Description : Beta adrenergic blockers lower intraocular tension by: A. Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adrenoceptors B. Constricting ciliary blood vessels ... action on trabecular meshwork D. Reducing aqueous formation unrelated to beta adrenoceptor mediation
Last Answer : A. Down regulating adenylyl cyclase in ciliary body through reduced activation of β2 adrenoceptors
Description : Digitalis is most suitable for treatment of CHF when it is due to: A. Cor pulmonale B. Arterio-venous shunt C. Thiamine deficiency D. Long-standing uncontrolled hypertension
Last Answer : D. Long-standing uncontrolled hypertensio
Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors
Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone
Description : The drug which produces vasoconstriction despite being an α adrenergic blocker is: A. Phenoxybenzamine B. Ergotamine C. Dihydroergotoxine D. Tolazoline
Last Answer : B. Ergotamine
Description : What vessel carries the venous blood to the lungs for oxygenation ? (1) Pulmonary arteries (2) Pulmonary veins (3) Pulmonary arterio-venous shunt (4) Right ventricle
Last Answer : Pulmonary arteries
Description : The following is true of propafenone except: A. It is a weak Na+ channel blocker B. It markedly delays recovery of myocardial Na+ channels C. It has additional β-adrenergic blocking property D. It slows anterograde as well as retrograde conduction in the WPW bypass tract
Last Answer : A. It is a weak Na+ channel blocker
Description : Procainamide differs from quinidine in the following respect(s): A. It does not cause paradoxical tachycardia B. It has no α adrenergic blocking activity C. It has little antivagal action D. Both ‘B’ and ‘C’ are corre
Last Answer : D. Both ‘B’ and ‘C’ are correct
Description : Procainamide differs from quinidine in the following respect(s): A. It does not cause paradoxical tachycardia B. It has no α adrenergic blocking activity C. It has little antivagal action D. Both ‘B’ and ‘C’ are correct
Description : The following drug claimed to have a therapeutic effect in senile dementia has α adrenergic blocking activity: A. Piracetam B. Pyritinol C. Codergocrine D. Methylphenidate
Last Answer : C. Codergocrine
Description : Labetalol has: A. More potent β adrenergic blocking than α blocking activity B. More potent α adrenergic blocking than β blocking activity C. Equal α and β adrenergic blocking activity D. β1 agonistic activity in addition to α and β adrenergic blockade
Last Answer : A. More potent β adrenergic blocking than α blocking activity
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve
Last Answer : C. Do not block any effect of injected adrenaline
Description : Adrenergic neurone blocking drugs: A. Block the action of adrenaline on neuronal α2 adrenoceptors B. Block both α and β adrenoceptor mediated effects of injected adrenaline C. Do not block any effect of injected adrenaline D. Do not block the effects of sympathetic nerve stimulation
Description : Olanzapine has the following features except: A. It is an antipsychotic drug with weak D2 receptor blocking action B. It has potent 5-HT2 blocking and antimuscarinic actions C. It lowers seizure threshold D. It produces prominent extrapyramidal side effects
Last Answer : D. It produces prominent extrapyramidal side effect
Description : The following antipsychotic drug has weak dopamine D2 but additional 5-HT2 blocking activity and benefits both positive and negative symptoms of schizophrenia: A. Loxapine B. Clozapine C. Pimozide D. Penfluridol
Last Answer : B. Clozapin
Description : What is true of risperidone: A. It is an atypical neuroleptic which produces few extrapyramidal side effects B. It has combined dopamine D2 and 5-HT2 receptor blocking activity C. It does not cause hyperprolactinemia D. Both 'A' and 'B' are correct
Last Answer : D. Both 'A' and 'B' are correct
Description : Compared to other antipsychotic drugs, the distinctive feature of penfluridol is: A. Very long duration of action B. Weak dopamine D2 blocking activity C. Lack of extrapyramidal side effects D. Additional 5-HT2 receptor blocking activity
Last Answer : A. Very long duration of action
Description : Rapid intravenous injection of clonidine causes rise in BP due to: A. Stimulation of vasomotor centre B. Release of noradrenaline from adrenergic nerve endings C. Agonistic action on vascular α2 adrenergic receptors D. Cardiac stimulation
Last Answer : C. Agonistic action on vascular α2 adrenergic receptors
Description : Finasteride acts by: A. Blocking testosterone receptors in the prostate gland B. Reducing testosterone secretion from testes C. Reducing LH secretion from pituitary D. Lowering circulating as well as prostatic dihydrotestosterone concentration
Last Answer : D. Lowering circulating as well as prostatic dihydrotestosterone concentration
Description : The nonsteroidal antiinflammatory drugs are more effective in migraine: A. Without aura B. With aura C. Than ergotamine D. When combined with propranolol
Last Answer : A. Without aura
Description : All of the following are true about neurogenic shock except: A. There is a decrease in systemic vascular resistance and an increase in venous capacitance. B. Tachycardia or bradycardia may be ... Severe head injury, spinal cord injury, and high spinal anesthesia may all cause neurogenic shock.
