Description : Select the compound that is preferred for high dose intravenous corticosteroid pulse therapy: A. Cortisone B. Hydrocortisone C. Triamcinolone D. Methyl prednisolone
Last Answer : D. Methyl prednisolone
Description : The following glucocorticoid has significant mineralocorticoid activity also: A. Hydrocortisone B. Triamcinolone C. Dexamethasone D. Betamethasone
Last Answer : A. Hydrocortisone
Description : A patient being treated with 20 mg prednisolone daily has to be shifted on to dexamethasone. What should be his daily dose of dexamethasone: A. 0.75 mg B. 3 mg C. 10 mg D. 40 mg
Last Answer : B. 3 mg
Description : Dexamethasone differs from prednisolone in that it is: A. Longer acting B. More potent C. More selective D. All of the above
Last Answer : D. All of the above
Description : The following measure can minimise pituitary-adrenal suppression during long-term corticosteroid therapy: A. Use of betamethasone in place of prednisolone B. Use of prednisolone on alternate days C. Division of ... in three equal 8 hourly doses D. Administration of the total daily dose at bed time
Last Answer : B. Use of prednisolone on alternate days
Description : The corticosteroid preferred for replacement therapy in Addison’s disease is: A. Aldosterone B. Fludrocortisone C. Hydrocortisone D. Betamethasone
Last Answer : C. Hydrocortisone
Description : Which of the following glucocorticoids has significant mineralocorticoid activity also ? (a) Hydrocortisone (b) Triamcinolone (c) Dexamethasone (d) Betamethasone
Last Answer : Ans: A
Description : A patient of chronic bronchial asthma maintained on oral prednisolone 20 mg daily and inhaled salbutamol as required develops chest infection. Which of the following measures is recommended: A. ... mg/day C. No change/increase in prednisolone dose D. Substitute prednisolone with inhaled budesonid
Last Answer : C. No change/increase in prednisolone dose
Description : 6 A patient of chronic bronchial asthma was maintained on oral prednisolone 20 mg/day for 3 months. It was decided to switch him over to inhaled beclomethasone dipropionate 200 μg 4 times a day. What should ... week and then tapered D. Its dose should be doubled for one week and then tapered (p. 2
Last Answer : C. It should be given at the same dose for one week and then tapered
Description : Select the drug which tends to reverse insulin resistance by increasing cellular glucose transporters: A. Glibenclamide B. Rosiglitazone C. Acarbose D. Prednisolone
Last Answer : B. Rosiglitazone
Description : Long-term thiazide therapy can cause hyperglycaemia by: A. Reducing insulin release B. Interfering with glucose utilization in tissues C. Increasing sympathetic activity D. Increasing corticosteroid secretion
Last Answer : A. Reducing insulin release
Description : Select the progestin preparation for coadministration with estrogen for hormone replacement therapy that does not counteract the beneficial effect of the latter on lipid profile due to lack of ... oral progesterone B. Norethindrone C. Lynestrenol D. Medroxyprogesterone acetate (p. 281-282)
Last Answer : Select the indication for which a progestin is used alone without combining with an estrogen: A. Threatened abortion B. Dysfunctional uterine bleeding C. Hormone replacement therapy D. Premenstrual tension
Description : Choose the correct statement about codeine: A. It has a lower oral: parenteral activity ratio than morphine B. It is devoid of abuse liability C. It is a weaker analgesic than morphine D. It is a more potent antitussive than morphine
Last Answer : C. It is a weaker analgesic than morphine
Description : The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling
Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine
Description : Cancer chemotherapy induced vomiting that is not controlled by metoclopramide alone can be suppressed by combining it with: A. Amphetamine B. Dexamethasone C. Hyoscine D. Cyclizine
Last Answer : B. Dexamethasone
Description : The following is true about use of prednisolone in malignant diseases except: A. It is curative in acute childhood leukaemia B. It is used in Hodgkin’s disease C. It controls hypercalcaemia in patients with bony metastasis D. It affords symptomatic relief in most cancer patients
