answer:Yes, I’ve had them in my knees and back for arthritis. They didn’t help my back. They do help my knees a bit. I have to have total knee replacements sooner or later, so I’m just putting off the inevitible. I get them every 3 months. They work best after a few days, but don’t last the full 3 months. My doctor won’t give them before 3 months. The shots hurt, but are worth a try. I’ve also tried acupuncture, and that helped as well. good luck.