Mast cells and basophils produce the histamine, which antihistamines block. The cytoplasm of a mast cell is filled with granules containing histamine and heparin. Histamine, released after injury or infection, stimulates local inflamation. People often take antihistamines to reduce cold symptoms. Basophils, blood cells that enter damaged tissues and enhance the inflammation process, also contain granules of histamine and haparin.