Last Answer : A. It is curative in acute childhood leukaemia
Description : The preferred drug for controlling an acute exacerbation of ulcerative colitis is: A. Prednisolone B. Sulfasalazine C. Mesalazine D. Vancomycin
Last Answer : . Prednisolone
Description : Hydrocortisone induces the synthesis of the following protein which in turn inhibits the enzyme phospholipase-A2: A. Heat shock protein-90 B. Inhibin C. Transcortin D. Lipocortin
Last Answer : D. Lipocortin
Description : Hydrocortisone exerts the following actions: A. Increases both K+ and Ca2+ excretion B. Decreases both K+ and Ca2+ excretion C. Decreases K+ but increases Ca2+ excretion D. Increases K+ but decreases Ca2+ excretion
Last Answer : A. Increases both K+ and Ca2+ excretion
Description : In a patient of diabetes mellitus maintained on insulin therapy, administration of the following drug can vitiate glycaemia control: A. Prednisolone B. Prazosin C. Paracetamol D. Phenytoin
Last Answer : A. Prednisolone
Description : 15.47 The following component of management protocol of status asthmaticus has now been shown to be useless: A. Intravenous aminophylline B. Intravenous hydrocortisone C. Nebulized salbutamol D. Nebulized ipratropium bromid
Last Answer : ntravenous aminophylline
Description : Drug cumulation is the basis of organ toxicity of the following drug when used for prolonged periods: A. Prednisolone B. Chloroquine C. Aspirin D. Hydralazine
Last Answer : B. Chloroquine
Description : A drug which is generally administered in standard doses without the need for dose individualization is: A. Insulin B. Mebendazole C. Prednisolone D. Digoxin
Last Answer : B. Mebendazole
Description : The following antirheumatic drug affords symptomatic relief but does not bring about remission in rheumatoid arthritis: A. Gold sodium thiomalate B. Prednisolone C. Hydroxychloroquine D. Leflunomide
Last Answer : B. Prednisolone
Description : Which of the following is a reserve drug but not a disease modifying drug in rheumatoid arthritis: A. Chloroquine B. Sulfasalazine C. Prednisolone D. Methotrexate
Last Answer : C. Prednisolone
Description : Choose the correct statement about nonsteroidal antiinflammatory drugs (NSAIDs): A. NSAIDs attenuate hypoglycaemic action of sulfonylureas B. NSAIDs potentiate antihypertensive action of ACE inhibitors C. ... D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Last Answer : D. Combined therapy with prednisolone and NSAIDs carries higher risk of gastric bleeding
Description : Bacteriostatic drugs are unlikely to effect cure of bacterial infection in the following category of patients except: A. Diabetic patients B. Patients with allergic disorders C. Patients on corticosteroid therapy D. Subacute bacterial endocarditis patient
Last Answer : B. Patients with allergic disorders
Description : ystemic corticosteroid therapy is not used routinely and is reserved only for severe cases of: A. Exfoliative dermatitis B. Posterior uveitis C. Acute rheumatic fever D. Hodgkin’s disease
Last Answer : C. Acute rheumatic feve
Description : Corticosteroid therapy is practically mandatory in the following condition: A. Septic shock B. Renal transplant C. Rheumatoid arthritis D. Ulcerative colitis
Last Answer : B. Renal transplan
Description : Budesonide is a: A. Nonsteroidal antiinflammatory drug B. High ceiling diuretic C. Inhaled corticosteroid for asthma D. Contraceptive
Last Answer : C. Inhaled corticosteroid for asthma
Description : Tinidazole differs from metronidazole in that: A. It is not active against anaerobic bacteria B. It has a broader spectrum of activity C. It has a longer elimination half life D. It has better oral absorption
Last Answer : C. It has a longer elimination half life
Description : Teicoplanin has the following feature(s): A. Antimicrobial activity and indications similar to vancomycin B. Long elimination half-life C. Efficacy in systemic infections by oral route D. Both ‘A’ and ‘B’ are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : 15.45 To be a useful inhaled glucocorticoid the drug should have: A. High oral bioavailability B. Low oral bioavailability C. Additional bronchodilator activity
Last Answer : B. Low oral bioavailability
