Description : The Volume of distribution of a drug administered at a dose of 300 mg and exhibiting 30 microgram/mL instantaneous concentration in plasma shall be (A)10 L (B) 100 L (C) 1.0 L (D) 0.10 L
Last Answer : (A)10 L
Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%
Last Answer : (C) 12.5%
Description : Sustained/controlled release oral dosage form is appropriate for the following type of drug: A. An antiarthritic with a plasma half life of 24 hr B. A sleep inducing hypnotic with a plasma half life of ... 3 hours D. An analgesic with a plasma half life of 6 hours used for relief of casual headache
Last Answer : C. An antihypertensive with a plasma half life of 3 hours
Last Answer : Microsomal enzyme induction has one of the following features: A. Takes about one week to develop B. Results in increased affinity of the enzyme for the substrate C. It is irreversible D. Can be used to treat acute drug poisonings
Description : The characteristic of non-linear pharmacokinetics include : (A) Area under the curve is proportional to the dose (B) Elimination half-life remains constant, (C) Area under the curve is not proportional to the dose (D) Amount of drug excreted through remains constant
Last Answer : (C) Area under the curve is not proportional to the dose
Description : Which one of the following is the commonly used bulking agent in the formulation of freeze dried low dose drug products? (A) Sodium chloride (B) Mannitol (C) Starch (D) HPMC
Last Answer : (B) Mannitol
Description : The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed
Last Answer : B. Drug metabolizing enzymes are immature
Description : If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr
Last Answer : B. 2.0 L/hr
Description : 3.0 ml of raw sewage is diluted to 300 ml. The D.O. concentration of the diluted sample at the beginning of the test was 8 mg/l. After 5 dayincubation at 20°C, the D.O. concentration was 5 mg/l. The BOD of raw sewerage is A. 100 mg/l B. 200 mg/l C. 300 mg/l D. 400 mg/l
Last Answer : ANS: C
Description : In the mixing of thymol and menthol the following type of incompatibility occurs : (A) Chemical incompatibility (B) Therapeutic incompatibility (C) Physical incompatibility (D) Tolerance incompatibility
Last Answer : (C) Physical incompatibility
Description : regarding paracetamol toxicity: - Not toxic if dose exceed 150-180 mg - Cause vomiting and neuropathy - Therapeutic effect after 4 hours - Use Deferoxamine -the liver enzyme reach the max. Level 4-6 hours after ingestion
Last Answer : the liver enzyme reach the max. Level 4-6 hours after ingestion
Description : How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL
Last Answer : (c) 1250 mL
Description : What quantities of 95 % v/v and 45 % v/v alcohols are to be mixed to make 800 mL of 65 % v/v alcohol? (A) 480 mL of 95 % and 320 mL of 45 % alcohol (B) 320 mL of 95 % and 480 mL of 45 % alcohol (C) 440 mL of 95 % and 360 mL of 45 % alcohol (D)360 mL of 95 % and 440 mL of 45 % alcohol
Last Answer : (B) 320 mL of 95 % and 480 mL of 45 % alcohol
Description : The amount of lime, `Ca(OH)_(2)` required to remove the hardness in 60 L of pond water containing 1.62 mg of calcium bicarbonate per 100 ml of water,
Last Answer : The amount of lime, `Ca(OH)_(2)` required to remove the hardness in 60 L of pond water containing 1.62 mg of ... 0.222g` C. `2.22 g` D. `0.444 g`
Description : One mg of Lycopodium spores used in quantitative microscopy contains an average of (A) 94,000 spores (B) 92,000 spores (C) 90,000 spores (D) 91,000 spores
Last Answer : (A) 94,000 spores
Description : If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L
Last Answer : B. 80 L
Description : 2 If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L
Description : If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μ g/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L
Description : Aliskiren acts by (A) inhibiting the conversion of Angiotensin I to II (B) inhibiting the release of rennin (C) inhibiting the binding of Angiotensin II to the receptor (D) inhibiting the action of aldosterone
Last Answer : (B) inhibiting the release of rennin
Description : In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm
Last Answer : (A) 350 nm
Description : ‘Drug efficacy’ refers to: A. The range of diseases in which the drug is beneficial B. The maximal intensity of response that can be produced by the drug C. The dose of the drug needed to produce half maximal effect D. The dose of the drug needed to produce therapeutic effect
Last Answer : B. The maximal intensity of response that can be produced by the drug
Description : Relatively higher dose of theophylline is required to attain therapeutic plasma concentration in: A. Smokers B. Congestive heart failure patients C. Those receiving erythromycin D. Those receiving cimetidine
Last Answer : A. Smokers
Description : The normal serum of concentration of copper in mg/100 ml varies between (A) 0–5 (B) 50–100 (C) 100–200 (D) 200–300
Last Answer : Answer : C
Description : The normal serum concentration of vitamin A in mg/100 ml is (A) 5–10 (B) 15–60 (C) 100–150 (D) 0–5
Last Answer : Answer : B
Description : The normal concentration of chlorine in mg/100 ml of C.S.F is about (A) 200 (B) 250 (C) 300 (D) 440
Last Answer : Answer : D
Description : The rate limiting step in cholesterol biosynthesis is one of the followings : (A) LDL-receptor concentration (B) VLDL secretion (C) Mevalonic acid formation (D) Co-enzyme A formation
Last Answer : (C) Mevalonic acid formation
Description : Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome positive patients with Chronic myeloid Leukemia? (A) Pentostatin (B) Methotrexate (C) Imatinib (D) L-Asparaginase
