The mechanism of synthesis of DNA and RNA are similar to all the following ways except (A) They involve release of pyrophosphate from each nucleotide added (B) They require activated nucleotide precursor and Mg2+ (C) The direction of synthesis is (D) They require a primer

The mechanism of synthesis of DNA and RNA are similar to all the following ways except (A) They involve release of pyrophosphate from each nucleotide added (B) They require activated nucleotide precursor and Mg2+ (C) The direction of synthesis is (D) They require a primer
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The mechanism of synthesis of DNA and RNA are similar in all the following ways except (A) They involve release of pyrophosphate from each nucleotide added (B) They require activated nucleotide precursor and Mg2+ (C) The direction of synthesis is 5’ → 3’ (D) They require a primer

Description : The mechanism of synthesis of DNA and RNA are similar in all the following ways except (A) They involve release of pyrophosphate from each nucleotide added (B) They require activated nucleotide precursor and Mg2+ (C) The direction of synthesis is 5’ → 3’ (D) They require a primer

Last Answer : Answer : A

Which one of the following statements correctly describes eukaryotic DNA? (A) They involve release of pyrophosphate from each nucleotide precussor and Mg2+ (B) The direction of synthesis is (C) They require a primer 5’→ 3’ (D) None of these

Description : Which one of the following statements correctly describes eukaryotic DNA? (A) They involve release of pyrophosphate from each nucleotide precussor and Mg2+ (B) The direction of synthesis is (C) They require a primer 5’→ 3’ (D) None of these

Last Answer : Answer : C

RNA synthesis requires (A) RNA primer (B) RNA template (C) DNA template (D) DNA primer

Description : RNA synthesis requires (A) RNA primer (B) RNA template (C) DNA template (D) DNA primer

Last Answer : Answer : C

Deoxyribonucleotides are added to RNA primer by (A) DNA polymerase I (B) DNA polymerase II (C) DNA polymerase III holoenzyme (D) All of these

Description : Deoxyribonucleotides are added to RNA primer by (A) DNA polymerase I (B) DNA polymerase II (C) DNA polymerase III holoenzyme (D) All of these

Last Answer : Answer : C

After formation of replication fork (A) Both the new strands are synthesized discontinuously (B) One strand is synthesized continuously and the other discontinuously (C) Both the new strands are synthesized continuously (D) RNA primer is required only for the synthesis of one new strand

Description : After formation of replication fork (A) Both the new strands are synthesized discontinuously (B) One strand is synthesized continuously and the other discontinuously (C) Both the new strands are synthesized continuously (D) RNA primer is required only for the synthesis of one new strand

Last Answer : Answer : B

The major determinant of the overall rate of denovo purine nucleotide biosynthesis is the concentration of (A) 5-phosphoribosyl 1-pyrophosphate (B) 5-phospho β-D-ribosylamine (C) Glycinamide ribosyl-5-phosphate (D) Formylglycinamide ribosyl-5-phosphate

Description : The major determinant of the overall rate of denovo purine nucleotide biosynthesis is the concentration of (A) 5-phosphoribosyl 1-pyrophosphate (B) 5-phospho β-D-ribosylamine (C) Glycinamide ribosyl-5-phosphate (D) Formylglycinamide ribosyl-5-phosphate

Last Answer : Answer : A

Which of the following statements are true of oxidants? A. In addition to their pathophysiologic roles in inflammation, injury, and infection, oxidants also have physiologic roles. B. Oxidants may be generated from activated neutrophils and during reperfusion following a period of ischemia. C. The deleterious effects of oxidants include lipid peroxidation and cell membrane damage, oxidative damage to DNA, and inhibition of adenosine triphosphate (ATP) synthesis. D. The mechanism of ischemia-reperfusion injury involved the catalytic production of superoxide anion (O 2•) by the enzyme xanthine oxidase.

Description : Which of the following statements are true of oxidants? A. In addition to their pathophysiologic roles in inflammation, injury, and infection, oxidants also have physiologic roles. B. Oxidants may ... involved the catalytic production of superoxide anion (O 2 ) by the enzyme xanthine oxidase.

