Name various Novel drug Delivery systems.

Name various Novel drug Delivery systems.
by

1 Answer

Answer :

1. Implants

2. Liposome drug carriers

3. Nanoparticles

4. Prodrugs

5. Films and strips

6. Resealed Erythrocytes etc.
by

Related questions

What are various ‘ Novel drug delivery systems’- explain implants.

Description : What are various ‘ Novel drug delivery systems’- explain implants. 

Last Answer : Various drug delivery systems are:  1. Implants 2. Liposome drug carriers 3. Nanoparticles 4. Prodrugs 5. Films and strips 6. Erythrocytes Implants: The hypodermic tablets are placed under the ... placed in the upper thigh at a depth of 5 mm. These implants are useful in hormone therapy.

Discuss novel drug delivery system.

Description : Discuss novel drug delivery system.

Last Answer : New drug delivery system delivers or aimed at maximizing the drug effectiveness or minimizing the side effects. Some of the Novel dosage forms are: 1) Implants 2) Controlled drug delivery system 3) Sustained ... these days are I. Zero order release film. II. Buccal Stip. III. Spray bandages.

Define aseptic techniques. What are the various sources of contamination?

Description : Define aseptic techniques. What are the various sources of contamination?

Last Answer : Definition: Aseptic technique  The method which is used to prevent the access of microorganism during the preparation of parenteral product and their testing are called Aseptic Technique Sources of ... are also a source of contamination. A handkerchief is the richest source of contamination. 

Describe in detail various oral cavity tablet.

Description : Describe in detail various oral cavity tablet.

Last Answer : Oral cavity tablet:  i. Buccal Tablet. ii. Sublingual Tablet. iii. Lozenge tablet and tracheas. iv. Dental cones. 1] Buccal Tablet's - a. These tablets are to be placed in buccal pouch or ... Chloride or it may be amines acid. f. These cones generally get dissolved in 20 to 40 min time.

Describe various factors affecting size reduction.

Description : Describe various factors affecting size reduction.

Last Answer : i. Hardness: Soft material easy break than hard. ii. Toughness: Drug with fibrous nature or those having high moisture content are tough and hard to reduce in size. iii. Stickiness: Material ... of the size reduction of the material in a machine depends upon the bulk density of the substance.

Name various types of closures.

Description : Name various types of closures.

Last Answer : i. Plug type. ii. Crown type. iii. Push-fit cap. iv. Screw closure

Name various mechanisms of size reduction.

Description : Name various mechanisms of size reduction.

Last Answer : i. Cutting ii. Compression iii. Impact iv. Attrition v. Combined impact and attrition

Draw a well labelled diagram of ‘Soxhlet apparatus.’ Mention the various limitations of continuous hot percolation process.

Description : Draw a well labelled diagram of ‘Soxhlet apparatus.’ Mention the various limitations of continuous hot percolation process. 

Last Answer : Limitation: 1. Physical character of the drug: If the drug would block the soxhlet apparatus then this process cannot be used for extraction. Eg opium. Gum, resin, ... for drugs having thermolabile active constituents such as enzymes, alkaloids, anthraquinone derivatives, esters, etc. 

Explain the term aseptic techniques. What are the various points to be considered while designing an aseptic room?

Description : Explain the term aseptic techniques. What are the various points to be considered while designing an aseptic room?

Last Answer : Definition: The method which is used to prevent the access of microorganism during the preparation of parenteral product and their testing are called aseptic Technique . Design of aseptic room: 1. Site: ... connection. Vacuum. Disposable waste. 6. Furniture: Shack type. Fume -cupboard.

Differentiate between filtration and clarification. Enlist various filter media used in Pharmacy.

Description : Differentiate between filtration and clarification. Enlist various filter media used in Pharmacy.

Last Answer : Sr. no. Filtration Clarification 1 It is process of removal of solids or suspended matter in a liquid or gas by passing through a porous medium in which solids are retained. ... wool iv) Asbestos v) Fine muslin vi) Filter cloth vii) Membrane filters viii) Sintered glass filters.