Description : The quarternary analogues of belladonna alkaloids are preferred over the natural alkaloids for antisecretory/ antispasmodic indications because: A. They have additional nicotinic receptor blocking activity B. They are ... of CNS and ocular effects D. Dose to dose they are more potent than atropine
Last Answer : C. They are devoid of CNS and ocular effects
Description : Select the correct statement abut donepezil: A. It is a topical carbonic anhydrase inhibitor used in glaucoma B. It is a catechol-'O'-methyl transferase inhibitor used as adjuvant in ... affords symptomatic improvement in Alzheimer's disease D. It is a synthetic cannabinoid with antiemetic property
Last Answer : C. It is a cerebroselective anticholinesterase that affords symptomatic improvement in Alzheimer's diseas
Description : Select the antifungal drug which is administered only by the oral route: A. Amphotericin B B. Ketoconazole C. Griseofulvin D. Tolnaftate
Last Answer : C. Griseofulvin
Description : Select the fluoroquinolone which has high oral bioavailability, longer elimination half-life and which does not inhibit metabolism of theophylline: A. Norfloxacin B. Pefloxacin C. Lomefloxacin D. Ciprofloxacin
Last Answer : C. Lomefloxacin
Description : Select the oral iron preparation which does not impart metallic taste and has good oral tolerability despite high iron content but whose efficacy in treating iron deficiency anaemia has been questioned: A. Iron hydroxy polymaltose B. Ferrous succinate C. Ferrous fumarate D. Ferrous gluconate
Last Answer : A. Iron hydroxy polymaltose
Description : Select the most appropriate drug for regular prophylactic therapy in a 10 year old child who suffers from exercise induced asthma: A. Oral salbutamol B. Oral theophylline C. Inhaled sodium cromoglycate D. Inhaled salmeterol
Last Answer : C. Inhaled sodium cromoglycate
Description : Select the first choice drug for acute gout: A. Cochicine B. Indomethacin C. Allopurinol D. Dexamethasone
Last Answer : B. Indomethacin
Description : Select the drug which is neither analgesic, nor antiinflammatory, nor uricosuric, but is highly efficacious in acute gout: A. Prednisolone B. Colchicine C. Naproxen D. Sulfinpyrazone
Last Answer : B. Colchicine
Description : Select the macrolide antibiotic having clinically useful antileprotic activity: A. Azithromycin B. Clarithromycin C. Erythromycin D. Roxithromycin
Last Answer : B. Clarithromycin
Description : Select the drug having a narrow spectrum antiepileptic activity restricted to absence seizures: A. Lamotrigine B. Ethosuccimide C. Sodium valproate D. Primidone
Last Answer : . Ethosuccimide
Description : Select the compound which used for hormone replacement therapy in postmenopausal women serves the purpose of both estrogen and progestin with weak androgenic activity: A. Tibolone B. Mestranol C. Desogestrel D. Gestodene
Last Answer : A. Tibolone
Description : Select the drug that is neither bronchodilator nor antiinflammatory, but has antihistaminic and mast cell stabilizing activity: A. Sodium cromoglycate B. Ketotifen C. Beclomethasone dipropionate D. Chlorpheniramine
Last Answer : B. Ketotifen
Description : The barbiturate having higher anticonvulsant: sedative activity ratio is: A. Pentobarbitone B. Phenobarbitone C. Butabarbitone D. Thiopentone
Last Answer : B. Phenobarbitone
Description : Methyldopa lowers BP by: A. Inhibiting dopa decarboxylase in adrenergic nerve endings B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone C. Generating α-methyl ... as a false transmitter in peripheral adrenergic nerve endings D. Activating vascular dopamine receptors
Last Answer : B. Generating α-methyl noradrenaline in brain which reduces sympathetic tone
Description : The following androgen does not produce cholestatic jaundice as an adverse effect: A. Testosterone propionate B. Methyl testosterone C. Fluoxymesterone D. Stanozolo
Last Answer : A. Testosterone propionate
Description : Which of the following anticholinergic drugs is primarily used in preanaesthetic medication and during surgery: A. Glycopyrrolate B. Pipenzolate methyl bromide C. Isopropamide D. Dicyclomine
Last Answer : A. Glycopyrrolate
Description : The most efficacious inhibitor of catecholamine synthesis in the body is: A. α-methyl-p-tyrosine B. α-methyldopa C. α-methyl-norepinephrine D. Entacapone
Last Answer : A. α-methyl-p-tyrosine