Description : Actions of adenosine include the following except: A. Depression of A-V node B. Coronary vasodilatation C. Bronchodilatation D. Fall in BP
Last Answer : C. Bronchodilatation
Description : Which of the following statements regarding cytokines is incorrect? A. Cytokines act directly on target cells and may potentiate the actions of one another. B. Interleukin 1 (IL-1) ... organ dysfunction syndrome because of its multiple actions and the secondary cascades that it stimulates.
Last Answer : Answer: C DISCUSSION: Cytokines are soluble peptide molecules that are synthesized and secreted by a number of cell types in response to injury, inflammation, and infection. Cytokines, which ... is thought to play a central role in the stress response, particularly in response to endotoxemia
Description : Actions of bradykinin include the following except: A. Fall in blood pressure B. Cardiac depression C. Increase in capillary permeability D. Bronchoconstriction
Last Answer : B. Cardiac depression
Description : The following are true about chemicals involved in allergic reaction: a. thromboxane -leukocyte activation b. prostaglandin-2 - vasodilatation c. platelet-activating factor - leukocyte activation d. heparin - augments inactivation of prostaglandins
Last Answer : prostaglandin-2 - vasodilatation
Description : Extract of the following plant has platelet activating factor (PAF) antagonistic activity and is claimed to benefit cognitive disorders due to cerebral ischaemia: A. Ginkgo biloba B. Claviceps purpurea C. Amanita muscaria D. Artemisia annua (p. 440) 33.12 3 3 . 1 2 A Aim4aii
Last Answer : A. Ginkgo biloba
Description : The following class(es) of drugs are clinically beneficial in bronchial asthma: A. Histamine H1 receptor antagonists B. Platelet activating factor (PAF) antagonists C. Leukotriene ( cys LT1) receptor antagonists D. All of the above
Last Answer : C. Leukotriene ( cys LT1) receptor antagonists
Description : Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin
Last Answer : A. Thromboxane
Description : Platelet activating factor is: a. Generated by the action of phospholipase A2 on membrane phospholipids b. Antiinflammatory in most of its actions c. Synthesized by endothelial and other cells d. Exerts a variety of biologic effects which are platelet-independent
Last Answer : Answer: a, c, d Like the eicosanoids, platelet-activating factor (PAF) is not stored in cells but is rapidly produced during inflammation. PAF exerts a variety of biologic effects ... and LTB4. There is considerable overlap and redundancy in the effects produced by PAF and eicosanoids
Description : Eicosanoids mediate inflammation in a variety of ways. Of the following statements, which are true with regard to this? a. Eicosanoids are stored in cytoplasmic granules ... include vasodilatation, vasoconstriction, increased vascular permeability and both chemotaxis and chemoattractant inhibition
Last Answer : Answer: b, d The eicosanoids are derived from arachidonic acid (eicosatetraenoic acid) and consist of prostaglandins, thromboxanes, leukotrienes and lipoxins. The eicosanoids are not ... nervous system d. Mononuclear phagocytes release a variety of proinflammatory cytokines and growth factors
Description : Leukotrienes cause (A) Increase in capillary permeability (B) Aggregation of platelets (C) Bronchodilatation (D) None of these
Last Answer : Answer : A
Description : All of the following are true regarding platelet-activating factor (PAF) EXCEPT: C A. Induces platelet aggregation B. Stimulates platelet secretion C. It is a preformed molecule present in various cells D. None of these
Last Answer : It is a preformed molecule present in various cells
Description : The primary mechanism by which prostaglandins promote ulcer healing is: A. Inhibition of gastric acid secretion B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa C. Increased bicarbonate secretion in gastric juice D. Increased turnover of gastric mucosal cell
Last Answer : B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa
Description : The following is true of proton pump inhibitors except: A. They are the most effective drugs for Zolinger Ellison syndrome B. Their prolonged use can cause atrophy of gastric mucosa C. They inhibit growth of H. pylori in stomach D. They have no effect on gastric motilit
Last Answer : B. Their prolonged use can cause atrophy of gastric mucosa
