The primary mechanism of action of benzodiazepines is: A. Dopamine antagonism B. Adenosine antagonism C. Opening of neuronal chloride channels D. Facilitation of GABA-mediated chloride influx

The primary mechanism of action of benzodiazepines is:
A. Dopamine antagonism
B. Adenosine antagonism
C. Opening of neuronal chloride channels
D. Facilitation of GABA-mediated chloride influx
by

1 Answer

Answer :

D. Facilitation of GABA-mediated chloride influx
by

Related questions

The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Description : The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Last Answer : D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Select the correct statement about benzodiazepines (BZDs): A. All BZDs facilitate GABA mediated Cl¯ influx into neurones B. Different BZDs exert the same degrees of hypnotic, anxiolytic and anticonvulsant actions C. The BZD receptor is homogeneous at all neuronal sites D. The muscle relaxant action of BZDs is not blocked by flumazenil

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Last Answer : A. All BZDs facilitate GABA mediated Cl¯ influx into neurones

The mechanism of action of barbiturates differs from that of benzodiazepines in that they: A. Do not affect the GABA-benzodiazepine receptor-chloride channel complex B. Act as inverse agonists at the benzodiazepine receptor C. Increase the frequency of chloride channel opening without affecting its life time D. Have both GABA-facilitatory as well as GABA-mimetic actions

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e primary mechanism by which general anaesthetics produce their action is: A. Affecting receptor operated ion channels in cerebral neurones B. Blocking voltage sensitive Na+ channels in neuronal membrane C. Depressing metabolic activity of cerebral neurones D. Blocking production of high energy phosphates in the brain

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he primary mechanism by which heparin prevents coagulation of blood is: A. Direct inhibition of prothrombin to thrombin conversion B. Facilitation of antithrombin III mediated inhibition of factor Xa and thrombin C. Activation of antithrombin III to inhibit factors IX and XI D. Inhibition of factors XIIa and XIIIa

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The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of dopamine methylation in the brain C. Inhibition of oxidative deamination of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries

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Methylxanthines exert the following action(s) at cellular/molecular level: A. Intracellular release of Ca2+ B. Antagonism of adenosine C. Inhibition of phosphodiesterase D. All of the above

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Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve stimulation

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6.12 The most prominent action of bromocriptine is: A. Dopamine D2 agonism B. Dopamine D2 antagonism C. Dopamine D1 antagonism D. α adrenergic antagonism

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Sodium valproate has been shown to: A. Prolong neuronal Na+ channel inactivation B. Attenuate ‘T’ type Ca2+ current in neurones C. Inhibit degradation of GABA by GABA-transaminase D. All of the above

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The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is: A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme B. Mutational acquisition of aminoglycoside hydrolysing enzyme C. Mutation reducing affinity of ribosomal protein for the antibiotic D. Mutational loss of porin channels

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TThe most important mechanism of antiinflammatory action of glucocorticoids is: A. Inhibition of lysosomal enzymes B. Restriction of recruitment of inflammatory cells at the site of inflammation C. Antagonism of action of interleukins D. Suppression of complement function

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Local anaesthetics block nerve conduction by: A. Blocking all cation channels in the neuronal membrane B. Hyperpolarizing the neuronal membrane C. Interfering with depolarization of the neuronal membrane D. Both ‘B’ and ‘C’ are correct

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The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes and inhibit bacterial protein synthesis C. They bind to 50S ribosomes and interfere with translocation of the growing peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria

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Methylxanthines exert the following action (s) at cellular/molecular level (a) Intracellular release of Ca2+ (b) Antagonism of adenosine (c) Inhibition of phosphodiesterase (d) All of the above

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The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is (a) Plasmid mediated acquisition of aminoglycoside conjugating enzyme (b) Mutational acquisition of aminoglycoside hydrolyzing enzyme (c) Mutation reducing affinity of ribosomal protein for the antibiotic (d) Mutational loss of porin channels

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Beneficial effects of β-adrenoceptor blockers in CHF include the following except: A. Antagonism of ventricular wall stress enhancing action of sympathetic overactivity B. Antagonism of vasoconstriction due to sympathetic overactivity C. Prevention of pathological remodeling of ventricular myocardium D. Prevention of dangerous cardiac arrhythmias

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Parkinson’s disease (characterized by tremors and progressive rigidity of limbs) is caused by degeneration of brain neurons that are involved in movement control and make use of neurotransmitter (a) acetylcholine (b) norepinephrine (c) dopamine (d) GABA.

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Alzheimer’s disease in humans is associated with the deficiency of (a) glutamic acid (b) acetylcholine (c) gamma aminobutyric acid (GABA) (d) dopamine.

