Description : The following is true about entacapone except: A. It acts by inhibiting degradation of dopamine in the brain B. If prolongs the therapeutic effect of levodopacarbidopa in parkinsonism C. It can accentuate levodopa induced dyskinesias D. It can cause diarrhoea as a side effec
Last Answer : A. It acts by inhibiting degradation of dopamine in the brain
Description : Though bromocriptine acts directly on dopamine receptors, it is used in parkinsonism only as a supplement to levodopa because: A. It has low efficacy B. It produces marked dyskinesias C. ... its effective doses produce intolerable side effects D. Its therapeutic effect takes long time to develop
Last Answer : C. Used alone, its effective doses produce intolerable side effect
Description : Which of the following is a valid therapeutic use of interaction? A. Use of Probenecid with Penicillin B. Giving Aspirin with warfarin C. Instructing patient to take levofloxacin with milk or antacid D. Treatment of depression of MAO Inhibitor and Citalopram
Last Answer : A. Use of Probenecid with Penicillin
Description : __________ is the common and dose related side effect of salbutamol. a) Decrease in blood pressure b) Muscle tremor c) Central nervous system stimulation d) Hyperglycaemia
Last Answer : c) Central nervous system stimulation
Description : Which of the following drug is implicated in the causation of osteomalacia of the bone? A. Steroid B. Estrogen C. Heparin D. Phenytoin
Last Answer : D. Phenytoin
Description : GCP are seen in all of the following except a) Phase I trial b) Phase II trial c) Preclinical trials d) Phase IV trial
Last Answer : c) Preclinical trials
Description : You are asked to compare the cost of four different antibacterial medicines. Which of the following treatment courses is the lowest cost? a) Medicine A costs £17.00 for 28 tablets. The adult dose is one ... 14 tablets. The adult dose is one tablet each day and the usual treatment duration is 5 days.
Last Answer : c) Medicine C costs £20.00 for 25 tablets. The adult dose is one tablet twice a day and the usual treatment duration is 5 days.
Description : What is informed consent in a clinical trial? a) The subjects do not know which study treatment they receive b) Patients injected with placebo and active doses c) Fake treatment d) Signed document of the recruited patient for the clinical trial procedures
Last Answer : d) Signed document of the recruited patient for the clinical trial procedures
Description : Side effects of Valproic acid is ___________ a) Rhinitis b) Thrombocytopenia c) Hypothyroidism d) Confusion
Last Answer : b) Thrombocytopenia
Description : ___________ is indicated in agitation and restlessness in the elderly, despite the high incidence of extrapyramidal side-effects. a) Prochlorperazine b) Clozapine c) Haloperidol d) Flupentixol
Last Answer : c) Haloperidol
Description : Which of the following terms does not describe an Adverse Drug Reaction? a) Idiosyncrasy b) Anaphylaxis c) Teratogenic effect d) Placebo effect
Last Answer : d) Placebo effect
Description : Why should care be taken when prescribing warfarin and amiodarone in combination? A. Amiodarone and warfarin both have an anticoagulant effect. B. Amiodarone may reverse the anticoagulant ... anticoagulant effect of warfarin. D. Warfarin may reverse the antiarrhythmic effect of amiodarone.
Last Answer : C. Amiodarone may increase the anticoagulant effect of warfarin.
Description : Which of the following reaction is called Augmented adverse drug reactions? a) Genetically determined effects. b) Idiosyncracy. c) Rebound effect on discontinuation d) Allergic reactions & anaphylaxis.
Last Answer : c) Rebound effect on discontinuation
Description : In the treatment of parkinsonism, bromocriptine differs from levodopa in the following respects except: A. It does not need conversion to an active metabolite B. It has a longer duration of ... with little/antagonistic action on D1 receptors D. It does not produce behavioral/psychiatric side effect
Last Answer : D. It does not produce behavioral/psychiatric side effects
Description : What is the most important reason for restricted clinical use of chloramphenicol ? (a) Its narrow spectrum of activity (b) Emergence of chloramphenicol resistance (c) Its potential to cause bone marrow depression (d) Its potential to cause superinfections
Last Answer : Ans: C
Description : Palliation refers to a) relief of symptoms associated with cancer. Palliation is the goal for care in terminal cancer patients. b) hair loss. Alopecia is the term that refers to hair loss. c) ... the lowest point of white blood cell depression after therapy that has toxic effects on the bone marrow.
