Bioavailability of drug refers to:
A. Percentage of administered dose that reaches
systemic circulation in the unchanged form
B. Ratio of oral to parenteral dose
C. Ratio of orally administered drug to that excreted in the faeces
D. Ratio of drug excreted unchanged in urine to
that excreted as metabolites

1 Answer

Answer :

A. Percentage of administered dose that reaches
systemic circulation in the unchanged form

Related questions

Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa

Last Answer : C. Altering gut flora

Description : Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to ... in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

Last Answer : A. Percentage of administered dose that reaches systemic circulation in the unchanged form

Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination

Last Answer : A. Have low oral bioavailability

Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination

Last Answer : A. Have low oral bioavailability

Description : 08. What does the term bioavailability mean? a) Plasma protein binding degree of substance b) Permeability through the brain-blood barrier c) Fraction of an uncharged drug reaching the systemic ... following any route administration d) Amount of a substance in urine relative to the initial doze

Last Answer : C

Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Last Answer : C. Is incompletely absorbed

Description : Bioavailability differences among oral formulations of a drug are most likely to occur if the drug: A. Is freely water soluble B. Is completely absorbed C. Is incompletely absorbed D. Undergoes little first-pass metabolism

Last Answer : C. Is incompletely absorbed

Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

Last Answer : D. Total body clearanc

Description : Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal

Last Answer : A. Oral

Description : Drug administered through the following route is most likely to be subjected to first-pass metabolism: A. Oral B. Sublingual C. Subcutaneous D. Rectal

Last Answer : A. Oral

Description : If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr

Last Answer : B. 2.0 L/hr

Description : A drug which is generally administered in standard doses without the need for dose individualization is: A. Insulin B. Mebendazole C. Prednisolone D. Digoxin

Last Answer : B. Mebendazole

Description : In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Last Answer : C. Orally administered diuretics may not be effective, but the same may work parenterally

Description : In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Last Answer : C. Orally administered diuretics may not be effective, but the same may work parenterally

Description : Which of the following drugs is administered by intranasal spray/application for systemic action: A. Phenylephrine B. Desmopressin C. Azelastine D. Beclomethasone dipropionate

Last Answer : B. Desmopressin

Description : Which of the following drugs is administered by intranasal spray/application for systemic action: A. Phenylephrine B. Desmopressin C. Azelastine D. Beclomethasone dipropionate

Last Answer : B. Desmopressin

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

Description : ‘Drug efficacy’ refers to: A. The range of diseases in which the drug is beneficial B. The maximal intensity of response that can be produced by the drug C. The dose of the drug needed to produce half maximal effect D. The dose of the drug needed to produce therapeutic effect

Last Answer : B. The maximal intensity of response that can be produced by the drug

Description : The following statement is not true of potency' of a drug: A. Refers to the dose of the drug needed to produce a certain degree of response B. Can be related to that of its congeners by ... consideration in the choice of a drug D. It reflects the capacity of the drug to produce a drastic response

Last Answer : D. It reflects the capacity of the drug to produce a drastic response

Description : ‘Drug efficacy’ refers to: A. The range of diseases in which the drug is beneficial B. The maximal intensity of response that can be produced by the drug C. The dose of the drug needed to produce half maximal effect D. The dose of the drug needed to produce therapeutic effect

Last Answer : B. The maximal intensity of response that can be produced by the drug

Description : The following statement is not true of potency' of a drug: A. Refers to the dose of the drug needed to produce a certain degree of response B. Can be related to that of its congeners by ... consideration in the choice of a drug D. It reflects the capacity of the drug to produce a drastic response

Last Answer : D. It reflects the capacity of the drug to produce a drastic response

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

Description : Weakly acidic drugs: A. Are bound primarily to α1 acid glycoprotein in plasma B. Are excreted faster in alkaline urine C. Are highly ionized in the gastric juice D. Do not cross blood-brain barrier

Last Answer : B. Are excreted faster in alkaline urine

Description : Fixed dose combination formulations are not necessarily appropriate for: A. Drugs administered in standard doses B. Drugs acting by the same mechanism C. Antitubercular drugs D. Antihypertensive drugs

Last Answer : B. Drugs acting by the same mechanism

Description : Maximum quantity of sodium is excreted through (A) Urine (B) Faeces (C) Sweat (D) None of these

Last Answer : Answer : A

Description : Cholesterol is excreted as such into ________. (A) Urine (B) Faeces (C) Bile (D) Tears FATS AND FATTY ACID METABOLISM 99

