Description : The end product of purine catabolism in man is (A) Inosine (B) Hypoxanthine (C) Xanthine (D) Uric acid
Last Answer : Answer : D
Description : Uric acid is the end product of purine as well as protein catabolism in (A) Man (B) Fish (C) Birds (D) None of these
Last Answer : Answer : C
Description : In humans purine are catabolised to uric acid due to lack of the enzyme: (A) Urease (B) Uricase (C) Xanthine oxidase (D) Guanase
Last Answer : Answer : B
Description : The correct sequence of the reactions of catabolism of adenosine to uric acid is (A) Adenosine→hypoxanthine→xanthine→uric acid (B) Adenosine→xanthine→inosine→uric acid (C) Adenosine→inosine→hypoxanthine→ xanthine uric acid (D) Adenosine→xanthine→inosine→hypoxanthine uric acid
Description : In humans, the principal metabolic product of pyrimidines is (A) Uric acid (B) Allantoin (C) Hypoxanthine (D) β-alanine
Description : When NH3 is perfused through a dog’s liver ______ is formed, while ______ is formed in the birds liver. (A) Urea, Uric acid (B) Urea, allantoin (C) Uric acid, creatinine (D) Uric acid, Urea
Last Answer : Answer : A
Description : Uric acid on oxidation with alkaline KMnO4 forms : (a) Urea (b) Barbituric acid (c) Allantoin (d) Caffeine
Last Answer : Allantoin
Description : In most mammals, except primates, uric acid is metabolized by (A) Oxidation to allantoin (B) Reduction to NH3 (C) Hydrolysis to allantoin (D) Hydrolysis to NH3
Description : All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate
Description : In mammals other than higher primates uric acid is converted by (A) Oxidation to allantoin (B) Reduction to ammonia (C) Hydrolysis to ammonia (D) Hydrolysis to allantoin
Description : The end product of amino acid nitrogen metabolism in uricotelic organisms (reptiles and birds) is (A) Bilirubin (B) Urea (C) Uric acid (D) Biliverdin
Description : The major end product of protein nitrogen metabolism in man is (A) Glycine (B) Uric acid (C) Urea (D) NH3
Description : In humans, NH3 is detoxified in liver as (A) Creatinine (B) Uric acid (C) Urea (D) Uronic acid
Description : β -Aminoisobytyrate is formed from catabolism of (A) Cytosine (B) Uracil (C) Thymine (D) Xanthine
Description : Which pathway is correct for catabolism of purines to form uric acid? (A) Guanylate→Adenylate→Xanthine→hypoxanthine→Uric acid (B) Guanylate→inosinate→Xanthine→hypoxanthine→Uric acid (C) Adenylate→Inosinate→Xanthine hypoxanthine→Uric acid (D) Adenylate→Inosinate→hypoxanthine Xanthine→Uric acid
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme Xanthine oxidase is (A) Aspirin (B) Allopurinal (C) Colchicine (D) Phenyl benzoate
Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase
Description : Schardinger’s enzyme is (A) Lactate dehydrogenase (B) Xanthine dehydrogenase (C) Uric oxidase (D) L amino acid dehydrogenase
Description : Xanthuric acid is an abnormal metabolite of (A) Xanthine (B) Uric acid (C) Tyrosine (D) Tryptophan
Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid
Last Answer : B
Description : Mammals other than higher primates do not suffer from gout because they (A) Lack xanthine oxidase (B) Lack adenosine deaminase (C) Lack purine nucleoside phosphorylase (D) Possess uricase
Description : The enzyme common to catabolism of all the purines is (A) Adenosine deaminase (B) Purine nucleoside phosphorylase (C) Guanase (D) None of these
Description : Gout is a metabolic disorder of catabolism of (A) Pyrimidine (B) Purine (C) Alanine (D) Phenylalanine
Description : The major catabolic product of pyrimidines in human is (A) β-Alanine (B) Urea (C) Uric acid (D) Guanine
Description : In inherited deficiency of hypoxanthine guanine phosphoribosyl transferase (A) De novo synthesis of purine nucleotides is decreased (B) Salvage of purines is decreased (C) Salvage of purines is increased (D) Synthesis of uric acid is decreased
Description : A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation
Last Answer : Answers-1 The aetiology of gout can broadly be divided into cases where there is underexcretion of urate via the kidney (90%) or endogenous overproduction of uric acid (10%) although in practical ... diuretic use. Excessive dietary intake of purines is unlikely to be the main cause in this case.
