he primary mechanism by which heparin prevents coagulation of blood is: A. Direct inhibition of prothrombin to thrombin conversion B. Facilitation of antithrombin III mediated inhibition of factor Xa and thrombin C. Activation of antithrombin III to inhibit factors IX and XI D. Inhibition of factors XIIa and XIIIa

he primary mechanism by which heparin prevents
coagulation of blood is:
A. Direct inhibition of prothrombin to thrombin
conversion
B. Facilitation of antithrombin III mediated inhibition of factor Xa and thrombin
C. Activation of antithrombin III to inhibit factors
IX and XI
D. Inhibition of factors XIIa and XIIIa
by

1 Answer

Answer :

B. Facilitation of antithrombin III mediated inhibition of factor Xa and thrombi
by

Related questions

The following action(s) of heparin is/are essential for inhibition of factor Xa: A. Facilitation of antithrombin III mediated inhibition of factor XIIa B. Provision of scaffold for the clotting factor to interact with antithrombin III C. Induction of a configurational change in antithrombin III to expose its interacting sites D. Both ‘A’ and ‘B

Description : The following action(s) of heparin is/are essential for inhibition of factor Xa: A. Facilitation of antithrombin III mediated inhibition of factor XIIa B. Provision of scaffold for the clotting factor ... configurational change in antithrombin III to expose its interacting sites D. Both A' and B

Last Answer : C. Induction of a configurational change in antithrombin III to expose its interacting sites

Mini-dose heparin has been shown to be useful in the prophylaxis of postoperative venous thrombosis. Mechanism(s) by which low-dose heparin is/are thought to protect against venous thrombosis include: a. Enhancement of antithrombin III activity b. A decrease in thrombin availability c. Inhibition of platelet aggregation and subsequent platelet release action d. A mild prolongation of activated partial thromboplastin time

Description : Mini-dose heparin has been shown to be useful in the prophylaxis of postoperative venous thrombosis. Mechanism(s) by which low-dose heparin is/are thought to protect against venous ... aggregation and subsequent platelet release action d. A mild prolongation of activated partial thromboplastin time

Last Answer : Answer: a, b, c Low-dose heparin is thought to protect against venous thrombosis through three different mechanisms. First, antithrombin III activity with its inhibition of activated Factor X is ... release reaction. The standard doses of heparin administered (5000 units bid) does not affect aPTT

Assertion: Heparin is an anticoagulant found in mammals. Reason: Heparin prevents the conversion of prothrombin to thrombin

Description : Assertion: Heparin is an anticoagulant found in mammals. Reason: Heparin prevents the conversion of prothrombin to thrombin

Last Answer : Assertion: Heparin is an anticoagulant found in mammals. Reason: Heparin prevents the conversion of ... . If both Assertion & Reason are false.

Unfractionated heparin binds to antithrombin III and inactivates clotting factor(s) (a) Xa (b) Ixa (c) Iia (d) All of the above (e) None of the above

Description : Unfractionated heparin binds to antithrombin III and inactivates clotting factor(s) (a) Xa (b) Ixa (c) Iia (d) All of the above (e) None of the above

Last Answer : Ans: D

Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning coagulation tests? a. Prothrombin time (PT) measures both the intrinsic and extrinsic clotting pathways and fibrinogen b. Activated partial thromboplastin time (aPTT) can be used to monitor both oral anticoagulation with Warfarin and intravenous anticoagulation with heparin c. Thrombin clotting time (TCT) is a measurement of the time it takes for exogenously administered thrombin to turn plasma fibrinogen into fibrin clot d. Whole blood activated clotting time (ACT) is a measurement of the ability of whole blood to clot and is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascu

Description : Tests of coagulation are used to monitor anticoagulation treatment and detect intrinsic abnormalities in coagulation. Which of the following statement(s) is/are true concerning ... is used to monitor heparin levels intraoperatively during cardiovascular and peripheral vascular operations

Last Answer : Answer: a, c, d Coagulation tests include prothrombin time (PT), which measures the intrinsic and extrinsic pathways of fibrinogen production and is the most common method for ... more while for peripheral vascular applications, values of 250 seconds or greater are considered appropriate

