Description : Tinidazole differs from metronidazole in that: A. It is not active against anaerobic bacteria B. It has a broader spectrum of activity C. It has a longer elimination half life D. It has better oral absorption
Last Answer : C. It has a longer elimination half life
Description : Select the antibiotic whose dose must be reduced in patients with renal insufficiency: A. Ampicillin B. Chloramphenicol C. Tobramycin D. Erythromycin
Last Answer : C. Tobramycin
Description : Metronidazole is used in peridontal abscess because of activity against: A. Entamoeba histolytica B. Giardia lamblia C. Anaerobic bacilli D. Aerobic gram positive cocci
Last Answer : C. Anaerobic bacilli
Description : Metronidazole is selectively active against anaerobic organisms because: A. Aerobes have an active transport mechanism to pump it out of their cell B. Only anaerobes reduce it to generate the reactive ... inactivated in the presence of oxygen D. It binds to DNA of anaerobes with high affinity
Last Answer : B. Only anaerobes reduce it to generate the reactive nitro radical
Description : Combination therapy with two (or more) antimicrobials is superior to monotherapy with any single effective drug in case of the following diseases except: A. Typhoid fever B. Leprosy C. AIDS D. Subacute bacterial endocarditis
Last Answer : A. Typhoid fever
Description : The following antibiotic is highly active against anaerobic bacteria including Bacteroides fragilis: A. Ciprofloxacin B. Clarithromycin C. Clindamycin D. Tobramycin
Last Answer : C. Clindamycin
Description : An adult patient of acute diarrhoea presents with abdominal pain, fever, mucus and blood in stools and is suspected to be suffering from Shigella enteritis. What antimicrobial treatment would be most appropriate: A. No antimicrobial treatment B. Metronidazole C. Norfloxacin D. Chloramphenicol
Last Answer : C. Norfloxacin
Description : Select the antibiotic whose dose must be reduced in patients with renal insufficiency (a) Ampicillin (b) Chloramphenicol (c) Tobramycin (d) Erythromycin
Last Answer : Ans: C
Description : In addition to fungi, amphotericin B is active against the following pathogen: A. Anaerobic bacteria B. Giardia C. Leishmania D. Rickettsiae
Last Answer : C. Leishmania
Description : Choose the most effective drug for mild intestinal amoebiasis and asymptomatic cyst passers: A. Metronidazole B. Emetine C. Quiniodochlor D. Diloxanide furoate
Last Answer : D. Diloxanide furoate
Description : Emetine is now used only as a reserve drug for amoebiasis because: A. It is less effective than metronidazole B. It produces a slower response than metronidazole C. It has cardiotoxic potential D. It is not effective in extraintestinal amoebiasis
Last Answer : C. It has cardiotoxic potentia
Description : Choose the correct statement(s) about metronidazole: A. It is a first line drug for amoebic dysentery as well as amoebic liver abscess B. It affords the most rapid symptom relief in amoebic dysentery C. It is the most effective drug in eradicating amoebic cysts from the colon D. All of the above
Last Answer : A. It is a first line drug for amoebic dysentery as well as amoebic liver abscess
Description : Choose the antimicrobial which acts by interfering with DNA function in the bacteria: A. Chloramphenicol B. Ciprofloxacin C. Streptomycin D. Vancomycin
Last Answer : B. Ciprofloxacin
Description : Select the drug which is active against a variety of diarrhoea producing organisms like Giardia, Shigella, Salmonella as well as S. typhi and Trichomonas vaginalis, but is not a first line treatment for any of these: A. Metronidazole B. Mepacrine C. Cotrimoxazole D. Furazolidone
Last Answer : D. Furazolidone
Description : Empiric therapy with chloramphenicol is valid in the following conditions except: A. Urinary tract infection B. Pelvic abscess C. Endophthalmitis D. Meningitis in a 4-year-old child
Last Answer : A. Urinary tract infection
Description : Drug destroying type of bacterial resistance is important for the following antibiotics except: A. Cephalosporins B. Tetracyclines C. Chloramphenicol D. Aminoglycosides
Last Answer : B. Tetracyclines
Description : Cross resistance among different members of the following class of antimicrobials is absent / incomplete or unidirectional: A. Aminoglycosides B. Macrolides C. Tetracyclines D. Both ‘B’ and ‘C’ are correct
Last Answer : A. Aminoglycosides
Description : Choose the condition which is mostly treated with a combination of antimicrobials: A. Lobar pneumonia B. Typhoid C. Peritonitis D. Syphilis
Last Answer : C. Peritonitis
Description : A patient of congestive heart failure was being treated with furosemide and digoxin. He developed urinary tract infection. Which of the following antimicrobials should be avoided: A. Ampicillin B. Gentamicin C. Norfloxacin D. Cotrimoxazole
