Description : CHOOSE THE MOST APPROPRIATE RESPONSE 23.1 Which of the following drugs is a nondepolarizing neuromuscular blocker: A. Succinylcholine B. Vecuronium C. Decamethonium D. Dantrolene sodium
Last Answer : B. Vecuronium
Description : Select the muscle relaxant that is used to control spasticity associated with upper motor neurone paralysis: A. Vecuronium B. Succinylcholine C. Chlorzoxazone D. Baclofen
Last Answer : D. Baclofen
Description : ostoperative muscle soreness may be a side effect of the following neuromuscular blocker: A. d-tubocurarine B. Succinylcholine C. Pancuronium D. Atracurium
Last Answer : B. Succinylcholine
Description : The most rapidly acting nondepolarizing neuromuscular blocking agent which can be used as an alternative to succinylcholine for tracheal intubation is: A. Rocuronium B. Pancuronium C. Doxacurium D. Pipecuronium
Last Answer : A. Rocuronium
Description : Select the skeletal muscle relaxant that is commonly used for endotracheal intubation despite causing histamine release, K+ efflux from muscles and cardiovascular changes: A. Pipecuroniun B. Succinylcholine C. Pancuronium D. Cisatracurium
Description : Which of the following is applicable to mivacurium: A. It undergoes Hoffmann elimination B. It is the shortest acting nondepolarizing neuromuscular blocker C. It is excreted unchanged by kidney D. It does not cause histamine release
Last Answer : B. It is the shortest acting nondepolarizing neuromuscular blocker
Description : Only one of the following amines will lose its nitrogen atom as trimethyl amine by repeated Hofmann elimination reactions:
Last Answer : Only one of the following amines will lose its nitrogen atom as trimethyl amine by repeated Hofmann elimination reactions: A. B. C. D.
Description : Quartenry ammonium salt after Hofmann elimination gives--- a. Alcohol b. Alkene c. Alkyne d. Ammmonia
Last Answer : b. Alkene
Description : The following antibiotic accentuates the nuromuscular blockade produced by pancuronium: A. Streptomycin B. Erythromycin C. Penicillin G D. Chloramphenicol
Last Answer : A. Streptomycin
Description : Pancuronium differs from tubocurarine in that: A. It is a depolarizing blocker B. Its action is not reversed by neostigmine C. It can cause rise in BP on rapid I.V. injection D. It causes marked histamine release
Last Answer : C. It can cause rise in BP on rapid I.V. injection
Description : Succinylcholine is the preferred muscle relaxant for tracheal intubation because: A. It produces rapid and complete paralysis of respiratory muscles with quick recovery B. It does not alter heart rate or ... C. It does not cause histamine release D. It does not produce postoperative muscle soreness
Last Answer : A. It produces rapid and complete paralysis of respiratory muscles with quick recovery
Description : Succinylcholine produces spastic paralysis in: A. Rabbits B. Frogs C. Birds D. Patients with atypical pseudocholinesterase
Last Answer : C. Birds
Description : Which of the following most readily undergoes `E_(2)` elimination with a strong base?
