due to: A. Stimulation of vasomotor centre B. Release of noradrenaline from adrenergic nerve endings C. Agonistic action on vascular α2 adrenergic receptors D. Cardiac stimulation
Last Answer : C. Agonistic action on vascular α2 adrenergic receptors
Description : Insulin release from pancreatic β cells is augmented by the following except: A. Ketone bodies B. Glucagon C. Vagal stimulation D. Alfa adrenergic agonists
Last Answer : D. Alfa adrenergic agonist
Description : Superactive GnRH agonists cause: A. Initial as well as sustained release of gonadotropins B. Initial inhibition followed by stimulation of gonadotropin release after 1-2 weeks C. Initial stimulation ... release after 1-2 weeks D. Initial as well as sustained inhibition of gonadotropin release
Last Answer : C. Initial stimulation followed by inhibition of gonadotropin release after 1-2 weeks
Description : 16.17 Superactive GnRH agonists cause: A. Initial as well as sustained release of gonadotropins B. Initial inhibition followed by stimulation of gonadotropin release after 1-2 weeks C. Initial ... release after 1-2 weeks D. Initial as well as sustained inhibition of gonadotropin release
Description : In contrast to Eukaryotic mRNA, prokaryotic mRNA is characterized by (A) Having 7-methyl guanosine triphosphate at the 5’ end (B) Being polycystronic (C) Being only monocystronic (D) Being synthesized with introns
Description : 5’-Terminus of mRNA molecule is capped with (A) Guanosine triphosphate (B) 7-Methylguanosine triphophate (C) Adenosine triphosphate (D) Adenosine diphosphate
Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors
Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation
Description : All of the following statements about post-transcriptional processing of tRNA are true except (A) Introns of some tRNA precursors are removed (B) CCA is added at 3′ end (C) 7-Methylguanosine triphosphate cap is added at 5′ end (D) Some bases are methylated