Description : The drug that can directly release histamine from mast cells without involving antigen-antibody reaction is: A. Aspirin B. Procaine C. Morphine D. Sulfadiazine
Last Answer : C. Morphine
Description : Morphine induced fall in blood pressure involves the following factors except: A. Direct cardiac depression B. Direct reduction of vascular tone C. Vasomotor centre depression D. Histamine release
Last Answer : A. Direct cardiac depression
Description : Which of the following constitutes ‘drug abuse’: A. Physician prescribed use of penicillin G for the cure of viral fever B. Self administration of aspirin to relieve headache C. Repeated self administration of morphine to derive euphoria D. All of the above
Last Answer : C. Repeated self administration of morphine to derive euphoria
Description : Answer: b, c, d Eosinophils constitute 1% to 3% of the leukocyte population of the bloodstream. They also reside in tissues and they exhibit phagocytic capabilities. They are less ... the cycle of events that result in recruitment and activation of inflammatory cells at sites of inflammation
Last Answer : Cellular injury from oxidants may be manifest by which of the following? a. Cell membrane lipid peroxidation b. DNA strand breaks c. Cytoskeletal disassembly d. ATP depletion
Description : Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin
Last Answer : B. Ticlopidine
Description : Theophylline is believed to benefit asthma patients by exerting the following actions except: A. Bronchodilatation B. Augmentation of diaphragmatic contractility C. Reduced mediator release D. Inhibition of antigen: antibody reaction
Last Answer : D. Inhibition of antigen: antibody reaction
Description : Select the sulfonamide drug which is active against Pseudomonas and is used by topical application for prophylaxis of infection in burn cases: A. Sulfadiazine B. Silver sulfadiazine C. Sulfadoxine D. Sulfamethoxazole
Last Answer : B. Silver sulfadiazine
Description : Morphine analgesia differs from that produced by aspirin in the following respect(s): A. It has a higher ceiling B. It covers both perception as well as psychic processing of the pain C. Visceral and ischaemic pain is relieved better than somatic inflammatory pain D. All of the above are correct
Last Answer : D. All of the above are correct
Description : By which of the following mechanism reduces Aspirin pain: A. It is anti inflammatory by the release of histamine B. It blocks the cyclo-oxygenase pathway.
Last Answer : B. It blocks the cyclo-oxygenase pathway.
Description : Which of the following is an idiosyncratic adverse drug reaction: A. Muscle dystonia caused by triflupromazine B. Insomnia after taking pentobarbitone C. Precipitation of asthma by morphine D. Gum hyperplasia caused by phenytoin
Last Answer : B. Insomnia after taking pentobarbitone
Description : Histamine is synthesised in (A) Brain (B) Mast cells (C) Basophils (D) All of these
Last Answer : Answer : D
Description : Histamine (a) May be released from mast cells by a number of therapeutic agents (b) Causes sedation (c) Decreases the force of contraction of ventricular muscle (d) Can cause strong contractions of the gravid human uterus
Last Answer : Ans: D
Description : A mast cell (or mastocyte) is a resident cells of several types of tissues and contains many granules rich in_______. a) Acetylcholine b) Nicotine c) Epinephrine d) Histamine e) Histadine
Description : In mammals, histamine is secreted by (a) lymphocytes (b) mast cells (c) fibroblasts (d) histiocytes.
Last Answer : b) mast cells
Description : Mast cells of connective tissue contain (a) vasopressin and relaxin (b) heparin and histamine (c) heparin and calcitonin (d) serotonin and melanin.
Last Answer : (b) heparin and histamine
Description : Mast cells secrete (a) haemoglobin (b) hippurin (c) myoglobin (d) histamine
Last Answer : (d) histamine.
