Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues
Last Answer : B. It is inducible
Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues
Last Answer : Ans: B
Description : Aspirin in low doses produces longlasting inhibition of platelet cyclooxygenase (COX) because: A. Platelets contain low quantity of COX B. Platelets cannot synthesize fresh COX molecules C. Platelets bind aspirin with high affinity D. Platelet COX is inducible
Last Answer : B. Platelets cannot synthesize fresh COX molecules
Description : The following nonsteroidal antiinflammatory drug is a preferential cyclooxygenase-2 (COX-2) inhibitor: A. Tenoxicam B. Meloxicam C. Diclofenac sod. D. Ketoprofen
Last Answer : B. Meloxicam
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that: A. They catalyse different pathways in prostanoid biosynthesis B. COX-1 is inhibited by aspirin but not COX-2 C. COX-2 is inhibited by ibuprofen but not COX-1 D. COX-1 is constitutive while COX-2 is largely
Last Answer : D. COX-1 is constitutive while COX-2 is largely
Description : The selective COX-2 inhibitors have the following advantage(s) over the nonselective NSAIDs: A. They are less likely to cause gastric ulcers and their complications B. They are likely to be more ... in rheumatoid arthritis C. They are not likely to produce renal complications D. All of the above
Last Answer : A. They are less likely to cause gastric ulcers and their complications
Description : Choose the correct statement about cysteinyl leukotrienes (LT-C4/D4): A. They produce long lasting bronchoconstriction B. They produce sustained rise in blood pressure C. They are responsible ... and sequestrating neutrophils at the site of inflammation D. Their production is inhibited by rofecoxib
Last Answer : A. They produce long lasting bronchoconstriction
Description : The cyclooxygenase isoenzymes COX-1 and COX-2 differ from each other in that (a) They catalyse different pathways in prostanoid biosynthesis (b) COX–1 is inhibited by aspirin but not COX–2 (c) COX–2 is inhibited by ibuprofen but not COX–1 (d) COX–1 is constitutive while COX–2 is inducible
Last Answer : Ans: D
Description : Sucralfate promotes healing of duodenal ulcer by: A. Enhancing gastric mucus and bicarbonate secretion B. Coating the ulcer and preventing the action of acid-pepsin on ulcer base C. Promoting regeneration of mucosa D. Both ‘A’ and ‘B’ are correct
Last Answer : B. Coating the ulcer and preventing the action of acid-pepsin on ulcer base
Description : Choose the antiulcer drug that inhibits gastric acid secretion, stimulates gastric mucus and bicarbonate secretion and has cytoprotective action on gastric mucosa: A. Misoprostol B. Sucralfate C. Carbenoxolone sodium D. Colloidal bismuth subcitrate
Last Answer : A. Misoprostol
Description : The primary mechanism by which prostaglandins promote ulcer healing is: A. Inhibition of gastric acid secretion B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa C. Increased bicarbonate secretion in gastric juice D. Increased turnover of gastric mucosal cell
Last Answer : B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa
Description : The following is true of proton pump inhibitors except: A. They are the most effective drugs for Zolinger Ellison syndrome B. Their prolonged use can cause atrophy of gastric mucosa C. They inhibit growth of H. pylori in stomach D. They have no effect on gastric motilit
Last Answer : B. Their prolonged use can cause atrophy of gastric mucosa
Description : Histamine H2 blockers attenuate the gastric secretory response to acetylcholine and pentagastrin as well because: A. H2 blockers block gastric mucosal cholinergic and gastrin receptors as well B. H2 ... acetylcholine and gastrin all act through the phospholipase C-IP3:DAG pathway in gastric mucosa
Last Answer : C. Acetylcholine and gastrin act partly by releasing histamine in gastric mucosa
Description : Oxethazaine is used for anaesthetizing gastric mucosa because: A. It is not absorbed from the gastrointestinal tract B. It remains largely unionized in acidic medium C. It is highly ionized in acidic medium D. It produces no systemic effects even at high doses
Last Answer : B. It remains largely unionized in acidic medium
Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs
Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation
Description : The actions of platelet activating factor include the following except: A. Increased capillary permeability B. Bronchodilatation C. Vasodilatation D. Erosion of gastric mucosa
Last Answer : B. Bronchodilatation
Description : The regulatory i gene of lac operon (A) Is inhibited by lacotse (B) Is inhibited by its own product, the repressor protein (C) Forms a regulatory protein which increases the expression of downstream structural genes (D) Is constitutively expressed
Last Answer : Answer : D
Description : The cells which are responsible for the production of antibodies are – (1) red blood cells (2) neutrophils (3) lymphocytes (4) platelets
Last Answer : (3) lymphocytes Explanation: An antibody (Ab), also known as an immunoglobulin (Ig), is a large Y-shaped protein produced by B-cells that is used by the immune system to identify and ... called antigens usually on the outside of an invading organism. This is called the antigen-antibody reaction.
