Description : At therapeutic doses, actions of amphetamine include the following except: A. Prolongation of attention span B. Wakefulness C. Lowering of seizure threshold D. Delaying fatigue
Last Answer : C. Lowering of seizure threshold
Description : Imipramine produces the following actions except: A. Euphoria B. Dryness of mouth C. Tachycardia D. Lowering of seizure threshold
Last Answer : A. Euphoria
Description : The following is true about actions of ethylalcohol: A. It exerts anticonvulsant action followed by lowering of seizure threshold B. It lowers pain threshold C. It increases confidence and reduces number of errors D. It increases heat production and helps to keep warm in cold weather
Last Answer : A. It exerts anticonvulsant action followed by lowering of seizure threshold
Description : Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects
Last Answer : D. It produces prominent extrapyramidal side effect
Description : Which of the following adverse effects of neuroleptic drugs is positively correlated to the antipsychotic potency of the different compounds: A. Sedation B. Extrapyramidal motor disturbances C. Postural hypotension D. Lowering of seizure threshold
Last Answer : B. Extrapyramidal motor disturbances
Description : In man sedation caused by morphine is characterised by: A. Little or no motor incoordination B. Initial excitement C. Rise in seizure threshold D. All of the abov
Last Answer : A. Little or no motor incoordination
Description : The following antiepileptic drug raises pentylene tetrazol seizure threshold but does not modify maximal electroshock seizures: A. Ethosuximide B. Carbamazepine C. Primidone D. Phenobarbitone
Last Answer : A. Ethosuximide
Description : Advantages of selective serotonin reuptake inhibitors (SSRIs) include the following except: A. No interference with ejaculation and orgasm B. Minimal sedative action C. Unlikely to cause fall in BP D. Lack of seizure precipitating potential
Last Answer : A. No interference with ejaculation and orgasm
Description : Angiotensin converting enzyme inhibitors afford maximum protection against progression of heart failure when used: A. At the higher therapeutic dose range over long term B. At the maximum tolerated dose only till ... restored C. At low doses over long term D. At low doses along with diuretics/digoxi
Last Answer : A. At the higher therapeutic dose range over long term
Description : Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. ... its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop
Last Answer : C. Used alone, its effective doses produce intolerable side effect
Description : When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action
Last Answer : C. Therapeutic window phenomenon
Description : Metabolic effects that generally attend antiinflammatory doses of aspirin include the following except: A. Increased CO2 production B. Hepatic glycogen depletion C. Metabolic acidosis D. Compensated respiratory alkalosis
Last Answer : C. Metabolic acidosis
Description : An undesirable effect of a drug that occurs at therapeutic doses and can be predicted from its pharmacological actions is called: A. Side effect B. Toxic effect C. Allergic reaction D. Idiosyncrasy
Last Answer : A. Side effect
Description : Choose the most suitable antihypertensive drug for a 45-year-old male company executive who has a travelling job. His blood pressure is 160/100 mm Hg, and he is a diabetic ... → rebound hypertension. Hydrochlorothiazide: May worsen diabetes; more likely to produce weakness, fatigue and impotenc
Last Answer : B. Enalapril
Description : Beneficial effect/effects of diuretics in CHF patients include the following: A. Symptomatic relief B. Regression of pathological changes C. Prolongation of life expectancy D. Both ‘A’ and ‘C’
Last Answer : A. Symptomatic relief
Description : Indications of tricyclic antidepressants include the following except: A. Attention deficit-hyperactive disorder in children B. Mania C. Prophylaxis of migraine D. Panic disorder
Last Answer : B. Mania
Description : Actions of adenosine include the following except: A. Depression of A-V node B. Coronary vasodilatation C. Bronchodilatation D. Fall in BP
Last Answer : C. Bronchodilatation
Description : Actions of bradykinin include the following except: A. Fall in blood pressure B. Cardiac depression C. Increase in capillary permeability D. Bronchoconstriction
Last Answer : B. Cardiac depression
Description : Actions of morphine include the following except: A. Vagal stimulation B. Miosis C. Antiemetic D. Postural hypotensio
Last Answer : C. Antiemetic
Description : Actions of chlorpromazine include the following except: A. Indifference to external stimuli B. Postural hypotension C. Hypoprolactinemia D. Hypothermia in cold surroundings
Last Answer : C. Hypoprolactinemia
Description : Actions of oxytocin include the following except: A. Vasoconstriction B. Increased water reabsorption in renal collecting ducts C. Contraction of mammary myoepithelium D. Release of prostaglandins from endometrium
Last Answer : A. Vasoconstriction
Description : Actions of progesterone include the following except: A. Rise in body temperature B. Endometrial proliferation C. Proliferation of acini in mammary gland D. Suppression of cell mediated immunity
Last Answer : B. Endometrial proliferatio
Description : Actions of thyroxine include the following except: A. Induction of negative nitrogen balance B. Reduction in plasma cholesterol level C. Fall in plasma free fatty acid level D. Rise in blood sugar leve
Last Answer : C. Fall in plasma free fatty acid level
Description : 17.5 Actions of thyroxine include the following except: A. Induction of negative nitrogen balance B. Reduction in plasma cholesterol level C. Fall in plasma free fatty acid level D. Rise in blood sugar level
