A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

A prodrug is:
A. The prototype member of a class of drugs
B. The oldest member of a class of drugs
C. An inactive drug that is transformed in the
body to an active metabolite
D. A drug that is stored in body tissues and is then gradually released in the circulation
by

1 Answer

Answer :

C. An inactive drug that is transformed in the
body to an active metabolite
by

Related questions

A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

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Last Answer : C. An inactive drug that is transformed in the body to an active metabolite

The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of codeine into morphine C. Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

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Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamo

Which of the following is a prodrug: A. Hydralazine B. Clonidine C. Captopril D. Enalapril

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Last Answer : A. Percentage of administered dose that reaches systemic circulation in the unchanged form

Bioavailability of drug refers to: A. Percentage of administered dose that reaches systemic circulation in the unchanged form B. Ratio of oral to parenteral dose C. Ratio of orally administered drug to that excreted in the faeces D. Ratio of drug excreted unchanged in urine to that excreted as metabolites

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The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high

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Study of drug-receptor interaction has now shown that: A. Maximal response occurs only when all receptors are occupied by the drug B. Drugs exert an ‘all or none’ action on a receptor C. Receptor and drugs acting on it have rigid complementary ‘lock and key’ structural features D. Properties of ‘affinity’ and ‘intrinsic activity’ are independently variable

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What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

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Which of the following cytochrome P450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions: A. CYP 3A4 B. CYP 2C9 C. CYP 2E1 D. CYP 1A2

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Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

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Tricyclic antidepressants can alter the oral absorption of many drugs by: A. Complexing with the other drug in the intestinal lumen B. Altering gut motility C. Altering gut flora D. Damaging gut mucosa

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The most important factor which governs diffusion of drugs across capillaries other than those in the brain is: A. Blood flow through the capillary B. Lipid solubility of the drug C. pKa value of the drug D. pH of the medium

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The dose of the following class of drugs has to be adjusted by repeated measurement of the affected physiological parameter: A. Oral contraceptives B. Antiepileptics C. Antidepressants D. Oral anticoagulants

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A fixed dose combination preparation meant for internal use must not contain the following class of drug: A. Thiazide diuretic B. Fluoroquinolone antimicrobial C. Corticosteroid D. H2 blocker

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Monitoring of blood levels of diuretic drugs is not practised because: A. No sensitive methods for measuring blood levels of diuretics are available B. It is easier to measure the effect of these drugs C. Response to diuretics is not related to their blood levels D. Diuretics need activation in the body

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Last Answer : B. It is easier to measure the effect of these drugs

Which of the following drugs acts by inhibiting an enzyme in the body: A. Atropine B. Allopurinol C. Levodopa D. Metoclopramide

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Last Answer : B. Allopurinol

Monitoring of blood levels of diuretic drugs is not practised because: A. No sensitive methods for measuring blood levels of diuretics are available B. It is easier to measure the effect of these drugs C. Response to diuretics is not related to their blood levels D. Diuretics need activation in the body

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Last Answer : B. It is easier to measure the effect of these drugs

Fatty acids are a major energy source for the body. Which of the following statement(s) is/are true concerning the use of fatty acids as an energy source? a. Fatty acids are stored in adipocytes as triglycerides b. Hormone-sensitive lipase is present only in adipose tissue c. Fatty acids are released into the circulation traveling freely in plasma d. Approximately 25% of total nonprotein caloric needs supplied via total parenteral nutrition should be in the form of fat

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If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

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2 If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

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Last Answer : B. 80 L

If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

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If a drug is eliminated by first order kinetics: A. A constant amount of the drug will be eliminated per unit time B. Its clearance value will remain constant C. Its elimination half life will increase with dose D. It will be completely eliminated from the body in 2 × half life period

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Last Answer : B. Its clearance value will remain constant

If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μ g/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

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Last Answer : B. 80 L

If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr

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Last Answer : B. 2.0 L/hr

The mechanism by which neostigmine improves contraction of myasthenic muscle involves: A. Repetitive binding of the acetylcholine molecules to the same receptors at the muscle endplate B. Diffusion of acetylcholine released from motor nerve endings to a wider area activating neighbouring receptors C. Activation of motor end-plate receptors by neostigmine molecules themselves D. All of the above

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The most vulnerable period of pregnancy for the causation of foetal malformations due to drugs is: A. 18-55 days of gestation B. 56-84 days of gestation C. Second trimester D. 36 weeks onwards

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Last Answer : A. 18-55 days of gestation

In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

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Last Answer : C. Orally administered diuretics may not be effective, but the same may work parenterally

The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

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In patients of hepatic cirrhosis: A. The extent of change in pharmacokinetics of drugs can be predicted from the values of liver function tests B. High doses of furosemide can be safely used C. Metformin is the preferred oral hypoglycaemic D. Disposition of atenolol is not significantly affected

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Last Answer : D. Disposition of atenolol is not significantly affected

If the effect of combination of two drugs is equal to the sum of their individual effects, the two drugs are exhibiting: A. Potentiation B. Synergism C. Cross tolerance D. Antagonism

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