Description : The cells which are responsible for the production of antibodies are (1) red blood cells (2) neutrophils (3) lymphocytes (4) platelets
Last Answer : lymphocytes
Description : Aspirin in low doses produces longlasting inhibition (a) Platelets contain low quantity of COX (b) Platelets cannot synthesize fresh COX molecules (c) Platelets bind aspirin with high affinity (d) Platelet COX is inducible
Description : Glycophorin is present in cell membranes of (A) Erythrocytes (B) Platelets (C) Neutrophils (D) Liver
Last Answer : Answer : A
Description : Select the antibiotic which inhibits drug metabolizing isoenzyme CYP3A4 resulting in potentially fatal drug interaction with terfenadine: A. Erythromycin B. Clindamycin C. Gentamicin D. Vancomycin
Last Answer : A. Erythromycin
Description : The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of ... for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine
Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol
Description : Select the antihistaminic which blocks cardiac K+ channels when given in high doses or along with drugs that inhibit CYP3A4 isoenzyme: A. Chlorpheniramine B. Promethazine C. Astemizole D. Loratadine
Last Answer : C. Astemizole
Description : Corticosteroids exert antiinflammatory action by inhibiting the following enzyme: A. Cyclooxygenase B. Lipoxygenase C. Phospholipase-A D. Phosphodiesterase
Last Answer : C. Phospholipase-A
Description : Select the drug which inhibits cyclooxygenase in the brain but not at peripheral sites of inflammation: A. Nimesulide B. Paracetamol C. Ketorolac D. Mephenamic acid
Last Answer : B. Paracetamol
Description : What is true of nimesulide: A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition B. It is preferred for long-term use in rheumatoid arthritis C. It is contraindicated in aspirin intolerant asthma patients D. All of the above
Last Answer : A. It exerts antiinflammatory action by several mechanisms in addition to cyclooxygenase inhibition
Description : Which of the following is an efficacious antiinflammatory drug but a relatively weak inhibitor of cyclooxygenase: A. Nimesulide B. Paracetamol C. Ketoprofen D. Indomethacin
Last Answer : A. Nimesulide
Description : Which of the following is an irreversible inhibitor of cyclooxygenase: A. Aspirin B. Phenylbutazone C. Indomethacin D. Piroxicam
Last Answer : A. Aspirin
Description : Choose the correct statement about nefopam: A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis B. It is an orally active opioid analgesic C. It is an analgesic with potent antiinflammatory activity D. It is a preferential COX-2 inhibitor
Last Answer : A. It is a nonopioid analgesic which does not inhibit prostaglandin synthesis
Description : A 60-year-old patient presented with anorexia, weakness, paresthesia and mental changes. His tongue was red, tendon reflexes were diminished, haemoglobin was 6 g% with large red cells and neutrophils had ... be responsible for his condition: A. Folic acid B. Vitamin B12 C. Pyridoxine D. Riboflavin
Last Answer : B. Vitamin B12
Description : Angiotensinogen is a protein produced and secreted by (a) juxtaglomerular (JG) cells (b) macula densa cells (c) endothelial cells (cells lining the blood vessels) (d) liver cells.
Last Answer : d) liver cells.