Name the various manufacturing defects in tablets.

Description : Name the various manufacturing defects in tablets. 

Last Answer : 1.Capping: In this there is partial or complete removal of top or bottom portion of tablet. Reasons: Excessive fine. Defective punch die. High speed of machine. Granules too dried ... ejection of tablet and give second impression. This can be controlled by managing the movement of punch.

Name the various standards of sieves.

Description : Name the various standards of sieves.

Last Answer : According to I.P. standards for sieves are as follows I .Approximate sieve number ii. Nominal mesh aperture size iii. Approximate percentage of sieving area iv. Tolerance average aperture size  According to I.P. sieves must confirm the above mentioned specifications for the given sieve number. 

What are the various factors which affect the size reduction of the drugs?

Description : What are the various factors which affect the size reduction of the drugs?

Last Answer : 1. Hardness: Soft material easy break than hard.  2. Toughness: Drug with fibrous nature or those having high moisture content are tough and hard to reduce in size.  3. Stickiness: Material ... of the size reduction of the material in a machine depends upon the bulk density of the substance. 

In which year various editions of pharmacopoeia of India came out?

Description : In which year various editions of pharmacopoeia of India came out?

Last Answer : 1. First Edition in 1955 2. Second Edition in 1966 3. Third Edition in 1985 4. Fourth Edition in 1996 5. Fifth Edition in 2007 6. Sixth Edition in 2010 7. Seventh Edition 2014

Define tables. Enlist various excipients used in tablet manufacturing with one example each.

Description : Define tables. Enlist various excipients used in tablet manufacturing with one example each.

Last Answer : Definition:  Tablet is a solid unit dosage form congaing medicament/s usually circular in shape and may be flat or biconvex. OR Tablet is a solid unit dosage form prepared by compression. ... Glidants& lubricants: e.g. talc and magnesium stearate. vi. Colours, flavours and sweetening agents: 

List the various equipment’s used for liquid mixing and explain how vortex formation can be avoided in liquid mixing.

Description : List the various equipment’s used for liquid mixing and explain how vortex formation can be avoided in liquid mixing. 

Last Answer : Equipment used for mixing of liquid:  1. Propeller mixture. 2. Turbine Mixture. 3. Paddle mixture. Vortex formation can be avoided in liquid mixing by making the following changes in the position of the ... the side of vessels. 4. Using push pull propeller. 5. Using baffles.

What is aseptic technique? List the various sources of contamination and explain the sterility test.

Description : What is aseptic technique? List the various sources of contamination and explain the sterility test.

Last Answer : Aseptic technique:  The method which is used to prevent the access of microorganism during the preparation of parenteral product and their testing are called Aseptic Technique . Sources of contamination: 1) ... the sample is declared to have pass the test and same test is repeated for two times.

Explain various grades of powders

Description : Explain various grades of powders

Last Answer : According to IP 2010 official grades of powders are as follows:  i. Coarse powder: A powder of which all particles pass through sieve no 10 with nominal aperture size 1.7mm and not more than 40% pass ... powder: A powder of which not less than 90%by weight of particles are less than 10 µm in size.

Describe various stages of sugar coating.

Description : Describe various stages of sugar coating. 

Last Answer : Steps of sugar coating of tablet:-  i) Sieving ii) Sealing iii) Sub-coating iv) Syrup coating v) Finishing vi) Polishing i) Sieving :- The tablets to be coated are shaken in a suitable ... so the wax coated tablets are rubbed on the canvas cloth. This gives a proper shining to the tablets

Define ‘drug’ and ‘dosage form’.

Description : Define ‘drug’ and ‘dosage form’. 

Last Answer : i. Drug: A chemical agent intended for use in the diagnosis, mitigation, treatment, cure or prevention of disease in man or in other animals.   ii. Dosage Form: Dosage form is a ... of a pure chemical compound into a predetermined form by admixing drug components with non drug components. 

