DefinitionThe creatinine clearance test compares the level of creatinine in urine with the creatinine level in the blood. (Creatinine is a breakdown product of creatine, which is an important part of muscle.) The test helps provide information on kidney function.See also:Creatinine - blood testCreatinine - urine testHow the test is performedThis test requires both a blood and urine sample. You will collect your urine for 24 hours, and then have blood taken.For information on giving a blood sample, see: venipuncture.For information on how to collect the urine sample, see: 24-hour urine collection.The samples are sent to a laboratory. The laboratory specialist measures the level of creatinine in both the urine and blood samples, and looks at how much urine you collected in 24 hours.The clear