Allopurinol is indicated in the following category of chronic gout patients: A. Over producers of uric acid B. Under excretors of uric acid C. Those with tophi and/or renal urate stones D. All of the above

Allopurinol is indicated in the following category of chronic gout patients: A. Over producers of uric acid B. Under excretors of uric acid C. Those with tophi and/or renal urate stones D. All of the above
by

1 Answer

Answer :

D. All of the above
by

Related questions

A 35-year-old male presented with an attack of acute gout. He was treated with a 10 day course of naproxen. His blood uric acid level is high. What future line of treatment is most appropriate: A. No regular medication. Treat attacks of acute gout when they occur with naproxen. B. Regular long-term treatment with naproxen C. Regular long-term treatment with allopurinol D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment

Description : A 35-year-old male presented with an attack of acute gout. He was treated with a 10 day course of naproxen. His blood uric acid level is high. What future line of treatment is ... treatment with allopurinol D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment

Last Answer : D. Start with allopurinol + naproxen for 2 months followed by long-term allopurinol treatment

Select the drug which is used in chronic gout but is not uricosuric: A. Probenecid B. Phenylbutazone C. Sulfinpyrazone D. Allopurinol

Description : Select the drug which is used in chronic gout but is not uricosuric: A. Probenecid B. Phenylbutazone C. Sulfinpyrazone D. Allopurinol

Last Answer : D. Allopurinol

Select the first choice drug for acute gout: A. Cochicine B. Indomethacin C. Allopurinol D. Dexamethasone

Description : Select the first choice drug for acute gout: A. Cochicine B. Indomethacin C. Allopurinol D. Dexamethasone

Last Answer : B. Indomethacin

The NSAIDs aggravate the following diseases except: A. Hypertension B. Congestive heart failure C. Peptic ulcer D. Chronic gout

Description :  The NSAIDs aggravate the following diseases except: A. Hypertension B. Congestive heart failure C. Peptic ulcer D. Chronic gout

Last Answer : D. Chronic gout

Disease modifying antirheumatic drugs are indicated in rheumatoid arthritis: A. In place of NSAIDs in patients who donot tolerate the latter B. Along with NSAIDs in patients with progressive disease C. Only when NSAIDs fail to afford symptomatic relief D. In all patients irrespective of disease status/ concurrent medication

Description : Disease modifying antirheumatic drugs are indicated in rheumatoid arthritis: A. In place of NSAIDs in patients who donot tolerate the latter B. Along with NSAIDs in patients with progressive ... to afford symptomatic relief D. In all patients irrespective of disease status/ concurrent medication

Last Answer : B. Along with NSAIDs in patients with progressive disease

All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate

Description : All of the following statements about uric acid are true except (A) It can be formed from allantoin (B) Formation of uric acid stones in kidneys can be decreased by alkalinisation of urine (C) Uric acid begins to dissociate at pH above 5.8 (D) It is present in plasma mainly as monosodium urate

Last Answer : Answer : A

Allopurinol has a therapeutic effect in the following conditions except: A. Radiotherapy induced hyperuricaemia B. Hydrochlorothiazide induced hyperuricaemia C. Acute gouty arthritis D. Kala-azar

Description : Allopurinol has a therapeutic effect in the following conditions except: A. Radiotherapy induced hyperuricaemia B. Hydrochlorothiazide induced hyperuricaemia C. Acute gouty arthritis D. Kala-azar

Last Answer : C. Acute gouty arthritis

All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase

Description : All of the following statements about allopurinol are true except (A) It is a structural analogue of uric acid (B) It can prevent uric acid stones in the kidneys (C) It increases the urinary excretion of xanthine and hypoxanthine (D) It is a competitive inhibitor of xanthine oxidase

Last Answer : Answer : A

Match the items given in column I with those in column II and select the correct option given below. Column I Column II A. Glycosuria (i) Accumulation of uric acid in joints B. Gout (ii) Mass of crystallised salts within the kidney C. Renal calculi (iii) Inflammation in glomeruli D. Glomerular (iv) Presence of glucose in nephritis urine A B C D (a) (iii) (ii) (iv) (i) (b) (i) (ii) (iii) (iv) (c) (ii) (iii) (i) (iv) (d) (iv) (i) (ii) (iii)

