As compared to treatment with HBOT for many classical indications, HBOT used at lower pressures (e.g. 1.3 to 1.5 atm and oxygen at 24 to 100%) has started to be investigated to treat certain neurological disorders, some of which are considered to have few efficacious treatments. For example, recent studies have investigated lower pressure HBOT for traumatic brain injury (TBI) in both animal models [ 6- 10] and humans [ 11-23 ]. In a recent prospective trial of 16 patients with TBI, HBOT at 1.5 atm/100% oxygen (40 hourly treatments over 30 days) resulted in significant improvements in their neurological exam, IQ, memory, post- traumatic stress symptoms, depression, anxiety and quality of life. Patients also displayed objective improvements in brain perfusion measured by pre- and post-HBOT single photon emission computed tomography (SPECT) scans [ 17]. The human studies of TBI also include a controlled retrospective review and a controlled prospective clinical trial [ 15, 18]. Larger multicenter trials are ongoing in attempt to confirm these controlled clinical studies [