Last Answer : Answer: ABCD DISCUSSION: Oxidants are reactive oxygen metabolites that have both physiologic and pathophysiologic roles. As potent oxidizing agents, oxidants are involved in cytochrome P ... leukocyte infiltration and activation, causing further tissue damage by the release of cytotoxic proteases

The normal function of restriction endonucleases is to (A) Excise introns from hrRNA (B) Polymerize nucleotides to form RNA (C) Remove primer from okazaki fragments (D) Protect bacteria from foreign DNA

Description : The normal function of restriction endonucleases is to (A) Excise introns from hrRNA (B) Polymerize nucleotides to form RNA (C) Remove primer from okazaki fragments (D) Protect bacteria from foreign DNA

Last Answer : Answer : D

Ribonucleotides of RNA primer are replaced by deoxyribonucleotides by the enzyme: (A) DNA polymerase I (B) DNA polymerase II (C) DNA polymerase III holoenzyme (D) All of these

Description : Ribonucleotides of RNA primer are replaced by deoxyribonucleotides by the enzyme: (A) DNA polymerase I (B) DNA polymerase II (C) DNA polymerase III holoenzyme (D) All of these

Last Answer : Answer : A

RNA primer is formed by the enzyme: (A) Ribonuclease (B) Primase (C) DNA polymerase I (D) DNA polymerase III

Description : RNA primer is formed by the enzyme: (A) Ribonuclease (B) Primase (C) DNA polymerase I (D) DNA polymerase III

Last Answer : Answer : B

Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin

Description : Fully activated pyruvate carboxylase depends upon the presence of (A) Malate and Niacin (B) Acetyl CoA and biotin (C) Acetyl CoA and thiamine pyrophosphate (D) Oxaloacetate and biotin

Last Answer : Answer : B

Gabapentin acts: A. As GABAA agonist B. As precursor of GABA C. By enhancing GABA release D. By GABA independent mechanism

Description : Gabapentin acts: A. As GABAA agonist B. As precursor of GABA C. By enhancing GABA release D. By GABA independent mechanism

Last Answer : C. By enhancing GABA release

The most important mechanism by which tetracycline antibiotics exert antiimicrobial action is (a) They chelate Ca2+ ions and alter permeability of bacterial cell membrane (b) They bind to 30S ribosomes and inhibit bacterial protein synthesis (c) They bind to 50S ribosomes and interfere with translocation of the growing peptide chain in the bacteria (d) They interfere with DNA mediated RNA synthesis in bacteria

Description : The most important mechanism by which tetracycline antibiotics exert antiimicrobial action is (a) They chelate Ca2+ ions and alter permeability of bacterial cell membrane (b) They bind to 30S ribosomes ... peptide chain in the bacteria (d) They interfere with DNA mediated RNA synthesis in bacteria

Last Answer : Ans: B

The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes and inhibit bacterial protein synthesis C. They bind to 50S ribosomes and interfere with translocation of the growing peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria

Description : The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes ... peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria

Last Answer : B. They bind to 30S ribosomes and inhibit bacterial protein synthesis

Template-directed DNA synthesis occurs in all the following except (A) The replication fork (B) Polymerase chain reaction (C) Growth of RNA tumor viruses (D) Expression of oncogenes

Description : Template-directed DNA synthesis occurs in all the following except (A) The replication fork (B) Polymerase chain reaction (C) Growth of RNA tumor viruses (D) Expression of oncogenes

Last Answer : Answer : C

Template-directed DNA synthesis occurs in all the following except (A) The replication fork (B) Polymerase chain reaction (C) Growth of RNA tumor viruses (D) Expression of oneogenes

Description : Template-directed DNA synthesis occurs in all the following except (A) The replication fork (B) Polymerase chain reaction (C) Growth of RNA tumor viruses (D) Expression of oneogenes

Last Answer : Answer : C

The genetic code operates through (A) The protein moiety of DNA (B) Cistrom of DNA (C) Nucleotide sequence of m RNA (D) The anticodons of tRNA

Description : The genetic code operates through (A) The protein moiety of DNA (B) Cistrom of DNA (C) Nucleotide sequence of m RNA (D) The anticodons of tRNA

Last Answer : Answer : C

All of the following enzymes are unique to purine nucleotide synthesis except (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Adenylosuccinate synthetase (D) IMP dehydrogenase

Description : All of the following enzymes are unique to purine nucleotide synthesis except (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Adenylosuccinate synthetase (D) IMP dehydrogenase

Last Answer : Answer : A

All of the following statements about RNA-dependent DNA polymerase are true except: (A) It synthesizes DNA using RNA as a template (B) It is also known as reverse transcriptase (C) It synthesizes DNA in 5’→3’ direction (D) It is present in all the viruses