Description : Match the items given in column I with those in column II and select the correct option given below. Column I Column II A. Glycosuria (i) Accumulation of uric acid in joints B. Gout (ii) Mass of crystallised salts within the kidney ... (iii) (iv) (c) (ii) (iii) (i) (iv) (d) (iv) (i) (ii) (iii)

Last Answer : (d) (iv) (i) (ii) (iii)

In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is: A. Acid-base and electrolyte disturbances B. Hypersensitivity and idiosyncratic reactions C. Gastric mucosal damage D. Salicylism

Description :  In the treatment of chronic inflammatory diseases, the most important limitation of aspirin is: A. Acid-base and electrolyte disturbances B. Hypersensitivity and idiosyncratic reactions C. Gastric mucosal damage D. Salicylism

Last Answer : C. Gastric mucosal damage

Select the drug which is neither analgesic, nor antiinflammatory, nor uricosuric, but is highly efficacious in acute gout: A. Prednisolone B. Colchicine C. Naproxen D. Sulfinpyrazone

Description : Select the drug which is neither analgesic, nor antiinflammatory, nor uricosuric, but is highly efficacious in acute gout: A. Prednisolone B. Colchicine C. Naproxen D. Sulfinpyrazone

Last Answer : B. Colchicine

Nonsteroidal antiinflammatory drugs are more commonly used than colchicine in acute gout because: A. They are more effective B. They act more rapidly C. They have additional uricosuric action D. They are better tolerated

Description : Nonsteroidal antiinflammatory drugs are more commonly used than colchicine in acute gout because: A. They are more effective B. They act more rapidly C. They have additional uricosuric action D. They are better tolerated

Last Answer : D. They are better tolerated

Recombinant human erythropoietin is indicated for: A. Megaloblastic anaemia B. Haemolytic anaemia C. Anaemia in patients of thalassemia D. Anaemia in chronic renal failure patients

Description : Recombinant human erythropoietin is indicated for: A. Megaloblastic anaemia B. Haemolytic anaemia C. Anaemia in patients of thalassemia D. Anaemia in chronic renal failure patients

Last Answer : D. Anaemia in chronic renal failure patients

Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome

Description : Complete absence of hypoxanthine guanine phospharibosyl transferase causes (A) Primary gout (B) Immunodeficiency (C) Uric acid stones (D) Lesh-Nyhan syndrome

Last Answer : Answer : D

All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males

Description : All of the following statements about primary gout are true except (A) Uric acid stones may be formed in kidneys (B) Arthritis of small joints occurs commonly (C) Urinary excretion of uric acid is decreased (D) It occurs predominantly in males

Last Answer : Answer : C

A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation

Description : A 73 year old male presented with an acute attack of gout in his left knee. What is the most likely underlying metabolic cause? 1) decreased renal excretion of uric acid 2) endogenous overproduction of uric acid 3) excessive dietary purine intake 4) lactic acidosis 5) starvation

Last Answer : Answers-1 The aetiology of gout can broadly be divided into cases where there is underexcretion of urate via the kidney (90%) or endogenous overproduction of uric acid (10%) although in practical ... diuretic use. Excessive dietary intake of purines is unlikely to be the main cause in this case.

Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation

Description :  Selective COX-2 inhibitors differ from nonselective COX-1/COX-2 inhibitors in that they: A. Are antiinflammatory but not analgesic B. Donot bring down fever C. Have no renal effects D. Do not inhibit platelet aggregation

Last Answer : D. Do not inhibit platelet aggregation

Prostaglandins play pathophysiological role in the following except: A. Patency of ductus arteriosus B. Regulation of renal tubular salt absorption C. Ventricular remodeling after myocardial infarction D. Initiation of labour

Description :  Prostaglandins play pathophysiological role in the following except: A. Patency of ductus arteriosus B. Regulation of renal tubular salt absorption C. Ventricular remodeling after myocardial infarction D. Initiation of labour

