The correct sequence of the reactions of catabolism of adenosine to uric acid is (A) Adenosine→hypoxanthine→xanthine→uric acid (B) Adenosine→xanthine→inosine→uric acid (C) Adenosine→inosine→hypoxanthine→ xanthine uric acid (D) Adenosine→xanthine→inosine→hypoxanthine uric acid

The correct sequence of the reactions of catabolism of adenosine to uric acid is (A) Adenosine→hypoxanthine→xanthine→uric acid (B) Adenosine→xanthine→inosine→uric acid (C) Adenosine→inosine→hypoxanthine→ xanthine uric acid (D) Adenosine→xanthine→inosine→hypoxanthine uric acid
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The end product of purine catabolism in man is (A) Inosine (B) Hypoxanthine (C) Xanthine (D) Uric acid

Description : The end product of purine catabolism in man is (A) Inosine (B) Hypoxanthine (C) Xanthine (D) Uric acid

Last Answer : Answer : D

In humans end product of purine catabolism is (A) Uric acid (B) Urea (C) Allantoin (D) Xanthine

Description : In humans end product of purine catabolism is (A) Uric acid (B) Urea (C) Allantoin (D) Xanthine

Last Answer : Answer : A

Which pathway is correct for catabolism of purines to form uric acid? (A) Guanylate→Adenylate→Xanthine→hypoxanthine→Uric acid (B) Guanylate→inosinate→Xanthine→hypoxanthine→Uric acid (C) Adenylate→Inosinate→Xanthine hypoxanthine→Uric acid (D) Adenylate→Inosinate→hypoxanthine Xanthine→Uric acid

Description : Which pathway is correct for catabolism of purines to form uric acid? (A) Guanylate→Adenylate→Xanthine→hypoxanthine→Uric acid (B) Guanylate→inosinate→Xanthine→hypoxanthine→Uric acid (C) Adenylate→Inosinate→Xanthine hypoxanthine→Uric acid (D) Adenylate→Inosinate→hypoxanthine Xanthine→Uric acid

Last Answer : Answer : D

β -Aminoisobytyrate is formed from catabolism of (A) Cytosine (B) Uracil (C) Thymine (D) Xanthine

Description : β -Aminoisobytyrate is formed from catabolism of (A) Cytosine (B) Uracil (C) Thymine (D) Xanthine

Last Answer : Answer : C

A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate

Last Answer : Answer : B

All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase

Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase

Last Answer : Answer : A

Uric acid is the end product of purine as well as protein catabolism in (A) Man (B) Fish (C) Birds (D) None of these

Description : Uric acid is the end product of purine as well as protein catabolism in (A) Man (B) Fish (C) Birds (D) None of these

Last Answer : Answer : C

In humans purine are catabolised to uric acid due to lack of the enzyme: (A) Urease (B) Uricase (C) Xanthine oxidase (D) Guanase

Description : In humans purine are catabolised to uric acid due to lack of the enzyme: (A) Urease (B) Uricase (C) Xanthine oxidase (D) Guanase

Last Answer : Answer : B

Schardinger’s enzyme is (A) Lactate dehydrogenase (B) Xanthine dehydrogenase (C) Uric oxidase (D) L amino acid dehydrogenase

Description : Schardinger’s enzyme is (A) Lactate dehydrogenase (B) Xanthine dehydrogenase (C) Uric oxidase (D) L amino acid dehydrogenase

Last Answer : Answer : B

Xanthuric acid is an abnormal metabolite of (A) Xanthine (B) Uric acid (C) Tyrosine (D) Tryptophan

Description : Xanthuric acid is an abnormal metabolite of (A) Xanthine (B) Uric acid (C) Tyrosine (D) Tryptophan

Last Answer : Answer : D

A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Last Answer : B

Mammals other than higher primates do not suffer from gout because they (A) Lack xanthine oxidase (B) Lack adenosine deaminase (C) Lack purine nucleoside phosphorylase (D) Possess uricase

Description : Mammals other than higher primates do not suffer from gout because they (A) Lack xanthine oxidase (B) Lack adenosine deaminase (C) Lack purine nucleoside phosphorylase (D) Possess uricase

Last Answer : Answer : D

The enzyme common to catabolism of all the purines is (A) Adenosine deaminase (B) Purine nucleoside phosphorylase (C) Guanase (D) None of these