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Use of adenosine for terminating an episode of paroxysmal supraventricular tachycardia has the following advantages except: A. It does not produce any side effect B. It can be given to patients with low blood pressure C. Its action lasts less than 1 min after bolus intravenous injection D. It is effective in patients not responding to verapamil

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Select the drug that antagonises diazepam action noncompetitively: A. Adenosine B. Flumazenil C. Bicuculline D. Valproic acid

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Which of the following is an orally active drug that blocks sodium channels and decreases action potential duration? (a) Adenosine (b) Amiodarone (c) Disopyramide (d) Esmolol (e) Mexiletine

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The symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) Inceased vascular permeability of bronchial tissue (d) Decreased calcium influx into the mast cell (e) Decreased prostaglandin production

Description : The symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) ... bronchial tissue (d) Decreased calcium influx into the mast cell (e) Decreased prostaglandin production

Last Answer : Ans: A

The Symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) Increased vascular permeability of bronchial tissue (d) Decreased calcium influx into the mast cells (e) Decreased prostaglandin production

Description : The Symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) ... bronchial tissue (d) Decreased calcium influx into the mast cells (e) Decreased prostaglandin production

Last Answer : Ans: A

Which of the following terms best describes the antagonism of leukotriene’s bronchoconstrictor effect (mediated at leukotriene receptors) by terbutaline (acting a adrenoceptors) in a patient with asthma? (a) Pharmacologic antagonist (b) Partial agonist (c) Physiologic antagonist (d) Chemical antagonist (e) Noncompetitive antagonist

Description : Which of the following terms best describes the antagonism of leukotriene's bronchoconstrictor effect (mediated at leukotriene receptors) by terbutaline (acting a adrenoceptors) in a patient with ... ) Partial agonist (c) Physiologic antagonist (d) Chemical antagonist (e) Noncompetitive antagonist

Last Answer : Ans: C

Compared to other antipsychotic drugs, the distinctive feature of penfluridol is: A. Very long duration of action B. Weak dopamine D2 blocking activity C. Lack of extrapyramidal side effects D. Additional 5-HT2 receptor blocking activity

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In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of action C. It activates dopamine D2 receptors, with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect

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The antidotal effect of sodium nitrite in cyanide poisoning is dependent upon: A. Chemical combination of sodium nitrite with cyanide B. Vasodilatation caused by sodium nitrite C. Conversion of haemoglobin to methaemoglobin by sodium nitrite D. Facilitation of cyanocobalamine formation by sodium nitrite

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Last Answer : C. Conversion of haemoglobin to methaemoglobin by sodium nitrite

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Last Answer : D. Both ‘B’ and ‘C

At the muscle end-plate, d-tubocurarine reduces the: A. Number of Na+ channels B. Duration for which the Na+ channels remain open C. Ion conductance of the open Na+ channel D. Frequency of Na+ channel opening

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Last Answer : D. Frequency of Na+ channel opening

Choose the correct statement about nateglinide: A. It is a long acting oral hypoglycaemic drug B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C. It lowers blood glucose in both type 1 and type 2 diabetes mellitus D. It acts by opening K+ channels in myocytes and adipocytes

Description : Choose the correct statement about nateglinide: A. It is a long acting oral hypoglycaemic drug B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus C. It lowers ... 1 and type 2 diabetes mellitus D. It acts by opening K+ channels in myocytes and adipocytes

Last Answer : B. Taken just before a meal, it limits postprandial hyperglycaemia in type 2 diabetes mellitus

The antiviral action of amantadine is exerted through: A. Interaction with the viral M2 protein B. Interaction with a virus directed thymidine kinase C. Inhibition of a viral protease enzyme D. Inhibition of viral RNA mediated DNA synthesi

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Last Answer : A. Interaction with the viral M2 protein

Aminoglycoside antibiotics exert the following action(s) on sensitive bacteria: A. Induce synthesis of defective proteins B. Make bacterial cell membrane more leaky C. Augment their own carrier mediated entry into the bacteria D. All of the above

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The following is true of loperamide except: A. It is absorbed from intestines and exerts centrally mediated antidiarrhoeal action B. It acts on the opioid receptors in the gut C. It increases tone and segmenting activity of the intestines D. It inhibits intestinal secretion by binding to calmodulin in the mucosal cells

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Description : Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop ... C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion

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Description : When therapeutic effects decline both below and above a narrow range of doses, a drug is said to exhibit: A. Ceiling effect B. Desensitization C. Therapeutic window phenomenon D. Nonreceptor mediated action

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Description : The following action of 5-Hydroxy tryptamine is mediated by the 5-HT3 receptor: A. Vasoconstriction B. Bradycardia C. EDRF release D. Platelet aggregation

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The distinctive features of fluoxetine compared to the typical tricyclic antidepressants include the following except: A. It is less likely to produce cardiac arrhythmias in overdose B. It infrequently produces sedative and anticholinergic side effects C. It can elevate mood of apparently nondepressed patients suffering from chronic somatic illness D. It does not block neuronal uptake of biogenic amines

Description : The distinctive features of fluoxetine compared to the typical tricyclic antidepressants include the following except: A. It is less likely to produce cardiac arrhythmias in overdose B. It infrequently ... suffering from chronic somatic illness D. It does not block neuronal uptake of biogenic amines

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The following is not true of local anaesthetics: A. The local anaesthetic is required in the unionized form for penetrating the neuronal membrane B. The local anaesthetic approaches its receptor only from the intraneuronal face of the Na+ channel C. The local anaesthetic binds to its receptor mainly when the Na+ channel is in the resting state D. The local anaesthetic combines with its receptor in the ionized cationic form

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Last Answer : C. The local anaesthetic binds to its receptor mainly when the Na+ channel is in the resting state