Description : All of the following statements about RNA-dependent DNA polymerase are true except: (A) It synthesizes DNA using RNA as a template (B) It is also known as reverse transcriptase (C) It synthesizes DNA in 5’→3’ direction (D) It is present in all the viruses

Last Answer : Answer : D

5-Phosphoribosyl-1-pyrophosphate is required for the synthesis of (A) Purine nucleotides (B) Pyrimidine nucleotides (C) Both (A) and (B) (D) None of these

Description : 5-Phosphoribosyl-1-pyrophosphate is required for the synthesis of (A) Purine nucleotides (B) Pyrimidine nucleotides (C) Both (A) and (B) (D) None of these

Last Answer : Answer : C

The key substance in the synthesis of purine, phosphoribosyl pyrophosphate is formed by (A) α-D-ribose 5-phosphate (B) 5-phospho β-D-ribosylamine (C) D-ribose (D) Deoxyribose

Description : The key substance in the synthesis of purine, phosphoribosyl pyrophosphate is formed by (A) α-D-ribose 5-phosphate (B) 5-phospho β-D-ribosylamine (C) D-ribose (D) Deoxyribose

Last Answer : Answer : A

Consider the following statements: (1) Copper is present in cytochrome oxidane (2) Pantothenic acid is precursor of co-enzyme-A (3) Thiamine prohosphate is the prosthetic group in decarboxylases (4) Zinc is present in RNA and DNA polymerases

Description : Consider the following statements: (1) Copper is present in cytochrome oxidane (2) Pantothenic acid is precursor of co-enzyme-A (3) Thiamine prohosphate is the prosthetic group in decarboxylases (4) Zinc is present in RNA and DNA polymerases

Last Answer : Ans. ((b))

Mini-dose heparin has been shown to be useful in the prophylaxis of postoperative venous thrombosis. Mechanism(s) by which low-dose heparin is/are thought to protect against venous thrombosis include: a. Enhancement of antithrombin III activity b. A decrease in thrombin availability c. Inhibition of platelet aggregation and subsequent platelet release action d. A mild prolongation of activated partial thromboplastin time

Description : Mini-dose heparin has been shown to be useful in the prophylaxis of postoperative venous thrombosis. Mechanism(s) by which low-dose heparin is/are thought to protect against venous ... aggregation and subsequent platelet release action d. A mild prolongation of activated partial thromboplastin time

Last Answer : Answer: a, b, c Low-dose heparin is thought to protect against venous thrombosis through three different mechanisms. First, antithrombin III activity with its inhibition of activated Factor X is ... release reaction. The standard doses of heparin administered (5000 units bid) does not affect aPTT

Select the correct option. Direction of Direction of reading of RNA synthesis the template DNA strand (a) 5′ – 3′ 3′ – 5′ (b) 3′ – 5′ 5′ – 3′ (c) 5′ – 3′ 5′ – 3′ (d) 3′ – 5′ 3′ – 5′

Description : Select the correct option. Direction of Direction of reading of RNA synthesis the template DNA strand (a) 5′ – 3′ 3′ – 5′ (b) 3′ – 5′ 5′ – 3′ (c) 5′ – 3′ 5′ – 3′ (d) 3′ – 5′ 3′ – 5′

Last Answer : (d) 3′ – 5′ 3′ – 5′

Select the correct option. Direction of Direction of reading of RNA synthesis the template DNA strand (a) 5′ – 3′ 3′ – 5′ (b) 3′ – 5′ 5′ – 3′ (c) 5′ – 3′ 5′ – 3′ (d) 3′ – 5′ 3′ – 5′

Description : Select the correct option. Direction of Direction of reading of RNA synthesis the template DNA strand (a) 5′ – 3′ 3′ – 5′ (b) 3′ – 5′ 5′ – 3′ (c) 5′ – 3′ 5′ – 3′ (d) 3′ – 5′ 3′ – 5′

Last Answer : (a) 5′ – 3′ 3′ – 5′

Formation of RNA primer: (A) Precedes replication (B) Follows replication (C) Precedes transcription (D) Follows transcription

Description : Formation of RNA primer: (A) Precedes replication (B) Follows replication (C) Precedes transcription (D) Follows transcription

Last Answer : Answer : A

An enzyme promotes a chemical reaction by (A) Lowering the energy of activation (B) Causing the release of heat which acts as a primer (C) Increasing molecular motion (D) Changing the free energy difference between substrate and product