Description : The enzyme common to catabolism of all the purines is (A) Adenosine deaminase (B) Purine nucleoside phosphorylase (C) Guanase (D) None of these

Last Answer : Answer : B

Enzymic deficiency in β-aminoisobutyric aciduria is (A) Adenosine deaminase (B) Xanthine oxidase (C) Orotidylate decarboxylase (D) Transaminase

Description : Enzymic deficiency in β-aminoisobutyric aciduria is (A) Adenosine deaminase (B) Xanthine oxidase (C) Orotidylate decarboxylase (D) Transaminase

Last Answer : Answer : D

An autosomal recessive disorder, xanthinuria is due to deficiency of the enzymes: (A) Adenosine deaminase (B) Xanthine oxidase (C) HGPRTase (D) Transaminase

Description : An autosomal recessive disorder, xanthinuria is due to deficiency of the enzymes: (A) Adenosine deaminase (B) Xanthine oxidase (C) HGPRTase (D) Transaminase

Last Answer : Answer : B

Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase

Description : Lesch-Nyhan syndrome, the sex linked recessive disorder is due to the lack of the enzyme: (A) Hypoxanthine-guanine phosphoribosyl transferse (B) Xanthine oxidase (C) Adenine phosphoribosyl transferase (D) Adenosine deaminase

Last Answer : Answer : A

Insoinic acid is the biological precursor of (A) Cytosine and Uric acid (B) Adenylve acid and Glucine floc acid (C) Orotic acid and Uridylic acid (D) Adenosine acid Thymidine

Description : Insoinic acid is the biological precursor of (A) Cytosine and Uric acid (B) Adenylve acid and Glucine floc acid (C) Orotic acid and Uridylic acid (D) Adenosine acid Thymidine

Last Answer : Answer : B

Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above

Description : Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above

Last Answer : C. Uric acid

A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Last Answer : (B) Allopurinol

Which of the following statements are true of oxidants? A. In addition to their pathophysiologic roles in inflammation, injury, and infection, oxidants also have physiologic roles. B. Oxidants may be generated from activated neutrophils and during reperfusion following a period of ischemia. C. The deleterious effects of oxidants include lipid peroxidation and cell membrane damage, oxidative damage to DNA, and inhibition of adenosine triphosphate (ATP) synthesis. D. The mechanism of ischemia-reperfusion injury involved the catalytic production of superoxide anion (O 2•) by the enzyme xanthine oxidase.

Description : Which of the following statements are true of oxidants? A. In addition to their pathophysiologic roles in inflammation, injury, and infection, oxidants also have physiologic roles. B. Oxidants may ... involved the catalytic production of superoxide anion (O 2 ) by the enzyme xanthine oxidase.

Last Answer : Answer: ABCD DISCUSSION: Oxidants are reactive oxygen metabolites that have both physiologic and pathophysiologic roles. As potent oxidizing agents, oxidants are involved in cytochrome P ... leukocyte infiltration and activation, causing further tissue damage by the release of cytotoxic proteases

The common features of introns include all the following except (A) The base sequence begins with GU (B) The base sequence ends with AG (C) The terminal AG sequence is preceded by a purine rich tract of ten nucleotides (D) An adenosine residue in branch site participates in splicing

Description : The common features of introns include all the following except (A) The base sequence begins with GU (B) The base sequence ends with AG (C) The terminal AG sequence is preceded by a purine rich tract of ten nucleotides (D) An adenosine residue in branch site participates in splicing

Last Answer : Answer : C

Which of the following enzymes is ultimately responsible for the production of prostaglandins associated with inflammatory reactions? (a) Phospholipase (b) Lipoxygenase (c) Cyclooxygenase-I (d) Cyclooxygenase II (e) Xanthine oxidase

Description : Which of the following enzymes is ultimately responsible for the production of prostaglandins associated with inflammatory reactions? (a) Phospholipase (b) Lipoxygenase (c) Cyclooxygenase-I (d) Cyclooxygenase II (e) Xanthine oxidase

Last Answer : Ans: D

An enzyme involved in catabolism of catecholamines is (A) Dopa decarboxylase (B) Aromatic amino acid decarboxylase (C) Monoamine oxidase (D) Catechol oxidas

Description : An enzyme involved in catabolism of catecholamines is (A) Dopa decarboxylase (B) Aromatic amino acid decarboxylase (C) Monoamine oxidase (D) Catechol oxidas