Last Answer : a) relief of symptoms associated with cancer. Palliation is the goal for care in terminal cancer patients.
Description : The most important toxicity of amphotericin B is: A. Nephrotoxicity B. Neurotoxicity C. Hepatotoxicity D. Bone marrow depression
Last Answer : A. Nephrotoxicity
Description : What are Good Clinical Practices? a. Regulations set in place by Government that how clinical trials are supposed to be managed. b. Clinical practices that adhere to the best standards of ... practice during clinical trials d. The FDA's requirements for how trials are conducted and documented
Last Answer : d. The FDA’s requirements for how trials are conducted and documented
Description : Organogenesis occurs during ______________stage. a) Pre-embryonic. b) Embryonic. c) Pre-Fetal. d) Fetal.
Last Answer : b) Embryonic.
Description : ___________ is contraindicated during pregnancy due to its Teratogenicity. a) Folic acid b) Calcium c) Retinol d) Iron
Last Answer : c) Retinol
Description : Which of the following statements best describes a lead compound? a) A compound that contains the element lead b) A compound from the research laboratory that is chosen to go forward for preclinical and ... of a drug. d) The first compound of a structural class of compounds to reach the market.
Last Answer : c) A molecule that shows some activity or property of interest and serves as the starting point for the development of a drug.
Description : Which of the following patients are at the highest risk of suffering from an adverse drug reaction? a) An 8 month year old infant receiving a prescription for an antibiotic. b) A 22 year old patient ... ACE Inhibitor. d) A 68 year old patient who has oedema receiving a prescription for a diuretic.
Last Answer : d) A 68 year old patient who has oedema receiving a prescription for a diuretic.
Description : Which of the following adverse drug reactions would you report to the Medicines and Healthcare Products regulatory Agency (MHRA) via the yellow card system for reporting? a) A patient ... started taking ramipril. d) A patient complains they have experienced diarrhoea since taking azilsartan.
Last Answer : d) A patient complains they have experienced diarrhoea since taking azilsartan.
Description : Pharmacovigilance is done for monitoring of a) Drug price b) Unethical practises c) Drug safety d) Pharmacy students
Last Answer : c) Drug safety
Description : Which of the following is Type B ADRS? a) Hypoglycaemia caused by Insulin b) Dryness of mouth caused by Atropine c) Anaemia in patient with G6PD deficiency caused by Primaquine d) Hyperglycaemia caused by thiazide diuretics
Last Answer : c) Anaemia in patient with G6PD deficiency caused by Primaquine
Description : Which of the following would you classify as a pharmacodynamics interaction? a) ACE inhibitors with potassium-sparing diuretics cause life-threatening hyperkalaemia b) Antacids reduce the absorption ... Increased bleeding due to cimetidine and warfarin d) Probenecid increases half-life of penicillin
Last Answer : a) ACE inhibitors with potassium-sparing diuretics cause life-threatening hyperkalaemia
Description : When tetracycline is given with antacids the absorption of tetracycline ----------------. a) Increases b) Decreases c) Minimally altered d) Not altered at all
Last Answer : b) Decreases
Description : Absorption of Griseofulvin increases with --------------diet. a) Carbohydrate b) Fatty c) protein d) vitamin
Last Answer : b) Fatty
Description : Gary baby syndrome occur in new born with a) Tetracycline b) Chloramphenicol c) Penicillin d) Erythromycin
Last Answer : b) Chloramphenicol
Description : Patient counselling helps to a) Know chemical structure of drug b) Develop business relations with pharmacist c) Motivate the patient to take medicine for improvement of his/her health status. d) Pass time at old age
Last Answer : c) Motivate the patient to take medicine for improvement of his/her health status.
Description : Which of the following drug is not needed to be TDM? a) Carbamazepine. b) Penicillin. c) Digoxin. d) Gentamicin.
Last Answer : b) Penicillin.
