Immunodeficiency: a) A localized protective reaction of tissue to irritation, injury, or infection, characterized by pain, redness, swelling, and sometimes a loss of function b) A disorder or deficiency of the normal immune response c) A disease resulting from an immune reaction produced by an individual's white blood cells or antibodies acting on the body's own tissues or extracellular proteins d) A disease caused by immune system when the drug passes 1st pass effect and damage the liver. e) It is an immunity disorder which is genetically transferred.