Description : Intestinal nucleosidases act on nucleosides and produce (A) Purine base only (B) Phosphate only (C) Sugar only (D) Purine or pyrimidine bases and sugars
Last Answer : Answer : D
Description : A nucleotide consists of (A) A nitrogenous base like choline (B) Purine + pyrimidine base + sugar + phosphorous (C) Purine or pyrimidine base + sugar (D) Purine or pyrimidine base + phosphorous
Last Answer : Answer : B
Description : A nucleoside consists of (A) Nitrogenous base (B) Purine or pyrimidine base + sugar (C) Purine or pyrimidine base + phosphorous (D) Purine + pyrimidine base + sugar + phosphorous
Description : Thiamine is (A) Water-soluble vitamin (B) Fat soluble vitamin (C) Purine base (D) Pyrimidine base
Description : Thymine is (A) Water soluble vitamin (B) Fat soluble vitamin (C) Purine base (D) Pyrimidine base
Description : In thalassemia, an amino acid is substituted in (A) Alpha chain (B) Beta chain (C) Alpha and beta chains (D) Any chain MINERAL METABOLISM 195
Description : A nucleotide is formed of (a) purine, pyrimidine and phosphate (b) purine, sugar and phosphate (c) nitrogen base, sugar and phosphate (d) pyrimidine, sugar and phosphate
Last Answer : (c) nitrogen base, sugar and phosphate
Description : Name a pyrimidine (pron: pie-rim-eh-den) base.
Last Answer : ANSWER: THYMINE or CYTOSINE or URACIL
Description : Which of the following opioid analgesics is similar to codeine in pharmacological profile but is less constipating ? (a) Methadone (b) Buprenorphine (c) Butorphanol (d) Dextropropoxyphene
Last Answer : Ans: D
Description : Three medications referred to as the ABC drugs' are currently the main pharmacological therapy for multiple sclerosis. Which of the following statements reflects information to be included in patient ... on an empty stomach. Glatiramer acetate is administed by intramuscular injection once a week.
Last Answer : a) Flu-like symptoms can be controlled with nonsteroidal antiinflammatory drugs (NSAIDs) and usually resolve after a few months of therapy. Seventy-five percent of patients taking one of the ... symptoms that can be controlled with NSAIDS and usually resolve after a few months of therapy.
Description : Which of the following statements reflect current research regarding the utilization of non-pharmacological measures in the management of burn pain? a) Music therapy may provide reality orientation, distraction, ... of burn pain. Pet therapy has not proven effective in the management of burn pain.
Last Answer : a) Music therapy may provide reality orientation, distraction, and sensory stimulation. Researchers have found that music affects both the physiologic and psychological aspects of the pain experience ... orientation, distraction, and sensory stimulation. It also allows for patient self-expression.
Description : Which of the following newer pharmacological therapies used for the treatment of osteoarthritis is thought to improve cartilage function and retard degradation as well as have some antiinflammatory effects ... function and retard breakdown of cartilage. d) Capsaicin Capsaicin is a topical analgesic.
Last Answer : a) Viscosupplementation Viscosupplementation, the intraarticular injection of hyaluronic acid, is thought to improve cartilage function and retard degradation. It may also have some anti-inflammatory effects.
Description : With view to Nitrous Oxide what is the major pharmacological problem? A. Contraindicated in pregnancy B. Contra indicated in cardiac dysrhythmias C. Diffusion hypoxia at the end of the case due to slow solubility of the agent in blood
Last Answer : C. Diffusion hypoxia at the end of the case due to slow solubility of the agent in blood
Description : The stability protocol of a tablet formulation must include? A. Vendor list for raw materials B. Batch No. C. Pharmacological category of the active substance D. Layout of the manufacturing area
Last Answer : B. Batch No.