Define the following terms: (i) Drug (ii) Dosage forms (iii) Excipients

Description : Define the following terms:  (i) Drug (ii) Dosage forms (iii) Excipients

Last Answer : (i) Drug- A chemical agent intended for use in the diagnosis, mitigation, treatment, cure or prevention of disease in man or in other animals. (ii) Dosage forms- Dosage form is a ... along with Active Pharmaceutical Ingredients make up the dosage forms. Eg. suspending agent ,emulsifying agent etc.

Differentiate Maceration for organized drug and Maceration for unorganized drug

Description : Differentiate Maceration for organized drug and Maceration for unorganized drug

Last Answer : Maceration for organized drug Maceration for unorganized drug 1 Drug along with whole of menstrum is used in maceration process  Drug along with 4/5th of the menstrum is used ... lemon Example of tincture: Tincture of tolu, Tincture of catechu, compound tincture of benzoin.

Why imbibition is necessary before packing of the drug into the percolator?

Description : Why imbibition is necessary before packing of the drug into the percolator?

Last Answer : . Imbibition is done in order to: i. It allow the swelling of tissue of drug before packing. ii .It is imbibed for uniform packing in percolator. iii. It allows the entrapped air to escape. iv. Quantity of menstrum required can be reduced.

Define (i) Drug (ii) Dosage forms

Description : Define (i) Drug (ii) Dosage forms

Last Answer : (i) Drug- A chemical agent intended for use in the diagnosis, mitigation, treatment, cure or prevention of disease in man or in other animals.  (ii) Dosage forms- Dosage form is a ... of a pure chemical compound into a predetermined form by admixing drug components with non- drug components. 

Define drug. Classify different types of dosage forms with examples

Description : Define drug. Classify different types of dosage forms with examples

Last Answer : Drug- A chemical agent intended for use in the diagnosis, mitigation, treatment, cure or prevention of disease in man or in other animals.

Transdermal drug delivery systems offer the following advantages except: A. They produce high peak plasma concentration of the drug B. They produce smooth and nonfluctuating plasma concentration of the drug C. They minimise interindividual variations in the achieved plasma drug concentration D. They avoid hepatic first-pass metabolism of the drug

Description : Transdermal drug delivery systems offer the following advantages except: A. They produce high peak plasma concentration of the drug B. They produce smooth and nonfluctuating plasma concentration of the ... the achieved plasma drug concentration D. They avoid hepatic first-pass metabolism of the drug

Last Answer : A. They produce high peak plasma concentration of the drug

Transdermal drug delivery systems offer the following advantages except: A. They produce high peak plasma concentration of the drug B. They produce smooth and nonfluctuating plasma concentration of the drug C. They minimise interindividual variations in the achieved plasma drug concentration D. They avoid hepatic first-pass metabolism of the drug

Description : Transdermal drug delivery systems offer the following advantages except: A. They produce high peak plasma concentration of the drug B. They produce smooth and nonfluctuating plasma concentration of the ... the achieved plasma drug concentration D. They avoid hepatic first-pass metabolism of the drug

Last Answer : A

Explain principle and working of fluid energy mill with a diagram.

Description : Explain principle and working of fluid energy mill with a diagram.

Last Answer : Principle  It works on the principle of impact and attrition. Working: The air or inert gas is introduced with a very high pressure through nozzles. Solids are introduced into air stream through inlet. ... 100 mesh and then passed through fluid energy mill. Diagram of fluid energy mill :

Give application of simple distillation. What is the principle of fractional distillation?

Description : Give application of simple distillation. What is the principle of fractional distillation?

Last Answer : Applications of simple distillation:  i. It is used for the preparation of distilled water and water for injection. ii. Preparation of many volatile oils and aromatic water. iii. Purification ... becomes richer with the liquid having the lower boiling point which gets condensed in a condenser. 

Mention official and unofficial evaluation test for tablets. Describe weight variation test.

