The principal action common to all class I antiarrhythmic drugs is: A. Na+ channel blockade B. K+ channel opening C. Depression of impulse conduction D. Prolongation of effective refractory period

The principal action common to all class I antiarrhythmic
drugs is:
A. Na+ channel blockade
B. K+ channel opening
C. Depression of impulse conduction
D. Prolongation of effective refractory period
by

1 Answer

Answer :

A. Na+ channel blockade
by

Related questions

The most significant feature of the antiarrhythmic action of lignocaine is: A. Suppression of phase-4 depolarization in ventricular ectopic foci B. Prolongation of action potential duration C. Prolongation of effective refractory period D. Depression of membrane responsiveness

Description : The most significant feature of the antiarrhythmic action of lignocaine is: A. Suppression of phase-4 depolarization in ventricular ectopic foci B. Prolongation of action potential duration C. Prolongation of effective refractory period D. Depression of membrane responsiveness

Last Answer : A. Suppression of phase-4 depolarization in ventricular ectopic foci

A resting nerve is relatively resistant to blockade by lignocaine compared to one which is repeatedly stimulated because: A. Lignocaine penetrates resting nerve membrane poorly B. Lignocaine binds more avidly to the inactivated Na+ channel C. Nerve impulse promotes ionization of lignocaine D. Nodes of Ranvier are inaccessible in the resting state

Description : A resting nerve is relatively resistant to blockade by lignocaine compared to one which is repeatedly stimulated because: A. Lignocaine penetrates resting nerve membrane poorly B. Lignocaine binds ... promotes ionization of lignocaine D. Nodes of Ranvier are inaccessible in the resting state

Last Answer : B. Lignocaine binds more avidly to the inactivated Na+ chan

The most probable mechanism of anticonvulsant action of phenytoin is: A. Facilitation of GABAergic inhibitory transmission B. Hyperpolarization of neurones C. Interaction with Ca2+ channels to promote Ca2+ influx D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

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Last Answer : D. Prolongation of voltage sensitive neuronal Na+ channel inactivation

yocardial Na+ channel blockade by lignocaine has the following characteristic: A. It blocks inactivated Na+ channels more than activated channels B. It blocks activated Na+ channels more than inactivated channels C. It delays rate of recovery of Na+ channels D. It produces more prominent blockade of atrial than ventricular Na+ channels

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Last Answer : A. It blocks inactivated Na+ channels more than activated channels

Lignocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because: A. It has a rapidly developing and titratable antiarrhythmic action B. It causes little myocardial depression and hypotension C. It has broad spectrum antiarrhythmic efficacy in atrial as well as ventricular arrhythmias D. Both ‘A’ and ‘B’ are correct

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Last Answer : D. Both ‘A’ and ‘B’ are correct

The following is not true of quinidine: A. It blocks myocardial Na+ channels primarily in the open state B. It has no effect on myocardial K+ channels C. It produces frequency dependent blockade of myocardial Na+ channels D. It delays recovery of myocardial Na+ channels

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The following statement about lithium is not correct: A. It has a sedative action in normal individuals B. It controls mania, but takes 1–2 weeks to produce the effect C. It has prophylactic effect in recurrent unipolar depression D. It can be combined with tricyclic antidepressants for refractory cases of major depression

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Choose the correct statement(s) about dofetilide: A. It is a pure class III antiarrhythmic B. It has no adrenergic/cholinergic receptor blocking property C. It selectively depresses the rapid component of delayed rectifier K+ current in myocardial fibres D. All of the above

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Last Answer : D. All of the above

The following is true of propafenone except: A. It is a weak Na+ channel blocker B. It markedly delays recovery of myocardial Na+ channels C. It has additional β-adrenergic blocking property D. It slows anterograde as well as retrograde conduction in the WPW bypass tract

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Last Answer : A. It is a weak Na+ channel blocker

Potassium therapy tends to counteract the cardiac toxicity of digitalis by: A. Reducing the affinity of sarcolemal Na+ K+ATPase for digitalis B. Suppressing ectopic automaticity enhanced by digitalis C. Promoting A-V conduction D. Both 'A' and 'B' are correct

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Last Answer : D. Both 'A' and 'B' are correct

At the muscle end-plate, d-tubocurarine reduces the: A. Number of Na+ channels B. Duration for which the Na+ channels remain open C. Ion conductance of the open Na+ channel D. Frequency of Na+ channel opening

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Which of the following drugs is a class III antiarrhythmic agent that is effective in the acute management of atrial fibrillation or atrial flutter of recent onset ? (a) Bretylium (b) Lbutilide (c) Metoprolol (d) Disopyramide

