DefinitionCollagen is a tough, glue-like protein that makes up 30% of body protein. It shapes the structure of tendons, bones, and connective tissues. Problems with the immune system can affect these structures. This is known as collagen vascular disease.Collagen vascular diseases include:DermatomyositisPolyarteritis nodosaRheumatoid arthritisSclerodermaSystemic lupus erythematosusSymptomsSymptoms of collagen vascular disease may include:AnemiaFeverJoint inflammationWeakness