I live in Denver and head up to the mountains regularly. Without question every time I change altitude I feel a difference. When I first moved here, it took a few days to adjust under normal conditions, but getting my endurance up to what I could do at sea level took months. Similarly, when I jog at sea level now, I can go way more miles before I’m even winded. When I go snowboarding or hiking, it is way harder to catch my breath walking around at 10–12000 ft. It generally takes a few days to acclimate, and water boils at a slightly lower temperature the higher you go. Because of that, you have to cook pasta and whatnot longer than at sea level. I haven’t noticed any problems with TVs.