Last Answer : (C) Imatinib
Description : The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C
Last Answer : (D) temperature between 2c C and S: C
Description : Nicotinic action of acetylcholine is blocked by the drug (A) Atropine (B) Carvedilol (C) Neostigmine ( D ) d-Tubocurarine
Last Answer : ( D ) d-Tubocurarine
Description : Measurement of inulin renal clearance is a measure for (A) Effective renal blood flow (B) Renal drug excretion rate (C) Active renal secretion (D) Glomerular filtration rate
Last Answer : (D) Glomerular filtration rate
Description : Which one of the following is a flocculating agent for a negatively charged drug? (A) Aluminium chloride (B) Bentonite (C) Tragacanth (D) Sodium biphosphate
Last Answer : (A) Aluminium chloride
Description : Identify the drug which is NOT used in the treatment of malaria caused by Plasmodium falciparum : (A.) Artemisinin (B) Primaquine (C) Quinine (D) Mefloquine
Last Answer : (B) Primaquine
Description : The regimen(s) used for postcoital emergency contraception is/are: A. Levonorgestrel 0.5 mg + ethinylestradiol 0.1 mg taken twice 12 hour apart B. Levonorgestrel 0.75 mg taken twice 12 hour apart C. Mifepristone 600 mg single dose D. All of the abov
Last Answer : D. All of the abov
Description : A girl is walking at a speed of 15 km/hr along a railway track. If she is 600 m ahead of the train which is 300 m long and runs at a speed of 180 km/hr in same direction, then what is the time required to pass a girl? A) 19.63sec B) 32sec C) 8.2sec D) 28.3sec
Last Answer : ANSWER:A Explanation: Speed of a girl = 15 km/hr speed of train = 180 km/hr By using the condition, The speed values of train and the moving object are subtracted if they are moving in same ... /45.83 = 19.63 Hence the time taken by the train to cross the girl is 19.63seconds
Description : When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after: A. 2–3 half lives B. 4–5 half lives C. 6–7 half lives D. 8–10 half lives
Last Answer : B. 4–5 half lives
Description : The therapeutic effect of sulfasalazine in ulcerative colitis is exerted by: A. Inhibitory action of the unabsorbed drug on the abnormal colonic flora B. Breakdown of the drug in ... locally C. Release of sulfapyridine having antibacterial property D. Systemic immunomodulatory action of the drug
Last Answer : B. Breakdown of the drug in colon to release 5-aminosalicylic acid which suppresses inflammation locally
Description : If a bus keeps moving at 60 km/hr, how many hours will it take for the bus to travel the 600 km distance from Manila to Sorsogon?
Last Answer : 10 hours
Description : Lead concentration in blood is considered alarming if it is (a) 20 mg / 100 mL (b) 30 mg / 100 mL (c) 4 - 6 mg / 100 mL (d) 10 mg / 100 mL.
Last Answer : (b) 30 mg / 100 mL
Description : The concentration of Total Dissolved Solids (TDS) in drinking water should not exceed (A) 500 mg/L (B) 400 mg/L (C) 300 mg/L (D) 200 mg/L
Last Answer : (A) 500 mg/L
Description : The product of serum calcium concentration (mg/dl) and serum inorganic phosphorous concentration (mg/dl) in children is about (A) 30 (B) 40 (C) 50 (D) 60
Description : The product of serum calcium concentration (mg/dl) and serum inorganic phosphorous concentration (mg/dl) in adults is about (A) 30 (B) 40 (C) 50 (D) 60
Last Answer : Answer : A
Description : As per the world health organisation (WHO) specification, the maximum permissible concentration (i.e., TLV) of particulate matter in air is __________ μg/m3 .(μg-microgram) (A) 10 (B) 90 (C) 800 (D) 750
Last Answer : (B) 90
Description : Which of the following statement(s) is/are true concerning the management of a patient with hemophilia A undergoing an elective surgical operation? a. Concentrates of factor VIII should be given ... observed e. A new recombinant preparation of factor VIII offers the advantage of being virus-free
Last Answer : Answer: b, c, e Although the half-life of factor VIII is 2.9 days in normal individuals, the half-life of factor VIII concentrates is 9 to l8 hours. Levels of 80% to ... infection in the hemophilia population. A new recombinant preparation of factor VIII offers the advantage of being virus-free
Description : What is the potential difference between 10sinθcosφ/r 2 at A(1,30,20) and B(4,90,60)? a) 2.386 b) 3.386 c) 4.386 d) 5.386
Last Answer : c) 4.386
Description : The principles of antihypertensive drug usage enunciated in JNC VI and WHO-ISH guidelines include the following except: A. Therapy for grade I and II hypertension should be initiated with a single drug ... initially fails to lower BP, it should be replaced by a drug/combination from another class
Last Answer : C. All subjects with BP higher than 140/90 mmHg should be put on antihypertensive medication immediately
Description : _____ is when an antimicrobial drug should harm the infectious agent but not the host. a. Selective toxicity b. Toxic dose c. Therapeutic dose d. Chemotherapeutic index
Last Answer : a. Selective toxicity
Description : The following drug/drugs does/do not produce any overt CNS effect in normal individuals but exert(s) clear cut therapeutic effect at the same dose in the presence of a specific neurological/psychiatric disorder: A. Chlorpromazine B. Levodopa C. Imipramine D. All of the above
Last Answer : B. Levodopa
Description : Benzodiazepines differ from barbiturates in the following aspects except: A. They have a steeper dose response curve B. They have higher therapeutic index C. They have lower abuse liability D. They do not induce microsomal drug metabolizing enzymes
Last Answer : A. They have a steeper dose response curve