If you do not remove or clean the dirt inside the nails, then it is not possible to get rid of it. If you have dirt on your toes, take it out and keep it clean , and before you go to bed at night , after cleaning your toes, apply a little drop of cannula powder on the toes and drop 1 drop of dermasim , it will not cause pain and infection. In this way you will get good benefits if you give it for several days.