The corticosteroid preferred for replacement therapy in Addison’s disease is: A. Aldosterone B. Fludrocortisone C. Hydrocortisone D. Betamethasone

The corticosteroid preferred for replacement therapy
in Addison’s disease is:
A. Aldosterone
B. Fludrocortisone
C. Hydrocortisone
D. Betamethasone
by

1 Answer

Answer :

C. Hydrocortisone
by

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A 15-year-old girl was seen by her family physician because of increasing lethargy. She had a recent history of the "flu". Biochemistry tests show that she has renal impairement. serum sodium 140 mmol/L (137 - 144) serum potassium 4.2 mmol/L (3.5 - 4.9) serum urea 28 mol/L (2.5 - 7.5) serum creatinine 280 µmol/L (60 - 110) Her condition does not improve after several weeks on corticosteroid therapy, so a renal biopsy is performed. The biopsy demonstrates the presence of segmental sclerosis of 3 of 10 glomeruli identified in the biopsy specimen. Immunofluorescence studies and electron microscopy do not reveal evidence for immune deposits. What is the most appropriate advice to give regarding her condition? 1) She has an underlying malignancy 2) She may require a renal transplant in 10 years

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Corticosteroid therapy is practically mandatory in the following condition. (a) Septic shock (b) Renal transplant (c) Rheumatoid arthritis (d) Ulcerative colitis

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Last Answer : Ans: B

Choose the correct statement about methenamine (hexamine): A. It acts by getting converted to mandelic acid in the urinary tract B. It releases formaldehyde in acidic urine which inturn kills bacteria C. It is highly effective in acute urinary tract infections D. It is the preferred urinary antiseptic in patients with liver disease

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Last Answer : D. Both 'A' and 'B' are correct

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Last Answer : B. It is less liable to cause lactic acidosis

Which of the following is true concerning a 68 year old male with type 2 diabetes diagnosed with type IV renal tubal acidosis? 1) Aminoaciduria would be expected. 2) Fludrocortisone treatment is effective 3) Increased Glomerular filtration rate is expected. 4) Increased urinary bicarbonate would be expected. 5) Normal renal handling of K+ and H+

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Choose the correct statement about amiloride: A. It antagonises the action of aldosterone B. It can be used to treat lithium induced diabetes insipidus C. It increases calcium loss in urine D. It is dose to dose less potent than triamterene

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Last Answer : B. It can be used to treat lithium induced diabetes insipidus

Triamterene differs from spironolactone in that: A. It has greater natriuretic action B. Its K+ retaining action is not dependent on presence of aldosterone C. It acts from the luminal membrane side of the distal tubular cells D. Both ‘B’ and ‘C’ are correct

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Last Answer : D. Both ‘B’ and ‘C’ are correct

Aldosterone increases Na+ reabsorption and K+ excretion in the renal collecting duct cells by: A. Inducing synthesis of Na+K+ATPase B. Inducing synthesis of amiloride sensitive Na+ channels C. Translocating Na+ channels from cytosolic site to luminal membrane D. All of the above

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Last Answer : D. All of the above

Nonsteroidal antiinflammatory drugs reduce the diuretic action of furosemide by: A. Preventing prostaglandin mediated intrarenal haemodynamic actions B. Blocking the action in ascending limb of loop of Henle. C. Enhancing salt and water reabsorption in distal tubule D. Increasing aldosterone secretion

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Last Answer : A. Preventing prostaglandin mediated intrarenal haemodynamic actions

Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl– cotransport in the ascending limb of loop of Henle C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone

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Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K

Secretion of K+ in the late distal tubule and collecting ducts of kidney depends on: A. Intracellular K+ content B. Unabsorbed Na+ load presented to the distal segment C. Aldosterone level D. All of the above

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Last Answer : D. All of the above

Bradykinin and angiotensin II have the following feature common to both: A. They both cause fall in BP B. They both are degraded by Kininase II C. Their precursor proteins are plasma α2 globulins D. They both release aldosterone from adrenal cortex

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Angiotensin III is equipotent to angiotensin II in: A. Releasing aldosterone from adrenal cortex B. Promoting Na+ and water reabsorption by direct intrarenal action C. Causing vasoconstriction D. Contracting intestinal smooth muscle

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Last Answer : A. Releasing aldosterone from adrenal cortex

Aldosterone enhances Na+ reabsorption in renal tubules by: A. Stimulating carbonic anhydrase B. Activating Na+ K+ ATPase C. Inducing the synthesis of Na+ K+ ATPase D. Inducing renal prostaglandin synthesis

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Last Answer : C. Inducing the synthesis of Na+ K+ ATPase

The Na+ retaining action of aldosterone is exerted on the: A. Proximal convoluted tubule B. Ascending limb of loop of Henle C. Cortical diluting segment D. Distal convoluted tubul

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What is true of acyclovir treatment of genital herpes simplex: A. Topical treatment affords symptomatic relief in primary as well as recurrent disease B. Oral therapy for 10 days affords symptomatic relief as well as prevents recurrences C. Oral therapy for 10 days affords symptomatic relief but does not prevent recurrences D. Continuous long-term topical therapy is recommended to prevent recurrences

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Currently, under the mass programme (WHO/NLEP), the duration of multidrug therapy for multibacillary leprosy is: A. Two years fixed duration for all cases B. One year fixed duration for all cases C. Two years or more till disease inactivity is attained D. One year for cases with bacillary index 3 or less and two years for cases with bacillary index 4 or more

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Specific drug therapy to lower serum triglycerides (TG) in a subject with normal LDL-cholesterol level is indicated: A. In all subjects with serum TG> 150 mg/dl B. In subjects with existing coronary artery disease and serum TG > 150 mg/dl C. In subjects with HDL-cholesterol < 40 mg/dl and serum TG > 150 mg/dl D. Both 'B' and 'C' are correct

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