Low molecular weight heparins differ from unfractionated heparin in that: A. They selectively inhibit factor Xa B. They do not significantly prolong clotting time C. They are metabolized slowly and have longer duration of action D. All of the above are correct

Description : Low molecular weight heparins differ from unfractionated heparin in that: A. They selectively inhibit factor Xa B. They do not significantly prolong clotting time C. They are metabolized slowly and have longer duration of action D. All of the above are correct

Last Answer : D. All of the above are correct

The primary mechanism of action of benzodiazepines is: A. Dopamine antagonism B. Adenosine antagonism C. Opening of neuronal chloride channels D. Facilitation of GABA-mediated chloride influx

Description : The primary mechanism of action of benzodiazepines is: A. Dopamine antagonism B. Adenosine antagonism C. Opening of neuronal chloride channels D. Facilitation of GABA-mediated chloride influx

Last Answer : D. Facilitation of GABA-mediated chloride influx

As thrombin generation proceeds, the body has natural anticoagulant systems opposing further thrombus formation. Natural anticoagulants include: a. Tissue plasminogen activator (TPA) b. Antithrombin III c. Activated protein C d. Heparin cofactor II

Description : As thrombin generation proceeds, the body has natural anticoagulant systems opposing further thrombus formation. Natural anticoagulants include: a. Tissue plasminogen activator (TPA) b. Antithrombin III c. Activated protein C d. Heparin cofactor II

Last Answer : Answer: b, c, d Just as thrombin generation is the key to coagulation, antithrombin III is the most central anticoagulant proteins. This glycoprotein binds to thrombin, preventing its removal of ... in the body. Therefore, TPA is part of the fibrinolytic system rather than a natural anticoagulant

When compared to unfractionated heparin, low molecular weight heparins have (a) Preferential binding affinity to factor Xa relative to Iia (thrombin) (b) Shorter half-lives (c) Dose – dependent renal clearance

Description : When compared to unfractionated heparin, low molecular weight heparins have (a) Preferential binding affinity to factor Xa relative to Iia (thrombin) (b) Shorter half-lives (c) Dose – dependent renal clearance

Last Answer : Ans: A

Which of the following statements about the coagulation cascade is/are true? A. The intrinsic pathway of coagulation is the predominant pathway in vivo for hemostasis and coagulation. B. The intrinsic pathway beginning with the activation of factor XII is the predominant in vivo mechanism for activation of the coagulation cascade. C. Deficiencies of factor VIII and IX cause highly significant coagulation abnormalities. D. Deficiencies of factor XII cause severe clinical bleeding syndromes.

Description : Which of the following statements about the coagulation cascade is/are true? A. The intrinsic pathway of coagulation is the predominant pathway in vivo for hemostasis and coagulation. ... coagulation abnormalities. D. Deficiencies of factor XII cause severe clinical bleeding syndromes.

Last Answer : Answer: AC DISCUSSION: Although it was previously held that two somewhat distinct pathways existed for the activation of the coagulation cascade, it is now recognized that the predominant ... bleeding. This further emphasizes the secondary role that the intrinsic pathway plays in coagulation

Blood does not clot in the blood vessels due to the presence of – (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Description : Blood does not clot in the blood vessels due to the presence of – (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Last Answer : (3) Heparin Explanation: There are two major facets of the clotting mechanism — the platelets, and the thrombin system. The thrombin system consists of several blood proteins that, when bleeding occurs, become activated.

Blood does not clot in the blood vessels due to the presence of (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Description : Blood does not clot in the blood vessels due to the presence of (1) Thrombin (2) Fibrinogen (3) Heparin (4) Prothrombin

Last Answer : Thrombin

Blood level of which clotting factor declines most rapidly after the initiation of warfarin therapy: A. Factor VII B. Factor IX C. Factor X D. Prothrombin

Description : Blood level of which clotting factor declines most rapidly after the initiation of warfarin therapy: A. Factor VII B. Factor IX C. Factor X D. Prothrombin

Last Answer : A. Factor VII

The following are true about blood coagulation: a. heparin inhibits blood coagulation through its interference with vitamin K metabolism in the liver b. addition of vitamin K to freshly drawn blood delays clotting c. thrombin converts fibrinogen to fibrin d. platelets are essential for blood clot