Last Answer : B. Gentamicin
Description : Chloramphenicol is more active than tetracyclines against: A. Bateroides fragilis B. Treponema pallidum C. Streptococci D. Staphylococci
Last Answer : a
Description : he aminoglycoside antibiotic which is distinguished by its resistance to bacterial aminoglycoside inactivating enzymes is: A. Kanamycin B. Sisomicin C. Amikacin D. Tobramycin
Last Answer : C. Amikacin
Description : The treatment of the following patient should include: a. Initial empiric therapy directed against both aerobes and anaerobes b. The addition of anti-fungal therapy in an elderly patient ... therapy is appropriate if the agents selected possess activity against both aerobic and anaerobic bacteria
Last Answer : Answer: a, e The primary treatment for a perforated viscus is surgical, however antimicrobial therapy is an extremely important adjunct. Empiric antibiotic therapy for secondary ... whereas longer periods are indicated for immunosuppressed patients and with patients with extensive contamination
Description : Distinctive features of gatifloxacin include the following except: A. Higher affinity for the enzyme topoisomerase IV B. Activity restricted to gram negative bacteria C. Potential to prolong QTc interval D. Employed to treat community acquired pneumonia
Last Answer : B. Activity restricted to gram negative bacteria
Description : Drugs effective in bipolar illness include the following except: A. Olanzapine B. Diazepam C. Sodium valproate D. Lamotrigine
Last Answer : B. Diazepam
Description : The following is true of vancomycin except: A. It is a bactericidal antibiotic active primarily against gram positive bacteria B. It acts by inhibiting bacterial protein synthesis C. It is an alternative to penicillin for enterococcal endocarditis D. It can cause deafness as a dose related toxicity
Last Answer : B. It acts by inhibiting bacterial protein synthesis
Description : Cefotaxime has the following properties except: A. It is highly active against aerobic gram negative bacteria B. It is the most active cephalosporin against Pseudomonas aeruginosa C. It produces an active metabolite D. It has achieved high cure rates in serious hospital acquired infections
Last Answer : B. It is the most active cephalosporin against Pseudomonas aeruginosa
Description : The following fluoroquinolones have augmented activity against gram positive bacteria except: A. Lomefloxacin B. Levofloxacin C. Gatifloxacin D. Moxifloxacin
Last Answer : A. Lomefloxacin
Description : The distinctive features of azithromycin include the following except: A. Efficacy against organisms which have developed resistance to erythromycin B. Marked tissue distribution and intracellular penetration ... D. Low propensity to drug interactions due to inhibition of cytochrome P450 enzymes
Last Answer : A. Efficacy against organisms which have developed resistance to erythromycin
Description : The following statement is not true of sulbactam: A. It is a broad spectrum β-lactamase inhibitor B. It does not augment the activity of ampicillin against bacteria that are sensitive ... β-lactamases D. Combined with ampicillin, it is highly effective against penicillinase producing N. gonorrhoeae
Last Answer : C. It induces chromosomal β-lactamases
Description : Which of the following drugs is effective against Trichomonas vaginalis C A. Penicillin B. Streptomycin C. Metronidazole D. Pentamidine
Last Answer : Metronidazole
Description : The following is true of levamisole except: A. A single dose cures over 90% cases of round worm infestation B. It is more effective against Necator americanus than against Ancylostoma duodenale C. It has immunomodulating action D. Its prolonged use causes severe reactions
Last Answer : B. It is more effective against Necator americanus than against Ancylostoma duodenale
Description : The following precaution should be advised to the patient while prescribing metronidazole: A. To avoid driving B. To get leucocyte count checked every second day C. To avoid fatty/fried food D. To avoid alcoholic beverages
Last Answer : D. To avoid alcoholic beverages
Description : Select the drug which is used to treat antibiotic associated pseudomembranous enterocolitis and is a component of anti-H.pylori triple drug regimen: A. Amoxicillin B. Vancomycin C. Metronidazole D. Clotrimazole
Last Answer : C. Metronidazole
Description : In addition to amoebiasis, metronidazole is used for: A. Roundworm infestation B. Hookworm infestation C. Kala-azar D. Giardiasis
Last Answer : D. Giardiasis