Description : Which of the following is the main nitrogenous waste in humans ? (1) Ammonia (2) Urea (3) Uric Acid (4) Ammonium Nitrate
Last Answer : Uric Acid
Description : Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above
Last Answer : C. Uric acid
Last Answer : (B) Allopurinol
Description : In humans, the principal break down product of purines is (A) NH3 (B) Allantin (C) Alanine (D) Uric acid
Description : Choose the correct statement about allopurinol: A. It is a purine antimetabolite with antineoplastic activity B. It is a competitive inhibitor of xanthine oxidase C. It is inactive itself ... D. Both allopurinol as well as its metabolite alloxanthine are noncompetitive inhibitors of xanthine oxidase
Last Answer : B. It is a competitive inhibitor of xanthine oxidase
Description : Organic compound of small molecular size is (A) Urea (B) Uric acid (C) Creatinine (D) Phosphates
Description : Gout is characterized by increased plasma levels of (A) Urea (B) Uric acid (C) Creatine (D) Creatinine
Description : Ammonia is excreted as ammonium salts during metabolic acidosis but the majority is excreted as (A) Phosphates (B) Creatine (C) Uric acid (D) Urea
Description : The unwanted amino acids abstracted from the tissues are either used up by the tissue or in the liver converted into (A) Ammonia (B) Urea (C) Ammonium salts (D) Uric acid
Description : Mechanism by which NH3 is removed from the kidneys is (A) Urea formation (B) Uric acid formation (C) Creatinine formation (D) None of these
Description : NH3 is removed from brain mainly by (A) Creatinine formation (B) Uric acid production (C) Urea formation (D) Glutamine formation
Description : NH3 is detoxified in brain chiefly as (A) Urea (B) Uric acid (C) Creatinine (D) Glutamine
Description : Non-protein nitrogenous substances in blood include all of the following except (A) Urea (B) Uric acid (C) Creatinine (D) Inositol
Description : Benedict’s test is less likely to give weakly positive results with concentrated urine due to the action of (A) Urea (B) Uric acid (C) Ammonium salts (D) Phosphates
Description : Select the option which shows correct matching of animal with its excretory organ and excretory product. Animal Excretory Excretory organ product (a) Labeo (Rohu) Nephridial Ammonia tubes (b) Salamander Kidneys Urea (c) Peacock Kidneys Urea (d) Housefly Renal tubules Uric acid
Last Answer : (b) Salamander Kidneys Urea
Description : Assertion: Uric acid is produced by the metabolism of purine and pyrimidine. Reason: Uric acid has high toxicity and is soluble in water.
Last Answer : Assertion: Uric acid is produced by the metabolism of purine and pyrimidine. Reason: Uric acid has ... D. If both Assertion and Reason are false
Description : Uric acid is the catabolic end product of (A) Porphyrine (B) Purines (C) Pyrimidines (D) Pyridoxine
Description : After being counseled about lifestyle and dietary changes, the patient was started on atorvastatin. During his treatment with atorvastatin, it is important to routinely monitor serum concentrations of (a) ... Alanine and aspartate aminotransferase (c) Platelets (d) Red blood cells (e) Uric acid
Last Answer : Ans: D
Description : Which one of the following is an abnormal constituent of urine? (1) Creatinine (2) Urea (3) Uric acid (4) Ketone bodies
Last Answer : (4) Ketone bodies Explanation: Ketone bodies are three watersoluble compounds that are produced as byproducts when fatty acids are broken down for energy in the liver. Two of the three are ... exceeds the rate of utilization, their concentration in blood increases, this is known as ketonemia.
Description : The first organic compound synthesized in the laboratory was - (1) Urea (2) Uric acid (3) Lactic acid (4) Glucose
Last Answer : (1) Urea Explanation: In 1828, German chemist Friedrish Wohler synthesized first organic compound, urea in the laboratory by heating ammonium cyanate (an inorganic compound).
Description : Under normal conditions which one is completely reabsorbed in the renal tubule? (a) Urea (b) Uric acid (c) Salts (d) Glucose
Last Answer : d) Glucose
Description : Nitrogenous waste products are eliminated mainly as (a) urea in tadpole and ammonia in adult frog (b) ammonia in tadpole and urea in adult frog (c) urea in both tadpole and adult frog (d) urea in tadpole and uric acid in adult frog.
Last Answer : (b) ammonia in tadpole and urea in adult frog
Description : The ornithine cycle removes two waste products from the blood in liver. These products are (a) CO2 and ammonia (b) ammonia and uric acid (c) CO2 and urea (d) ammonia and urea.
Last Answer : a) CO2 and ammonia
Description : Diethyl malonate reacts with urea in the presence of sodium ethoxide to form (a) Uric acid (b) Barbituric acid (c) Phenobarbital (d) Barbital
Last Answer : Barbituric acid