Description : An enzyme promotes a chemical reaction by (A) Lowering the energy of activation (B) Causing the release of heat which acts as a primer (C) Increasing molecular motion (D) Changing the free energy difference between substrate and product

Last Answer : Answer : A

Heterogeneous nuclear RNA is the precursor of (A) mRNA (B) rRNA (C) tRNA (D) None of these

Description : Heterogeneous nuclear RNA is the precursor of (A) mRNA (B) rRNA (C) tRNA (D) None of these

Last Answer : Answer : A

Most bacteria do not require the ion a. Mg2+ b. Ca2+ c. Na+ d. Fe+2

Description : Most bacteria do not require the ion a. Mg2+ b. Ca2+ c. Na+ d. Fe+2

Last Answer : Ans: C

Glycogenin is (A) Uncoupler of oxidative phosphorylation (B) Polymer of glycogen molecules (C) Protein primer for glycogen synthesis (D) Intermediate in glycogen breakdown

Description : Glycogenin is (A) Uncoupler of oxidative phosphorylation (B) Polymer of glycogen molecules (C) Protein primer for glycogen synthesis (D) Intermediate in glycogen breakdown

Last Answer : C

Direction of RNA synthesis is (A) 5′ → 3’ (B) 3′ → 5’ (C) Both (A) and (B) (D) None of these

Description : Direction of RNA synthesis is (A) 5′ → 3’ (B) 3′ → 5’ (C) Both (A) and (B) (D) None of these

Last Answer : Answer : A

The correct statement concerning RNA and DNA polymerases is (A) RNA polymerase use nucleoside diphosphates (B) RNA polymerase require primers and add bases at 5’ end of the growing polynucleotide chain (C) DNA polymerases can add nucleotides at both ends of the chain (D) All RNA and DNA polymerases can add nucleotides only at the 3’ end of the growing polynucleotide chain

Description : The correct statement concerning RNA and DNA polymerases is (A) RNA polymerase use nucleoside diphosphates (B) RNA polymerase require primers and add bases at 5' end of the growing polynucleotide ... and DNA polymerases can add nucleotides only at the 3' end of the growing polynucleotide chain

Last Answer : Answer : D

Translocase is an enzyme required in the process of (A) DNA replication (B) RNA synthesis (C) Initiation of protein synthesis (D) Elongation of peptides

Description : Translocase is an enzyme required in the process of (A) DNA replication (B) RNA synthesis (C) Initiation of protein synthesis (D) Elongation of peptides

Last Answer : Answer : D

Ciprofloxacin inhibits the synthesis of (A) DNA in prokaryotes (B) DNA in prokaryotes and eukaryotes (C) RNA in prokaryotes (D) RNA in prokaryotes and eukaryotes

Description : Ciprofloxacin inhibits the synthesis of (A) DNA in prokaryotes (B) DNA in prokaryotes and eukaryotes (C) RNA in prokaryotes (D) RNA in prokaryotes and eukaryotes

Last Answer : Answer : A

Synthesis of RNA and a DNA template is known as (A) Replication (B) Translation (C) Transcription (D) Mutation

Description : Synthesis of RNA and a DNA template is known as (A) Replication (B) Translation (C) Transcription (D) Mutation

Last Answer : Answer : C

Reverse transcriptase catalyses (A) Synthesis of RNA (B) Breakdown of RNA (C) Synthesis of DNA (D) Breakdown of DNA

Description : Reverse transcriptase catalyses (A) Synthesis of RNA (B) Breakdown of RNA (C) Synthesis of DNA (D) Breakdown of DNA

Last Answer : Answer : C

After termination of the synthesis of RNA molecule, the core enzymes separate from the DNA template. The core enzymes then recognize a promoter at which the synthesis of a new RNA molecule commences, with the assistance of (A) Rho (ρ) factor (B) δ factor (C) β factor (D) σ factor

Description : After termination of the synthesis of RNA molecule, the core enzymes separate from the DNA template. The core enzymes then recognize a promoter at which the synthesis of a new RNA molecule commences, with the assistance of (A) Rho (ρ) factor (B) δ factor (C) β factor (D) σ factor

Last Answer : Answer : D

Termination of the synthesis of the RNA molecule is signaled by a sequence in the template strand of the DNA molecule, a signal that is recognized by a termination protein, the (A) Rho (ρ) factor (B) σ factor (C) δ factor (D) ε factor