Last Answer : C. Ventricular remodeling after myocardial infarction 

Phenylbutazone should be used only in patients not responding to other nonsteroidal antiinflammatory drugs (NSAIDs) because: A. It has lower antiinflammatory efficacy than other NSAIDs B. It has potential to cause agranulocytosis C. It has weak analgesic action D. It alters the protein binding and metabolism of many drugs

Description : Phenylbutazone should be used only in patients not responding to other nonsteroidal antiinflammatory drugs (NSAIDs) because: A. It has lower antiinflammatory efficacy than other NSAIDs B. It has potential ... It has weak analgesic action D. It alters the protein binding and metabolism of many drugs

Last Answer : B. It has potential to cause agranulocytosis

Prophylactic therapy of migraine: A. Is recommended in all cases B. Benefits upto 70% patients of moderate to severe migraine C. Needs to be continued lifelong without interruption D. Reduces the severity but increases the frequency of migraine attacks

Description : Prophylactic therapy of migraine: A. Is recommended in all cases B. Benefits upto 70% patients of moderate to severe migraine C. Needs to be continued lifelong without interruption D. Reduces the severity but increases the frequency of migraine attacks

Last Answer : B. Benefits upto 70% patients of moderate to severe migraine

The probable metabolic defect in gents is (A) A defect in excretion of uric acid by kidney (B) An overproduction of pyrimidines (C) An overproduction of uric acid (D) Rise in calcium leading to deposition of calcium urate

Description : The probable metabolic defect in gents is (A) A defect in excretion of uric acid by kidney (B) An overproduction of pyrimidines (C) An overproduction of uric acid (D) Rise in calcium leading to deposition of calcium urate

Last Answer : Answer : C

All of the following statements about uric acid are true except (A) It is a catabolite of purines (B) It is excreted by the kidneys (C) It is undissociated at pH above 5.8 (D) It is less soluble than sodium urate

Description : All of the following statements about uric acid are true except (A) It is a catabolite of purines (B) It is excreted by the kidneys (C) It is undissociated at pH above 5.8 (D) It is less soluble than sodium urate

Last Answer : Answer : C

A patient of chronic renal failure maintained on intermittent haemodialysis has anaemia not responding to iron therapy. Which of the following additional drug is indicated: A. Epoetin B. Cyanocobalamin C. Folic acid D. Pyridoxine

Description : A patient of chronic renal failure maintained on intermittent haemodialysis has anaemia not responding to iron therapy. Which of the following additional drug is indicated: A. Epoetin B. Cyanocobalamin C. Folic acid D. Pyridoxine

Last Answer : A. Epoetin

What is the best food to lower uric acid for those with gout?

Description : What is the best food to lower uric acid for those with gout?

Last Answer : The best thing you can do to help lower uric acid levels is to eat plenty of fruits and vegetables. Salads are great for your health and will also help to lower uric acid. Nuts are also good for lowering uric acid.

A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Last Answer : B

Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above

Description : Allopurinol lowers the plasma concentration of: A. Hypoxanthine B. Xanthine C. Uric acid D. All of the above

Last Answer : C. Uric acid

A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Description : A drug which prevents uric acid synthesis by inhibiting the enzyme xanthine oxidase is (A) Aspirin (B) Allopurinol (C) Colchicine (D) Probenecid

Last Answer : (B) Allopurinol

Which of the following analgesics itself frequently causes headache as a side effect: A. Indomethacin B. Mephenamic acid C. Piroxicam D. Metamizol

Description : Which of the following analgesics itself frequently causes headache as a side effect: A. Indomethacin B. Mephenamic acid C. Piroxicam D. Metamizol

Last Answer : A. Indomethacin

Select the drug which inhibits cyclooxygenase irreversibly: A. Aspirin B. Mephenamic acid C. Naproxen D. Diclofenac

Description : Select the drug which inhibits cyclooxygenase irreversibly: A. Aspirin B. Mephenamic acid C. Naproxen D. Diclofenac

Last Answer : A. Aspirin

Actions of prostaglandin E2 include the following except: A. Fall in blood pressure B. Bronchoconstriction C. Uterine contraction D. Inhibition of gastric acid secretion