Last Answer : Answer: C DISCUSSION: Neurogenic shock occurs when severe head injury, spinal cord injury, or pharmacologic sympathetic blockade leads to sympathetic denervation and loss of vasomotor tone. ... of treatment. The use of alpha-adrenergic agonist is infrequently necessary to treat neurogenic shock
Description : Select the action of vasopressin exerted through the V1 subtype receptors: A. Release of coagulation factor VIII and von Willebrands factor from vascular endothelium B. Increased peristalsis of gut C. Dilatation of blood vessels D. Increased water permeability of renal collecting ducts
Last Answer : B. Increased peristalsis of gut
Description : Dihydroergotamine (DHE) differs from ergotamine in the following respect: A. It is a more potent oxytocic B. It has antiemetic property C. It has high oral bioavailability D. It is a more potent α adrenergic blocker and less potent vasoconstrictor
Last Answer : D. It is a more potent α adrenergic blocker and less potent vasoconstrictor
Description : Choose the ergot alkaloid that is well absorbed orally, has weak vascular but prominent uterine stimulant action: A. Ergometrine B. Ergotamine C. Dihydroergotamine D. Dihydroergotoxine
Last Answer : A. Ergometrine
Description : Choose the correct statement(s) about dofetilide: A. It is a pure class III antiarrhythmic B. It has no adrenergic/cholinergic receptor blocking property C. It selectively depresses the rapid component of delayed rectifier K+ current in myocardial fibres D. All of the above
Last Answer : D. All of the above
Description : Which of the following is a long acting neuroleptic having specific antidopaminergic action, but little adrenergic or cholinergic blocking activity: A. Triflupromazine B. Thioridazine C. Clozapine D. Pimozide
Last Answer : D. Pimozide
Description : Procainamide differs from quinidine in the following respect (a) It does not cause paradoxical tachycardia (b) It has no alfa adrenergic blocking activity (c) It has little antivagal action (d) Both (b ... a) Pacemaker function (b) Resting potential (c) Action potential duration (d) All of the above
Last Answer : Ans: D
Description : Blood flow in the following vascular bed generally decreases under the influence of glyceryl trinitrate: A. Coronary B. Cutaneous C. Renal D. Cranial
Last Answer : C. Renal
Description : The following vascular bed is constricted by caffeine: A. Coronary B. Cutaneous C. Cranial D. Mesenteric
Last Answer : C. Cranial
Description : The primary reason for preferring phentolamine as the α adrenergic blocker for performing diagnostic test for pheochromocytoma is: A. It produces rapid and short lasting α-adrenergic blockade B. It equally ... It is the most potent α blocker D. It has no additional β adrenergic blocking property
Last Answer : A. It produces rapid and short lasting α-adrenergic blockade
Description : Select the β -adrenergic blocker that has additional α 1 blocking, vasodilator and antioxidant properties: A. Carvedilol B. Celiprolol C. Acebutolol D. Metoprolol
Last Answer : A. Carvedilol
Description : Strychnine produces convulsions by: A. Stimulating NMDA receptors B. Facilitating the excitatory transmitter glutamate C. Blocking the inhibitory transmitter GABA D. Blocking the inhibitory transmitter glycine
Last Answer : D. Blocking the inhibitory transmitter glycine
Description : Choose the correct statement about lamotrigine: A. It is a dopaminergic agonist used in parkinsonism B. It acts by blocking NMDA-type of glutamate receptors C. It is a broad spectrum antiepileptic drug D. It suppresses tonic-clonic seizures, but worsens absence seizures
Last Answer : C. It is a broad spectrum antiepileptic drug
Description : Neuromuscular blocking drugs do not produce central actions because: A. They do not cross the blood-brain barrier B. Nicotinic receptors are not present in the brain C. They are sequestrated in the periphery by tight binding to the skeletal muscles D. They do not ionise at the brain pH
Last Answer : A. They do not cross the blood-brain barrier
Description : Which of the following is not the basis for subclassifying β adrenergic receptors into β1 and β2 : A. Selectivity of agonists B. Selectivity of antagonists C. Transducer pathway of response effectuation D. Organ selective location
Last Answer : C. Transducer pathway of response effectuation
Description : Which of the following is not the basis for subclassifying β adrenergic receptors into β 1 and β 2: A. Selectivity of agonists B. Selectivity of antagonists C. Transducer pathway of response effectuation D. Organ selective location
Description : Intravenous furosemide promptly mitigates dyspnoea in acute left ventricular failure by: A. Producing bronchodilatation B. Causing rapid diuresis and reducing circulating blood volume C. Increasing venous capacitance and reducing cardiac preload. D. Stimulating left ventricular contractility
Last Answer : C. Increasing venous capacitance and reducing cardiac preload.