Description : The β-lactam antibiotic(s) that prolong(s) bleeding time by altering surface receptors on platelets is/are: A. Carbenicillin B. Piperacillin C. Cefotaxime D. Both `A’ and `B’ are correct
Last Answer : A. Carbenicillin
Description : Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time
Last Answer : B. It prevents ADP mediated platelet adenylylcyclase inhibition
Description : The following drug increases cyclic-AMP in platelets and inhibits their aggregation without altering levels of thromboxane A2 or prostacyclin: A. Aspirin B. Sulfinpyrazone C. Dipyridamole D. Abciximab
Last Answer : C. Dipyridamole
Description : Inhibition of thromboxane synthesis by aspirin in platelets lasts for 5-7 days because: A. Aspirin persists in the body for 5-7 days B. Aspirin induced depletion of arachidonic acid lasts 5-7 ... 5-7 days D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days
Last Answer : D. Platelets cannot generate fresh thromboxane synthetase and their turnover time is 5-7 days
Description : Aspirin prolongs bleeding time by inhibiting the synthesis of: A. Clotting factors in liver B. Prostacyclin in vascular endothelium C. Cyclic AMP in platelets D. Thromboxane A2 in platelets
Last Answer : D. Thromboxane A2 in platelets
Description : Low doses of aspirin prolong bleeding time by selectively inhibiting synthesis of the following mediator in the platelets: A. Thromboxane A2 B. 5-Hydroxytryptamine C. Platelet activating factor D. Prostacyclin
Last Answer : A. Thromboxane
Description : The success of oral rehydration therapy of diarrhoea depends upon the following process in the intestinal mucosa: A. Sodium pump mediated Na+ absorption B. Glucose coupled Na+ absorption C. Bicarbonate coupled Na+ absorption D. Passive Na+ diffusion secondary to nutrient absorption
Last Answer : B. Glucose coupled Na+ absorption
Description : A patient presented with abdominal pain and frequent unsatisfactory bowel movement. For the last one year he has been using a purgative twice weekly to open his bowel. On colonoscopy the colon was found to ... that the patient has been using: A. Liquid paraffin B. Ispaghula C. Senna D. Lactulose
Last Answer : C. Senna
Description : Select the correct statement about nitrous oxide: A. It irritates the respiratory mucosa B. It has poor analgesic action C. It is primarily used as a carrier and adjuvant to other anaesthetics D. It frequently induces post anaesthetic nausea and retching
Last Answer : C. It is primarily used as a carrier and adjuvant to other anaesthetics
Description : The most likely complication of prolonged use of nasal decongestant drops is: A. Atrophic rhinitis B. Hypertrophy of nasal mucosa C. Naso-pharyngeal moniliasis D. Blockage of eustachian tubes
Last Answer : A. Atrophic rhinitis
Description : .E.coli cells with a mutated z gene of the lac operon cannot grow in medium containing only lactose as the source of energy because (a) the lac operon is constitutively active in these cells ( ... coli cells do not utilise lactose (d) they cannot transport lactose from the medium into the cell.
Last Answer : (b) they cannot synthesise functional beta galactosidase
Description : Prostaglandins stimulate (A) Aggregation of platelets (B) Lipolysis in adipose tissue (C) Bronchodilatation (D) Gastric acid secretion
Last Answer : Answer : C
Description : Deficiency of vitamin B12 can occur because of (A) Decreased intake of vitamin B12 (B) Atrophy of gastric mucosa (C) Intestinal malabsorption (D) All of these
Description : All of the following statements about cholecystokinin pancreozymin are true except (A) It is secreted by mucosa of small intestine (B) It stimulates secretion of pancreatic juice rich in enzymes (C) It stimulates contraction of gall bladder (D) It inhibits gastric motility
Description : Bromhexine acts by (a) Inhibiting cough center (b) Irritating gastric mucosa and reflexly increasing bronchial secretion (c) Depolymerizing mucopolysaccharides present (d) Desensitizing stretch receptors in the lungs
Last Answer : Ans: C
Description : Which of the following will result from blockade of H2 receptors? (a) Decreased camp in cardiac muscle (b) Increased camp in cardiac muscle (c) Decreased IP3 in gastric mucosa (d) Increased IP3 in gastric mucosa (e) Increased IP3 in smooth muscle
Last Answer : Ans: A