Description : Histamine causes all the following except (A) Stimulation of gastric secretion (B) Vasoconstriction (C) Pruritus (D) Increase in capillary permeability
Last Answer : Answer : B
Description : Actions of oxytocin include the following except: A. Vasoconstriction B. Increased water reabsorption in renal collecting ducts C. Contraction of mammary myoepithelium D. Release of prostaglandins from endometrium
Last Answer : A. Vasoconstriction
Description : 16.3 Actions of growth hormone include the following except: A. Increased protein synthesis B. Increased fat utilization C. Increased carbohydrate utilization D. Glucose intolerance
Last Answer : C. Increased carbohydrate utilization
Description : Select the correct statement about ethamsylate: A. It checks capillary bleeding B. It inhibits platelet aggregation C. It is an antifibrinolytic drug D. It is used to fibrose bleeding piles
Last Answer : ut ethamsylate: A
Description : Phases of multiorgan failure will include: a. Generalized increased capillary permeability b. A hypermetabolic state c. Organ malfunction d. All of the above
Last Answer : Answer: d Clinically the multiple-organ failure patient progresses through well-defined phases. These phases include: Phase 1-a generalized increased capillary permeability resulting in edema, weight gain, ... tissue damage in the lung or brain, the death of the entire organ is likely
Description : Morphine affords symptomatic relief of dyspnoea in acute left ventricular failure by the following mechanisms except: A. Bronchodilatation B. Depression of respiratory centre C. Reduction in cardiac preload D. Shift of blood from pulmonary to systemic circuit
Last Answer : A. Bronchodilatation
Description : Dipalmitoyl lecithin acts as (A) Platelet activating factor (B) Second messenger for hormones (C) Lung surfactant (D) Anti-ketogenic compound
Last Answer : Answer : C
Description : Which of the following statement(s) is/are correct concerning the immunoinflammatory response to shock? a. The anaphylactoxins, C3a and C5a, are products of activation of only the classical pathway ... effects d. Platelet-activating factor can be released by both circulating and fixed tissue cells
Last Answer : Answer: d Inflammatory mediators have recently been recognized as playing a significant role in the clinical manifestations and progression of shock and the development ... increased pulmonary vascular resistance, bronchoconstriction, peripheral vasodilatation, and increased vascular permeability
Description : Prolonged airway hyperreactivity is characteristically caused by: A. Histamine B. Prostaglandin E2 C. Platelet activating factor D. Bradykinin
Last Answer : C. Platelet activating factor
Description : Montelukast blocks the action of the following autacoid: A. Prostacyclin B. Platelet activating factor C. Leukotriene B4 D. Leukotriene C4/D4
Last Answer : D. Leukotriene C4/D4
Description : Dysmenorrhoea is often associated with excess production of the following autacoid by the endometrium: A. Bradykinin B. Prostaglandin C. Platelet activating factor D. 5-Hydroxytryptamine
Last Answer : B. Prostaglandin
Description : The vasopressin action(s) mediated by V2 receptors include(s): A. Increased water permeability of collecting duct cells B. Increased urea permeability of collecting duct cells C. Vasoconstriction D. Both 'A' and 'B
Last Answer : D. Both 'A' and 'B
Description : Metoclopramide has the following actions except: A. Increases lower esophageal sphincter tone B. Increases tone of pyloric sphincter C. Increases gastric peristalsis D. Increases intestinal peristalsis
Last Answer : B. Increases tone of pyloric sphincter
Description : Cytokines with clearly defined actions in acute inflammation and early tissue injury include which of the following? a. Cysteine-X-Cysteine (C-X-C) chemokines b. Tumor Necrosis Factor (TNFa) c. Transforming Growth Factor-b (TGF-b) d. Interleukin-6 (IL-6) e. Platelet Derived Growth Factor (PDGF)
Last Answer : Answer: a, b, c, d, e Polypeptide mediators, such as TNFa and IL-1, are considered early response cytokines and are actively involved in the initiation of the ... of tissue repair. Thus, coagulation and platelet activation provide the initial foundation for subsequent cellular recruitment
Description : All of the following contribute to the antihypertensive action of propranolol except: A. Direct vasodilatation B. Decreased renin release from kidney C. Adaptation of blood vessels to reduced cardiac output D. Less noradrenaline release from sympathetic nerve endings