Description : The following are true about blood coagulation: a. heparin inhibits blood coagulation through its interference with vitamin K metabolism in the liver b. addition of vitamin K to freshly drawn ... delays clotting c. thrombin converts fibrinogen to fibrin d. platelets are essential for blood clot

Last Answer : thrombin converts fibrinogen to fibrin

Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time

Description : Choose the correct statement about ticlopidine: A. It blocks GPIIb/IIIa receptors on platelet membrane B. It prevents ADP mediated platelet adenylylcyclase inhibition C. It inhibits thromboxane A2 synthesis in platelets D. It does not prolong bleeding time

Last Answer : B. It prevents ADP mediated platelet adenylylcyclase inhibition

The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of dopamine methylation in the brain C. Inhibition of oxidative deamination of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries

Description : The primary action by which entacapone and tolcapone enhance the therapeutic effect of levodopa-carbidopa in parkinsonism is: A. Inhibition of levodopa methylation in the liver B. Inhibition of ... of dopamine in the brain D. Facilitation of active transport of levodopa across brain capillaries

Last Answer : A. Inhibition of levodopa methylation in the liver

The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes and inhibit bacterial protein synthesis C. They bind to 50S ribosomes and interfere with translocation of the growing peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria

Description : The most important mechanism by which tetracycline antibiotics exert antimicrobial action is: A. They chelate Ca2+ ions and alter permeability of bacterial cell membrane B. They bind to 30S ribosomes ... peptide chain in the bacteria D. They interfere with DNA mediated RNA synthesis in bacteria

Last Answer : B. They bind to 30S ribosomes and inhibit bacterial protein synthesis

The prothrombin time a. assess the extrinsic pathway of the blood coagulation cascade b. is prolonged in patients with fat absorption c. is increased by warfarin d. is increased by heparin

Description : The prothrombin time a. assess the extrinsic pathway of the blood coagulation cascade b. is prolonged in patients with fat absorption c. is increased by warfarin d. is increased by heparin

Last Answer : assess the extrinsic pathway of the blood coagulation cascade

Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and formation of a hemostatic plug. B. Interaction of tissue factor with factor VII circulating in the plasma. C. The production of thrombin via the coagulation cascade with conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.

Description : Hemostasis and the cessation of bleeding require which of the following processes? A. Adherence of platelets to exposed subendothelial glycoproteins and collagen with subsequent aggregation of platelets and ... conversion of fibrinogen to fibrin. D. Cross-linking of fibrin by factor XIII.

Last Answer : Answer: ABCD DISCUSSION: Hemostasis requires the interaction of platelets with the exposed subendothelial structures at the site of injury followed by aggregation of more platelets in that area. ... form a stable clot that incorporates the platelet plug and fibrin thrombus into a stable clot

Action of Insulin does not include the following: A. Facilitation of glucose transport into cells B. Facilitation of glycogen synthesis by liver C. Facilitation of neoglucogenesis by liver D. Inhibition of lipolysis in adipose tissue

Description : Action of Insulin does not include the following: A. Facilitation of glucose transport into cells B. Facilitation of glycogen synthesis by liver C. Facilitation of neoglucogenesis by liver D. Inhibition of lipolysis in adipose tissue

Last Answer : . Facilitation of neoglucogenesis by liver

The termination of heparin activity by protamine sulfate is due to (a) A chelating action (b) The inhibition of gastrointestinal absorption of heparin (c) The displacement of heparin-plasma protein binding (d) An acid-base interaction (e) The prothrombin-like activity of protamine

Description : The termination of heparin activity by protamine sulfate is due to (a) A chelating action (b) The inhibition of gastrointestinal absorption of heparin (c) The displacement of heparin-plasma protein binding (d) An acid-base interaction (e) The prothrombin-like activity of protamine

Last Answer : Ans: D

The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation C. Heparin is the physiologically active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

Description : The following is true of heparin except: A. Sudden stoppage of continuous heparin therapy causes rebound increase in blood coagulability B. High doses of heparin inhibit platelet aggregation ... active circulating anticoagulant D. Heparin clears lipemic plasma in vivo but not in vitro