Description : Mention official and unofficial evaluation test for tablets. Describe weight variation test. 

Last Answer : Official test list: 1. Size and shape of tablet. 2. Appearance. 3. Content of active ingredient. 4. Uniformity of weight/weight variation test 5. Uniformity of content 6. ... the percentage deviation given in the table and none should deviate by more than twice that percentage.

Draw a well labelled diagram of aerosol container and give its advantages and disadvantages.

Description : Draw a well labelled diagram of aerosol container and give its advantages and disadvantages.

Last Answer : Diagram of aerosol container Advantages:   1. Medicament can be delivered directly to affected areas. 2. Absence of air prevents oxidation. 3. Hydrolysis of medicament prevented ... on injured skin. 4. Difficulties occurred during formulation when drug not soluble in propellants.

Discuss working of ball mill with neat diagram.

Description : Discuss working of ball mill with neat diagram. 

Last Answer : Working: The drug to be ground is put into the cylinder of the mill and is rotated. The speed of the rotation is very different. At low speed, the mass of balls will slide or roll over each other and ... and passed through a sieve to get powder of the required size. Ball mill diagram:   

Define pharmaceutical container. Give qualities of an ideal container.

Description : Define pharmaceutical container. Give qualities of an ideal container.

Last Answer : Definition: Pharmaceutical container  A device that holds the drug and it may or may not be in direct contact with the pharmaceutical dosage form or preparations. Qualities of an ideal container:  1 ... and temperature. 7. Labelled easily 8. Non-toxic. 9. Closure easily removable/replaceable.

Write the official standards of powder.

Description : Write the official standards of powder.

Last Answer : i. Coarse powder: A powder of which all particles pass through sieve no 10 with nominal aperture size 1.7mm and not more than 40% pass through sieve no 44 with nominal aperture size 355um.  ii. ... powder: A powder of which all particles pass through sieve no 120 with nominal aperture size 125 um.

Write special application of capsule.

Description : Write special application of capsule. 

Last Answer : Applications of capsule:  1. Enteric coated capsule: These capsules do not disintegrate in stomach (Acidic Medium) but break up in intestine (Alkaline medium). On commercial scale, a coating ... gelatine commonly used Capsule punctured by using sterile needle and then instilled into the eye.

Give the principle and working of Fluidised bed dryer.

Description : Give the principle and working of Fluidised bed dryer.

Last Answer : Principle: In FBD, good contact between hot air and particles to be dried is obtained which cause rapid drying. Working of Fluidised bed dryer: Two types of FBD are used in pharmaceutical industry. There are ... ranging from 5 kg to 200 kg with an average drying time of about 20-40 min.

Give principal and working of silverson homogenizer with labelled diagram.

Description : Give principal and working of silverson homogenizer with labelled diagram.

Last Answer : Principal:   These work on the principal of braking large globules in to small globules by passing them under pressure through a narrow orifice. Working:   The emulsified head is placed in the vessel ... blades. So a fine emulsion is produced which is then expelled out. Diagram :

Define drying. Give application of drying in pharmacy.

Description : Define drying. Give application of drying in pharmacy.

Last Answer : Definition:  Drying: It is defined as final removal of liquid from solid by vaporization with aid of heat. Application:  1) In pharmaceutical industry it is used as a unit process in the ... of product, when powder is dried it gets solublised fast. 7) Drying ensures free flowing of powders.

Write the advantages and disadvantages of glass as a material for packaging. Merits of Glass container

Description : Write the advantages and disadvantages of glass as a material for packaging. Merits of Glass container

Last Answer : Economical. Available in variety of sizes and shapes.  Chemically inert, impermeable, strong and rigid. Does not deteriorate with age. Easy to label. Excellent barrier against light. ... easy to break. Heavy, Bulky to carry. Leaching and absorption of alkalis. Flak formation

Draw a well labelled diagram of filter candle. Give its working and disadvantages.

Description : Draw a well labelled diagram of filter candle. Give its working and disadvantages.