Last Answer : A. Direct vasodilatation
Description : Actions of angiotensin II include: a. increases the release of aldosterone b. reduces renin release from the kidney c. vasodilatation d. promotes microalbuminuria
Last Answer : promotes microalbuminuria
Description : Theophylline is believed to benefit asthma patients by exerting the following actions except: A. Bronchodilatation B. Augmentation of diaphragmatic contractility C. Reduced mediator release D. Inhibition of antigen: antibody reaction
Last Answer : D. Inhibition of antigen: antibody reaction
Description : Sucralfate promotes healing of duodenal ulcer by: A. Enhancing gastric mucus and bicarbonate secretion B. Coating the ulcer and preventing the action of acid-pepsin on ulcer base C. Promoting regeneration of mucosa D. Both ‘A’ and ‘B’ are correct
Last Answer : B. Coating the ulcer and preventing the action of acid-pepsin on ulcer base
Description : Choose the antiulcer drug that inhibits gastric acid secretion, stimulates gastric mucus and bicarbonate secretion and has cytoprotective action on gastric mucosa: A. Misoprostol B. Sucralfate C. Carbenoxolone sodium D. Colloidal bismuth subcitrate
Last Answer : A. Misoprostol
Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa
Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa
Description : Oxethazaine is used for anaesthetizing gastric mucosa because: A. It is not absorbed from the gastrointestinal tract B. It remains largely unionized in acidic medium C. It is highly ionized in acidic medium D. It produces no systemic effects even at high doses
Last Answer : B. It remains largely unionized in acidic medium
Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs
Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation
Description : The isoenzyme cyclooxygenase-2 (COX-2) is expressed constitutively at the following site: A. Gastric mucosa B. Neutrophils C. Blood platelets D. Juxtaglomerular apparatus
Last Answer : D. Juxtaglomerular apparatus
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues
Last Answer : B. It is inducible
Description : Select the action of vasopressin exerted through the V1 subtype receptors: A. Release of coagulation factor VIII and von Willebrands factor from vascular endothelium B. Increased peristalsis of gut C. Dilatation of blood vessels D. Increased water permeability of renal collecting ducts
Last Answer : B. Increased peristalsis of gut
Description : The constellation of adverse effects associated with nonsteroidal antiinflammatory drugs include the following except: A. Sedation B. Gastric irritation C. Fluid retention D. Rashes
Last Answer : A. Sedation
Description : Actions of morphine include the following except: A. Vagal stimulation B. Miosis C. Antiemetic D. Postural hypotensio
Last Answer : C. Antiemetic
Description : Actions of chlorpromazine include the following except: A. Indifference to external stimuli B. Postural hypotension C. Hypoprolactinemia D. Hypothermia in cold surroundings
Last Answer : C. Hypoprolactinemia
Description : Actions of progesterone include the following except: A. Rise in body temperature B. Endometrial proliferation C. Proliferation of acini in mammary gland D. Suppression of cell mediated immunity
Last Answer : B. Endometrial proliferatio
Description : Actions of thyroxine include the following except: A. Induction of negative nitrogen balance B. Reduction in plasma cholesterol level C. Fall in plasma free fatty acid level D. Rise in blood sugar leve
Last Answer : C. Fall in plasma free fatty acid level
Description : 17.5 Actions of thyroxine include the following except: A. Induction of negative nitrogen balance B. Reduction in plasma cholesterol level C. Fall in plasma free fatty acid level D. Rise in blood sugar level
Last Answer : D. Rise in blood sugar level
Description : At therapeutic doses, actions of amphetamine include the following except: A. Prolongation of attention span B. Wakefulness C. Lowering of seizure threshold D. Delaying fatigue
Last Answer : C. Lowering of seizure threshold
Description : The metabolic actions of adrenaline include the following except: A. Glycogenolysis in liver and muscle B. Inhibition of neoglucogenesis in liver C. Lipolysis in adipose tissue D. Release of potassium from liver followed by its uptake
Last Answer : B. Inhibition of neoglucogenesis in liver