Last Answer : C. Heparin is the physiologically active circulating anticoagulant

There are a number of hypercoaguable states which can be associated with arterial or venous thrombosis and embolic phenomenon. These include: a. Heparin-associated thrombocytopenia b. Antithrombin III deficiency c. Von Willebrand disease d. Vitamin C deficiency

Description : There are a number of hypercoaguable states which can be associated with arterial or venous thrombosis and embolic phenomenon. These include: a. Heparin-associated thrombocytopenia b. Antithrombin III deficiency c. Von Willebrand disease d. Vitamin C deficiency

Last Answer : Answer: a, b A number of hypercoaguable states are present. These include heparin-associated thrombocytopenia in which a heparin-dependent platelet antibody causes aggregation of ... soft tissue increasing vascular permeability and fragility resulting in the potential for bleeding disorders

Antithrombin III deficiency is a commonly observed hypercoaguable state. Which of the following statement(s) is/are true concerning this condition? a. A patient with this deficiency usually presents with thrombosis while on heparin or exhibits an inability to become adequately anticoagulated with heparin b. This deficiency may be either congenital or acquired c. Thrombotic episodes are related to predisposing events such as operations, childbirth, and infections d. Treatment involves acutely the administration of fresh frozen plasma followed by long-term treatment with Coumadin

Description : Antithrombin III deficiency is a commonly observed hypercoaguable state. Which of the following statement(s) is/are true concerning this condition? a. A patient with this deficiency usually ... involves acutely the administration of fresh frozen plasma followed by long-term treatment with Coumadin

Last Answer : Answer: a, b, c, d Antithrombin III deficiency accounts for about 2% of venous thrombotic event. This deficiency has been described in patients with pulmonary embolism, mesenteric venous ... is established, fresh frozen plasma should be administered followed by long-term treatment with Coumadin

Low doses of heparin prolong: A. Bleeding time B. Activated partial thromboplastin time C. Prothrombin time D. Both ‘B’ and ‘C’

Description : Low doses of heparin prolong: A. Bleeding time B. Activated partial thromboplastin time C. Prothrombin time D. Both ‘B’ and ‘C’

Last Answer : B. Activated partial thromboplastin time

The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Description : The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

Last Answer : D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. Synthesis of prostacyclin and prevents platelet aggregation C. Synthesis of prostaglandin and prevents production of blood platelets D. Thrombin and prevents formation of the fibrin network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors

Description : A patient who has been taking quantities of aspirin might show increased post operative bleeding because aspirin inhibits:** A. Synthesis of thromboxane A2 and prevents platelet aggregation B. ... network E. Increase the absorption of vitamin K and prevents synthesis of blood clotting factors

Last Answer : A. Synthesis of thromboxane A2 and prevents platelet aggregation

The antidotal effect of sodium nitrite in cyanide poisoning is dependent upon: A. Chemical combination of sodium nitrite with cyanide B. Vasodilatation caused by sodium nitrite C. Conversion of haemoglobin to methaemoglobin by sodium nitrite D. Facilitation of cyanocobalamine formation by sodium nitrite

Description : The antidotal effect of sodium nitrite in cyanide poisoning is dependent upon: A. Chemical combination of sodium nitrite with cyanide B. Vasodilatation caused by sodium nitrite C. ... haemoglobin to methaemoglobin by sodium nitrite D. Facilitation of cyanocobalamine formation by sodium nitrite

Last Answer : C. Conversion of haemoglobin to methaemoglobin by sodium nitrite

Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin

Description : Choose the drug which alters surface receptors on platelet membrane to inhibit aggregation, release reaction and to improve platelet survival in extracorporeal circulation: A. Dipyridamole B. Ticlopidine C. Aspirin D. Heparin

Last Answer : B. Ticlopidine

Low concentrations of heparin selectively interfere with the following coagulation pathway(s): A. Intrinsic pathway B. Extrinsic pathway C. Common pathway D. Both ‘A’ and ‘C’

Description : Low concentrations of heparin selectively interfere with the following coagulation pathway(s): A. Intrinsic pathway B. Extrinsic pathway C. Common pathway D. Both ‘A’ and ‘C’

Last Answer : A. Intrinsic pathway

The primary mechanism by which prostaglandins promote ulcer healing is: A. Inhibition of gastric acid secretion B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa C. Increased bicarbonate secretion in gastric juice D. Increased turnover of gastric mucosal cell