Description : Norepinephrine binds mainly to (A) α-Adrenergic receptors (B) β-Adrenergic receptrors (C) Muscarinic receptors (D) Nicotinic receptors
Last Answer : Answer : A
Description : Tyrosine kinase activity is present in (A) α-Adrenergic receptors (B) β-Adrenergic receptors (C) Cholinergic receptors (D) Insulin receptors
Last Answer : Answer : D
Description : Dopaminergic D1 and D2 as well as adrenergic α and β1, but not β2 receptors are activated by: A. Dopamine B. Dobutamine C. Methoxamine D. Phenylephrine
Last Answer : A. Dopamine
Description : Dopaminergic D1 and D2 as well as adrenergic α and β 1, but not β 2 receptors are activated by: A. Dopamine B. Dobutamine C. Methoxamine D. Phenylephrine
Description : Which of the following terms refers to enlarged, red, and tender lymph nodes? a) Lymphadenitis Acute lymphadenitis is demonstrated by enlarged, red and tender lymph nodes. b) Lymphangitis ... refers to a condition in which chronic swelling of the extremity recedes only slightly with elevation.
Last Answer : a) Lymphadenitis Acute lymphadenitis is demonstrated by enlarged, red and tender lymph nodes.
Description : Amiloride inhibits K+ excretion in the distal tubules and collecting ducts by blocking: A. Electrogenic K+ channels B. Electrogenic Na+ channels C. Nonelectrogenic Na+-Cl– symport D. H+K+ATPase
Last Answer : B. Electrogenic Na+ channels
Description : e primary mechanism by which general anaesthetics produce their action is: A. Affecting receptor operated ion channels in cerebral neurones B. Blocking voltage sensitive Na+ channels in neuronal ... activity of cerebral neurones D. Blocking production of high energy phosphates in the brain
Last Answer : A. Affecting receptor operated ion channels in cerebral neurones
Description : Local anaesthetics block nerve conduction by: A. Blocking all cation channels in the neuronal membrane B. Hyperpolarizing the neuronal membrane C. Interfering with depolarization of the neuronal membrane D. Both ‘B’ and ‘C’ are correct
Last Answer : C. Interfering with depolarization of the neuronal membrane
Description : 6.12 The most prominent action of bromocriptine is: A. Dopamine D2 agonism B. Dopamine D2 antagonism C. Dopamine D1 antagonism D. α adrenergic antagonism
Last Answer : A. Dopamine D2 agonism
Description : Prazosin is an effective antihypertensive while nonselective α adrenergic blockers are not because: A. It is the only orally active α blocker B. It improves plasma lipid profile C. It does not concurrently enhance noradrenaline release D. It improves urine flow in males with prostatic hypertrophy
Last Answer : C. It does not concurrently enhance noradrenaline release
Description : Vasomotor reversal phenomenon after administration of an α adrenergic blocker is seen with: A. Adrenaline B. Noradrenaline C. Isoprenaline D. All of the above drugs
Last Answer : A. Adrenaline