The following antibiotic penetrates blood-CSF barrier the best: A. Erythromycin B. Gentamicin C. Tetracycline D. Chloramphenicol

The following antibiotic penetrates blood-CSF barrier
the best:
A. Erythromycin
B. Gentamicin
C. Tetracycline
D. Chloramphenicol
by

1 Answer

Answer :

D. Chloramphenicol
by

Related questions

Which out of the following antibiotics penetrates blood-CSF barrier the best (a) Erythromycin (b) Gentamicin (c) Tetracycline (d) Chloramphenicol

Description : Which out of the following antibiotics penetrates blood-CSF barrier the best (a) Erythromycin (b) Gentamicin (c) Tetracycline (d) Chloramphenicol

Last Answer : Ans: D

An 8-year-old child presented with brownish discoloured and deformed anterior teeth. History of having received an antibiotic about 4 years earlier was obtained. Which antibiotic could be responsible for the condition: A. Chloramphenicol B. Tetracycline C. Erythromycin D. Gentamicin

Description : An 8-year-old child presented with brownish discoloured and deformed anterior teeth. History of having received an antibiotic about 4 years earlier was obtained. Which antibiotic could be responsible for the condition: A. Chloramphenicol B. Tetracycline C. Erythromycin D. Gentamicin

Last Answer : Tetracycline

Select the antibiotic which inhibits bacterial protein synthesis by interfering with translocation of elongating peptide chain from acceptor site back to the peptidyl site of the ribosome so that ribosome does not move along the mRNA and the peptide chain is prematurely terminated: A. Chloramphenicol B. Erythromycin C. Tetracycline D. Streptomycin

Description : Select the antibiotic which inhibits bacterial protein synthesis by interfering with translocation of elongating peptide chain from acceptor site back to the peptidyl site of the ribosome so that ... chain is prematurely terminated: A. Chloramphenicol B. Erythromycin C. Tetracycline D. Streptomycin

Last Answer : B. Erythromycin

2 Which antibiotic is primarily bacteriostatic but becomes bactericidal at higher concentrations: A. Erythromycin B. Tetracycline C. Chloramphenicol D. Ampicillin

Description : 2 Which antibiotic is primarily bacteriostatic but becomes bactericidal at higher concentrations: A. Erythromycin B. Tetracycline C. Chloramphenicol D. Ampicillin

Last Answer : A. Erythromycin Although erythromycin is primarily bacteriostatic, it is bactericidal at high concentrations for some Gram-positive species, such as group A streptococci and pneumococci

An 8-year-old child presented with brownish discoloured and deformed anterior teeth. History of having received an antibiotic about 4 years earlier was obtained. Which antibiotic could be responsible for the condition ? (a) Chloramphenicol (b) Tetracycline (c) Erythromycin (d) Genetamicin

Description : An 8-year-old child presented with brownish discoloured and deformed anterior teeth. History of having received an antibiotic about 4 years earlier was obtained. Which antibiotic could be responsible for the condition ? (a) Chloramphenicol (b) Tetracycline (c) Erythromycin (d) Genetamicin

Last Answer : Ans: B

Select the antibiotic which inhibits drug metabolizing isoenzyme CYP3A4 resulting in potentially fatal drug interaction with terfenadine: A. Erythromycin B. Clindamycin C. Gentamicin D. Vancomycin

Description : Select the antibiotic which inhibits drug metabolizing isoenzyme CYP3A4 resulting in potentially fatal drug interaction with terfenadine: A. Erythromycin B. Clindamycin C. Gentamicin D. Vancomycin

Last Answer : A. Erythromycin

A premature neonate suffered respiratory distress and was given an antibiotic 100 mg/kg/day orally. Over the next two days his condition worsened, he become dull, stopped feeding, developed abdominal distention and an ashen gray appearance. Which is the most likely antibiotic given to him: A. Ampicillin B. Chloramphenicol C. Erythromycin D. Ciprofloxacin

Description : A premature neonate suffered respiratory distress and was given an antibiotic 100 mg/kg/day orally. Over the next two days his condition worsened, he become dull, stopped feeding, developed ... most likely antibiotic given to him: A. Ampicillin B. Chloramphenicol C. Erythromycin D. Ciprofloxacin

Last Answer : B. Chloramphenico

Select the antibiotic whose dose must be reduced in patients with renal insufficiency: A. Ampicillin B. Chloramphenicol C. Tobramycin D. Erythromycin

Description : Select the antibiotic whose dose must be reduced in patients with renal insufficiency: A. Ampicillin B. Chloramphenicol C. Tobramycin D. Erythromycin

Last Answer : C. Tobramycin

The following antibiotic accentuates the nuromuscular blockade produced by pancuronium: A. Streptomycin B. Erythromycin C. Penicillin G D. Chloramphenicol

Description : The following antibiotic accentuates the nuromuscular blockade produced by pancuronium: A. Streptomycin B. Erythromycin C. Penicillin G D. Chloramphenicol