Description : A 3-year-old child was given one tablet three times a day to control loose motions. The diarrhoea stopped but next day the child was brought in a toxic condition with abdominal ... drug could have caused this condition: A. Iodochlorhydroxyquinoline B. Furazolidone C. Loperamide D. Metronidazole
Last Answer : C. Loperamide
Description : Patients treated with the following drug should be cautioned not to consume alcoholic beverages: A. Mebendazole B. Metronidazole C. Methimazole D. Metamizol
Last Answer : B. Metronidazole
Description : Which one of the following antibiotics is likely to be most effective agent in the treatment of an infection due to enterococci if used in conjuction with penicillin G? (a) Amikacin (b) Gentamicin (c) Netilmicin (d) Streptomycin (e) Tobramycin
Last Answer : Ans: D
Description : Highest incidence of antibiotic associated pseudomembranous enterocolitis has been noted with the use of: A. Ampicillin B. Chloramphenicol C. Vancomycin D. Clindamycin
Last Answer : D. Clindamycin
Description : Select the antibiotic which inhibits bacterial protein synthesis by interfering with translocation of elongating peptide chain from acceptor site back to the peptidyl site of the ribosome so that ... chain is prematurely terminated: A. Chloramphenicol B. Erythromycin C. Tetracycline D. Streptomycin
Last Answer : B. Erythromycin
Description : The primary reason why chloramphenicol is not being used as the first line drug for typhoid fever in most areas is: A. Toxic potential of chloramphenicol B. Delayed defervescence with ... C. Delayed bacteriological cure with chloramphenicol D. Spread of chloramphenicol resistance among S. typhi
Last Answer : D. Spread of chloramphenicol resistance among S. typhi
Description : What is the most important reason for the restricted use of systemic chloramphenicol: A. Emergence of chloramphenicol resistance B. Its potential to cause bone marrow depression C. Its potential to cause superinfections D. Its potential to inhibit the metabolism of many drugs
Last Answer : B. Its potential to cause bone marrow depression
Description : What is true of drug therapy of typhoid fever: A. Combination of chloramphenicol with ciprofloxacin is superior to either drug alone B. Ceftriaxone (i.v.) is one of the fastest acting ... C. Prolonged treatment with chloramphenicol eradicates typhoid carrier state D. All of the above are correct
Last Answer : B. Ceftriaxone (i.v.) is one of the fastest acting and most dependable treatment
Description : A premature neonate suffered respiratory distress and was given an antibiotic 100 mg/kg/day orally. Over the next two days his condition worsened, he become dull, stopped feeding, developed ... most likely antibiotic given to him: A. Ampicillin B. Chloramphenicol C. Erythromycin D. Ciprofloxacin
Last Answer : B. Chloramphenico
Description : The most important mechanism by which gram negative bacilli acquire chloramphenicol resistance is: A. Decreased permeability into the bacterial cell B. Acquisition of a plasmid encoded ... the bacterial ribosome for chloramphenicol D. Switching over from ribosomal to mitochondrial protein synthesi
Last Answer : B. Acquisition of a plasmid encoded for chloramphenicol acetyl transferas
Description : The following antibiotic penetrates blood-CSF barrier the best: A. Erythromycin B. Gentamicin C. Tetracycline D. Chloramphenicol
Last Answer : D. Chloramphenicol
Description : Chloramphenicol inhibits bacterial protein synthesis by: A. Binding to 30S ribosome and inhibiting attachment of aminoacyl tRNA B. Binding to 50S ribosome and preventing peptide bond formation C. Binding to ... chain D. Binding to both 30S and 50S ribosome and inducing misreading of mRNA code
Last Answer : B. Binding to 50S ribosome and preventing peptide bond formation
Description : A child presented with polyuria, weakness and fever. On the basis of investigations he was labelled to be suffering from Fancony syndrome. A history of taking some old left over antibiotic ... What could have been the antibiotic: A. Tetracycline B. Chloramphenicol C. Ampicillin D. Cephalexi
Last Answer : A. Tetracycline
Description : An 8-year-old child presented with brownish discoloured and deformed anterior teeth. History of having received an antibiotic about 4 years earlier was obtained. Which antibiotic could be responsible for the condition: A. Chloramphenicol B. Tetracycline C. Erythromycin D. Gentamicin
Last Answer : Tetracycline
Description : The following drug may cure typhoid fever, but does not prevent development of carrier state: A. Ciprofloxacin B. Cotrimoxazole C. Chloramphenicol D. Ceftriaxone
Last Answer : C. Chloramphenicol
Description : Currently the drug of choice for emperic treatment of typhoid fever is: A. Chloramphenicol B. Cotrimoxazole C. Ciprofloxacin D. Ampicillin
Last Answer : C. Ciprofloxacin