Last Answer : Which of the following most readily undergoes `E_(2)` elimination with a strong base? A. 2- ... -Bromo-2,2-dimethylpropane D. 2-Bromo-3-methylbutane
Description : Tinidazole differs from metronidazole in that: A. It is not active against anaerobic bacteria B. It has a broader spectrum of activity C. It has a longer elimination half life D. It has better oral absorption
Last Answer : C. It has a longer elimination half life
Description : The following is true of quinine: A. It has a longer elimination half-life than chloroquine B. It is not to be used for prophylaxis of malaria C. It is not active against P. vivax D. It should not be used along with sulfa-pyrimethamine
Last Answer : B. It is not to be used for prophylaxis of malaria
Description : The following is true of clofazimine except: A. It is cidal to Mycobacterium leprae B. It has additional antiinflammatory property C. It has a very long elimination half life D. It discolours skin and sweat
Last Answer : A. It is cidal to Mycobacterium leprae
Description : Teicoplanin has the following feature(s): A. Antimicrobial activity and indications similar to vancomycin B. Long elimination half-life C. Efficacy in systemic infections by oral route D. Both ‘A’ and ‘B’ are correct
Last Answer : D. Both ‘A’ and ‘B’ are correct
Description : The distinctive features of azithromycin include the following except: A. Efficacy against organisms which have developed resistance to erythromycin B. Marked tissue distribution and intracellular penetration ... D. Low propensity to drug interactions due to inhibition of cytochrome P450 enzymes
Last Answer : A. Efficacy against organisms which have developed resistance to erythromycin
Description : The following is true of clarithromycin except: A. It produces less gastric irritation and pain than erythromycin B. It is the most active macrolide antibiotic against Helicobacter pylori ... terfenadine or cisapride to cause cardiac arrhythmias D. It exhibits dose dependent elimination kinetics
Last Answer : C. It does not interact with terfenadine or cisapride to cause cardiac arrhythmias
Description : Select the fluoroquinolone which has high oral bioavailability, longer elimination half-life and which does not inhibit metabolism of theophylline: A. Norfloxacin B. Pefloxacin C. Lomefloxacin D. Ciprofloxacin
Last Answer : C. Lomefloxacin
Description : Antimicrobial drug combinations are aimed at achieving the following except: A. Faster and more complete elimination of the infecting organism B. Treat infection when nature and sensitivity of the infecting organism is not definite C. Prevent emergence of resistant strains D. Prevent superinfection
Last Answer : D. Prevent superinfection
Description : Thiazide diuretics enhance K+ elimination in urine primarily by: A. Inhibiting proximal tubular K+ reabsorption B. Inhibiting Na+ K+-2Cl- cotransport in the ascending limb of loop of Henle C ... in the distal tubular fluid to exchange with interstitial K+ D. Potentiating the action of aldosterone
Last Answer : C. Increasing the availability of Na+ in the distal tubular fluid to exchange with interstitial K
Description : Which of the following is not an attribute of amlodipine: A. Generation of an active metabolite B. Large volume of distribution C. High and consistent oral bioavailability D. Long elimination half life
Last Answer : A. Generation of an active metabolit
Description : The most important channel of elimination of digoxin is: A. Glomerular filtration B. Tubular secretion C. Hepatic metabolism D. Excretion in bile
Last Answer : A. Glomerular filtration
Description : The general principles in the use of hypnotics include the following except: A. A hypnotic may be used intermittently for upto 2-3 weeks in short-term insomnia due to emotional stress B ... sleep apnoea D. A hypnotic with slow elimination is preferred in patients with early morning awakening
Last Answer : B. In patients with chronic insomnia a hypnotic should be used regularl
Description : At a single hypnotic dose, the pharmacokinetics of diazepam is characterised by: A. Slow elimination and little redistribution B. Slow elimination with marked redistribution C. Rapid elimination and marked redistribution D. Ultra rapid elimination
Last Answer : B. Slow elimination with marked redistribution
Description : Compared to pork/beef insulins, the human insulins: A. Are more potent B. Have a faster kinetics of absorption and elimination C. Have longer biological action half life D. Penetrate blood-brain barrier more efficiently
Last Answer : B. Have a faster kinetics of absorption and elimination
Description : If a drug has a constant bioavailability and first order elimination, its maintenance dose rate will be directly proportional to its: A. Volume of distribution B. Plasma protein binding C. Lipid solubility D. Total body clearance