Last Answer : A. Streptomycin

A child presented with polyuria, weakness and fever. On the basis of investigations he was labelled to be suffering from Fancony syndrome. A history of taking some old left over antibiotic capsules was obtained. What could have been the antibiotic: A. Tetracycline B. Chloramphenicol C. Ampicillin D. Cephalexi

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Last Answer : A. Tetracycline

Ceftriaxone has all the following attributes except: A. It has a long plasma half life of 8 hours B. It can cause bleeding by prolonging prothrombin time C. It has attained high cure rates in multiresistant typhoid infection D. It penetrates CSF poorly and therefore not effective in meningitis

Description : Ceftriaxone has all the following attributes except: A. It has a long plasma half life of 8 hours B. It can cause bleeding by prolonging prothrombin time C. It has attained high cure rates in multiresistant typhoid infection D. It penetrates CSF poorly and therefore not effective in meningitis

Last Answer : D. It penetrates CSF poorly and therefore not effective in meningitis

Two drugs that affect cell wall synthesis are a. Erythromycin and penicillin. b. Vancomycin and cephalosporin. c. Tetracycline and polymyxin b. d. Chloramphenicol and streptomycin.

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Last Answer : a. Erythromycin and penicillin.

Gary baby syndrome occur in new born with a) Tetracycline b) Chloramphenicol c) Penicillin d) Erythromycin

Description : Gary baby syndrome occur in new born with a) Tetracycline b) Chloramphenicol c) Penicillin d) Erythromycin

Last Answer : b) Chloramphenicol 

The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling

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Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine

Choose the correct statement about rifampin: A. It is the most active drug on slow growing tubercle bacilli B. Its antitubercular efficacy is lower than that of isoniazid C. It is active against many atypical mycobacteria D. It does not effectively cross blood-CSF barrier

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Last Answer : C. It is active against many atypical mycobacteria

he dominant pharmacokinetic feature of penicillin G is: A. It is equally distributed extra- and intracellularly B. It is rapidly secreted by proximal renal tubules C. It has low oral bioavailability due to high first pass metabolism in liver D. It does not cross blood–CSF barrier even when meninges are inflamed

Description : he dominant pharmacokinetic feature of penicillin G is: A. It is equally distributed extra- and intracellularly B. It is rapidly secreted by proximal renal tubules C. It has low oral bioavailability ... pass metabolism in liver D. It does not cross blood-CSF barrier even when meninges are inflamed

Last Answer : B. It is rapidly secreted by proximal renal tubules

Select the antibiotic whose dose must be reduced in patients with renal insufficiency (a) Ampicillin (b) Chloramphenicol (c) Tobramycin (d) Erythromycin

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Last Answer : Ans: C

Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis? (a) Tetracycline (b) Erythromycin (c) Neomycin (d) Streptomycin

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Last Answer : (d) Streptomycin

.Which antibiotic inhibits interaction between tRNA and mRNA during bacterial protein synthesis? (a) Tetracycline (b) Erythromycin (c) Neomycin (d) Streptomycin

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Select the antibiotic which is equally effective whether injected 8 hourly or 24 hourly, provided the total daily dose remains the same: A. Gentamicin B. Sod. penicillin G C. Cefazolin D. Vancomycin

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Which aminoglycoside antibiotic causes more hearing loss than vestibular disturbance as toxic effect: A. Streptomycin B. Gentamicin C. Kanamycin D. Sisomicin

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Select the macrolide antibiotic having clinically useful antileprotic activity: A. Azithromycin B. Clarithromycin C. Erythromycin D. Roxithromycin

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Select the macrolide antibiotic that can be given once daily for 3 days for empirical treatment of ear-nosethroat, respiratory and genital infections: A. Erythromycin B. Azithromycin C. Roxithromycin D. Clarithromycin

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A single oral dose of the following antibiotic is curative in most patients of nonspecific urethritis due to Chlamydia trachomatis: A. Doxycycline B. Azithromycin C. Erythromycin D. Cotrimoxazole

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The following antibiotic is a first line drug for treatment of Mycobacterium avium complex infection in AIDS patients: A. Clindamycin B. Clarithromycin C. Roxithromycin D. Erythromycin

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Prolonged oral therapy with the following antibiotic can damage intestinal villi resulting in steatorrhoea and loose motions: A. Ampicillin B. Tetracycline C. Neomycin D. Nystatin

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Last Answer : C. Neomycin

Select the most potent tetracycline antibiotic: A. Demeclocycline B. Oxytetracycline C. Minocycline D. Doxycycline

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Two cyclic polypeptide antibiotics are a. Vancomycin and streptomycin. b. Penicillin and cephalosporin. c. Bacitracin and polymyxins d. .gentamicin and chloramphenicol

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Last Answer : c. Bacitracin and polymyxins

Neostigmine is preferred over physostigmine for treating myasthenia gravis because: A. It is better absorbed orally B. It has longer duration of action C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate D. It penetrates blood-brain barrier