Last Answer : Answer : C

A molybdenum containing oxidase is (A) Cytochrome oxidase (B) Xanthine oxidase (C) Glucose oxidase (D) L-Amino acid oxidase

Description : A molybdenum containing oxidase is (A) Cytochrome oxidase (B) Xanthine oxidase (C) Glucose oxidase (D) L-Amino acid oxidase

Last Answer : Answer : B

Catabolism of thymidylate gives (A) α-alanine (B) β-alanine (C) α-aminoisobutyrate (D) β-aminoisobutyrate

Description : Catabolism of thymidylate gives (A) α-alanine (B) β-alanine (C) α-aminoisobutyrate (D) β-aminoisobutyrate

Last Answer : Answer : D

Nitrosamine can deaminate (A) Cytosine to form uracil (B) Adenine to form xanthine (C) Guanine to form hypoxanthine (D) All of these

Description : Nitrosamine can deaminate (A) Cytosine to form uracil (B) Adenine to form xanthine (C) Guanine to form hypoxanthine (D) All of these

Last Answer : Answer : A

Hypouricaemia can occur in (A) Xanthine oxidase deficiency (B) Psoriasis (C) Leukaemia (D) None of these

Description : Hypouricaemia can occur in (A) Xanthine oxidase deficiency (B) Psoriasis (C) Leukaemia (D) None of these

Last Answer : Answer : A

An alternate substrate for orotate phosphoribosyl transferase is (A) Allopurinol (B) Xanthine (C) Hypoxanthine (D) Adenine

Description : An alternate substrate for orotate phosphoribosyl transferase is (A) Allopurinol (B) Xanthine (C) Hypoxanthine (D) Adenine

Last Answer : Answer : D

The following coenzyme is required for catabolism of pyrimidine bases: (A) NADH (B) NADPH (C) FADH2 (D) None of these

Description : The following coenzyme is required for catabolism of pyrimidine bases: (A) NADH (B) NADPH (C) FADH2 (D) None of these

Last Answer : Answer : B

β -Alanine is formed from catabolism of (A) Thymine (B) Thymine and cytosine (C) Thymine and uracil (D) Cytosine and uracil

Description : β -Alanine is formed from catabolism of (A) Thymine (B) Thymine and cytosine (C) Thymine and uracil (D) Cytosine and uracil

Last Answer : Answer : D

Free ammonia is liberated during the catabolism of (A) Cytosine (B) Uracil (C) Thymine (D) All of these

Description : Free ammonia is liberated during the catabolism of (A) Cytosine (B) Uracil (C) Thymine (D) All of these

Last Answer : Answer : D

Gout is a metabolic disorder of catabolism of (A) Pyrimidine (B) Purine (C) Alanine (D) Phenylalanine

Description : Gout is a metabolic disorder of catabolism of (A) Pyrimidine (B) Purine (C) Alanine (D) Phenylalanine

Last Answer : Answer : B

Conversion of inosine monophosphate to xanthine monophosphate is catalysed by (A) IMP dehydrogenase (B) Formyl transferase (C) Xanthine-guanine phosphoribosyl transferase (D) Adenine phosphoribosyl transferase

Description : Conversion of inosine monophosphate to xanthine monophosphate is catalysed by (A) IMP dehydrogenase (B) Formyl transferase (C) Xanthine-guanine phosphoribosyl transferase (D) Adenine phosphoribosyl transferase

Last Answer : Answer : A

The nitrogenous base present in the RNA molecule is (A) Thymine (B) Uracil (C) Xanthine (D) Hypoxanthine

Description : The nitrogenous base present in the RNA molecule is (A) Thymine (B) Uracil (C) Xanthine (D) Hypoxanthine

Last Answer : Answer : B

Molybdenum is a cofactor for (A) Xanthine oxidase (B) Aldehyde oxidase (C) Sulphite oxidase (D) All of these

Description : Molybdenum is a cofactor for (A) Xanthine oxidase (B) Aldehyde oxidase (C) Sulphite oxidase (D) All of these

Last Answer : Answer : D

Iron is present in all the following except (A) Peroxidase (B) Xanthine oxidase (C) Aconitase (D) Fumarase

Description : Iron is present in all the following except (A) Peroxidase (B) Xanthine oxidase (C) Aconitase (D) Fumarase

Last Answer : Answer : D

A copper containing oxidase is (A) Cytochrome oxidase (B) Flavin mononucleotide (C) Flavin adenine dinucleotide (D) Xanthine oxidase