Last Answer : Diagram : Working  : The filter candle is placed in a vessel containing the liquid to be filtered. When vacuum is applied, the pressure inside the candle is decreased. Due to ... Disadvantages   1. Chance of clogging/blocking. 2. Traces of material may come in the solution.

Explain the factors affecting evaporation of a liquid.

Description : Explain the factors affecting evaporation of a liquid.

Last Answer : Factor affecting evaporation  1. Temperature: The rate of evaporation is directly proportional to the temperature of the liquid. The evaporation can be accelerated by increasing the temperature but it ... of evaporation is maximum at its boiling point when the liquid has maximum vapour pressure.

Write the working of filter press with well labelled diagram.

Description : Write the working of filter press with well labelled diagram.

Last Answer : Working:  1. The slurry is pumped in under positive pressure up to 20 bar and fill each frame. 2. The filtrate passes through the cloths on opposite sides of the frame and runs down between the ... 6. Thickness of cake can be varied by using frame of different thickness. Diagram: 

Explain in detail evaporating still with its advantage and disadvantages.

Description : Explain in detail evaporating still with its advantage and disadvantages.

Last Answer : It consist of a hemispherical pan made from copper or stainless steel. It is surrounded by a steam jacket. Still is covered from top and connected to condenser. Hemispherical shape ... heat transfer is poor. Heating surface is limited. Not suitable for thermolabile material.

Define sterilisation and classify methods of sterilisation.

Description : Define sterilisation and classify methods of sterilisation.

Last Answer : Definition: Sterilizations is the process of complete destruction of all microorganisms along with their spores present in the system.  Methods of sterilization:  I. Physical methods:  1. Dry heat ... . Seitz filters  3. Sintered glass filters 4. Sintered metal filters  5. Membrane filters

Define Pharmacopoeia. List official books used in India.

Description : Define Pharmacopoeia. List official books used in India. 

Last Answer : Defination: Pharmakon means a drug and poeia means to make . Pharmacopoeia is defined as a compressive book which is issued under the authority of government and contains a list of drug ...  v) International Pharmacopeia  vi) Japanese Pharmacopoeia (J.P.)  vii) Martindale Extra Pharmacopoeia 

Give steps involved in moist granulation.

Description : Give steps involved in moist granulation.

Last Answer : Steps: i. Moisten of Medicament with excipients with granulating agent. ii. Sieving of moist mass through sieve number 8 or 10. iii. Drying of wet granules in hot air oven at ... sieve number 20 to collect granules of uniform size v. Lubrication of sifted granules with lubricating agent

List any four equipment used in drying.

Description : List any four equipment used in drying.

Last Answer : Equipment used for drying: i) Tray dryer ii) Tunnel dryer iii) Rotary dryer iv) Fluidized Bed Dryer v)Vacuum dryer vi) Freeze dryer.

Why injectables should not be stored in soda lime glass containers?

Description : Why injectables should not be stored in soda lime glass containers?

Last Answer : Soda lime glass container is not used for the storage of parenterals because: i. It yields an appreciable quantity of alkali to water. ii. Flakes separate comparatively easily. iii. On ... 's relatively high coefficient of expansion makes it liable to fracture with sudden changes of temperature. 

Define ‘menstruum’ and state three ideal qualities of a menstruum.

Description : Define ‘menstruum’ and state three ideal qualities of a menstruum.

Last Answer : Menstruum :- Solvent used to extract the drug.  Ideal properties of menstruum: i) Cheap. ii) Non-toxic. iii) Stable chemically and physically. iv) Selective i.e. remove the desired active constituents with minimum amount of inert materials.

Why are tablets coated ?

Description : Why are tablets coated ?

Last Answer : Reasons for coating of tablets: i. To mask the unpleasant taste and odour. ii. To improve the appearance of tablets. iii. To prevent the medicament from atmospheric effects. iv. To control the ... v. To produce the sustained release product. vi. To prevent the drug degradation in stomach pH.