What's better: lots of reps with low weights, or fewer reps with heavier weights?

What's better: lots of reps with low weights, or fewer reps with heavier weights?
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If you want to work on strength, that is, the ability of a muscle to apply force once, it’s definitely better to do higher weight, low reps, and high sets. T-nation has some good information about different programs, although there are tons of ads and various BS that you have to sift through to find the good stuff.
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