DefinitionNecrotizing soft tissue infection is a rare but very severe type of bacterial infection that can destroy the muscles, skin, and underlying tissue. Necrotizing refers to something that causes tissue death.Alternative NamesNecrotizing fasciitis; Fasciitis - necrotizing; Flesh-eating bacteria; Soft tissue gangrene; Gangrene - soft tissueCauses, incidence, and risk factorsMany different types of bacteria can cause this type of infection. A very severe and usually deadly form of necrotizing soft tissue infection is due to Streptococcus pyogenes, which is sometimes called "flesh-eating bacteria."Necrotizing soft tissue infection develops when the bacteria enters the body, usually through a minor cut or scrape. The bacteria begins to grow and release harmful substances (toxins) that:Dir