Which of the following terms best describes the antagonism of leukotriene’s bronchoconstrictor effect (mediated at leukotriene receptors) by terbutaline (acting a adrenoceptors) in a patient with asthma? (a) Pharmacologic antagonist (b) Partial agonist (c) Physiologic antagonist (d) Chemical antagonist (e) Noncompetitive antagonist

Which of the following terms best describes the antagonism of leukotriene’s bronchoconstrictor effect (mediated at leukotriene receptors) by terbutaline (acting a adrenoceptors) in a patient with asthma? (a) Pharmacologic antagonist (b) Partial agonist (c) Physiologic antagonist (d) Chemical antagonist (e) Noncompetitive antagonist
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Terbutaline has a preference for stimulation of which of the following receptors? (a) Alpha (b) Gamma (c) Beta 1 (d) Beta 2 (e) Dopaminergic

Description : Terbutaline has a preference for stimulation of which of the following receptors? (a) Alpha (b) Gamma (c) Beta 1 (d) Beta 2 (e) Dopaminergic

Last Answer : Ans: D

A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a: A. Physiological antagonist B. Competitive antagonist C. Noncompetitive antagonist D. Partial agonist

Description : A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a: A. Physiological antagonist B. Competitive antagonist C. Noncompetitive antagonist D. Partial agonist

Last Answer : C. Noncompetitive antagonist

A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a: A. Partial agonist B. Inverse agonist C. Competitive antagonist D. Noncompetitive antagonist

Description : A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a: A. Partial agonist B. Inverse agonist C. Competitive antagonist D. Noncompetitive antagonist

Last Answer : C. Competitive antagonist

A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a: A. Physiological antagonist B. Competitive antagonist C. Noncompetitive antagonist D. Partial agonist

Description : A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a: A. Physiological antagonist B. Competitive antagonist C. Noncompetitive antagonist D. Partial agonist

Last Answer : C. Noncompetitive antagonist

A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a: A. Partial agonist B. Inverse agonist C. Competitive antagonist D. Noncompetitive antagonist

Description : A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a: A. Partial agonist B. Inverse agonist C. Competitive antagonist D. Noncompetitive antagonist

Last Answer : C. Competitive antagonist

Which one of the following drugs is most suitable for management of essential tremor in a patient who has pulmonary disease? (a) Diazepam (b) Levodopa (c) Metoprolol (d) Propranolol (e) Terbutaline

Description : Which one of the following drugs is most suitable for management of essential tremor in a patient who has pulmonary disease? (a) Diazepam (b) Levodopa (c) Metoprolol (d) Propranolol (e) Terbutaline

Last Answer : Ans: C

Which of the following is a very longacting ß2 – selective agonist that is used for asthma prophylaxis? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Salmeterol

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Last Answer : Ans: E

In the emergency department, the preferred first-line therapy for asthma exacerbation is (a) Theophylline (b) A ß-agonist (c) A corticosteroid (d) Cromolyn sodium (e) An antihistamine

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Last Answer : Ans: B

In the emergency department, the preferred first-line therapy for asthma exacerbation is (a) Theophyline (b) A ß-agonist (c) A corticosteroid (d) Cromolyn sodium (e) An antihistamine

Description : In the emergency department, the preferred first-line therapy for asthma exacerbation is (a) Theophyline (b) A ß-agonist (c) A corticosteroid (d) Cromolyn sodium (e) An antihistamine

Last Answer : Ans: B

The symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) Inceased vascular permeability of bronchial tissue (d) Decreased calcium influx into the mast cell (e) Decreased prostaglandin production

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Last Answer : Ans: A

The Symptoms of allergen-mediated asthma result from which of the following? (a) Increased release of mediators from mast cells (b) Increased adrenergic responsiveness of the airways (c) Increased vascular permeability of bronchial tissue (d) Decreased calcium influx into the mast cells (e) Decreased prostaglandin production

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Last Answer : Ans: A

Select the correct statement about salmeterol. (a) It is a long acting selective ß2 agonist bronchodilator (b) It is a bronchodilator with anti-inflammatory property (c) It is a ß blocker that can be safely given to asthmatics (d) It is an antihistaminic with mast cells stabilizing property

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Last Answer : Ans: A

Which of the following best describes the mechanism of action of scopolamine ? (a) Irreversible antagonist at nicotinic receptors (b) Irreversible antagonist at muscarinic receptors (c) Physiologic antagonist at muscarinic receptors (d) Reversible antagonist at muscarinic receptors (e) Reversible antagonist at nicotinic receptors

