Description : It is required to maintain a therapeutic concentration of 10 microgram/mL for 12 hours of a drug having half life of 1.386 hr and Vd of 5 L. The dose required in a sustained release product will be (A) 600 mg (B) 300 mg (C) 30 mg (D) 60 mg
Last Answer : (B) 300 mg
Description : A drug (200 mg dose) administered in tablet form and as intravenous injection (50 mg dose) showed AUG of 100 and 200 microgram hr/mL, respectively. The absolute availability of the drug through oral administration is : (A) 125% (B) 250 % (C) 12.5% (D) 1.25%
Last Answer : (C) 12.5%
Description : If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L
Last Answer : B. 80 L
Description : 2 If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μg/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L
Description : If the total amount of a drug present in the body at a given moment is 2.0 g and its plasma concentration is 25 μ g/ml, its volume of distribution is: A. 100 L B. 80 L C. 60 L D. 50 L
Description : 3.0 ml of raw sewage is diluted to 300 ml. The D.O. concentration of the diluted sample at the beginning of the test was 8 mg/l. After 5 dayincubation at 20°C, the D.O. concentration was 5 mg/l. The BOD of raw sewerage is A. 100 mg/l B. 200 mg/l C. 300 mg/l D. 400 mg/l
Last Answer : ANS: C
Description : Which one of the following is the commonly used bulking agent in the formulation of freeze dried low dose drug products? (A) Sodium chloride (B) Mannitol (C) Starch (D) HPMC
Last Answer : (B) Mannitol
Description : The characteristic of non-linear pharmacokinetics include : (A) Area under the curve is proportional to the dose (B) Elimination half-life remains constant, (C) Area under the curve is not proportional to the dose (D) Amount of drug excreted through remains constant
Last Answer : (C) Area under the curve is not proportional to the dose
Description : The plasma half life of penicillin-G is longer in the new born because their: A. Plasma protein level is low B. Drug metabolizing enzymes are immature C. Glomerular filtration rate is low D. Tubular transport mechanisms are not well developed
Last Answer : B. Drug metabolizing enzymes are immature
Description : If a drug is excreted in urine at the rate of 10 mg/hr at a steady-state plasma concentration of 5 mg/L, then its renal clearance is: A. 0.5 L/hr B. 2.0 L/hr C. 5.0 L/hr D. 20 L/hr
Last Answer : B. 2.0 L/hr
Description : The normal serum of concentration of copper in mg/100 ml varies between (A) 0–5 (B) 50–100 (C) 100–200 (D) 200–300
Last Answer : Answer : C
Description : The normal concentration of chloride in mg/100 ml of plasma is about (A) 100 (B) 200 (C) 365 (D) 450
Description : The normal concentration of sodium (in mg/100 ml) of human plasma is (A) 100 (B) 200 (C) 250 (D) 330
Last Answer : Answer : D
Description : The normal concentration of chlorine in mg/100 ml of C.S.F is about (A) 200 (B) 250 (C) 300 (D) 440
Description : The loading dose of a drug is governed by its: A. Renal clearance B. Plasma half life C. Volume of distribution D. Elimination rate constant
Last Answer : C. Volume of distribution
Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance
Last Answer : D. Total body clearance
Last Answer : D. Total body clearanc
Description : Lead concentration in blood is considered alarming if it is (a) 20 mg / 100 mL (b) 30 mg / 100 mL (c) 4 - 6 mg / 100 mL (d) 10 mg / 100 mL.
Last Answer : (b) 30 mg / 100 mL
Description : How many mL of a 1:500 w/v stock solution should be used to make 5 liters of 1:2000 w/v solution? (A) 750 mL (B) 1000 mL (c) 1250 mL (D) 1500 mL
Last Answer : (c) 1250 mL
Description : What quantities of 95 % v/v and 45 % v/v alcohols are to be mixed to make 800 mL of 65 % v/v alcohol? (A) 480 mL of 95 % and 320 mL of 45 % alcohol (B) 320 mL of 95 % and 480 mL of 45 % alcohol (C) 440 mL of 95 % and 360 mL of 45 % alcohol (D)360 mL of 95 % and 440 mL of 45 % alcohol
Last Answer : (B) 320 mL of 95 % and 480 mL of 45 % alcohol
Description : One mg of Lycopodium spores used in quantitative microscopy contains an average of (A) 94,000 spores (B) 92,000 spores (C) 90,000 spores (D) 91,000 spores
Last Answer : (A) 94,000 spores
Description : The formula to calculate maximum urea clearance is U V× B , where U denotes (A) Concentration of urea in urine in gm/24hr (B) Concentration of urea in urine in mg/100 ml (C) Concentration of urea in blood in mg/100 ml (D) Volume of urine in ml/mt
Last Answer : Answer : B
Description : Which of the following statements are true of a patient with hyperglycemia and hyponatremia? A. The sodium concentration must be corrected by 5 mEq. per 100 mg. per 100 ml. elevation in blood ... . E. Early in treatment adequate urine output is a reliable measure of adequate volume resuscitation.
