2 If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

2 If the total amount of a drug present in the body at a
given moment is 2.0 g and its plasma concentration is
25 μg/ml, its volume of distribution is:
A. 100 L
B. 80 L
C. 60 L
D. 50 L
by

1 Answer

Answer :

B. 80 L
by

Related questions

If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

Description : If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

Last Answer : B. 80 L

If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μ g/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

Description : If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μ g/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L

Last Answer : B. 80 L

The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L

Description : The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L

Last Answer : (A)10 L

The plasma protein bound fraction of a drug: A. Contributes to the response at the given moment B. Remains constant irrespective of the total drug concentration C. Remains constant irrespective of the disease state D. Is not available for metabolism unless actively extracted by the liver

Description : The plasma protein bound fraction of a drug: A. Contributes to the response at the given moment B. Remains constant irrespective of the total drug concentration C. Remains constant irrespective of the disease state D. Is not available for metabolism unless actively extracted by the liver

Last Answer : D. Is not available for metabolism unless actively extracted by the liver

The plasma protein bound fraction of a drug: A. Contributes to the response at the given moment B. Remains constant irrespective of the total drug concentration C. Remains constant irrespective of the disease state D. Is not available for metabolism unless actively extracted by the liver

Description : The plasma protein bound fraction of a drug: A. Contributes to the response at the given moment B. Remains constant irrespective of the total drug concentration C. Remains constant irrespective of the disease state D. Is not available for metabolism unless actively extracted by the liver

Last Answer : D. Is not available for metabolism unless actively extracted by the liver

The plasma protein bound fraction of a drug: A. Contributes to the response at the given moment B. Remains constant irrespective of the total drug concentration C. Remains constant irrespective of the disease state D. Is not available for metabolism unless actively extracted by the liver

Description : The plasma protein bound fraction of a drug: A. Contributes to the response at the given moment B. Remains constant irrespective of the total drug concentration C. Remains constant irrespective of the disease state D. Is not available for metabolism unless actively extracted by the liver

Last Answer : D. Is not available for metabolism unless actively extracted by the liver

If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

Last Answer : D. Total body clearanc

If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr

Description : If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr

Last Answer : B. 2.0 L/hr

The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant

Description : The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant

Last Answer : C. Volume of distribution

The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding

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Last Answer : C. High plasma protein binding

The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding

Description : The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding

Last Answer : C. High plasma protein binding

The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant

Description : The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant

Last Answer : C. Volume of distribution

The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding

Description : The following attribute of a drug tends to reduce its volume of distribution: A. High lipid solubility B. Low ionisation at physiological pH values C. High plasma protein binding D. High tissue binding

Last Answer : C. High plasma protein binding

High plasma protein binding: A. Increases volume of distribution of the drug B. Facilitates glomerular filtration of the drug C. Minimises drug interactions D. Generally makes the drug long acting

Description : High plasma protein binding: A. Increases volume of distribution of the drug B. Facilitates glomerular filtration of the drug C. Minimises drug interactions D. Generally makes the drug long acting

Last Answer : D. Generally makes the drug long acting

High plasma protein binding: A. Increases volume of distribution of the drug B. Facilitates glomerular filtration of the drug C. Minimises drug interactions D. Generally makes the drug long acting

Description : High plasma protein binding: A. Increases volume of distribution of the drug B. Facilitates glomerular filtration of the drug C. Minimises drug interactions D. Generally makes the drug long acting

Last Answer : D. Generally makes the drug long acting

High plasma protein binding: A. Increases volume of distribution of the drug B. Facilitates glomerular filtration of the drug C. Minimises drug interactions D. Generally makes the drug long acting

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Last Answer : D. Generally makes the drug long acting

When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after: A. 2–3 half lives B. 4–5 half lives C. 6–7 half lives D. 8–10 half lives

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Last Answer : B. 4–5 half lives

If the clearance of a drug remains constant, doubling the dose rate will increase the steady-state plasma drug concentration by a factor of: A. × 3 B. × 2 C. × 1.5 D. × 1.3

Description : If the clearance of a drug remains constant, doubling the dose rate will increase the steady-state plasma drug concentration by a factor of: A. × 3 B. × 2 C. × 1.5 D. × 1.3