Description : Idiosyncrasy is_______________. a) Type A ADRs b) Type B ADRs c) Type C ADRs d) Type D ADRs
Last Answer : b) Type B ADRs
Description : A 75-year-old man had been receiving gentamicin (an aminoglycoside antibiotic) to treat an urinary tract infection. After three months of therapy patient's serum creatinine levels were 10 mg/ ... Type II allergic reaction b)Type III allergic reaction c) Pseudo allergic reaction d) Overdose toxicity
Last Answer : d) Overdose toxicity
Description : Which of the following is a technique pharmacists can use to humanize themselves to their patients? a) Using the patient's preferred name in conversation b) Delegating as many tasks as possible to an ... the text of a medication bottle verbatim to a patient d) Providing business cards at the desk
Last Answer : c) Reading the text of a medication bottle verbatim to a patient
Description : GCP provides public assurance that a) Rights and safety of participants are protected b) The rights, safety and wellbeing of research participants are protected and that research data are reliable. c) Results are reliable d) Safety of participant is observed and results are reliable
Last Answer : b) The rights, safety and wellbeing of research participants are protected and that research data are reliable.
Description : Which is person responsible for the conduct of the clinical trial at a trial site? a) Clinical Research Coordinator b) Monitor c) Investigator d) Sponsor
Last Answer : c) Investigator
Description : Cimetidine interacts with more drugs than ranitidine because; a) It is subjected to greater first pass metabolism b) It is a more potent enzyme inducer c) It is a more potent enzyme inhibitor d) It has better oral absorption
Last Answer : c) It is a more potent enzyme inhibitor
Description : The purpose of preclinical testing is: a. To verify that a drug is sufficiently safe and effective to be tested in humans. b. To undergo preliminary testing in healthy humans to monitor the ... for the larger scale future tests on a widespread population. d. To develop method of drug analysis
Last Answer : a. To verify that a drug is sufficiently safe and effective to be tested in humans.
Description : ______________ of clinical trial involves first time human trial in a small number of patients. a Phase I b Phase II c Phase III d Phase IV
Last Answer : a Phase I
Description : A 92-year-old woman is an inpatient in the geriatric unit. She has multivascular dementia. She is more confused and agitated. She has been given lorazepam 4 mg intramuscularly. She is now unconscious ... A. Activated charcoal B. Flumazenil C. N-acetyl cysteine D. Naloxone E. Protamine sulphate
Last Answer : B. Flumazenil
Description : Case control studies is called as A. Drug-oriented systems. B. Dose-oriented systems. C. Disease-oriented systems. D. Complication-oriented systems.
Last Answer : B. Dose-oriented systems.
Description : Which of the following medication is safe to use in the third trimester of pregnancy? A. Acetaminophen B. Warfarin C. Aspirin D. Oxycodone
Last Answer : A. Acetaminophen
Description : Which of the following antihypertensive agents should be avoided in the elderly patients? A. Amlodipine B. Atenolol C. Benazepril D. Methyldopa
Last Answer : D. Methyldopa
Description : How many people will be selected for phase II trial? a) The whole market will be under surveillance b) 500-3000 people c) 100-300 people d) 20-50 people
Last Answer : c) 100-300 people
Description : According to the principles of ICH GCP, what is the most important consideration when conducting a clinical trial? A. data accuracy B. protection of trial subjects C. Process adherence D. Statistical quality checks
Last Answer : B. protection of trial subjects
Description : Which of the following drug can result in result in cyanide poisoning? A. Amyl nitrite B. Hydroxycobalamine C. Sodium nitroprusside D. Sodium thiosulphate
Last Answer : C. Sodium nitroprusside
Description : The _______________ is the heart of the patient counselling session A) Preparing for the session. B) Opening the session. C) Counselling content. D) Closing the session.
Last Answer : C) Counselling content.
Description : How are prescription medicines different from OTC ones? A. They contain much smaller amounts of active ingredients B. They don't contain dyes or preservatives C. They're unsafe for use without medical supervision D. They can be toxic
Last Answer : C. They're unsafe for use without medical supervision
Description : Pharmaceutical equivalent that produce the same effects in patients A. Therapeutic equivalent B. Therapeutic window C. Minimum effective concentration (MEC) D. Minimum toxic concentration (MTC)
Last Answer : A. Therapeutic equivalent
Description : According to ICH GCP the investigator "should be qualified by........................... A. Training and experience B. Education, training and experience C. Education and experience D. Education and training
Last Answer : B. Education, training and experience