Description : The primary mechanism by which prostaglandins promote ulcer healing is: A. Inhibition of gastric acid secretion B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa C. Increased bicarbonate secretion in gastric juice D. Increased turnover of gastric mucosal cell

Last Answer : B. Augmentation of bicarbonate buffered mucus layer covering gastroduodenal mucosa

Which of the following statement(s) is/are true concerning hemophilia A? a. Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII b. A positive family history for bleeding disorders present in all patients c. Laboratory tests reveal a prolongation of aPTT, prothrombin time (PT), thrombin clotting time and platelet aggregation d. Spontaneous bleeding is unusual with factor VIII levels greater than 10% of normal

Description : Which of the following statement(s) is/are true concerning hemophilia A? a. Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII b. A positive family history for ... platelet aggregation d. Spontaneous bleeding is unusual with factor VIII levels greater than 10% of normal

Last Answer : Answer: a, d Hemophilia A is inherited as a sex-linked recessive deficiency of factor VIII although 0% of cases are secondary to spontaneous mutation. The incidence of this abnormality is ... factor levels as low as 1% have been noted and patients are at risk for spontaneous bleeding

I have some matchsticks set up like this: I + XI = X. If you do not know Roman numerals, here is a quick starter: I=1 II=2 III=3 IV=4 V=5 VI=6 VII=7 VIII=8 IX=9 X=10 XI=11 XII=12 XIII=13 XIV=14 XV=15...... Of course, I + XI = X is wrong. You are told to move the minimum number of matchsticks to make the question correct. So, how many do you have to move? -Riddles

Description : I have some matchsticks set up like this: I + XI = X. If you do not know Roman numerals, here is a quick starter: I=1 II=2 III=3 IV=4 V=5 VI=6 VII=7 VIII=8 IX=9 X=10 XI=11 ... are told to move the minimum number of matchsticks to make the question correct. So, how many do you have to move? -Riddles

Last Answer : Most people would get to one move at the least, but the real answer is zero moves. If you rotate the whole question around 180 degrees, it will display this: X = IX + I

A company has to choose between two projects whose cash flows are as indicated below; Project 1: i. Investment – Rs. 15 Lakhs ii. Annual cost savings – Rs. 4 lakhs. iii. Bi-annual maintenance cost – Rs. 50,000/- iv. Reconditioning and overhaul during 5th year: 6 lakhs v. Life of the project – 8 years vi. Salvage value – Rs. 5 lakhs Project 2: vii. Investment – Rs. 14 Lakhs viii. Annual cost savings – Rs. 3.5 lakhs. ix. Annual Maintenance cost – Rs. 20,000/- x. Reconditioning and overhaul during 4th year: 5 lakhs xi. Life of the project – 8 years xii. Salvage Value- 2 lakhs Which project should the company choose? The annual discount rate is 12

Description :  A company has to choose between two projects whose cash flows are as indicated  below; Project 1:  i. Investment - Rs. 15 Lakhs ii. Annual cost savings - Rs. 4 lakhs. iii. Bi-annual ... years xii. Salvage Value- 2 lakhs Which project should the company choose? The annual discount rate is 12

Last Answer : Year Project 1 Project 2 Outgo Saving NPV Outgo Saving NPV 0 15.0 0 =-15.0 14.0 0 = -14 1 0 4.0 = (4 / (1+.12)1 = 3.571 0.2 3.5 = (3.3 / (1+.12)1 = 2.95 2 0.5 4.0 = (3.5 / (1+.12)2 = 2.79 0.2 3.5 ... (1+.12)8 = 3.43 0.2 5.5  (3.5+2) = (5.3 / (1+.12)8 = 2.14 NPV = + 2.301 @12% = + 0.15

Hemophilia A is characterised by deficiency of Options: 1) Factor VII 2) Factor VIII 3) Factor IX 4) Factor XI

Description : Hemophilia A is characterised by deficiency of Options: 1) Factor VII 2) Factor VIII 3) Factor IX 4) Factor XI

Last Answer : Correct Answer: 2) Factor VIII

The antiviral action of amantadine is exerted through: A. Interaction with the viral M2 protein B. Interaction with a virus directed thymidine kinase C. Inhibition of a viral protease enzyme D. Inhibition of viral RNA mediated DNA synthesi