Description : Termination of the synthesis of the RNA molecule is signaled by a sequence in the template strand of the DNA molecule, a signal that is recognized by a termination protein, the (A) Rho (ρ) factor (B) σ factor (C) δ factor (D) ε factor

Last Answer : Answer : A

Which one of the following binds to specific nucleotide sequences that are upstream and most distant from the start site? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Description : Which one of the following binds to specific nucleotide sequences that are upstream and most distant from the start site? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Last Answer : Answer : A

Which one of the following binds to specific nucleotide sequences? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Description : Which one of the following binds to specific nucleotide sequences? (A) RNA polymerase (B) Repressor (C) Inducer (D) Restriction

Last Answer : Answer : A

mRNA is complementary to the nucleotide sequence of (A) Coding strand (B) Ribosomal RNA (C) tRNA (D) Template strand

Description : mRNA is complementary to the nucleotide sequence of (A) Coding strand (B) Ribosomal RNA (C) tRNA (D) Template strand

Last Answer : Answer : A

If no primer DNA was given, the following scientist could not have synthesized DNA. (A) Ochoa (B) Okazaki (C) Kornberg (D) Monod

Description : If no primer DNA was given, the following scientist could not have synthesized DNA. (A) Ochoa (B) Okazaki (C) Kornberg (D) Monod

Last Answer : Answer : C

The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP

Description : The first pyrimidine nucleotide to be formed in de novo synthesis pathway is (A) UMP (B) CMP (C) CTP (D) TMP

Last Answer : Answer : A

The first reaction unique to purine nucleotide synthesis is catalysed by (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Phosphoribosyl glycinamide synthetase (D) Formyl transferase

Description : The first reaction unique to purine nucleotide synthesis is catalysed by (A) PRPP synthetase (B) PRPP glutamyl amido transferase (C) Phosphoribosyl glycinamide synthetase (D) Formyl transferase

Last Answer : Answer : B

De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes

Description : De novo synthesis of purine nucleotide occurs in (A) Mitochondria (B) Cytosol (C) Microsmes (D) Ribosomes

Last Answer : Answer : B

All of the following statements about tRNA are true except (A) It is synthesized as a large precursor (B) It is processed in the nucelolus (C) It has no codons or anticodons (D) Genes for rRNA are present in single copies

Description : All of the following statements about tRNA are true except (A) It is synthesized as a large precursor (B) It is processed in the nucelolus (C) It has no codons or anticodons (D) Genes for rRNA are present in single copies

Last Answer : Answer : D

All the following statements about βendorphin are true except µ : (A) It is a polypeptide (B) Its precursor is pro-opio-melanocortin (C) Its receptors are represent in brain (D) Its action is blocked by morphine

Description : All the following statements about βendorphin are true except µ : (A) It is a polypeptide (B) Its precursor is pro-opio-melanocortin (C) Its receptors are represent in brain (D) Its action is blocked by morphine

Last Answer : Answer : D

All the following statements about proopiomelanocortin are true except (A) It is made up of 285 amino acids (B) It is synthesised in pars intermedia and anterior lobe of pituitary gland (C) It is the precursor of ACTH and melatonin (D) It is the precursor of corticotropin like intermediate lobe peptide and endorphins 218 MCQs IN BIOCHEMISTRY

Description : All the following statements about proopiomelanocortin are true except (A) It is made up of 285 amino acids (B) It is synthesised in pars intermedia and anterior lobe of pituitary gland ... ) It is the precursor of corticotropin like intermediate lobe peptide and endorphins 218 MCQs IN BIOCHEMISTRY

Last Answer : Answer : C

All the following statements about angiotensin are true except (A) Its precursor is an α2-globulin (B) Its active form is an octapeptide (C) It is a vasodilator (D) It increases the secretion of aldosterone

Description : All the following statements about angiotensin are true except (A) Its precursor is an α2-globulin (B) Its active form is an octapeptide (C) It is a vasodilator (D) It increases the secretion of aldosterone

Last Answer : Answer : C

All the following statements about pepsin are correct except (A) It is smaller than pepsinogen (B) It is formed by the action of HCl on its precursor (C) Its optimum pH is 1.0–2.0 (D) It hydrolyses the C-terminal and N-terminal peptide bonds of proteins

Description : All the following statements about pepsin are correct except (A) It is smaller than pepsinogen (B) It is formed by the action of HCl on its precursor (C) Its optimum pH is 1.0–2.0 (D) It hydrolyses the C-terminal and N-terminal peptide bonds of proteins

Last Answer : Answer : D