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Last Answer : Ans: B

Quinidine has the following action on electrophysiological properties of the heart except: A. Decreases automaticity of Purkinje fibres B. Abolishes after depolarizations C. Prolongs refractory period of atrial fibres D. Decreases membrane responsiveness of atrial and ventricular fibres

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Last Answer : B. Abolishes after depolarizations

The following action of digoxin is responsible for beneficial effect in auricular fibrillation: A. Increased myocardial contractility B. Suppression of SA node C. Depression of A-V conduction D. Enhanced Purkinje fibre automaticity

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A 70-year-old patient presented with weakness, tiredness and muscle cramps. The ECG showed Q-T prolongation, flattening of T wave and occasional A-V block. His serum K+ was low (2.8 mEq/L). He admitted taking a laxative every day for the past several months. Which laxative could be responsible for the above condition: A. Bisacodyl B. Liquid paraffin C. Methylcellulose D. Bran

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Which of the following drugs depresses automaticity of SA node as well as ectopic foci, abbreviates action potential duration of Purkinje fibres, and slows atrioventricular conduction: A. Propranolol B. Lignocaine C. Procainamide D. Bretylium

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The characteristic feature(s) of dihydropyridine calcium channel blockers is/are: A. They have minimal negative inotropic action on the heart B. They have no effect on A-V conduction C. They do not affect the activation-inactivation kinetics of the calcium channels D. All of the above

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During the propagation of a nerve impulse, the action potential results from the movement of (a) K+ ions from intracellular fluid to extracellular fluid (b) Na+ ions from extracellular fluid to intracellular fluid (c) K+ ions from extracellular fluid to intracellular fluid (d) Na+ ions from intracellular fluid to extracellular fluid.

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Choose the antiarrhythmic drug which prolongs action potential, can aggravate atrioventricular block but not heart failure, and has broad spectrum utility in acute as well as chronic, and ventricular as well as supraventricular arrhythmias: A. Quinidine B. Amiodarone C. Mexiletine D. Diltiazem

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The following antiarrhythmic drug has the most prominent anticholinergic action: A. Disopyramide B. Quinidine C. Procainamide D. Lignocaine

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Frequency dependent cardiac calcium channel blockade is exhibited by: A. Verapamil B. Nifedipine C. Felodipine D. Amlodipin

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The mechanism of action of barbiturates differs from that of benzodiazepines in that they: A. Do not affect the GABA-benzodiazepine receptor-chloride channel complex B. Act as inverse agonists at the benzodiazepine receptor C. Increase the frequency of chloride channel opening without affecting its life time D. Have both GABA-facilitatory as well as GABA-mimetic actions

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Choose the correct statement about long acting calcium channel blocking drugs as antihypertensives: A. They are the most effective drugs in suppressing hypertensive left ventricular hypertrophy B. They are as effective as diuretics or β blockers in reducing cardiovascular/total mortality C. They compromise quality of life more than β blockers D. They have no beneficial effect in hypertensive/diabetic nephropath

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Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl– cotransport in the ascending limb of loop of Henle C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone

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Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K

The positive inotropic action of digoxin takes several hours to develop because: A. Binding of digoxin to Na+K+ATPase is slow B. After Na+K+ATPase inhibition by digoxin, Ca2+ loading of myocardial fibres occurs progressively with each contraction C. Digoxin inhibits Na+K+ATPase through modification of gene function which takes time D. Both ‘A’ and ‘B’ are correc

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The following drugs exert their action through the GABAA-benzodiazepine–receptor Cl¯ channel complex except: A. Baclofen B. Zolpidem C. Bicuculline D. Phenobarbitone

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Lidocaine is the preferred antiarrhythmic for emergency control of cardiac arrhythmias following acute myocardial infarction because (a) It has a rapidly developing and titratable antiarrhythmic action (b) It casues little myocardial depression and hypotension (c) It has broad spectrum antiarrhythmic efficacy in atrial as well as ventricular arrhythmias (d) Both (a) and (b)

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Low concentration of bupivacaine is preferred for spinal / epidural obstetric analgesia because: A. It has a longer duration of action B. It can produce sensory blockade without paralysing abdominal muscles C. It distributes more in maternal tissues so that less reaches the foetus D. All of the above are correct

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Last Answer : D. All of the above are correct

Which of the following is not the reason for greater susceptibility of smaller sensory fibres to blockade by local anaesthetics than larger motor fibres: A. Sensory fibres are inherently more sensitive than motor fibres B. More slender fibres have shorter internodal distances C. Small sensory fibres generate higher frequency longer lasting action potential D. Smaller fibres have shorter critical lengths for blockade