Description : The antiviral action of amantadine is exerted through: A. Interaction with the viral M2 protein B. Interaction with a virus directed thymidine kinase C. Inhibition of a viral protease enzyme D. Inhibition of viral RNA mediated DNA synthesi

Last Answer : A. Interaction with the viral M2 protein

The most important mechanism by which tetracycline antibiotics exert antiimicrobial action is (a) They chelate Ca2+ ions and alter permeability of bacterial cell membrane (b) They bind to 30S ribosomes and inhibit bacterial protein synthesis (c) They bind to 50S ribosomes and interfere with translocation of the growing peptide chain in the bacteria (d) They interfere with DNA mediated RNA synthesis in bacteria

Description : The most important mechanism by which tetracycline antibiotics exert antiimicrobial action is (a) They chelate Ca2+ ions and alter permeability of bacterial cell membrane (b) They bind to 30S ribosomes ... peptide chain in the bacteria (d) They interfere with DNA mediated RNA synthesis in bacteria

Last Answer : Ans: B

The standard management oral anticoagulant therapy for chronic treatment of venous thromboembolism is with the drug warfarin. Which of the following statement(s) is/are true concerning the administration of warfarin? a. An important complication of warfarin therapy is skin necrosis in patients with protein C deficiency b. Warfarin interferes with vitamin K dependent clotting factors II, VII, IX, X c. For effective anticoagulation the prothrombin time (PT) should be kept at 2 control d. It is recommended that warfarin be continued for at least one year after initial episode of deep venous thrombosis

Description : The standard management oral anticoagulant therapy for chronic treatment of venous thromboembolism is with the drug warfarin. Which of the following statement(s) is/are true concerning the administration ... warfarin be continued for at least one year after initial episode of deep venous thrombosis

Last Answer : Answer: a, b Warfarin interferes with the vitamin K dependent clotting factors II, VII, IX and X, protein C, and protein S. An important complication of warfarin is skin ... the benefit from anticoagulant therapy and thus is the basis for discontinuing warfarin administration at this time

Which is the anticoagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Description : Which is the anticoagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Last Answer : (2) Heparin Explanation: Heparin, a highly sulfated glycosaminoglycan, is widely used as an inject able anticoagulant, and has the highest negative charge density of any known ... because blood anti-coagulation is achieved mostly by heparin sulfate proteoglyeans derived from endothelial cells.

Which is the anti-coagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Description : Which is the anti-coagulant substance in blood? (1) Fibrinogen (2) Heparin (3) Thrombin (4) Globin

Last Answer : Heparin

3 Select the antiemetic that prevents activation of emetogenic afferents in the gut and their central relay in chemoreceptor trigger zone/nucleus tractus solitarious, but has no effect on gastric motility: A. Ondansetron B. Domperidone C. Metoclopramide D. Cisaprid

Description : 3 Select the antiemetic that prevents activation of emetogenic afferents in the gut and their central relay in chemoreceptor trigger zone/nucleus tractus solitarious, but has no effect on gastric motility: A. Ondansetron B. Domperidone C. Metoclopramide D. Cisaprid

Last Answer : A. Ondansetron

The transfusion of fresh frozen plasma (FFP) is indicated for which of the following reasons? A. Volume replacement. B. As a nutritional supplement. C. Specific coagulation factor deficiency with an abnormal prothrombin time (PT) and/or an abnormal activated partial thromboplastin time (APTT). D. For the correction of abnormal PT secondary to warfarin therapy, vitamin K deficiency, or liver disease.

Description : The transfusion of fresh frozen plasma (FFP) is indicated for which of the following reasons? A. Volume replacement. B. As a nutritional supplement. C. Specific coagulation factor deficiency ... the correction of abnormal PT secondary to warfarin therapy, vitamin K deficiency, or liver disease.