Description : The following opioid analgesic is similar to codeine in pharmacological profile but is less constipating: A. Methadone B. Buprenorphine C. Butorphanol D. Dextropropoxyphene
Last Answer : D. Dextropropoxyphene
Description : Ganglion blocking drugs are no longer used in therapeutics because: A. They have few and weak pharmacological actions B. They produce many side effects C. They are inactive by oral route D. They have short duration of action
Last Answer : A. They have potent antiovulatory action of their own
Description : A ‘toxic effect’ differs from a ‘side effect’ in that: A. It is not a pharmacological effect of the drug B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication C. It must involve drug induced cellular injury D. It involves host defence mechanisms
Last Answer : B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication
Description : An undesirable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called: A. Side effect B. Toxic effect C. Allergic reaction D. Idiosyncrasy
Last Answer : A. Side effect
Description : 02. What does “pharmacokinetics” include? a) Pharmacological effects of drugs b) Unwanted effects of drugs c) Chemical structure of a medicinal agent d) Distribution of drugs in the organism
Last Answer : d) Distribution of drugs in the organism
Last Answer : B. They produce many side effects
Description : 5-Phosphoribosyl-1-pyrophosphate is required for the synthesis of (A) Purine nucleotides (B) Pyrimidine nucleotides (C) Both (A) and (B) (D) None of these
Last Answer : Answer : C
Description : The following is true in the treatment of epilepsy except: A. The choice of drug depends on the cause of epilepsy and not on the seizure type B. Treatment should be instituted as early as possible ... to response D. Withdrawal of drug can be attempted if no seizures have occurred for 3-5 years
Last Answer : A. The choice of drug depends on the cause of epilepsy and not on the seizure type
Description : Which one of the following contributes nitrogen atoms to both purine and pyrimidine rings? (A) Aspartate (B) Carbanoyl phosphate (C) Carbondioxide (D) Tetrahydrofolate
Last Answer : Answer : A
Description : Which one of the following causes frame shift mutation? (A) Transition (B) Transversion (C) Deletion (D) Substitution of purine to pyrimidine
Description : In DNA, genetic information is located in (A) Purine bases (B) Pyrimidine bases (C) Purine and pyrimidine bases (D) sugar
Description : The structural stability of the double helix of DNA is as cribbed largely to (A) Hydrogen bonding between adjacent purine bases (B) Hydrophobic bonding between staked purine and ... Hydrogen bonding between adjacent pyrimidine bases (E) Hydrogen bonding between purine and pyrimidine bases
Description : All of the following occur in orotic aciduria except (A) Increased synthesis of pyrimidine nucleotides (B) Increased excretion of orotic acid in urine (C) Decreased synthesis of cytidine triphosphate (D) Retardation of growth
Description : The following coenzyme is required for catabolism of pyrimidine bases: (A) NADH (B) NADPH (C) FADH2 (D) None of these
Description : De novo synthesis of pyrimidine nucleotides is regulated by (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Both (A) and (B) (D) None of these
Description : During de novo synthesis of pyrimidine nucleotides, the first ring compound to be formed is (A) Carbamoyl aspartic acid (B) Dihydro-orotic acid (C) Orotic acid (D) Orotidine monophosphate
Description : All the enzymes required for de novo synthesis of pyrimidine nucleotides are cytosolic except (A) Carbamoyl phosphate synthetase (B) Aspartate transcarbamoylase (C) Dihydro-orotase (D) Dihydro-orotate dehydrogenase
Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP
Description : Aspartate contributes the following carbon atoms of the pyrimidine nucelus: (A) C2 and C4 (B) C5 and C6 (C) C2, C4 and C6 (D) C4, C5 and C6
Description : The carbon atom at position 2 of pyrimidine nucleus is contributed by (A) CO2 (B) Glycine (C) Aspartate (D) Glutamine
Description : Nitrogen at position 3 of pyrimidine nucleus comes from (A) Glutamine (B) Glutamate (C) Glycine (D) Aspartate
Description : Nitrogen at position 1 of pyrimidine nucleus comes from (A) Glutamine (B) Glutamate (C) Glycine (D) Aspartate
Description : The carbon atoms of pyrimidine nucleus are provided by (A) Glycine and aspartate (B) CO2 and aspartate (C) CO2 and glutamate (D) CO2 and glutamine
Description : The nitrogen atoms of pyrimidine nucleus are provided by (A) Glutamate (B) Glutamate and aspartate (C) Glutamine (D) Glutamine and aspartate
Description : An enzyme common to de novo synthesis of pyrimidine nucleotides and urea is (A) Urease (B) Carbamoyl phosphate synthetase (C) Aspartate transcarbamoylase (D) Argininosuccinase
Description : De novo synthesis of pyrimidine nucleotides occurs in (A) Mitochondria (B) Cytosol (C) Microsomes (D) Ribosomes
Description : The available PRPP is used preferentially for (A) De novo synthesis of purine nucleotides (B) De novo synthesis of pyrimidine nucleotides (C) Salvage of purine bases (D) Salvage of pyrimidine bases
Description : Ultraviolet light can damage a DNA strand causing (A) Two adjacent purine residue to form a covalently bounded dimer (B) Two adjacent pyrimidine residues to form covalently bonded dimer (C) Disruption of phosphodiesterase linkage (D) Disruption of non-covalent linkage
Description : Genetic code is (A) Collection of codon (B) Collection of amino acids (C) Collection of purine nucleotide (D) Collection of pyrimidine nucleotide
Description : Gout is a metabolic disorder of catabolism of (A) Pyrimidine (B) Purine (C) Alanine (D) Phenylalanine
Description : The enzyme aspartate transcarbamoylase of pyrimidine biosynthesis is inhibited by (A) ATP (B) ADP (C) AMP (D) CTP
Description : An enzyme of pyrimidine nucleotides biosynthesis regulated at the genetic level by apparently coordinate repression and derepression is (A) Carbamoyl phosphate synthetase (B) Dihydroorotate dehydrogenase (C) Thymidine kinase (D) Deoxycytidine kinase
Description : An enzyme of pyrimidine nucleotide biosynthesis sensitive to allosteric regulation is (A) Aspartate transcarbamoylase (B) Dihydroorotase (C) Dihydroorotate dehydrogenase (D) Orotidylic acid decarboxylase
Description : A substrate for enzymes of pyrimidine nucleotide biosynthesis is (A) Allopurinol (B) Tetracylin (C) Chloramphenicol (D) Puromycin