Description : Which of the following best describes the mechanism of action of scopolamine ? (a) Irreversible antagonist at nicotinic receptors (b) Irreversible antagonist at muscarinic receptors (c) ... receptors (d) Reversible antagonist at muscarinic receptors (e) Reversible antagonist at nicotinic receptors

Last Answer : Ans: D

In a patient of bronchial asthma, inhaled salbutamol produces the following effect(s). (a) Inhibits antigen-antibody reaction in the lungs (b) Causes bronchodilatation (c) Reduces bronchial hyperreactivity (d) Both (b) and (c)

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Last Answer : Ans: B

Drugs that can dilate bronchi during an acute asthmatic attack include all of the following except (a) Epinephrine (b) Terbutaline (c) Nedocromil (d) Theophyline (e) Ipratropium

Description : Drugs that can dilate bronchi during an acute asthmatic attack include all of the following except (a) Epinephrine (b) Terbutaline (c) Nedocromil (d) Theophyline (e) Ipratropium

Last Answer : Ans: C

Eicosanoids mediate inflammation in a variety of ways. Of the following statements, which are true with regard to this? a. Eicosanoids are stored in cytoplasmic granules for release after receptor mediated signaling b. Eicosanoids include prostaglandins, thromboxanes, leukotrienes and lipoxins c. Eicosanoids generally have a plasma half-life measured in hours d. Physiologic responses to eicosanoids include vasodilatation, vasoconstriction, increased vascular permeability and both chemotaxis and chemoattractant inhibition

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Last Answer : Answer: b, d The eicosanoids are derived from arachidonic acid (eicosatetraenoic acid) and consist of prostaglandins, thromboxanes, leukotrienes and lipoxins. The eicosanoids are not ... nervous system d. Mononuclear phagocytes release a variety of proinflammatory cytokines and growth factors

The antiasthma drug which cannot be administered by inhalation is (a) Theophylline (b) Ipratropium bromide (c) Budesonide (d) Terbutaline

Description : The antiasthma drug which cannot be administered by inhalation is (a) Theophylline (b) Ipratropium bromide (c) Budesonide (d) Terbutaline

Last Answer : Ans: A

Which of the following tests is used at home to assess therapy and determine if a patient with asthma should seek emergency care? (a) Forced expiratory volume in one second (FEV1) (b) Forced vital capacity (FVC) (c) Total lung capacity (TLC) (d) Peak expiratory flow rate (PEFR) (e) Residual volume (RV)

Description : Which of the following tests is used at home to assess therapy and determine if a patient with asthma should seek emergency care? (a) Forced expiratory volume in one second (FEV1) (b) Forced vital capacity ... ) Total lung capacity (TLC) (d) Peak expiratory flow rate (PEFR) (e) Residual volume (RV)

Last Answer : Ans: D

Which of the following agents and dosage regimens is the best choice of treatment for an asthma patient with rheumatoid arthritis who is considered sensitive to aspirin (experiences bronchospasm with use)? (a) Lbuprofen, 800 mg three times daily (b) Acetaminophen, 650 mg every 4 hours (c) Gold injections, 25 mg intramuscularly once a week (d) Azathioprine, 75 mg daily (e) Cyclophosphamide, 100 mg daily

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Last Answer : Ans: C

Which of the following tests is used at home to assess therapy and determine if a patient with asthma should seek emergency care? (a) Forced expiratory volume in one second (FEV1) (b) Forced vital capacity (FVC) (c) Total lung capacity (TLC) (d) Peak expiratory flow rate (PEFR) (e) Residual volume (RV)

Description : Which of the following tests is used at home to assess therapy and determine if a patient with asthma should seek emergency care? (a) Forced expiratory volume in one second (FEV1) (b) Forced vital capacity ... ) Total lung capacity (TLC) (d) Peak expiratory flow rate (PEFR) (e) Residual volume (RV)

Last Answer : Ans: D

If therapy with multiple drugs causes induction of drug metabolism in your asthma patient, it will (a) Result in increased smooth endoplasmic reticulum (b) Result in increased rough endoplasmic reticulum (c) Result in decreased enzymes in the soluble cytoplasmic fraction (d) Require 3-4 months to reach completion (e) Be irreversible

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Last Answer : Ans: A

Which of the following β 2 agonist bronchodilators is given by inhalation, and is suitable for both terminating asthma attacks as well as for twice daily prophylaxis: A. Terbutaline B. Bambuterol C. Salmeterol D. Formoterol

Description : Which of the following β 2 agonist bronchodilators is given by inhalation, and is suitable for both terminating asthma attacks as well as for twice daily prophylaxis: A. Terbutaline B. Bambuterol C. Salmeterol D. Formoterol

