What are the effects of taking over 1000 mg of Ibuprofen (Advil) each day?

1 Answer

Answer :

answer:Not a good idea. Ibuprofen may impair the ability of the kidney to cope with low renal blood flow states due to inhibition of prostaglandin-dependent afferent arteriolar vasodilation. Renal function may be further compromised in patients with heart failure, hypovolemia, cirrhosis, nephrotic syndrome, or hypoalbuminemia. Additional risk factors for ibuprofen-induced renal insufficiency are advanced age and concomitant use of diuretics. A case-controlled study suggested that patients who consumed 5000 or more pills containing NSAIDs during their lifetime may be at increased risk of end-stage renal disease. Patients with reduced renal function may be at increased risk for renal side effects. Renal side effects have included mild renal insufficiency, urinary retention, nephrotic syndrome with or without renal failure, acute renal failure due to tubulointerstitial nephritis, papillary necrosis, and acute tubular necrosis. Source

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