The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of codeine into morphine C. Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of codeine into morphine C. Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine
by

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Answer :

A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamo
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The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of codeine into morphine C. Its altered form is responsible for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

Description : The following is not true of the cytochrome P450 isoenzyme CYP2D6: A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol B. It is involved in demethylation of ... for poor capacity to hydroxylate many drugs including metoprolol D. It is inhibited by quinidine

Last Answer : A. It generates the hepatotoxic metabolite N-acetyl benzoquinone immine from paracetamol

Which of the following cytochrome P450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions: A. CYP 3A4 B. CYP 2C9 C. CYP 2E1 D. CYP 1A2

Description : Which of the following cytochrome P450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions: A. CYP 3A4 B. CYP 2C9 C. CYP 2E1 D. CYP 1A2

Last Answer : A. CYP 3A4

N-acetyl cysteine is beneficial in acute paracetamol poisoning because: A. It reacts with paracetamol to form a nontoxic complex B. It inhibits generation of the toxic metabolite of paracetamol C. It is a free radical scavenger D. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

Description : N-acetyl cysteine is beneficial in acute paracetamol poisoning because: A. It reacts with paracetamol to form a nontoxic complex B. It inhibits generation of the toxic metabolite of ... scavenger D. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

Last Answer : D. It replenishes hepatic glutathione which in turn binds the toxic metabolite of paracetamol

Which of the following cytochrome P450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions: A. CYP 3A4 B. CYP 2C9 C. CYP 2E1 D. CYP 1A2

Description : Which of the following cytochrome P450 isoenzymes is involved in the metabolism of largest number of drugs in human beings and has been implicated in some dangerous drug interactions: A. CYP 3A4 B. CYP 2C9 C. CYP 2E1 D. CYP 1A2

Last Answer : A. CYP 3A4

The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it can cause systemic lupus erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine

Description : The following is true of procainamide except: A. It generates an active metabolite in the body B. Its plasma half-life is longer than that of quinidine C. On long-term use, it ... erythematosus like illness D. It is effective in many cases of ventricular extrasystoles, not responding to lignocaine

Last Answer : A. Disopyramide

The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues

Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is (a) It is not inhibited by indomethacin (b) It is inducible (c) It generates cytoprotective prostagladins in gastric mucosa (d) It is found only in foetal tissues

Last Answer : Ans: B

The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues

Description : The distinctive feature of the isoenzyme cyclooxygenase-2 is: A. It is not inhibited by indomethacin B. It is inducible C. It generates cytoprotective prostagladins in gastric mucosa D. It is found only in foetal tissues

Last Answer : B. It is inducible

A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Description : A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Last Answer : C. An inactive drug that is transformed in the body to an active metabolite

A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Description : A prodrug is: A. The prototype member of a class of drugs B. The oldest member of a class of drugs C. An inactive drug that is transformed in the body to an active metabolite D. A drug that is stored in body tissues and is then gradually released in the circulation

Last Answer : C. An inactive drug that is transformed in the body to an active metabolite

3 Diffusion of drugs across cell membrane: A. Is dependent upon metabolic activity of the cell B. Is competitively inhibited by chemically related drugs C. Is affected by extent of ionization of drug molecules D. Exhibits saturation kinetics

Description : 3 Diffusion of drugs across cell membrane: A. Is dependent upon metabolic activity of the cell B. Is competitively inhibited by chemically related drugs C. Is affected by extent of ionization of drug molecules D. Exhibits saturation kinetics

Last Answer : C. Is affected by extent of ionization of drug molecules

Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Last Answer : C. Diazepam (pentobarbitone)

Which of the following drugs is most likely to be absorbed from the stomach: A. Morphine sulfate B. Diclofenac sodium C. Hyoscine hydrobromide D. Quinine dihydrochloride

Description : Which of the following drugs is most likely to be absorbed from the stomach: A. Morphine sulfate B. Diclofenac sodium C. Hyoscine hydrobromide D. Quinine dihydrochloride

Last Answer : B. Diclofenac sodium

Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Description : Compared to the drug named within parenthesis, which of the following drugs has a higher potency but lower efficacy: A. Pethidine (morphine) B. Furosemide (hydrochlorothiazide) C. Diazepam (pentobarbitone) D. Enalapril (captopril)