Description : ________ bind to_________ on microbial invaders. a. Toll-like receptors; PAM Ps b. Mast cells; histamine c. Toll-like receptors; complement d. Macrophages; defensins
Last Answer : a. Toll-like receptors; PAM Ps
Description : Morphine dependence is characterized by: A. Marked drug seeking behaviour B. Physical dependence without psychic dependence C. Physical as well as psychic dependence D. Both ‘A’ and ‘C’ are correc
Last Answer : D. Both ‘A’ and ‘C’ are correc
Description : Histamine is involved as a mediator in the following pathological conditon (a) Cocaine (b) Dibucaine (c) Lidocaine (d) Procaine
Last Answer : Ans: B
Description : The following factor is not involved in the causation of hypotension due to spinal anaesthesia: A. Histamine release B. Reduced sympathetic vasoconstrictor tone C. Decreased venous return from the lower limbs D. Bradycardia
Last Answer : A. Histamine release
Description : Neostigmine reverses the following actions of d-tubocurarine except: A. Motor weakness B. Ganglionic blockade C. Histamine release D. Respiratory paralysis
Last Answer : C. Histamine release
Description : Which of the following is applicable to mivacurium: A. It undergoes Hoffmann elimination B. It is the shortest acting nondepolarizing neuromuscular blocker C. It is excreted unchanged by kidney D. It does not cause histamine release
Last Answer : B. It is the shortest acting nondepolarizing neuromuscular blocker
Description : Succinylcholine is the preferred muscle relaxant for tracheal intubation because: A. It produces rapid and complete paralysis of respiratory muscles with quick recovery B. It does not alter heart rate or ... C. It does not cause histamine release D. It does not produce postoperative muscle soreness
Last Answer : A. It produces rapid and complete paralysis of respiratory muscles with quick recovery
Description : Pancuronium differs from tubocurarine in that: A. It is a depolarizing blocker B. Its action is not reversed by neostigmine C. It can cause rise in BP on rapid I.V. injection D. It causes marked histamine release
Last Answer : C. It can cause rise in BP on rapid I.V. injection
Description : Select the skeletal muscle relaxant that is commonly used for endotracheal intubation despite causing histamine release, K+ efflux from muscles and cardiovascular changes: A. Pipecuroniun B. Succinylcholine C. Pancuronium D. Cisatracurium
Last Answer : B. Succinylcholine
Description : The fall in blood pressure caused by d-tubocurarine is due to: A. Reduced venous return B. Ganglionic blockade C. Histamine release D. All of the above
Last Answer : D. All of the above
Description : Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity: A. Sodium cromoglycate B. Ketotifen C. Beclomethasone dipropionate D. Chlorpheniramine
Last Answer : B. Ketotifen
Description : The following drug increases cyclic-AMP in platelets and inhibits their aggregation without altering levels of thromboxane A2 or prostacyclin: A. Aspirin B. Sulfinpyrazone C. Dipyridamole D. Abciximab
Last Answer : C. Dipyridamole
Last Answer : D. Differ from each other in the degree of attendant psychological dependence
Description : Indicate the sulfonamide whose sodium salt yields a nearly neutral solution which is suitable for topical use in the eye: A. Sulfadiazine B. Sulfacetamide C. Sulfadoxine D. Sulfamoxole
Last Answer : B. Sulfacetamide
Description : Clonal selection includes a. Antigen-receptor binding on B cells. b. Antibody secretion recognizing same epitope as on B cell receptors. c. Differentiation of B cells into plasma cells and memory cells. d. All the above (A—C) are correct.
Last Answer : d. All the above (A—C) are correct.
Description : The following class of gastric antisecretory drug also reduce gastric motility and have primary effect on juice volume, with less marked effect on acid and pepsin A. Histamine H2 blockers B. Anticholinergics C. Proton pump inhibitors D. Prostaglandins
Last Answer : B. Anticholinergics
Description : The most important receptor involved in cytotoxic drug induced vomiting is: A. Histamine H1 receptor B. Serotonin 5-HT3 receptor C. Dopamine D2 receptor D. Opioid μ receptor
Last Answer : B. Serotonin
Description : ___is rupture of red cells with release of intracellular haemoglobin can occur if the Antibody has the property of hemolysin. a) Agglutination b) Hemolysis c) Reaction
Last Answer : b) Hemolysis is the rupture of red blood cells with the release of intracellular hemoglobin, and it can occur if the antibody has the property of hemolysin. Hemolysis is the destruction or ... bacteria, and viruses, and it is a key principle in many diagnostic tests for infectious diseases.