Last Answer : D. Rise in blood sugar level
Description : 16.3 Actions of growth hormone include the following except: A. Increased protein synthesis B. Increased fat utilization C. Increased carbohydrate utilization D. Glucose intolerance
Last Answer : C. Increased carbohydrate utilization
Description : The metabolic actions of adrenaline include the following except: A. Glycogenolysis in liver and muscle B. Inhibition of neoglucogenesis in liver C. Lipolysis in adipose tissue D. Release of potassium from liver followed by its uptake
Last Answer : B. Inhibition of neoglucogenesis in liver
Description : The actions of platelet activating factor include the following except: A. Increased capillary permeability B. Bronchodilatation C. Vasodilatation D. Erosion of gastric mucosa
Last Answer : B. Bronchodilatation
Description : The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation ... active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro
Last Answer : C. Heparin is the physiologically active circulating anticoagulant
Description : he following is true of nifedipine except: A. It can aggravate urine voiding difficulty in elderly males with prostatic hypertrophy B. It promotes Na+ retention by a renal tubular action to ... release from pancreas D. At high doses it can paradoxically increase the frequency of angina pectori
Last Answer : B. It promotes Na+ retention by a renal tubular action to cause ankle oedema as side effect
Description : The following is true of pethidine except: A. At equianalgesic doses it causes less respiratory depression than morphine B. It is less constipating than morphine C. It is a poor antitussive D. In overdose it often produces excitatory effect
Last Answer : A. At equianalgesic doses it causes less respiratory depression than morph
Description : The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case
Last Answer : D. They are the preferred drugs in advanced cases
Description : The following is true about entacapone except: A. It acts by inhibiting degradation of dopamine in the brain B. If prolongs the therapeutic effect of levodopacarbidopa in parkinsonism C. It can accentuate levodopa induced dyskinesias D. It can cause diarrhoea as a side effec
Last Answer : A. It acts by inhibiting degradation of dopamine in the brain
Description : Benzodiazepines differ from barbiturates in the following aspects except: A. They have a steeper dose response curve B. They have higher therapeutic index C. They have lower abuse liability D. They do not induce microsomal drug metabolizing enzymes
Last Answer : A. They have a steeper dose response curve
Description : Features of atorvastatin include the following: A. Dose to dose most potent HMG-CoA reductase inhibitor B. Higher ceiling of LDL-cholesterol lowering action than lovastatin C. Antioxidant property D. All of the above
Last Answer : D. All of the above
Description : What is Seizure threshold?
Last Answer : What is the answer ?
Description : In man sedation caused by morphine is characterized by (a) Initial excitement (b) Little or no motor incoordination (c) Rise in seizure threshold (d) All of the above
Last Answer : Ans: B
Description : A 70-year-old patient presented with weakness, tiredness and muscle cramps. The ECG showed Q-T prolongation, flattening of T wave and occasional A-V block. His serum K+ was low (2.8 mEq ... could be responsible for the above condition: A. Bisacodyl B. Liquid paraffin C. Methylcellulose D. Bran
Last Answer : A. Bisacodyl
Description : The most significant feature of the antiarrhythmic action of lignocaine is: A. Suppression of phase-4 depolarization in ventricular ectopic foci B. Prolongation of action potential duration C. Prolongation of effective refractory period D. Depression of membrane responsiveness
Last Answer : A. Suppression of phase-4 depolarization in ventricular ectopic foci
Description : The principal action common to all class I antiarrhythmic drugs is: A. Na+ channel blockade B. K+ channel opening C. Depression of impulse conduction D. Prolongation of effective refractory period
Last Answer : A. Na+ channel blockade
Description : The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation
Last Answer : D. Prolongation of voltage sensitive neuronal Na+ channel inactivation
Description : The following is true of simvastatin except: A. It is more potent than lovastatin B. At the highest recommended dose, it causes greater LDL-cholesterol lowering than lovastatin C. It does not undergo ... metabolism in liver D. It can raise HDL-cholesterol level when the same is low at base line
Last Answer : C. It does not undergo first pass metabolism in liver
Description : Cancer chemotherapy induced vomiting that is not controlled by metoclopramide alone can be suppressed by combining it with: A. Amphetamine B. Dexamethasone C. Hyoscine D. Cyclizine
Last Answer : B. Dexamethasone
Description : The following drug has been used to stimulate respiratory and vasomotor centres as an expedient measure, because it has the least propensity to induce convulsions: A. Pentylenetetrazole B. Doxapram C. Bicuculline D. Amphetamine
Last Answer : B. Doxapram
Description : Select the drug that primarily reduces the static component of urinary obstruction in benign hypertrophy of prostate and takes more than 3 months to exert its beneficial effect: A. Tamsulosin B. Terazosin C. Finasteride D. Amphetamine
Last Answer : C. Finasteride
Description : Select the drug which can improve urinary flow rate in benign prostatic hypertrophy without affecting prostate size: A. Amphetamine B. Prazosin C. Finasteride D. Goserelin
Last Answer : B. Prazosin
Description : Amphetamine potentiates the following class of drugs: A. Diuretics B. Analgesics C. Neuroleptics D. Antihypertensives
Last Answer : B. Analgesics