Last Answer : Answer: CD DISCUSSION: The use of FFP as a volume expander is not indicated. There are currently several preparations (both crystalloid and colloid) that are equally effective and do not carry the infectious and ... vitamin K-dependent factors II, VII, IX, and X, as well as protein C and protein S

The mechanism of action of cyclosporine involves (a) Activation of calcineurin (b) Binding to cyclophilin to cause inhibition of a cytoplasmic phosphatase (c) Blockade of interleukin – 2- receptors (d) Inhibition of phospholipase A2 (e) Suppression of bone marrow progenitors

Description : The mechanism of action of cyclosporine involves (a) Activation of calcineurin (b) Binding to cyclophilin to cause inhibition of a cytoplasmic phosphatase (c) Blockade of interleukin – 2- receptors (d) Inhibition of phospholipase A2 (e) Suppression of bone marrow progenitors

Last Answer : Ans: B

The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is: A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme B. Mutational acquisition of aminoglycoside hydrolysing enzyme C. Mutation reducing affinity of ribosomal protein for the antibiotic D. Mutational loss of porin channels

Description : The most important mechanism of bacterial resistance to an aminoglycoside antibiotic is: A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme B. Mutational acquisition of aminoglycoside ... affinity of ribosomal protein for the antibiotic D. Mutational loss of porin channels

Last Answer : A. Plasmid mediated acquisition of aminoglycoside conjugating enzyme

Mammalian cells are not inhibited by low concentrations of tetracyclines that inhibit sensitive microorganisms because: A. Host cells lack active transport mechanism for tetracyclines B. Host cells actively pump out tetracyclines C. Protein synthesizing apparatus of host cells has low affinity for tetracyclines D. Both ‘A’ and ‘C’ are correct

Description : Mammalian cells are not inhibited by low concentrations of tetracyclines that inhibit sensitive microorganisms because: A. Host cells lack active transport mechanism for tetracyclines B. Host cells actively pump out ... host cells has low affinity for tetracyclines D. Both A' and C' are correct

Last Answer : D. Both ‘A’ and ‘C’ are correct

The opioid antidiarrhoeal drugs act by the following mechanism(s): A. They relax the intestinal smooth muscle B. They inhibit intestinal peristalsis C. They promote clearance of intestinal pathogens Aim4aiims.in D. All of the above

Description : The opioid antidiarrhoeal drugs act by the following mechanism(s): A. They relax the intestinal smooth muscle B. They inhibit intestinal peristalsis C. They promote clearance of intestinal pathogens Aim4aiims.in D. All of the above

Last Answer : B. They inhibit intestinal peristalsis

Assertion `:-` Porthrombinase enzymes converts prothrombin into active thrombin. Reason`:` Thrmoboplastin react with plasma protein in the presece of

Description : Assertion `:-` Porthrombinase enzymes converts prothrombin into active thrombin. Reason`:` Thrmoboplastin react with plasma protein in the presece of

Last Answer : Assertion `:-` Porthrombinase enzymes converts prothrombin into active thrombin. Reason`:` Thrmoboplastin ... If both Assertion & Reason are false.

Vitamin K is required for (a) change of prothrombin into thrombin (b) synthesis of prothrombin (c) change of fibrinogen to fibrin (d) formation of thromboplastin.

Description : Vitamin K is required for (a) change of prothrombin into thrombin (b) synthesis of prothrombin (c) change of fibrinogen to fibrin (d) formation of thromboplastin.

Last Answer : (b) synthesis of prothrombin

The aim of iodine therapy before subtotal thyroidectomy in Grave’s disease is: A. To render the patient euthyroid B. To restore the iodine content of the thyroid gland C. To inhibit peripheral conversion of thyroxine into triiodothyronine D. To reduce friability and vascularity of the thyroid gland

Description : The aim of iodine therapy before subtotal thyroidectomy in Grave’s disease is: A. To render the patient euthyroid B. To restore the iodine content of the thyroid gland C. To inhibit peripheral conversion of thyroxine into triiodothyronine D. To reduce friability and vascularity of the thyroid gland

Last Answer : D. To reduce friability and vascularity of the thyroid gland

Carbimazole differs from propylthiouracil in that: A. It is dose to dose less potent B. It has a shorter plasma half life C. It does not produce an active metabolite D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

Description : Carbimazole differs from propylthiouracil in that: A. It is dose to dose less potent B. It has a shorter plasma half life C. It does not produce an active metabolite D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine

Last Answer : D. It does not inhibit peripheral conversion of thyroxine to triiodothyronine