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Last Answer : A. Sensory fibres are inherently more sensitive than motor fibres

Tolerance does not develop to the vasodilator action of sodium nitroprusside while it develops to glyceryl trinitrate because: A. Intact sod. nitroprusside molecule acts like nitric oxide B. Enzymes which generate nitric oxide from nitroprusside are different C. Sod. nitroprusside has a long duration of action D. Sod. nitroprusside has additional K+ channel opening action

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Last Answer : B. Enzymes which generate nitric oxide from nitroprusside are different

What is true of docetaxel: A. It is used as a reserve drug for refractory breast and ovarian cancer B. It is a selective estrogen receptor modulator used for breast cancer C. It is effective only in estrogen receptor positive breast cancer D. Both 'B' and 'C' are correct

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A patient has an episode of hematemesis following streptokinase infused for the treatment of deep vein thrombosis. Which of the following drugs would be most effective in controlling the bleeding episode: A. Vitamin K B. Noradrenaline C. Epsilon aminocaproic acid D. Rutin

Description : A patient has an episode of hematemesis following streptokinase infused for the treatment of deep vein thrombosis. Which of the following drugs would be most effective in controlling the bleeding episode: A. Vitamin K B. Noradrenaline C. Epsilon aminocaproic acid D. Rutin

Last Answer : C. Epsilon aminocaproic acid

Which of the following drugs is a class IV antiarrhythmic that is primarily indicated for the treatment of supraventricular tachyarrhythmias? (a) Lbutilide (b) Mexiletine (c) Diltiazem (d) Quinidine (e) Propranolol

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Last Answer : Ans: C

Digitalis induced increase in refractory period of myocardial fibres is most consistent and pronounced in the: A. Atria B. Ventricles C. A-V node D. Purkinje fibres

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Last Answer : C. A-V node

The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case

Description : The antiparkinsonian action of central anticholinergics has the following features except: A. They control tremor more than rigidity B. They produce a low ceiling therapeutic effect C. They are effective in neuroleptic drug induced parkinsonism D. They are the preferred drugs in advanced case

Last Answer : D. They are the preferred drugs in advanced cases

Epidural anaesthesia differs from spinal anaesthesia in that: A. Epidural anaesthesia produces less cardiovascular complications B. Headache is more common after epidural anaesthesia C. Blood concentrations of the local anaesthetic are lower after epidural anaesthesia D. Greater separation between sensory and motor blockade can be obtained with epidural anaesthes

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Last Answer : D. Greater separation between sensory and motor blockade can be obtained with epidural anaesthesia

Beneficial effect/effects of diuretics in CHF patients include the following: A. Symptomatic relief B. Regression of pathological changes C. Prolongation of life expectancy D. Both ‘A’ and ‘C’

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At therapeutic doses, actions of amphetamine include the following except: A. Prolongation of attention span B. Wakefulness C. Lowering of seizure threshold D. Delaying fatigue

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At therapeutic doses, actions of amphetamine include the following except: A. Prolongation of attention span B. Wakefulness C. Lowering of seizure threshold D. Delaying fatigue

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Which of the following statements is not correct? (a) An action potential in an axon does not move backward because the segment behind is in a refractory phase. (b) Depolarisation of hair cells of cochlea results in the opening of the mechanically gated potassium-ion channels. (c) Rods are very sensitive and contribute to daylight vision. (d) In the knee-jerk reflex, stimulus is the stretching of muscle and response is its contraction.

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Last Answer : (c) Rods are very sensitive and contribute to daylight vision.

The distinctive action of chlorpromazine like drugs not possessed by any other class of drugs is: A. Relief of anxiety without producing sedation B. Suppression of agressive behaviour C. Mood elevation in depressed patients D. Correction of distortions of thoug

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When a neuron is in resting state i.e., not conducting any impulse, the axonal membrane is (a) comparatively more permeable to Na+ ions and nearly impermeable to K+ ions (b) equally permeable to both Na+ and K+ ions (c) impermeable to both Na+ and K+ ions (d) comparatively more permeable to K+ ions and nearly impermeable to Na+ ions.

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Granisetron is a: A. Second generation antihistaminic B. Drug for peptic ulcer C. Antiemetic for cancer chemotherapy D. New antiarrhythmic drug

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Last Answer : C. Antiemetic for cancer chemotherapy

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Last Answer : D. Amiodarone

The limitations of quinidine in the treatment of cardiac arrhythmias include the following except: A. It has narrow spectrum antiarrhythmic activity B. It is not tolerated by many patients C. It can precipitate myocardial decompensation D. It can cause marked hypotension

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