Description : The following statement(s) is/are true concerning newer detection methods of systemic infection. a. Enzyme-linked immunosorbent assay (ELISA) is a rapid immunologic assay used for ... detected using advanced molecular techniques include cytomegalovirus (CMV) and human immunodeficiency virus (HIV)
Last Answer : Answer: a, b, c, d Although the classic detection of infection based on clinical signs of infection and bacterial culture remain the most common clinical tools, increasing ... including CMV and HIV. Furthermore, preliminary investigations into possible detection of fungal pathogens are underway
Description : In a patient of bronchial asthma, inhaled salbutamol produces the following effect(s). (a) Inhibits antigen-antibody reaction in the lungs (b) Causes bronchodilatation (c) Reduces bronchial hyperreactivity (d) Both (b) and (c)
Description : Delayed allergy reaction (type IV allergic reaction) is: a) An An allergic or immune response that begins within a period lasting from a few minutes to about an hour after exposure to ... of antigen-antibody complexes that cause tissue damage e) An allergic disorder which is transferred genetically.
Description : Immediate allergy reaction (type I allergic reaction) is: a) An allergic or immune response that begins within a period lasting from a few minutes to about an hour after exposure to an ... cause tissue damage e) It occurs during blood transfusion reactions and in hemolytic disease of the newborn.
Last Answer : Ans: A
Description : Reaction of soluble antigen with antibody is ____A. Agglutination B. Precipitation C. Flocculation D. CFT
Last Answer : Precipitation
Description : Titer refers to a. The most concentrated antigen-antibody concentration showing a reaction. b. The first diluted antigen-antibody concentration showing a reaction. c. The precipitation line ... antigen-antibody reaction. d. The most dilute antigen-antibody concentration showing a reaction.
Last Answer : d. The most dilute antigen-antibody concentration showing a reaction.
Description : In a patient of bronchial asthma, inhaled salbutamol produces the following effect(s): A. Inhibits antigen-antibody reaction in the lungs B. Causes bronchodilatation C. Reduces bronchial hyperreactivity D. Both ‘B’ and ‘C’ are correct
Last Answer : B. Causes bronchodilatation
Description : Effector functions of antigen antibody reaction
Last Answer : 1) As two or more Fc portions are required to stimulate effector functions so effector functions are carried out only by molecules with bound antigens and not with free Ig. 2) Fc region of ... chains are called isotypes. Five heavy chain isotypes and two light chain isotypes are present in humans.
Description : The following antihypertensive drug has been found to suppress certain manifestations of morphine withdrawal syndrome and to block postoperative pain when injected intrathecally: A. Prazosin B. Clonidine C. Reserpine D. Ketanserin
Last Answer : B. Clonidine
Description : In a comatose patient suspected of poisoning, which of the following findings would be against the drug being morphine: A. Mydriasis B. Marked respiratory depression C. Cyanosis D. Fall in blood pressure
Last Answer : A. Mydriasis
Description : The following drug is routinely used in preanaesthetic medication for prolonged operations: A. Atropine B. Morphine C. Promethazine D. Ranitidine
Last Answer : D. Ranitidine
Description : Which of the following is not a semisynthetic penicillin: A. Procaine penicillin B. Ampicillin C. Cloxacillin D. Carbenicillin
Last Answer : A. Procaine penicillin
Description : The penicillin G preparation with the longest duration of action is: A. Benzathine penicillin B. Sodium penicillin C. Potassium penicillin D. Procaine penicillin
Last Answer : A. Benzathine penicillin
Description : The following local anaesthetic is poorly water soluble, PABA derivative and primarily used for anorectal lesions, wounds and ulcers: A. Benzocaine B. Dibucaine C. Procaine D. Benoxinate
Last Answer : A. Benzocaine
Description : Which of the following statements is true for lignocaine: A. It is an ester-linked local anaesthetic B. It is not likely to exhibit cross-sensitivity with procaine C. It has a shorter duration of action than procaine D. It is not a surface anaesthetic
Last Answer : B. It is not likely to exhibit cross-sensitivity with procaine
Description : The local anaesthetic having high cardiotoxic and arrhythmogenic potential is: A. Lignocaine B. Procaine C. Bupivacaine D. Ropivacaine
Last Answer : C. Bupivacaine