All three pain relievers can work wonders in the right circumstances, but chemically, they’re quite distinct; Advil and Aleve are non-steroidal anti-inflammatory drugs (NSAIDs), while Tylenol is classified as a non-aspirin pain reliever.NSAIDs work by blocking COX-1 enzymes, which promote inflammation. By preventing inflammation, the drugs can reduce pain and fever caused by a variety of conditions. COX-1 enzymes also protect the stomach, however, so these painkillers can cause stomach issues. When taken regularly, NSAIDs may also increase the risk of a heart attack or stroke.Here’s a quick breakdown of the other differences between the three:Advil is ibuprofen. Other brand names for this drug include Motrin and IBU. It has fewer side effects than many other NSAIDs, but can cause a rash or heartburn, in addition to the aforementioned stomach issues. You shouldn’t take it if you have liver or kidney problems. When taken regularly or excessively, ibuprofen can increase the risk of hypertension or heart attack.Aleve is naproxen. Other products with naproxen includeAnaprox, Midol Extended Relief, and Naprosyn. It stays in the system for longer than other pain relief drugs, so it’s typically used to treat pain that lasts longer than a few hours. It increases the user’s risk of suffering a heart attack, but not as much as ibuprofen.Tylenol is acetaminophen. Other brand namesfor this drug include Paracetamol and Panadol. Scientists don’t fully understand how acetaminophen reduces pain, but it may have some effect on COX enzymes like other pain relief drugs. Acetaminophen does not relieve inflammation, and as such, it’s primarily used for headaches and fevers. It also doesn’t cause as many stomach problems or other side effects as NSAIDs, so it’s often recommended for children and for people with Arthritis pain. Unlike many pain relievers, acetaminophen is safe to take after a heart attack. However, it doesn’t decrease the likelihood of heart attacks.Various other drugs are also available over-the-counter for pain relief. Aspirin is, of course, the most popular of these; it’s also an NSAID, but unlike other NSAIDs, it’s not associated with an increased risk of heart attacks. It actually has the opposite effect, so doctors often instruct high-risk patients to take it daily to reduce their risk of heart attacks and strokes.With any over-the-counter pain reliever, it’s important to read the side effects carefully. Don’t exceed the recommended dose, and remember that over-the-counter products can interact with prescription medications and alcohol.Check with your physician if you’re planning on taking any pain reliever on a regular basis, and always read the instructions carefully. With that said, if you’re confused about what to take, we whipped up a quick guide. If you have…A Headache or Toothache: Tylenol is an excellent choice for temporary pain, and it’s less likely to cause stomach issues than other OTC painkillers. However, any OTC painkiller should treat headaches and toothaches effectively.Arthritis: Aleve or Advil can treat arthritis pain effectively. If you have a history of Heart disease, however, aspirin is a better option.Inflammation: Any NSAID should help, but Aleve might be the best choice, since it stays in your system for longer than other over-the-counter painkillers.Menstrual Pain: Advil and Aleve should reduce cramping and inflammation. Again, aspirin’s a safer option for people who are at high risk of heart disease.Fever: Tylenol reduces fever, and it carries fewer side effects than other OTC options. Aspirin should also do the trick.