Last Answer : B. × 2

Transdermal drug delivery systems offer the following advantages except: A. They produce high peak plasma concentration of the drug B. They produce smooth and nonfluctuating plasma concentration of the drug C. They minimise interindividual variations in the achieved plasma drug concentration D. They avoid hepatic first-pass metabolism of the drug

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Monitoring plasma drug concentration is useful while using: A. Antihypertensive drugs B. Levodopa C. Lithium carbonate D. MAO inhibitors

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When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after: A. 2–3 half lives B. 4–5 half lives C. 6–7 half lives D. 8–10 half lives

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Last Answer : B. 4–5 half lives

If the clearance of a drug remains constant, doubling the dose rate will increase the steady-state plasma drug concentration by a factor of: A. × 3 B. × 2 C. × 1.5 D. × 1.3

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Last Answer : B. × 2

Transdermal drug delivery systems offer the following advantages except: A. They produce high peak plasma concentration of the drug B. They produce smooth and nonfluctuating plasma concentration of the drug C. They minimise interindividual variations in the achieved plasma drug concentration D. They avoid hepatic first-pass metabolism of the drug

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Which of the following is not a primary/fundamental, but a derived pharmacokinetic parameter: A. Bioavailability B. Volume of distribution C. Clearance D. Plasma half life

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Last Answer : D. Plasma half life

The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed

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Liquid "X" is at equilibrium with its vapor in a cylinder and piston apparatus. When the volume of the space above the liquid is 50 ml and the temperature 25!, the vapor pressure of "X" is 120 torr. What will the vapor pressure of "X" be when the volume above the liquid is 100 ml and the temperature 25!C? Some liquid is always present. w) 30 torr x) 60 torr y) 120 torr z) 240 torr

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Last Answer : ANSWER: Y -- 120 TORR

The normal serum concentration of 24,25- dihydroxycholecalciferol in ng/ml is (A) 8–20 (B) 25–50 (C) 1–5 (D) 60–100

Description : The normal serum concentration of 24,25- dihydroxycholecalciferol in ng/ml is (A) 8–20 (B) 25–50 (C) 1–5 (D) 60–100

Last Answer : Answer : C

The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

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The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

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In the resting state plasma concentration of cortisol is (A) 0.4–2.0 µg/100 ml (B) 2.0–4.0 µg/100 ml (C) 5.0–15.0 µg/100 ml (D) 18.0–25.0 µg/100 ml

Description : In the resting state plasma concentration of cortisol is (A) 0.4–2.0 µg/100 ml (B) 2.0–4.0 µg/100 ml (C) 5.0–15.0 µg/100 ml (D) 18.0–25.0 µg/100 ml

Last Answer : Answer : C

Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Last Answer : B. Plasma protein binding

A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Description : A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Last Answer : D. Redistribution

Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Description : Glomerular filtration of a drug is affected by its: A. Lipid solubility B. Plasma protein binding C. Degree of ionization D. Rate of tubular secretion

Last Answer : B. Plasma protein binding

A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of its action: A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

Description : A nonvolatile, highly lipid soluble drug is metabolized at a rate of 15% per hour. On intravenous injection it produces general anaesthesia for 10 min. Which process is responsible for termination of ... : A. Metabolism in liver B. Plasma protein binding C. Excretion by kidney D. Redistribution

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Sustained/controlled release oral dosage form is appropriate for the following type of drug: A. An antiarthritic with a plasma half life of 24 hr B. A sleep inducing hypnotic with a plasma half life of 2 hours C. An antihypertensive with a plasma half life of 3 hours D. An analgesic with a plasma half life of 6 hours used for relief of casual headache

Description : Sustained/controlled release oral dosage form is appropriate for the following type of drug: A. An antiarthritic with a plasma half life of 24 hr B. A sleep inducing hypnotic with a plasma half life of ... 3 hours D. An analgesic with a plasma half life of 6 hours used for relief of casual headache

Last Answer : Microsomal enzyme induction has one of the following features: A. Takes about one week to develop B. Results in increased affinity of the enzyme for the substrate C. It is irreversible D. Can be used to treat acute drug poisonings

It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg

Description : It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg

Last Answer : (B) 300 mg

If a drug is eliminated by first order kinetics: A. A constant amount of the drug will be eliminated per unit time B. Its clearance value will remain constant C. Its elimination half life will increase with dose D. It will be completely eliminated from the body in 2 × half life period