Last Answer : Answer: D DISCUSSION: Each 100-mg. per 100 ml. elevation in blood glucose causes a fall in serum sodium concentration of approximately 2 mEq. per liter. Excess serum glucose ... correction of the patient's associated acidosis produce movement of potassium ions into the intracellular compartment
Description : Rabies vaccine (living) is prepared using (A) Sheep blood (B) Mice lymph (C) Horse plasma (D) Fertile eggs
Last Answer : (D) Fertile eggs
Description : In organic molecules, fluorescence seldom results from absorption of UV radiation of wavelengths lower than (A) 350 nm (B) 200 nm (C) 300 nm (D) 250 nm
Last Answer : (A) 350 nm
Description : The normal serum concentration of vitamin A in mg/100 ml is (A) 5–10 (B) 15–60 (C) 100–150 (D) 0–5
Description : The rate limiting step in cholesterol biosynthesis is one of the followings : (A) LDL-receptor concentration (B) VLDL secretion (C) Mevalonic acid formation (D) Co-enzyme A formation
Last Answer : (C) Mevalonic acid formation
Description : Which one of the following drugs is prescribed for the treatment of Philadelphia chromosome positive patients with Chronic myeloid Leukemia? (A) Pentostatin (B) Methotrexate (C) Imatinib (D) L-Asparaginase
Last Answer : (C) Imatinib
Description : The temperature condition for storage of drug products under cold temperature is given as : (A) temperature between 8°C and 25°C (B) temperature below 20 C (C) temperature at 0°C (D) temperature between 2c C and S: C
Last Answer : (D) temperature between 2c C and S: C
Description : Nicotinic action of acetylcholine is blocked by the drug (A) Atropine (B) Carvedilol (C) Neostigmine ( D ) d-Tubocurarine
Last Answer : ( D ) d-Tubocurarine
Description : Measurement of inulin renal clearance is a measure for (A) Effective renal blood flow (B) Renal drug excretion rate (C) Active renal secretion (D) Glomerular filtration rate
Last Answer : (D) Glomerular filtration rate
Description : Which one of the following is a flocculating agent for a negatively charged drug? (A) Aluminium chloride (B) Bentonite (C) Tragacanth (D) Sodium biphosphate
Last Answer : (A) Aluminium chloride
Description : Identify the drug which is NOT used in the treatment of malaria caused by Plasmodium falciparum : (A.) Artemisinin (B) Primaquine (C) Quinine (D) Mefloquine
Last Answer : (B) Primaquine
Description : When the same dose of a drug is repeated at half life intervals, the steady-state (plateau) plasma drug concentration is reached after: A. 2–3 half lives B. 4–5 half lives C. 6–7 half lives D. 8–10 half lives
Last Answer : B. 4–5 half lives
Description : Coulter counter is used in determination of (A) particle surface area (B) particle size (C) particle volume (D)all of A, B, C
Last Answer : (D)all of A, B, C
Description : The normal concentration of calcium in C.S.F is (A) 1.5–2.5 mg/100 ml (B) 2.5–4 mg/100 ml (C) 4.5–5 mg/100 ml (D) 9–10 mg/100 ml
Description : The normal serum concentration of ceruloplasmin in mg/100 ml varies between (A) 5–10 (B) 10–20 (C) 25–43 (D) 50–100
Description : Deuterium oxide and inulin are injected into a normal 30-year-old man. The volume of distribution of deuterium oxide is found to be 42 L and that of inulin 14 L. a. The man's intracellular fluid ... fluid volume is about 9 L. e. The man's total body water cannot be calculated from these data
Last Answer : The man’s intracellular fluid volume is about 28 L.
Description : The normal concentration of magnesium in whole blood is (A) 0–1 mg/100 ml (B) 1–2 mg/100 ml (C) 2–4 mg/100 ml (D) 4–8 mg/100 ml
Description : Class 100 area is referred to (A) Manufacturing area (B) Aseptic area (C) Clean room (D) Ware house
Last Answer : (B) Aseptic area
Description : In the resting state plasma concentration of cortisol is (A) 0.4–2.0 µg/100 ml (B) 2.0–4.0 µg/100 ml (C) 5.0–15.0 µg/100 ml (D) 18.0–25.0 µg/100 ml
Description : The circulating concentration of ACTH in plasma is (A) 0.05 mµ/100 ml (B) 0.1–2.0 mµ/100 ml (C) 2.5–3.5 mµ/100 ml (D) 3.0–5.0 mµ/100 ml
Description : If the clearance of a drug remains constant, doubling the dose rate will increase the steady-state plasma drug concentration by a factor of: A. × 3 B. × 2 C. × 1.5 D. × 1.3
Last Answer : B. × 2
Description : The concentration of Total Dissolved Solids (TDS) in drinking water should not exceed (A) 500 mg/L (B) 400 mg/L (C) 300 mg/L (D) 200 mg/L
Last Answer : (A) 500 mg/L
Description : The normal content of protein bound iron (PBI) in the plasma of males is (A) 120–140 µg/100 ml (B) 200–300 µg/100 ml (C) 120–140 µg/100 ml (D) 200–300 µg/100 ml
Last Answer : Answer : A
Description : As per the world health organisation (WHO) specification, the maximum permissible concentration (i.e., TLV) of particulate matter in air is __________ μg/m3 .(μg-microgram) (A) 10 (B) 90 (C) 800 (D) 750
Last Answer : (B) 90
Description : The normal concentration of chloride in mg/100 ml of whole blood is about (A) 200 (B) 250 (C) 400 (D) 450