Description : A copper containing oxidase is (A) Cytochrome oxidase (B) Flavin mononucleotide (C) Flavin adenine dinucleotide (D) Xanthine oxidase

Last Answer : Answer : A

Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase

Description : Physostigmine is a competitive inhibitor of (A) Xanthine oxidase (B) Cholinesterase (C) Carbonic anhydrase (D) Monoamine oxidase

Last Answer : Answer : B

An enzyme which uses hydrogen acceptor as substrate is (A) Xanthine oxidase (B) Aldehyde oxidase (C) Catalase (D) Tryptophan oxygenase

Description : An enzyme which uses hydrogen acceptor as substrate is (A) Xanthine oxidase (B) Aldehyde oxidase (C) Catalase (D) Tryptophan oxygenase

Last Answer : Answer : C

Coenzyme A is required for catabolism of (A) Leucine (B) Isoleucine (C) Valine (D) All of these

Description : Coenzyme A is required for catabolism of (A) Leucine (B) Isoleucine (C) Valine (D) All of these

Last Answer : Answer : D

Insulin degradation of disulfide bond formation is effected by (A) Pyruvate dehydrogenase (B) Xylitol reductase (C) Gutathione reductase (D) Xanthine oxidase

Description : Insulin degradation of disulfide bond formation is effected by (A) Pyruvate dehydrogenase (B) Xylitol reductase (C) Gutathione reductase (D) Xanthine oxidase

Last Answer : Answer : C

Degradation of proteins to amino acids, glucose from carbohydrates and fatty acids from lipids is known as (A) Anabolism (B) Metabolism (C) Catabolism (D) Cretinism

Description : Degradation of proteins to amino acids, glucose from carbohydrates and fatty acids from lipids is known as (A) Anabolism (B) Metabolism (C) Catabolism (D) Cretinism

Last Answer : Answer : C

Sulphur containing amino acids after catabolism produces a substance which is excreted: (A) SO2 (B) HNO3 (C) H2SO4 (D) H3PO4

Description : Sulphur containing amino acids after catabolism produces a substance which is excreted: (A) SO2 (B) HNO3 (C) H2SO4 (D) H3PO4

Last Answer : Answer : C

Free ammonia is released during (A) Oxidative deamination of glutamate (B) Catabolism of purines (C) Catabolism of pyrimidines (D) All of these

Description : Free ammonia is released during (A) Oxidative deamination of glutamate (B) Catabolism of purines (C) Catabolism of pyrimidines (D) All of these

Last Answer : Answer : D

The degradative Processess are categorized under the heading of (A) Anabolism (B) Catabolism (C) Metabolism (D) None of the above

Description : The degradative Processess are categorized under the heading of (A) Anabolism (B) Catabolism (C) Metabolism (D) None of the above

Last Answer : B

Organic compound of small molecular size is (A) Urea (B) Uric acid (C) Creatinine (D) Phosphates

Description : Organic compound of small molecular size is (A) Urea (B) Uric acid (C) Creatinine (D) Phosphates

Last Answer : Answer : A

All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive

Description : All are true about lesch-nyhan syndrome except (A) Produces self-mutilation (B) Genetic deficiency of the enzyme (C) Elevated levels of uric acid in blood (D) Inheritance is autosomal recessive

Last Answer : Answer : B

In most mammals, except primates, uric acid is metabolized by (A) Oxidation to allantoin (B) Reduction to NH3 (C) Hydrolysis to allantoin (D) Hydrolysis to NH3

Description : In most mammals, except primates, uric acid is metabolized by (A) Oxidation to allantoin (B) Reduction to NH3 (C) Hydrolysis to allantoin (D) Hydrolysis to NH3

Last Answer : Answer : A

In humans, the principal metabolic product of pyrimidines is (A) Uric acid (B) Allantoin (C) Hypoxanthine (D) β-alanine

Description : In humans, the principal metabolic product of pyrimidines is (A) Uric acid (B) Allantoin (C) Hypoxanthine (D) β-alanine

Last Answer : Answer : D

In humans, the principal break down product of purines is (A) NH3 (B) Allantin (C) Alanine (D) Uric acid

Description : In humans, the principal break down product of purines is (A) NH3 (B) Allantin (C) Alanine (D) Uric acid

Last Answer : Answer : D