Description : Actions of prostaglandin E2 include the following except: A. Fall in blood pressure B. Bronchoconstriction C. Uterine contraction D. Inhibition of gastric acid secretion

Last Answer : B. Bronchoconstriction

The ‘amine’ ergot alkaloid differs from ‘amino acid’ ergot alkaloid in that it has: A. High oral bioavailability B. Better CNS penetrability C. Weaker oxytocic action D. Strong anti-5-HT action

Description : The ‘amine’ ergot alkaloid differs from ‘amino acid’ ergot alkaloid in that it has: A. High oral bioavailability B. Better CNS penetrability C. Weaker oxytocic action D. Strong anti-5-HT action

Last Answer : A. High oral bioavailability

Which of the following statements about hypertension in diabetes patients is/are correct? A. Hypertension worsens the macrovascular disease of diabetes patients. B. Hypertension accelerates the progression of diabetic nephropathy. C. Hypertension is associated with sodium retention in diabetes patients. D. Angiotensin-converting enzyme (ACE) inhibitors should be used in all patients with chronic hyperglycemia, regardless of the presence of hypertension. E. Diuretics, as single-drug therapy, are not indicated in the treatment of hypertension in diabetes patients.

Description : Which of the following statements about hypertension in diabetes patients is/are correct? A. Hypertension worsens the macrovascular disease of diabetes patients. B. Hypertension accelerates the ... single-drug therapy, are not indicated in the treatment of hypertension in diabetes patients.

Last Answer : Answer: ABCDE DISCUSSION: All of the answers listed are correct. By damaging endothelial cells, hypertension worsens macrovascular disease in all patients but especially in diabetics. Hypertension ... is not indicated because the chronic state of dehydration in such patients may become worse

Under normal conditions which one is completely reabsorbed in the renal tubule? (a) Urea (b) Uric acid (c) Salts (d) Glucose

Description : Under normal conditions which one is completely reabsorbed in the renal tubule? (a) Urea (b) Uric acid (c) Salts (d) Glucose

Last Answer : d) Glucose

Gout is characterized by increased plasma levels of (A) Urea (B) Uric acid (C) Creatine (D) Creatinine

Description : Gout is characterized by increased plasma levels of (A) Urea (B) Uric acid (C) Creatine (D) Creatinine

Last Answer : Answer : B

High level of uric acid in the blood causes – (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Description : High level of uric acid in the blood causes – (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Last Answer : (2) Gout Explanation: High levels of uric acid in the blood can cause solid crystals to form within joints. This causes a painful condition called gout. If gout remains untreated, these uric acid crystals can build up in the joints and nearby tissues, forming hard lumpy deposits called tophi.

In studies of the human body, which of the following terms is used to describe the hereditary condition associated with an excessively high level of uric acid in the blood? a) gout b) cystitis c) uric ptosis d) none of these

Description : In studies of the human body, which of the following terms is used to describe the hereditary condition associated with an excessively high level of uric acid in the blood? a) gout b) cystitis c) uric ptosis d) none of these

Last Answer : ANSWER: A -- GOUT 

High level of uric acid in the blood causes (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Description : High level of uric acid in the blood causes (1) Arthritis (2) Gout (3) Rheumatism (4) Asthma

Last Answer : Gout

While prescribing a first generation H1 antihistaminic the patient should be advised to avoid: A. Driving motor vehicles B. Consuming processed cheese C. Strenuous physical exertion D. All of the above

Description : While prescribing a first generation H1 antihistaminic the patient should be advised to avoid: A. Driving motor vehicles B. Consuming processed cheese C. Strenuous physical exertion D. All of the above

Last Answer : A. Driving motor vehicles

The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug

Description : The capacity of an antihistaminic to produce sedation depends on the following except: A. Relative affinity for central versus peripheral H1 receptors B. Ability to penetrate blood-brain barrier C. Individual susceptibility D. Ratio of H1:H2 blockade produced by the drug

Last Answer : D. Ratio of H1:H2 blockade produced by the drug

The conventional H1 antihistaminics possess the following additional properties except: A. Local anaesthetic B. Vasopressor C. Antiarrhythmic D. Catecholamine potentiating