Last Answer : D. Total body clearance
Description : If a drug is eliminated by first order kinetics: A. A constant amount of the drug will be eliminated per unit time B. Its clearance value will remain constant C. Its elimination half life will increase with dose D. It will be completely eliminated from the body in 2 × half life period
Last Answer : B. Its clearance value will remain constant
Description : Which of the following purgatives undergoes enterohepatic circulation to produce prolonged action: A. Docusates B. Phenolphthalein C. Castor oil D. Mag. sulfate
Last Answer : B. Phenolphthalein
Description : Select the organic nitrate which undergoes minimal first-pass metabolism in the liver: A. Glyceryl trinitrate B. Isosorbide dinitrate C. Isosorbide mononitrate D. Erythrityl tetranitrate
Last Answer : C. Isosorbide mononitrate
Description : The following is not true of morphine: A. Its 2-glucuronide metabolite is an active analgesic B. Its active metabolite penetrates blood-brain barrier better than morphine C. Its oral: parenteral activity ratio is 1:4 D. It undergoes enterohepatic cycling
Last Answer : B. Its active metabolite penetrates blood-brain barrier better than morphine
Description : If a drug undergoes net tubular secretion, its renal clearance will be: A. More than the glomerular filtration rate B. Equal to the glomerular filtration rate C. Less than the glomerular filtration rate D. Equal to the rate of urine formation
Last Answer : A. More than the glomerular filtration rate
Description : Drugs which undergo high degree of first-pass metabolism in liver: A. Have low oral bioavailability B. Are excreted primarily in bile C. Are contraindicated in liver disease D. Exhibit zero order kinetics of elimination
Last Answer : A. Have low oral bioavailability
Description : Myasthenia gravis is diagnosed with improved neuromuscular function by using (A) Donepezil (B) Edrophonium (C) Atropine (D) Pancuronium
Last Answer : (B) Edrophonium
Description : Depolarizing block may be done by A. Atracurium B. Neostegmin C. Succinylcholine D. rocuronuim
Last Answer : Ans: C
Description : Succinylcholine can produce all except A) Induce malignant hyperthermia in susceptible patients B) Prolonged paralysis occurs in case of butyrylcholinesterase abnormalities (as succinylcholine is not metabolized) C) Tachycardia, particularly in children D) Increase intraocular pressure
Description : In the hofmann-bromamide degradation reaction, the number of moles of NaOH and `Br_(2)` used per mole of amine produced are
Last Answer : In the hofmann-bromamide degradation reaction, the number of moles of NaOH and `Br_(2)` used per mole of ... moles of NaOH and one mole of `Br_(2)`
Description : under Hofmann conditions will give :
Last Answer : under Hofmann conditions will give : A. B. C. D.
Description : Hofmann rearrangement In the Hofmann rearrangement an unsubstituted amide is treated with sodium hydroxide and bromide to give a primary amine that ha
Last Answer : Hofmann rearrangement In the Hofmann rearrangement an unsubstituted amide is treated with sodium hydroxide and bromide to ... . `II gt I gt IV gt III`
Last Answer : Hofmann rearrangement In the Hofmann rearrangement an unsubstituted amide is treated with sodium hydroxide and bromide to ... O)overset(||)(C)-NH_(2)`
Description : The conversion of an amide by reaction `NaOH` and `Br_(2)` to primary amine that has one carbon than the strating amide is known as Hofmann-Bromoamide
Last Answer : The conversion of an amide by reaction `NaOH` and `Br_(2)` to primary amine that has one carbon than the ... ` Mechanism: A. B. C. D. all of these
Last Answer : The conversion of an amide by reaction `NaOH` and `Br_(2)` to primary amine that has one carbon than the strating ... : Find X and Y: A. B. C. D.
Last Answer : The conversion of an amide by reaction `NaOH` and `Br_(2)` to primary amine that has one carbon than the strating ... reaction: A. 1 B. 2 C. 3 D. 4
Description : Which of the following will give Hofmann-Bromoamide reaction?
Last Answer : Which of the following will give Hofmann-Bromoamide reaction? A. B. C. D.
Description : In the Hofmann-Bromamide rearrangement intermediate compounds are:
Last Answer : In the Hofmann-Bromamide rearrangement intermediate compounds are: A. `R -CONHBr` B. `[R-overset(O)overset(||)(C)- ... ` C. `R -N=C=O` D. all of these
Description : Which of the following is Hofmann mustard oil reaction?
Last Answer : Which of the following is Hofmann mustard oil reaction? A. Reaction of primary amine with `CHCI_(3 ... 2)` D. Reaction of armoatic amine with iodoform
Description : Is Hans hofmann a modern artist?
Last Answer : Need answer