DefinitionThrombocytopenia is any disorder in which there is an abnormally low amount of platelets. Platelets are parts of the blood that help blood to clot. This condition is sometimes associated with abnormal bleeding.Causes, incidence, and risk factorsThrombocytopenia is often divided into three major causes of low platelets:Low production of platelets in the bone marrowIncreased breakdown of platelets in the bloodstream (called intravascular)Increased breakdown of platelets in the spleen or liver (called extravascular)Disorders that involve low production in the bone marrow include:Aplastic anemiaCancer in the bone marrowCirrhosis (chronic liver disease)Folate deficiencyInfections in the bone marrow (very rare)MyelodysplasiaVitamin B12 deficiencyUse of certain drugs may also lead to a