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Last Answer : C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate

Neostigmine is preferred over physostigmine for treating myasthenia gravis because: A. It is better absorbed orally B. It has longer duration of action C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate D. It penetrates blood-brain barrier

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Last Answer : C. It has additional direct agonistic action on nicotinic receptors at the muscle end plate

A high school student presents with headache, fever, and cough of 2 day’s duration. Sputum is scant and nonpurulent and a Gram stain reveals many white cells but no organisms. Since this patient appears to have atypical pneumonia. You should initiate treatment with (a) Cefazolin (b) Clindamycin (c) Erythromycin (d) Gentamicin (e) Trovafloxacin

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Last Answer : Ans: C

Peptidyl transferase activity of 50 S ribosomal subunits is inhibited by (A) Rifampicin (B) Cycloheximide (C) Chloramphenicol (D) Erythromycin

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Last Answer : Answer : C

Binding of formylmehtionyl tRNA to 30 S ribosomal subunit of prokaryotes is inhibited by (A) Streptomycin (B) Chloramphenicol (C) Erythromycin (D) Mitomycin

Description : Binding of formylmehtionyl tRNA to 30 S ribosomal subunit of prokaryotes is inhibited by (A) Streptomycin (B) Chloramphenicol (C) Erythromycin (D) Mitomycin

Last Answer : Answer : A

Which one of the following is considered as the drug of last resort for human beings? (1) Penicillin (2) Tetracycline (3) Chloramphenicol (4) Streptomycin

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Last Answer : (3) Chloramphenicol Explanation: Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis.

Which one of the following antibiotics is a potent inducer of hepatic drug-metabolizing enzymes? (a) Ciprofloxacin (b) Cyclosporine (c) Erythromycin (d) Rifampin (e) Tetracycline

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Last Answer : Ans: A

In the empiric treatment of severe bacterial infections of unidentified entiology, this drug, often used in combination with an aminoglycoside, provides coverage against many staphylococci (a) Amoxicillin (b) Clavulanic acid (c) Erythromycin (d) Nafcillin (e) Tetracycline

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Last Answer : Ans: D

_____ cause a yellow-gray-brown discoloration of teeth and stunted bones in children, which have limited its use to adults. a. Methicillin b. Vancomycin c. Tetracycline d. Erythromycin

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Last Answer : c. Tetracycline

An adult patient of acute diarrhoea presents with abdominal pain, fever, mucus and blood in stools and is suspected to be suffering from Shigella enteritis. What antimicrobial treatment would be most appropriate: A. No antimicrobial treatment B. Metronidazole C. Norfloxacin D. Chloramphenicol

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Last Answer : C. Norfloxacin

What is true of cefpirome: A. It is a fourth generation cephalosporin B. It easily penetrates porin channels of gram negative bacteria C. It inhibits type I β-lactamase producing enterobacteriaceae D. All of the above

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Last Answer : . All of the above

A resting nerve is relatively resistant to blockade by lignocaine compared to one which is repeatedly stimulated because: A. Lignocaine penetrates resting nerve membrane poorly B. Lignocaine binds more avidly to the inactivated Na+ channel C. Nerve impulse promotes ionization of lignocaine D. Nodes of Ranvier are inaccessible in the resting state

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Last Answer : B. Lignocaine binds more avidly to the inactivated Na+ chan

Which aminoglycoside antibiotic causes more hearing loss than vestibular disturabance as toxic effect ? (a) Streptomycin (b) Gentamicin (c) Kanamycin (d) Sisomicin

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A 75-year-old man had been receiving gentamicin (an aminoglycoside antibiotic) to treat an urinary tract infection. After three months of therapy patient's serum creatinine levels were 10 mg/dL ( normal 0.5-1.2) and serum gentamicin concentrations obtained just before the last dose were 9 mg/dL (normal < 2). Which of the following is the most likely adverse drug reaction the patient was suffering from? a) Type II allergic reaction b)Type III allergic reaction c) Pseudo allergic reaction d) Overdose toxicity

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Last Answer : d) Overdose toxicity 

Acidic urine augments the antibacterial action of the following drug: A. Ciprofloxacin B. Cotrimoxazole C. Gentamicin D. Nitrofurantoin

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Last Answer : D. Both ‘B’ and ‘C’ are correct

60-year-old patient with creatinine clearance 50 ml/min has to be treated with gentamicin. His daily dose of gentamicin should be reduced to the following percentage of the usual adult dose: A. 70% B. 50% C. 40% D. 30%

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Last Answer : B. 50%

A 60-year-old patient with creatinine clearance 50 ml/min has to be treated with gentamicin. His daily dose of gentamicin should be reduced to the following percentage of the usual adult dose: A. 70% B. 50% C. 40% D. 30%

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Last Answer : B. 50%

The following is true for gentamicin: A. It is more active in acidic medium B. It has a wide margin of safety C. It is excreted unchanged, mainly by glomerular filtration D. It primarily inhibits gram positive bacteria

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