Last Answer : D. Formoterol

In an asthma patient treated with systemic corticosteroids, bronchodilator drugs (a) Are not needed (b) Are contraindicated (c) May be used on ‘as and when required’ basis (d) Are ineffective

Description : In an asthma patient treated with systemic corticosteroids, bronchodilator drugs (a) Are not needed (b) Are contraindicated (c) May be used on ‘as and when required’ basis (d) Are ineffective

Last Answer : Ans: C

Methylxanthines exert the following action (s) at cellular/molecular level (a) Intracellular release of Ca2+ (b) Antagonism of adenosine (c) Inhibition of phosphodiesterase (d) All of the above

Description : Methylxanthines exert the following action (s) at cellular/molecular level (a) Intracellular release of Ca2+ (b) Antagonism of adenosine (c) Inhibition of phosphodiesterase (d) All of the above

Last Answer : Ans: D

The 5-HT antagonist that has antihypertensive property is (a) Methysergide (b) Cyproheptadine (c) Ketanserin (d) Ondansetron

Description : The 5-HT antagonist that has antihypertensive property is (a) Methysergide (b) Cyproheptadine (c) Ketanserin (d) Ondansetron

Last Answer : Ans: C

What is symport ? (a) Counter transport (b) Contransport (c) Carrier mediated diffusion (d) Solvent drug

Description : What is symport ? (a) Counter transport (b) Contransport (c) Carrier mediated diffusion (d) Solvent drug

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The action of 5-Hydroxy tryptamine mediated by the 5-HT3 receptor is (a) Vasoconstriction (b) Bradycardia (c) EDRF release (d) Platelet aggregation

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Losartan is a: A. Selective AT1 receptor antagonist B. Selective AT2 receptor antagonist C. Nonselective AT1 + AT2 receptor antagonist D. AT1 receptor partial agonist

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Last Answer : A. Selective AT1 receptor antagonist

Which of the following will result from blockade of H2 receptors? (a) Decreased camp in cardiac muscle (b) Increased camp in cardiac muscle (c) Decreased IP3 in gastric mucosa (d) Increased IP3 in gastric mucosa (e) Increased IP3 in smooth muscle

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Last Answer : Ans: A

Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial or viral pneumonia (b) Hypersensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events

Description : Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial or viral pneumonia (b) Hypersensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events

Last Answer : Ans: D

Relative to fexofenadine, diphenhydramine is more likely to (a) Be used for treatment of asthma (b) Be used for treatment of gastroesophageal reflux disease (c) Cause cardiac arrhythmias in overdose (d) Have efficacy in the prevention of motion sickness (e) Increase the serum concentration of warfarin

Description : Relative to fexofenadine, diphenhydramine is more likely to (a) Be used for treatment of asthma (b) Be used for treatment of gastroesophageal reflux disease (c) Cause cardiac arrhythmias in ... ) Have efficacy in the prevention of motion sickness (e) Increase the serum concentration of warfarin

Last Answer : Ans: D

A drug useful in the treatment of asthma but lacking bronchodilator action, is (a) Cromolyn (b) Ephedrine (c) Isoproterenol (d) Metaproterenol (e) Metoprolol

Description : A drug useful in the treatment of asthma but lacking bronchodilator action, is (a) Cromolyn (b) Ephedrine (c) Isoproterenol (d) Metaproterenol (e) Metoprolol

Last Answer : Ans: A

Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial of viral pneumonia (b) Hypertsensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events

Description : Acute exacerbations of asthma can be triggered by all of the following except (a) Bacterial of viral pneumonia (b) Hypertsensitivity reaction to penicillin (c) Discontinuation of asthma medication (d) Hot, dry weather (e) Stressful emotional events

Last Answer : Ans: D

Which of the following is a direct bronchodilator that is most often used in asthma by the oral route? (a) Aminophyline (b) Cromolyn (c) Epinephrine (d) Ipratropium (e) Metaproterenol

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Last Answer : Ans: A

The primary goals of asthma therapy include all of the following except (a) maintain normal activity levels (b) maintain control of symptoms (c) avoid adverse effects of asthma medications (d) prevent acute exacerbations and chronic symptoms (e) prevent destruction of lung tissue

Description : The primary goals of asthma therapy include all of the following except (a) maintain normal activity levels (b) maintain control of symptoms (c) avoid adverse effects of asthma medications (d) prevent acute exacerbations and chronic symptoms (e) prevent destruction of lung tissue