Last Answer : C. Diazepam (pentobarbitone)

Which of the following drugs is most likely to be absorbed from the stomach: A. Morphine sulfate B. Diclofenac sodium C. Hyoscine hydrobromide D. Quinine dihydrochloride

Description : Which of the following drugs is most likely to be absorbed from the stomach: A. Morphine sulfate B. Diclofenac sodium C. Hyoscine hydrobromide D. Quinine dihydrochloride

Last Answer : B. Diclofenac sodium

Which one of the following statements about cytochrome P450 is wrong? (a) It is a coloured cell. (b) It is an enzyme involved in oxidation reactions. (c) It has an important role in metabolism. (d) It contains iron

Description : Which one of the following statements about cytochrome P450 is wrong? (a) It is a coloured cell. (b) It is an enzyme involved in oxidation reactions. (c) It has an important role in metabolism. (d) It contains iron

Last Answer : (a) It is a coloured cell.

The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin

Description : The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin

Last Answer : A. Constipation caused by codeine

The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin

Description : The side effect of a drug which has been used as a therapeutic effect in another condition is: A. Constipation caused by codeine B. Cough caused by captopril C. Uterine stimulation caused by quinine D. Diarrhoea caused by ampicillin

Last Answer : A. Constipation caused by codeine

Which of the following adverse drug reactions is due to a specific genetic abnormality: A. Tetracycline induced sunburn like skin lesions B. Quinidine induced thrombocytopenia C. Metoclopramide induced muscle dystonia D. Primaquine induced massive haemolysis

Description : Which of the following adverse drug reactions is due to a specific genetic abnormality: A. Tetracycline induced sunburn like skin lesions B. Quinidine induced thrombocytopenia C. Metoclopramide induced muscle dystonia D. Primaquine induced massive haemolysis

Last Answer : D. Primaquine induced massive haemolysis

Which of the following constitutes ‘drug abuse’: A. Physician prescribed use of penicillin G for the cure of viral fever B. Self administration of aspirin to relieve headache C. Repeated self administration of morphine to derive euphoria D. All of the above

Description : Which of the following constitutes ‘drug abuse’: A. Physician prescribed use of penicillin G for the cure of viral fever B. Self administration of aspirin to relieve headache C. Repeated self administration of morphine to derive euphoria D. All of the above

Last Answer : D. Differ from each other in the degree of attendant psychological dependence

Which of the following is an idiosyncratic adverse drug reaction: A. Muscle dystonia caused by triflupromazine B. Insomnia after taking pentobarbitone C. Precipitation of asthma by morphine D. Gum hyperplasia caused by phenytoin

Description : Which of the following is an idiosyncratic adverse drug reaction: A. Muscle dystonia caused by triflupromazine B. Insomnia after taking pentobarbitone C. Precipitation of asthma by morphine D. Gum hyperplasia caused by phenytoin

Last Answer : B. Insomnia after taking pentobarbitone

Significant tolerance does not develop to the following action of morphine: A. Analgesia B. Euphoria C. Sedation D. Miosis

Description : Significant tolerance does not develop to the following action of morphine: A. Analgesia B. Euphoria C. Sedation D. Miosis

Last Answer : D. Miosis

Cytochrome P450 is: a. involves in phase I metabolic reactions b. found in lysosomes c. found in hepatocytes d. found in mitochondria

Description : Cytochrome P450 is: a. involves in phase I metabolic reactions b. found in lysosomes c. found in hepatocytes d. found in mitochondria

Last Answer : found in hepatocytes

Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above

Description : Many xenobiotics are oxidized by cytochrome P450 in order to (A) increase their biological activity (B) increase their disposition in lipophilic compartments of the body (C) increase their aqueous solubility (D) all of the above

Last Answer : (D) all of the above

The polyene antibiotics act by: A. Inhibiting fungal cytochrome P450 enzyme B. Binding to ergosterol and creating micropores in fungal cell membrane C. Inhibiting fungal DNA synthesis D. Disorienting microtubules in fungal cells

Description : The polyene antibiotics act by: A. Inhibiting fungal cytochrome P450 enzyme B. Binding to ergosterol and creating micropores in fungal cell membrane C. Inhibiting fungal DNA synthesis D. Disorienting microtubules in fungal cells