Description : If a drug is eliminated by first order kinetics: A. A constant amount of the drug will be eliminated per unit time B. Its clearance value will remain constant C. Its elimination half life will increase with dose D. It will be completely eliminated from the body in 2 × half life period

Last Answer : B. Its clearance value will remain constant

If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance

Last Answer : D. Total body clearance

Deuterium oxide and inulin are injected into a normal 30-year-old man. The volume of distribution of deuterium oxide is found to be 42 L and that of inulin 14 L. a. The man’s intracellular fluid volume is about 14 L. b. The man’s intracellular fluid volume is about 28 L. c. The man’s plasma volume is about 7 L. d. The man’s interstitial fluid volume is about 9 L. e. The man’s total body water cannot be calculated from these data

Description : Deuterium oxide and inulin are injected into a normal 30-year-old man. The volume of distribution of deuterium oxide is found to be 42 L and that of inulin 14 L. a. The man's intracellular fluid ... fluid volume is about 9 L. e. The man's total body water cannot be calculated from these data

Last Answer : The man’s intracellular fluid volume is about 28 L.

In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Description : In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Last Answer : C. Orally administered diuretics may not be effective, but the same may work parenterally

In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Description : In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Last Answer : C. Orally administered diuretics may not be effective, but the same may work parenterally

The normal serum concentration of 25-hydroxycholecalciferol in ng/ml is (A) 0–8 (B) 60–100 (C) 100–150 (D) 8–55

Description : The normal serum concentration of 25-hydroxycholecalciferol in ng/ml is (A) 0–8 (B) 60–100 (C) 100–150 (D) 8–55

Last Answer : Answer : D

The normal serum concentration of 1,25- dihydroxycholecalciferol in pg/ml is (A) 26–65 (B) 1–5 (C) 5–20 (D) 80–100

Description : The normal serum concentration of 1,25- dihydroxycholecalciferol in pg/ml is (A) 26–65 (B) 1–5 (C) 5–20 (D) 80–100

Last Answer : Answer : A

Which of the following constitutes ‘drug abuse’: A. Physician prescribed use of penicillin G for the cure of viral fever B. Self administration of aspirin to relieve headache C. Repeated self administration of morphine to derive euphoria D. All of the above

Description : Which of the following constitutes ‘drug abuse’: A. Physician prescribed use of penicillin G for the cure of viral fever B. Self administration of aspirin to relieve headache C. Repeated self administration of morphine to derive euphoria D. All of the above

Last Answer : D. Differ from each other in the degree of attendant psychological dependence

The daily dietary requirement of vit B12 by an adult is: A. 1-3 μg B. 50-100 μg C. 0.1-0.5 mg D. 1-3 mg

Description : The daily dietary requirement of vit B12 by an adult is: A. 1-3 μg B. 50-100 μg C. 0.1-0.5 mg D. 1-3 mg

Last Answer : A. 1-3 μg

The amount of lime, `Ca(OH)_(2)` required to remove the hardness in 60 L of pond water containing 1.62 mg of calcium bicarbonate per 100 ml of water,

Description : The amount of lime, `Ca(OH)_(2)` required to remove the hardness in 60 L of pond water containing 1.62 mg of calcium bicarbonate per 100 ml of water,

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The circulating concentration of ACTH in plasma is (A) 0.05 mµ/100 ml (B) 0.1–2.0 mµ/100 ml (C) 2.5–3.5 mµ/100 ml (D) 3.0–5.0 mµ/100 ml

Description : The circulating concentration of ACTH in plasma is (A) 0.05 mµ/100 ml (B) 0.1–2.0 mµ/100 ml (C) 2.5–3.5 mµ/100 ml (D) 3.0–5.0 mµ/100 ml

Last Answer : Answer : B

What would be the heart rate of a person if the cardiac output is 5 L, blood volume in the ventricles at the end of diastole is 100 mL and at the end of ventricular systole is 50 mL ? (a) 125 beats per minute (b) 50 beats per minute (c) 75 beats per minute (d) 100 beats per minute

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Last Answer : (d) 100 beats per minute

The normal serum concentration of ceruloplasmin in mg/100 ml varies between (A) 5–10 (B) 10–20 (C) 25–43 (D) 50–100

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Last Answer : Answer : C

A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Description : A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Last Answer : C. An inactive drug that is transformed in the body to an active metabolite