Last Answer : Answer : C

Description : Glycosuria is a condition where a man (a) Eats more sugar (b) Excretes sugar in urine (c) Sugar is excreted in faeces (d) Has low sugar level in blood

Last Answer : (b) Excretes sugar in urine

Description : The dose of the following class of drugs has to be adjusted by repeated measurement of the affected physiological parameter: A. Oral contraceptives B. Antiepileptics C. Antidepressants D. Oral anticoagulants

Last Answer : D. Oral anticoagulants

Description : A drug which produces qualitatively different actions when administered through different routes is: A. Phenytoin sodium B. Hydralazine C. Magnesium sulfate D. Nitroglycerine

Last Answer : C. Magnesium sulfate

Description : To be used as a topically applied ocular beta blocker a drug should have the following properties except: A. Strong local anaesthetic activity B. High lipophilicity C. High ocular capture D. Low systemic activity

Last Answer : A. Strong local anaesthetic activity

Description : The following allergic drug reaction is caused by circulating antibodies: A. Serum sickness B. Anaphylactic shock C. Systemic lupus erythematosus D. Angioedema

Last Answer : A. Serum sickness

Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%

Last Answer : (C) 12.5%

Description : The most commonly occurring conjugation reaction for drugs and their metabolites is: A. Glucuronidation B. Acetylation C. Methylation D. Glutathione conjugation

Last Answer : A. Glucuronidation

Description : A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Last Answer : C. An inactive drug that is transformed in the body to an active metabolite

Description : A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Last Answer : C. An inactive drug that is transformed in the body to an active metabolite

Description : Sustained/controlled release oral dosage form is appropriate for the following type of drug: A. An antiarthritic with a plasma half life of 24 hr B. A sleep inducing hypnotic with a plasma half life of ... 3 hours D. An analgesic with a plasma half life of 6 hours used for relief of casual headache

Last Answer : Microsomal enzyme induction has one of the following features: A. Takes about one week to develop B. Results in increased affinity of the enzyme for the substrate C. It is irreversible D. Can be used to treat acute drug poisonings

Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation

Description : Adrenaline is inactive orally because it is: A. Not absorbed from the gastrointestinal tract B. Destroyed by gastric acid C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation D. Taken up by adrenergic nerve endings of the intestinal wall, liver and lungs

Last Answer : C. Completely metabolized in the intestinal mucosa and liver before reaching systemic circulation

Description : Which of the following is not a primary/fundamental, but a derived pharmacokinetic parameter: A. Bioavailability B. Volume of distribution C. Clearance D. Plasma half life

Last Answer : D. Plasma half life

Description : Reflex bronchoconstriction is most likely to occur with the following form of inhaled antiasthma medication: A. Metered dose spray of drug in solution B. Dry powder rotacap C. Nebuliser D. Nebuliser with spacer

Last Answer : B. Dry powder rotacap

Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa

Last Answer : B. Altering gut motility

Description : Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa

Last Answer : B. Altering gut motility

Description : A ‘toxic effect’ differs from a ‘side effect’ in that: A. It is not a pharmacological effect of the drug B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication C. It must involve drug induced cellular injury D. It involves host defence mechanisms

Last Answer : B. It is a more intense pharmacological effect that occurs at high dose or after prolonged medication

Description : A drug which does not produce any action by itself but decreases the slope of the log dose-response curve and suppresses the maximal response to another drug is a: A. Physiological antagonist B. Competitive antagonist C. Noncompetitive antagonist D. Partial agonist

Last Answer : C. Noncompetitive antagonist

Description : A drug ‘R’ producing no response by itself causes the log dose-response curve of another drug ‘S’ to shift to the right in a parallel manner without decreasing the maximal response: Drug ‘R’ is a: A. Partial agonist B. Inverse agonist C. Competitive antagonist D. Noncompetitive antagonist

Last Answer : C. Competitive antagonist

Description : The therapeutic index of a drug is a measure of its: A. Safety B. Potency C. Efficacy D. Dose variability

Last Answer : A. Safety

Description : If the dose-response curves of a drug for producing different actions are widely separated on the dose axis, the drug is: A. Highly potent B. Highly efficacious C. Highly toxic D. Highly selective

Last Answer : D. Highly selective

Description : The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant

Last Answer : C. Volume of distribution

Description : When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after: A. 2–3 half lives B. 4–5 half lives C. 6–7 half lives D. 8–10 half lives

Last Answer : B. 4–5 half lives