Last Answer : B. Binding to ergosterol and creating micropores in fungal cell membrane

The distinctive features of azithromycin include the following except: A. Efficacy against organisms which have developed resistance to erythromycin B. Marked tissue distribution and intracellular penetration C. Long terminal elimination half-life D. Low propensity to drug interactions due to inhibition of cytochrome P450 enzymes

Description : The distinctive features of azithromycin include the following except: A. Efficacy against organisms which have developed resistance to erythromycin B. Marked tissue distribution and intracellular penetration ... D. Low propensity to drug interactions due to inhibition of cytochrome P450 enzymes

Last Answer : A. Efficacy against organisms which have developed resistance to erythromycin

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood

Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage of lipid soluble drugs into the brain C. It limits entry of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Description : Which of the following is not true of the blood-brain barrier: A. It is constituted by tight junctions between the endothelial cells of brain capillaries and the glial tissue B. It allows passage ... of highly ionized drugs into the brain D. It regulates passage of substances from brain into blood

Last Answer : D. It regulates passage of substances from brain into blood

The metabolite which sustains urea cycle is (A) Ornithine (B) Citrulline (C) Carbamoyl phosphate (D) n-acetyl glutamate

Description : The metabolite which sustains urea cycle is (A) Ornithine (B) Citrulline (C) Carbamoyl phosphate (D) n-acetyl glutamate

Last Answer : Answer : C

The following statement is not true of carbamazepine: A. It generates an active metabolite B. Its plasma half life decreases to nearly half of the original value after chronic use C. It is being used in mania D. It is not effective in complex partial seizures

Description : The following statement is not true of carbamazepine: A. It generates an active metabolite B. Its plasma half life decreases to nearly half of the original value after chronic use C. It is being used in mania D. It is not effective in complex partial seizures

Last Answer : D. It is not effective in complex partial seizures

The following statement is true in relation to ‘drug toxicity’ and ‘poisoning’: A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning

What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Last Answer : C. Agonists induce a conformational change in the receptoR

The following statement is true in relation to ‘drug toxicity’ and ‘poisoning’: A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Description : The following statement is true in relation to drug toxicity' and poisoning': A. The two terms are synonymous B. When a toxic effect requires specific treatment, it is called poisoning C. ... is called poisoning D. Toxicity is caused by drugs while poisoning is caused by other harmful chemicals

Last Answer : C. A toxic effect which endangers life by markedly affecting vital functions is called poisoning

What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Description : What is true in relation to drug receptors: A. All drugs act through specific receptors B. All drug receptors are located on the surface of the target cells C. Agonists induce a conformational change in the receptor D. Partial agonists have low affinity for the receptor

Last Answer : C. Agonists induce a conformational change in the receptor

The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling

Description : The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling

Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine

The following statement is not true of ‘potency’ of a drug: A. Refers to the dose of the drug needed to produce a certain degree of response B. Can be related to that of its congeners by the relative position of its dose-response curve on the dose axis C. It is often not a major consideration in the choice of a drug D. It reflects the capacity of the drug to produce a drastic response

Description : The following statement is not true of potency' of a drug: A. Refers to the dose of the drug needed to produce a certain degree of response B. Can be related to that of its congeners by ... consideration in the choice of a drug D. It reflects the capacity of the drug to produce a drastic response

Last Answer : D. It reflects the capacity of the drug to produce a drastic response

The following statement is not true of ‘potency’ of a drug: A. Refers to the dose of the drug needed to produce a certain degree of response B. Can be related to that of its congeners by the relative position of its dose-response curve on the dose axis C. It is often not a major consideration in the choice of a drug D. It reflects the capacity of the drug to produce a drastic response

Description : The following statement is not true of potency' of a drug: A. Refers to the dose of the drug needed to produce a certain degree of response B. Can be related to that of its congeners by ... consideration in the choice of a drug D. It reflects the capacity of the drug to produce a drastic response

Last Answer : D. It reflects the capacity of the drug to produce a drastic response

Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Description : Biotransformation of drugs is primarily directed to: A. Activate the drug B. Inactivate the drug C. Convert lipid soluble drugs into nonlipid soluble metabolites D. Convert nonlipid soluble drugs into lipid soluble metabolites

Last Answer : C. Convert lipid soluble drugs into nonlipid soluble metabolites

The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Description : The blood-brain barrier, which restricts entry of many drugs into brain, is constituted by: A. P-glycoprotein efflux carriers in brain capillary cells B. Tight junctions between endothelial cells of brain capillaries C. Enzymes present in brain capillary walls D. All of the above

Last Answer : D. All of the above

Opium alkaloids are: (1) Codeine (2) Diethyllysergic acid (3) Morphine (4) Saffron

Description : Opium alkaloids are: (1) Codeine (2) Diethyllysergic acid (3) Morphine (4) Saffron

Last Answer : Ans. ((d))

Choose the correct statement about codeine: A. It has a lower oral: parenteral activity ratio than morphine B. It is devoid of abuse liability C. It is a weaker analgesic than morphine D. It is a more potent antitussive than morphine

Description : Choose the correct statement about codeine: A. It has a lower oral: parenteral activity ratio than morphine B. It is devoid of abuse liability C. It is a weaker analgesic than morphine D. It is a more potent antitussive than morphine

Last Answer : C. It is a weaker analgesic than morphine

Which of the following antitubercular drugs is not hepatotoxic: A. Isoniazid B. Rifampicin C. Pyrazinamide D. Ethambutol

Description : Which of the following antitubercular drugs is not hepatotoxic: A. Isoniazid B. Rifampicin C. Pyrazinamide D. Ethambutol

Last Answer : D. Ethambutol

Out of morphine, N-Acetyl-para-aminophenol, Diazepam and tetrahydrocatenol, which can be used as analgesic without causing addiction ?

Description : Out of morphine, N-Acetyl-para-aminophenol, Diazepam and tetrahydrocatenol, which can be used as analgesic without causing addiction ?

Last Answer : Ans. N-Acetyl-para-aminophenol. 

All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive

Description : All the following statements about acetyl CoA carboxylase are true except: (A) It is activated by citrate (B) It is inhibited by palmitoyl CoA (C) It can undergo covalent modification (D) Its dephosphorylated form is inactive

Last Answer : Answer : D

The most vulnerable period of pregnancy for the causation of foetal malformations due to drugs is: A. 18-55 days of gestation B. 56-84 days of gestation C. Second trimester D. 36 weeks onwards

Description : The most vulnerable period of pregnancy for the causation of foetal malformations due to drugs is: A. 18-55 days of gestation B. 56-84 days of gestation C. Second trimester D. 36 weeks onwards

Last Answer : A. 18-55 days of gestation

In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Description : In congestive heart failure patients: A. Volume of distribution of all drugs is increased B. Hepatic clearance of drugs is unaffected C. Orally administered diuretics may not be effective, but the same may work parenterally D. Inotropic action of digoxin is attenuated

Last Answer : C. Orally administered diuretics may not be effective, but the same may work parenterally

The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Description : The following statement is not correct for uremic patients: A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened B. Pethidine can cause seizures C. Diazepam produces exaggerated CNS depression D. Tetracyclines further raise blood urea level

Last Answer : A. Attainment of steady-state plasma concentration of drugs eliminated through the kidney is hastened

In patients of hepatic cirrhosis: A. The extent of change in pharmacokinetics of drugs can be predicted from the values of liver function tests B. High doses of furosemide can be safely used C. Metformin is the preferred oral hypoglycaemic D. Disposition of atenolol is not significantly affected

Description : In patients of hepatic cirrhosis: A. The extent of change in pharmacokinetics of drugs can be predicted from the values of liver function tests B. High doses of furosemide can be safely used C. Metformin is the preferred oral hypoglycaemic D. Disposition of atenolol is not significantly affected

Last Answer : D. Disposition of atenolol is not significantly affected

The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high

Description : The pharmacokinetics of drugs in the neonate differs from that in adults, because their: A. Intestinal transit is fast B. Drug metabolizing enzymes are overactive C. Tubular transport mechanisms are not well developed D. Glomerular filtration rate is high

Last Answer : C. Tubular transport mechanisms are not well developed