Description : The conventional H1 antihistaminics possess the following additional properties except: A. Local anaesthetic B. Vasopressor C. Antiarrhythmic D. Catecholamine potentiating

Last Answer : B. Vasopressor

The following H1 antihistaminic has additional anti 5-HT, anticholinergic, sedative and appetite stimulating properties: A. Promethazine B. Terfenadine C. Cyproheptadine D. Hydroxyzine

Description : The following H1 antihistaminic has additional anti 5-HT, anticholinergic, sedative and appetite stimulating properties: A. Promethazine B. Terfenadine C. Cyproheptadine D. Hydroxyzine

Last Answer : C. Cyproheptadine

High anticholinergic property is present in the following antihistaminic: A. Diphenhydramine B. Astemizole C. Cetirizine D. Terfenadine

Description : High anticholinergic property is present in the following antihistaminic: A. Diphenhydramine B. Astemizole C. Cetirizine D. Terfenadine

Last Answer : A. Diphenhydramine

The action of histamine that is not mediated through H1 receptors is: A. Release of EDRF from vascular endothelium resulting in vasodilatation B. Direct action on vascular smooth muscle causing vasodilatation C. Bronchoconstriction D. Release of catecholamines from adrenal medulla

Description : The action of histamine that is not mediated through H1 receptors is: A. Release of EDRF from vascular endothelium resulting in vasodilatation B. Direct action on vascular smooth muscle causing vasodilatation C. Bronchoconstriction D. Release of catecholamines from adrenal medulla

Last Answer : B. Direct action on vascular smooth muscle causing vasodilatation

Which of the following is a selective H1 receptor agonist: A. 4-methyl histamine B. Impromidine C. 2-Thiazolyl ethylamine D. Chlorpheniramine

Description : Which of the following is a selective H1 receptor agonist: A. 4-methyl histamine B. Impromidine C. 2-Thiazolyl ethylamine D. Chlorpheniramine

Last Answer : C. 2-Thiazolyl ethylamine

Autacoids differ from hormones in that: A. Autacoids are involved only in the causation of pathological states B. Autacoids do not have a specific cell/tissue of origin C. Autacoids generally act locally at the site of generation and release D. Both ‘B’ and ‘C’ are correct

Description : Autacoids differ from hormones in that: A. Autacoids are involved only in the causation of pathological states B. Autacoids do not have a specific cell/tissue of origin C. Autacoids generally act locally at the site of generation and release D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct

Probenecid has the following action(s): A. Uricosuric B. Analgesic C. Antiinflammatory D. Both ‘A’ and ‘C’

Description : Probenecid has the following action(s): A. Uricosuric B. Analgesic C. Antiinflammatory D. Both ‘A’ and ‘C’

Last Answer : A. Uricosuric

The most important dose-limiting adverse effect of colchicine is: A. Sedation B. Kidney damage C. Diarrhoea D. Muscle paralysis

Description : The most important dose-limiting adverse effect of colchicine is: A. Sedation B. Kidney damage C. Diarrhoea D. Muscle paralysis

Last Answer : C. Diarrhoea

What is true of disease modifying antirheumatic drugs: A. Their beneficial effect is manifest only after 1-3 months of therapy B. The disease does not recurr once they induce remission C. They are to be used life long D. Concurrent use of more than one disease modifying drug is not recommended

Description : What is true of disease modifying antirheumatic drugs: A. Their beneficial effect is manifest only after 1-3 months of therapy B. The disease does not recurr once they induce remission C. They are to be used life long D. Concurrent use of more than one disease modifying drug is not recommended

Last Answer : A. Their beneficial effect is manifest only after 1-3 months of therapy

Sulfasalazine is used in the following disease(s): A. Bacillary dysentery B. Ulcerative colitis C. Rheumatoid arthritis D. Both ‘B’ and ‘C’ are correct

Description : Sulfasalazine is used in the following disease(s): A. Bacillary dysentery B. Ulcerative colitis C. Rheumatoid arthritis D. Both ‘B’ and ‘C’ are correct

Last Answer : D. Both ‘B’ and ‘C’ are correct