Last Answer : Ans: E

Isoxuprine is used to treat (a) Asthma (b) Severe hypotension (c) Nasal congestion (d) Premature labor (e) Hypertension

Description : Isoxuprine is used to treat (a) Asthma (b) Severe hypotension (c) Nasal congestion (d) Premature labor (e) Hypertension

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Which of the following may precipitate an asthma attack? (a) Respiratory acidosis (b) Viran and bacterial infections (c) Respiratory alkalosis (d) Cranberry jiuce (e) Chocolate or Coca Cola

Description : Which of the following may precipitate an asthma attack? (a) Respiratory acidosis (b) Viran and bacterial infections (c) Respiratory alkalosis (d) Cranberry jiuce (e) Chocolate or Coca Cola

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A drug administered by inhalation of powder as a prophylactic for asthma is (a) Ephedrine (b) Disodium cromolyn (c) Isoproterenol (d) Ocytriphylline (e) Epinephrine

Description : A drug administered by inhalation of powder as a prophylactic for asthma is (a) Ephedrine (b) Disodium cromolyn (c) Isoproterenol (d) Ocytriphylline (e) Epinephrine

Last Answer : Ans: B

The antidotal action of sodium nitrite in cyanide poisoning is based on: A. Physical antagonism B. Chemical antagonism C. Physiological antagonism D. Noncompetitive antagonism

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The antidotal action of sodium nitrite in cyanide poisoning is based on: A. Physical antagonism B. Chemical antagonism C. Physiological antagonism D. Noncompetitive antagonism

Description : The antidotal action of sodium nitrite in cyanide poisoning is based on: A. Physical antagonism B. Chemical antagonism C. Physiological antagonism D. Noncompetitive antagonism

Last Answer : B. Chemical antagonism

Smooth muscle relaxation is due to stimulation of which type of histamine receptors (a) H1 (b) H2 (c) H3 (d) All of the above

Description : Smooth muscle relaxation is due to stimulation of which type of histamine receptors (a) H1 (b) H2 (c) H3 (d) All of the above

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Bromhexine acts by (a) Inhibiting cough center (b) Irritating gastric mucosa and reflexly increasing bronchial secretion (c) Depolymerizing mucopolysaccharides present (d) Desensitizing stretch receptors in the lungs

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Last Answer : Ans: C

The capacity of an antihistaminic to produce sedation depends on the following except (a) Relative affinity for central versus peripheral H1 receptors (b) Ability to penetrate blood-brain barrier (c) Individual susceptibility (d) Ratio of H1 : H2 blockade produced by the drug

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Last Answer : Ans: D

Which xanthine derivative has no function in asthma ? (a) Theophylline (b) Pentoxyphyllin (c) Enprofylin (d) None of the above

Description : Which xanthine derivative has no function in asthma ? (a) Theophylline (b) Pentoxyphyllin (c) Enprofylin (d) None of the above

Last Answer : Ans: B

All the following are employed in inhalation therapy of asthma except (a) Beclomethasone (b) Budesonide (c) Dexamethasone (d) Triamcinolone

Description : All the following are employed in inhalation therapy of asthma except (a) Beclomethasone (b) Budesonide (c) Dexamethasone (d) Triamcinolone

Last Answer : Ans: C

Budesonide is a (a) Nonsteroidal anti-inflammatory drug (b) High ceiling diuretic (c) Inhaled corticosteroid for asthma (d) Contraceptive

Description : Budesonide is a (a) Nonsteroidal anti-inflammatory drug (b) High ceiling diuretic (c) Inhaled corticosteroid for asthma (d) Contraceptive

Last Answer : Ans: C

In patients of bronchial asthma inhaled corticosteroids achieve the following except (a) Reduce the need for bronchodilator medication (b) Control an attack of refractory asthma (c) Reduce bronchial hyperreactivity (d) Reverse diminished responsiveness to sympathomimetic bronchodilators

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Last Answer : Ans: B

The most consistent, pronounced and sustained relief of symptoms in chronic bronchial asthma is afforded by (a) ß2 sympathomimetics (b) Anticholinergics (c) Sodium cromoglycate (d) Corticosteroids

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A 10 year old child suffers from exercise induced asthma: Which is the most suitable first line drug for regular prophylactic therapy ? (a) Oral salbutamol (b) Oral theophylline (c) Inhaled sodium cromoglycate (d) Inhaled beclomethasone dipropionate

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Last Answer : Ans: C

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Description : H1 antihistaminics are beneficial in (a) All types of allergic disorders (b) Certain type I allergic reactions only (c) Anaphylactic shock(d) Bronchial asthma

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